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    Mrgprf MAS-related GPR, member F [ Mus musculus (house mouse) ]

    Gene ID: 211577, updated on 2-Nov-2024

    Summary

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    Official Symbol
    Mrgprfprovided by MGI
    Official Full Name
    MAS-related GPR, member Fprovided by MGI
    Primary source
    MGI:MGI:2384823
    See related
    Ensembl:ENSMUSG00000031070 AllianceGenome:MGI:2384823
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Mgrc; MrgF
    Summary
    Predicted to enable G protein-coupled receptor activity. Predicted to be involved in G protein-coupled receptor signaling pathway. Predicted to be located in nuclear membrane. Predicted to be active in plasma membrane. Orthologous to human MRGPRF (MAS related GPR family member F). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Broad expression in stomach adult (RPKM 33.6), colon adult (RPKM 25.5) and 15 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Mrgprf in Genome Data Viewer
    Location:
    7 F5; 7 89.05 cM
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (144854646..144863294)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (145300909..145309557)

    Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_20566 Neighboring gene predicted gene 45181 Neighboring gene two pore segment channel 2 Neighboring gene STARR-seq mESC enhancer starr_20567 Neighboring gene VISTA enhancer mm1497 Neighboring gene small integral membrane protein 38 Neighboring gene STARR-seq mESC enhancer starr_20570 Neighboring gene CapStarr-seq enhancer MGSCv37_chr7:152429156-152429339 Neighboring gene STARR-positive B cell enhancer ABC_E3765 Neighboring gene STARR-seq mESC enhancer starr_20571 Neighboring gene STARR-seq mESC enhancer starr_20573 Neighboring gene MAS-related GPR, member D

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. The ORF49 protein of murine gammaherpesvirus 68 cooperates with RTA in regulating virus replication. Lee S, et al. J Virol, 2007 Sep. PMID 17634244, Free PMC Article
    2. The effect of inflammation on the expression and distribution of the MAS-related gene receptors MrgE and MrgF in the murine ileum. Avula LR, et al. Histochem Cell Biol, 2011 Nov. PMID 21912971
    3. Single-cell profiling reveals heterogeneity and functional patterning of GPCR expression in the vascular system. Kaur H, et al. Nat Commun, 2017 Jun 16. PMID 28621310, Free PMC Article
    4. Orphan G protein-coupled receptors MrgA1 and MrgC11 are distinctively activated by RF-amide-related peptides through the Galpha q/11 pathway. Han SK, et al. Proc Natl Acad Sci U S A, 2002 Nov 12. PMID 12397184, Free PMC Article
    5. A diverse family of GPCRs expressed in specific subsets of nociceptive sensory neurons. Dong X, et al. Cell, 2001 Sep 7. PMID 11551509

    See all (21) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. The number of enteric neurons expressing MrgE and MrgF receptors was significantly reduced during intestinal schistosomiasis and ileitis.
      Title: The effect of inflammation on the expression and distribution of the MAS-related gene receptors MrgE and MrgF in the murine ileum.
    2. ORF49 protein promoted the ability of RTA to activate downstream target promoters and enhanced murine gammaherpesvirus 68 replication
      Title: The ORF49 protein of murine gammaherpesvirus 68 cooperates with RTA in regulating virus replication.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Clone Names

    • MGC18825

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables G protein-coupled receptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables G protein-coupled receptor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in G protein-coupled receptor signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in G protein-coupled receptor signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in nuclear membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nuclear membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    mas-related G-protein coupled receptor member F
    Names
    G protein-coupled receptor RTA
    Mas-related G protein-coupled receptor c
    mas-related gene F protein

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_145379.2 → NP_663354.1  mas-related G-protein coupled receptor member F

      See identical proteins and their annotated locations for NP_663354.1

      Status: PROVISIONAL

      Source sequence(s)
      AC132081
      Consensus CDS
      CCDS22056.1
      UniProtKB/Swiss-Prot
      Q8VCJ6, Q91ZB6
      Related
      ENSMUSP00000033386.6, ENSMUST00000033386.12
      Conserved Domains (1) summary
      pfam00001
      Location:62 → 291
      7tm_1; 7 transmembrane receptor (rhodopsin family)

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000073.7 Reference GRCm39 C57BL/6J

      Range
      144854646..144863294
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006508537.5 → XP_006508600.1  mas-related G-protein coupled receptor member F isoform X1

      See identical proteins and their annotated locations for XP_006508600.1

      UniProtKB/TrEMBL
      Q3TZA7
      Conserved Domains (1) summary
      cd15109
      Location:29 → 302
      7tmA_MrgprF; mas-related G protein-coupled receptor subtype F, member of the class A family of seven-transmembrane G protein-coupled receptors
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8VCJ6.1 GenPept UniProtKB/Swiss-Prot:Q8VCJ6

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Chemical Information
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