Zfp385a zinc finger protein 385A [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Zfp385aprovided by MGI
Official Full Name: zinc finger protein 385Aprovided by MGI
Primary source: MGI:MGI:1352495
See related: Ensembl:ENSMUSG00000000552 AllianceGenome:MGI:1352495
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Hzf; Zfp385; Znf385a
Summary: Enables mRNA 3'-UTR binding activity. Involved in DNA damage response and apoptotic process. Acts upstream of or within several processes, including myeloid cell differentiation; platelet alpha granule organization; and post-transcriptional regulation of gene expression. Located in dendrite and neuronal cell body. Is expressed in several structures, including branchial arch; central nervous system; genitourinary system; hemolymphoid system; and sensory organ. Orthologous to human ZNF385A (zinc finger protein 385A). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Ubiquitous expression in testis adult (RPKM 30.8), cerebellum adult (RPKM 17.9) and 27 other tissues See more
Orthologs: human all
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Genomic context

Location:: 15 F3; 15 58.88 cM

Exon count:: 15

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	15	NC_000081.7 (103222322..103248537, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	15	NC_000081.6 (103313895..103340086, complement)

Chromosome 15 - NC_000081.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

DISC1 binds ITPR1 mRNA with HZF, thereby regulating its dendritic transport for synaptic plasticity.
Title: Disrupted-in-schizophrenia 1 regulates transport of ITPR1 mRNA for synaptic plasticity.
Hzf and HuR independently associate with the 3'UTR of p53 mRNA and together regulate the translation of p53 mRNA and regulate the nuclear export of p53 mRNA in response to signals that induce p53 activation.
Title: Cooperative role of the RNA-binding proteins Hzf and HuR in p53 activation.
Hzf physically interacts with the 3' untranslated region of C/EBPalpha mRNA to enhance its translation during adipogenesis.
Title: Hzf regulates adipogenesis through translational control of C/EBPalpha.
In the present study we demonstrated that mice lacking Hzf (Hzf(-/-) mice) exhibited severe impairments of motor coordination and cerebellum-dependent motor learning.
Title: Impaired motor functions in mice lacking the RNA-binding protein Hzf.
Hzf determines cell survival under genotoxic stress by modulating p53 transactivation.
Title: Hzf Determines cell survival upon genotoxic stress by modulating p53 transactivation.
Hzf is essential for megakaryopoiesis and hemostasis in vivo
Title: Zinc finger protein, Hzf, is required for megakaryocyte development and hemostasis.
Hzf is an RNA-binding protein that controls the dendritic mRNA localization and activity-dependent translation of type 1 inositol 1,4,5-trisphosphate receptor mRNA, a process that is impaired in Hzf mutant mice
Title: Hzf protein regulates dendritic localization and BDNF-induced translation of type 1 inositol 1,4,5-trisphosphate receptor mRNA.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Gene trapped (1) 1 citation
Targeted (1) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

Zfp385 (e-PCR), detects polymorphism
- UniSTS:468185

Zfp385 (e-PCR), detects polymorphism
- UniSTS:468186

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables mRNA 3'-UTR binding	IBA Inferred from Biological aspect of Ancestor more info
enables mRNA 3'-UTR binding	IDA Inferred from Direct Assay more info	PubMed
enables p53 binding	IEA Inferred from Electronic Annotation more info
enables p53 binding	ISO Inferred from Sequence Orthology more info
enables zinc ion binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in DNA damage response	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in apoptotic process	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within hemostasis	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within intracellular mRNA localization	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within learning or memory	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within locomotory behavior	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in mRNA localization resulting in post-transcriptional regulation of gene expression	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within mRNA localization resulting in post-transcriptional regulation of gene expression	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within megakaryocyte development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in megakaryocyte development	NAS Non-traceable Author Statement more info	PubMed
involved_in negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within platelet alpha granule organization	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within platelet formation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within positive regulation of fat cell differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of cytoplasmic translation	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within regulation of cytoplasmic translation	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in chromatin	IEA Inferred from Electronic Annotation more info
located_in chromatin	ISO Inferred from Sequence Orthology more info
located_in cytosol	IEA Inferred from Electronic Annotation more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
located_in dendrite	IDA Inferred from Direct Assay more info	PubMed
is_active_in neuronal cell body	IBA Inferred from Biological aspect of Ancestor more info
located_in neuronal cell body	IDA Inferred from Direct Assay more info	PubMed
located_in nucleolus	IEA Inferred from Electronic Annotation more info
located_in nucleoplasm	IEA Inferred from Electronic Annotation more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: zinc finger protein 385A

