Taf2 TATA-box binding protein associated factor 2 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Taf2provided by MGI
Official Full Name: TATA-box binding protein associated factor 2provided by MGI
Primary source: MGI:MGI:2443028
See related: Ensembl:ENSMUSG00000037343 AllianceGenome:MGI:2443028
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: TAF2B; CIF150; TAFII150; TAFII-150; 4732460C16Rik
Summary: Predicted to enable chromatin binding activity and transcription cis-regulatory region binding activity. Predicted to contribute to RNA polymerase II general transcription initiation factor activity. Predicted to be involved in G2/M transition of mitotic cell cycle; positive regulation of transcription initiation by RNA polymerase II; and transcription by RNA polymerase II. Predicted to be located in nucleus. Predicted to be part of transcription factor TFIID complex and transcription factor TFTC complex. Is expressed in tail. Human ortholog(s) of this gene implicated in autosomal recessive intellectual developmental disorder 40. Orthologous to human TAF2 (TATA-box binding protein associated factor 2). [provided by Alliance of Genome Resources, Oct 2024]
Expression: Ubiquitous expression in CNS E11.5 (RPKM 13.6), CNS E14 (RPKM 10.8) and 28 other tissues See more
Orthologs: human all
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Genomic context

Location:: 15 D1; 15 21.96 cM

Exon count:: 27

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	15	NC_000081.7 (54878525..54935580, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	15	NC_000081.6 (55015129..55072187, complement)

Chromosome 15 - NC_000081.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

TAF8 regions important for TFIID lobe B assembly or for TAF2 interactions are required for embryonic stem cell survival.
Title: TAF8 regions important for TFIID lobe B assembly or for TAF2 interactions are required for embryonic stem cell survival.

Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (1)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
contributes_to RNA polymerase II general transcription initiation factor activity	IBA Inferred from Biological aspect of Ancestor more info
enables chromatin binding	IBA Inferred from Biological aspect of Ancestor more info
enables transcription cis-regulatory region binding	IBA Inferred from Biological aspect of Ancestor more info
enables transcription cis-regulatory region binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in G2/M transition of mitotic cell cycle	ISO Inferred from Sequence Orthology more info
involved_in RNA polymerase II preinitiation complex assembly	ISO Inferred from Sequence Orthology more info
involved_in RNA polymerase II preinitiation complex assembly	ISS Inferred from Sequence or Structural Similarity more info
involved_in mRNA transcription by RNA polymerase II	ISO Inferred from Sequence Orthology more info
involved_in mRNA transcription by RNA polymerase II	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of DNA-templated transcription	NAS Non-traceable Author Statement more info	PubMed
involved_in positive regulation of transcription initiation by RNA polymerase II	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of transcription initiation by RNA polymerase II	ISS Inferred from Sequence or Structural Similarity more info
involved_in regulation of DNA repair	NAS Non-traceable Author Statement more info	PubMed
involved_in regulation of transcription by RNA polymerase II	ISO Inferred from Sequence Orthology more info
involved_in transcription initiation at RNA polymerase II promoter	IBA Inferred from Biological aspect of Ancestor more info
involved_in transcription initiation at RNA polymerase II promoter	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in nucleus	ISO Inferred from Sequence Orthology more info
located_in nucleus	ISS Inferred from Sequence or Structural Similarity more info
part_of transcription factor TFIID complex	IBA Inferred from Biological aspect of Ancestor more info
part_of transcription factor TFIID complex	ISO Inferred from Sequence Orthology more info	PubMed
part_of transcription factor TFIID complex	ISS Inferred from Sequence or Structural Similarity more info
part_of transcription factor TFTC complex	ISO Inferred from Sequence Orthology more info
part_of transcription factor TFTC complex	NAS Non-traceable Author Statement more info	PubMed

General protein information

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Preferred Names: transcription initiation factor TFIID subunit 2

Names: TAF2 RNA polymerase II, TATA box binding protein (TBP)-associated factor; TBP-associated factor 150 kDa; transcription initiation factor TFIID 150 kDa subunit

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001081288.1 → NP_001074757.1 transcription initiation factor TFIID subunit 2

See identical proteins and their annotated locations for NP_001074757.1

Status: VALIDATED

Source sequence(s)

AC137950

Consensus CDS

CCDS37075.1

UniProtKB/Swiss-Prot

Q8BKQ7, Q8C176

UniProtKB/TrEMBL

B9EJX5

Related

ENSMUSP00000043733.8, ENSMUST00000041733.9

Conserved Domains (1) summary

cd09839
Location:27 → 541

M1_TAF2; TATA binding protein (TBP) associated factor 2

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000081.7 Reference GRCm39 C57BL/6J

Range

54878525..54935580 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_011245657.4 → XP_011243959.1 transcription initiation factor TFIID subunit 2 isoform X1

UniProtKB/Swiss-Prot

Q8BKQ7, Q8C176

Conserved Domains (1) summary

cd09839
Location:28 → 527

M1_like_TAF2; TATA binding protein (TBP) associated factor 2
XM_006521076.5 → XP_006521139.1 transcription initiation factor TFIID subunit 2 isoform X2

UniProtKB/Swiss-Prot

Q8BKQ7, Q8C176

Conserved Domains (1) summary

cd09839
Location:28 → 523

M1_like_TAF2; TATA binding protein (TBP) associated factor 2