Trmt12 tRNA methyltransferase 12 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Trmt12provided by MGI
Official Full Name: tRNA methyltransferase 12provided by MGI
Primary source: MGI:MGI:1915510
See related: Ensembl:ENSMUSG00000037085 AllianceGenome:MGI:1915510
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Tyw2; 4632406N01Rik
Summary: Predicted to enable tRNA methyltransferase activity. Predicted to be involved in tRNA methylation and wybutosine biosynthetic process. Predicted to be active in cytoplasm. Orthologous to human TRMT12 (tRNA methyltransferase 12 homolog). [provided by Alliance of Genome Resources, Oct 2024]
Orthologs: human all
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Genomic context

Location:: 15 D1; 15 25.09 cM

Exon count:: 1

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	15	NC_000081.7 (58744498..58748630)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	15	NC_000081.6 (58872649..58876781)

Chromosome 15 - NC_000081.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (2)

General gene information

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Markers

AI449275 (e-PCR)
- UniSTS:165928

AW742727 (e-PCR)
- UniSTS:209089

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables tRNA 4-demethylwyosine alpha-amino-alpha-carboxypropyltransferase activity	IEA Inferred from Electronic Annotation more info
enables tRNA methyltransferase activity	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in tRNA methylation	IBA Inferred from Biological aspect of Ancestor more info
involved_in tRNA modification	IEA Inferred from Electronic Annotation more info
involved_in wybutosine biosynthetic process	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: tRNA wybutosine-synthesizing protein 2 homolog

Names: alpha-amino-alpha-carboxypropyl transferase TYW2; tRNA methyltranferase 12 homolog; tRNA(Phe) (4-demethylwyosine(37)-C(7)) aminocarboxypropyltransferase; tRNA-yW-synthesizing protein 2

NP_080918.2

EC 2.5.1.114

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_026642.2 → NP_080918.2 tRNA wybutosine-synthesizing protein 2 homolog

See identical proteins and their annotated locations for NP_080918.2

Status: VALIDATED

Source sequence(s)

AC107772

Consensus CDS

CCDS37081.1

UniProtKB/Swiss-Prot

Q0P5W5, Q7TNQ8, Q8BG71, Q9D2N1

Related

ENSMUSP00000047831.8, ENSMUST00000036937.9

Conserved Domains (2) summary

COG0270
Location:228 → 313

Dcm; Site-specific DNA-cytosine methylase [Replication, recombination and repair]

pfam02475
Location:122 → 324

Met_10; Met-10+ like-protein