Names: hematopoietic zinc finger protein; zinc finger protein 385

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001356627.2 → NP_001343556.1 zinc finger protein 385A isoform 2

Status: VALIDATED

Source sequence(s)

AC164069

Consensus CDS

CCDS88860.1

Related

ENSMUSP00000155498.2, ENSMUST00000229373.2

Conserved Domains (2) summary

sd00020
Location:183 → 205

ZF_C2H2; C2H2 Zn finger [structural motif]

pfam12874
Location:241 → 265

zf-met; Zinc-finger of C2H2 type
NM_001411887.1 → NP_001398816.1 zinc finger protein 385A isoform 2

Status: VALIDATED

Source sequence(s)

AC164069
NM_001411888.1 → NP_001398817.1 zinc finger protein 385A isoform 2

Status: VALIDATED

Source sequence(s)

AC164069
NM_001411889.1 → NP_001398818.1 zinc finger protein 385A isoform 2

Status: VALIDATED

Source sequence(s)

AC164069
NM_013866.3 → NP_038894.2 zinc finger protein 385A isoform 1

See identical proteins and their annotated locations for NP_038894.2

Status: VALIDATED

Source sequence(s)

AC164069

Consensus CDS

CCDS49743.1

UniProtKB/Swiss-Prot

G3UWA5, Q8VD12, Q9QY68

Related

ENSMUSP00000130176.2, ENSMUST00000168828.3

Conserved Domains (2) summary

sd00020
Location:203 → 225

ZF_C2H2; C2H2 Zn finger [structural motif]

pfam12874
Location:262 → 285

zf-met; Zinc-finger of C2H2 type

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000081.7 Reference GRCm39 C57BL/6J

Range

103222322..103248537 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006521053.4 → XP_006521116.1 zinc finger protein 385A isoform X2

See identical proteins and their annotated locations for XP_006521116.1

UniProtKB/Swiss-Prot

Q8VD12

Conserved Domains (2) summary

sd00020
Location:183 → 205

ZF_C2H2; C2H2 Zn finger [structural motif]

pfam12874
Location:241 → 265

zf-met; Zinc-finger of C2H2 type
XM_011245656.4 → XP_011243958.1 zinc finger protein 385A isoform X2

See identical proteins and their annotated locations for XP_011243958.1

UniProtKB/Swiss-Prot

Q8VD12

Conserved Domains (2) summary

sd00020
Location:183 → 205

ZF_C2H2; C2H2 Zn finger [structural motif]

pfam12874
Location:241 → 265

zf-met; Zinc-finger of C2H2 type
XM_006521054.5 → XP_006521117.1 zinc finger protein 385A isoform X3

UniProtKB/TrEMBL

A0A2R8VHX5

Related

ENSMUSP00000155501.2, ENSMUST00000229551.2

Conserved Domains (2) summary

sd00020
Location:164 → 186

ZF_C2H2; C2H2 Zn finger [structural motif]

pfam12874
Location:223 → 246

zf-met; Zinc-finger of C2H2 type
XM_006521056.3 → XP_006521119.1 zinc finger protein 385A isoform X4

See identical proteins and their annotated locations for XP_006521119.1

Conserved Domains (2) summary

sd00020
Location:154 → 176

ZF_C2H2; C2H2 Zn finger [structural motif]

pfam12874
Location:213 → 236

zf-met; Zinc-finger of C2H2 type
XM_036159454.1 → XP_036015347.1 zinc finger protein 385A isoform X1

Conserved Domains (2) summary

sd00020
Location:236 → 258

ZF_C2H2; C2H2 Zn finger [structural motif]

pfam12874
Location:294 → 318

zf-met; Zinc-finger of C2H2 type
XM_006521055.5 → XP_006521118.1 zinc finger protein 385A isoform X4

See identical proteins and their annotated locations for XP_006521118.1

Conserved Domains (2) summary

sd00020
Location:154 → 176

ZF_C2H2; C2H2 Zn finger [structural motif]

pfam12874
Location:213 → 236

zf-met; Zinc-finger of C2H2 type