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    CETN1 centrin 1 [ Homo sapiens (human) ]

    Gene ID: 1068, updated on 2-Nov-2024

    Summary

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    Official Symbol
    CETN1provided by HGNC
    Official Full Name
    centrin 1provided by HGNC
    Primary source
    HGNC:HGNC:1866
    See related
    Ensembl:ENSG00000177143 MIM:603187; AllianceGenome:HGNC:1866
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    CEN1; CETN
    Summary
    The protein encoded by this gene plays important roles in the determination of centrosome position and segregation, and in the process of microtubule severing. This protein is localized to the centrosome of interphase cells, and redistributes to the region of the spindle poles during mitosis, reflecting the dynamic behavior of the centrosome during the cell cycle. [provided by RefSeq, Jan 2015]
    Orthologs
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    Genomic context

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    See CETN1 in Genome Data Viewer
    Location:
    18p11.32
    Exon count:
    1
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 18 NC_000018.10 (580380..582114)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 18 NC_060942.1 (734775..736509)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 18 NC_000018.9 (580380..582114)

    Chromosome 18 - NC_000018.10Genomic Context describing neighboring genes Neighboring gene collectin subfamily member 12 Neighboring gene uncharacterized LOC107985155 Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr18:394012-395211 Neighboring gene ReSE screen-validated silencer GRCh37_chr18:419844-420037 Neighboring gene OCT4 hESC enhancer GRCh37_chr18:420584-421135 Neighboring gene Sharpr-MPRA regulatory region 14658 Neighboring gene ReSE screen-validated silencer GRCh37_chr18:505812-505991 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 13020 Neighboring gene long intergenic non-protein coding RNA 1925 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr18:535941-536594 Neighboring gene H3K27ac hESC enhancer GRCh37_chr18:564852-565352 Neighboring gene H3K27ac hESC enhancer GRCh37_chr18:565353-565853 Neighboring gene ReSE screen-validated silencer GRCh37_chr18:596737-596866 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 9239 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr18:597469-597968 Neighboring gene RN7SK pseudogene 146 Neighboring gene Sharpr-MPRA regulatory region 12053 Neighboring gene uncharacterized LOC105371952 Neighboring gene clusterin like 1 Neighboring gene MED14-independent group 3 enhancer GRCh37_chr18:641155-642354

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Exome sequencing and functional analyses revealed CETN1 variants leads to impaired cell division and male fertility. Sudhakar DVS, et al. Hum Mol Genet, 2023 Jan 27. PMID 36048845
    2. Conformational scanning of individual EF-hand motifs of calcium sensor protein centrin-1. Phanindranath R, et al. Biochem Biophys Res Commun, 2021 Sep 17. PMID 34273620
    3. The GIT-associated kinase PAK targets to the centrosome and regulates Aurora-A. Zhao ZS, et al. Mol Cell, 2005 Oct 28. PMID 16246726
    4. CETN1 is a cancer testis antigen with expression in prostate and pancreatic cancers. Kim JJ, et al. Biomark Res, 2013 Jun 13. PMID 24252580, Free PMC Article
    5. Knockdown of CETN1 inhibits breast cancer cells proliferation. Shuangta X, et al. J BUON, 2014 Jul-Sep. PMID 25261648

    See all (33) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Exome sequencing and functional analyses revealed CETN1 variants leads to impaired cell division and male fertility.
      Title: Exome sequencing and functional analyses revealed CETN1 variants leads to impaired cell division and male fertility.
    2. Human SFI1 and Centrin form a complex critical for centriole architecture and ciliogenesis.
      Title: Human SFI1 and Centrin form a complex critical for centriole architecture and ciliogenesis.
    3. Conformational scanning of individual EF-hand motifs of calcium sensor protein centrin-1.
      Title: Conformational scanning of individual EF-hand motifs of calcium sensor protein centrin-1.
    4. important spectral and hydrodynamic characteristics of human Centrin-1, accounting that HsCentrin-1 has moderate affinity for Ca(2+). Centrin-1 does not gain structure as seen by far- and near-UV circular dichroism, rather there is a loss of ellipticity, though inconsiderable upon binding Ca(2+).
      Title: Optimization of purification method and characterization of recombinant human Centrin-1.
    5. A chirality change in XPC- and Sfi1-derived peptides affects their affinity for centrin.
      Title: A chirality change in XPC- and Sfi1-derived peptides affects their affinity for centrin.
    6. CETN1 is overexpressed in breast cancer tissue and promotes cells'proliferation, tumor growth and metastasis.
      Title: Knockdown of CETN1 inhibits breast cancer cells proliferation.
    7. These data demonstrate a functional role for CaM binding to CP110 and suggest that CP110 cooperates with CaM and centrin to regulate progression through cytokinesis.
      Title: CP110 cooperates with two calcium-binding proteins to regulate cytokinesis and genome stability.
    Submit: New GeneRIF Correction

    Phenotypes

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    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Genotypes

    HIV-1 interactions

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    Protein interactions

    Protein Gene Interaction Pubs
    Pr55(Gag) gag Studies using a combined approach of immunofluorescence detection of Gag protein and in situ hybridization detection of viral genomic RNA indicate Gag co-localizes with Psi+ RNA in the perinuclear region and also co-localizes with centrins PubMed

    Go to the HIV-1, Human Interaction Database

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables G-protein beta/gamma-subunit complex binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables calcium ion binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables heterotrimeric G-protein binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables microtubule binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in cell division IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in cellular response to heat IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in centriole replication IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in microtubule cytoskeleton organization IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in centriole IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in centriole IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in centrosome IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in centrosome IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in centrosome IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    located_in cytosol TAS
    Traceable Author Statement
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in photoreceptor connecting cilium ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in spindle pole IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    centrin-1
    Names
    EF-hand protein
    calcium binding protein
    caltractin
    centrin, EF-hand protein, 1
    testicular tissue protein Li 37

    NCBI Reference Sequences (RefSeq)

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    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_004066.3 → NP_004057.1  centrin-1

      Status: REVIEWED

      Source sequence(s)
      AI198628, AP001178, BC029515
      Consensus CDS
      CCDS11820.1
      UniProtKB/Swiss-Prot
      B2R536, Q12798
      UniProtKB/TrEMBL
      A0A140VJG3
      Related
      ENSP00000319052.3, ENST00000327228.5
      Conserved Domains (1) summary
      PTZ00183
      Location:22 → 172
      PTZ00183; centrin; Provisional

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000018.10 Reference GRCh38.p14 Primary Assembly

      Range
      580380..582114
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060942.1 Alternate T2T-CHM13v2.0

      Range
      734775..736509
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q12798.1 GenPept UniProtKB/Swiss-Prot:Q12798

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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