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    CT45A6 cancer/testis antigen family 45 member A6 [ Homo sapiens (human) ]

    Gene ID: 541465, updated on 28-Oct-2024

    Summary

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    Official Symbol
    CT45A6provided by HGNC
    Official Full Name
    cancer/testis antigen family 45 member A6provided by HGNC
    Primary source
    HGNC:HGNC:33271
    See related
    Ensembl:ENSG00000278289 MIM:300797; AllianceGenome:HGNC:33271
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    CT45-5; CT45-6; CT45.6; CT45A5; CT45A7
    Expression
    Restricted expression toward testis (RPKM 10.1) See more
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    Genomic context

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    See CT45A6 in Genome Data Viewer
    Location:
    Xq26.3
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) X NC_000023.11 (135794685..135802787, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) X (PATCHES) NW_004070887.1 (725828..733930, complement)

    Chromosome X - NC_000023.11Genomic Context describing neighboring genes Neighboring gene cancer/testis antigen family 45 member A3 Neighboring gene cancer/testis antigen family 45 member A5 Neighboring gene cancer/testis antigen family 45 member A2 Neighboring gene cancer/testis antigen family 45 member A7

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. Identification of cancer/testis-antigen genes by massively parallel signature sequencing. Chen YT, et al. Proc Natl Acad Sci U S A, 2005 May 31. PMID 15905330, Free PMC Article
    2. Therapeutic targeting of the USP2-E2F4 axis inhibits autophagic machinery essential for zinc homeostasis in cancer progression. Xiao W, et al. Autophagy, 2022 Nov. PMID 35253629, Free PMC Article
    3. The DNA sequence of the human X chromosome. Ross MT, et al. Nature, 2005 Mar 17. PMID 15772651, Free PMC Article
    4. LukS-PV inhibits hepatocellular carcinoma cells migration by downregulating HDAC6 expression. Xu X, et al. BMC Cancer, 2022 Jun 8. PMID 35676659, Free PMC Article
    5. Histone deacetylase inhibitors inhibit cervical cancer growth through Parkin acetylation-mediated mitophagy. Sun X, et al. Acta Pharm Sin B, 2022 Feb. PMID 35256949, Free PMC Article

    See all (7) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Phenotypes

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    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Genotypes

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    General protein information

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    Preferred Names
    cancer/testis antigen family 45 member A6
    Names
    Cancer/testis antigen 45-5
    Cancer/testis antigen 45A5
    Cancer/testis antigen 45A7
    Cancer/testis antigen family 45 member A5
    Cancer/testis antigen family 45 member A7
    cancer/testis antigen 45-4/6
    cancer/testis antigen 45-6
    cancer/testis antigen 45A4/45A6
    cancer/testis antigen 45A6
    cancer/testis antigen CT45-6
    cancer/testis antigen family 45 member A4/A6

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001017438.3 → NP_001017438.2  cancer/testis antigen family 45 member A6

      See identical proteins and their annotated locations for NP_001017438.2

      Status: VALIDATED

      Source sequence(s)
      AC240441
      Consensus CDS
      CCDS35407.1
      UniProtKB/Swiss-Prot
      P0DMU7, P0DMU8, P0DMV0
      Related
      ENSP00000479608.2, ENST00000620654.2
      Conserved Domains (1) summary
      pfam15300
      Location:122 → 183
      INT_SG_DDX_CT_C; INTS6/SAGE1/DDX26B/CT45 C-terminus

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000023.11 Reference GRCh38.p14 Primary Assembly

      Range
      135794685..135802787 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011531351.3 → XP_011529653.1  cancer/testis antigen family 45 member A6 isoform X1

      See identical proteins and their annotated locations for XP_011529653.1

      UniProtKB/Swiss-Prot
      P0DMU7, P0DMU8, P0DMV0
      Related
      ENSP00000483910.1, ENST00000612878.4
      Conserved Domains (1) summary
      pfam15300
      Location:122 → 183
      INT_SG_DDX_CT_C; INTS6/SAGE1/DDX26B/CT45 C-terminus

    2. XM_005262425.5 → XP_005262482.2  cancer/testis antigen family 45 member A6 isoform X1

      See identical proteins and their annotated locations for XP_005262482.2

      UniProtKB/Swiss-Prot
      P0DMU7, P0DMU8, P0DMV0
      Conserved Domains (1) summary
      pfam15300
      Location:122 → 183
      INT_SG_DDX_CT_C; INTS6/SAGE1/DDX26B/CT45 C-terminus
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P0DMU7.1 GenPept UniProtKB/Swiss-Prot:P0DMU7

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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