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    Trmt12 tRNA methyltransferase 12 [ Mus musculus (house mouse) ]

    Gene ID: 68260, updated on 28-Oct-2024

    Summary

    Official Symbol
    Trmt12provided by MGI
    Official Full Name
    tRNA methyltransferase 12provided by MGI
    Primary source
    MGI:MGI:1915510
    See related
    Ensembl:ENSMUSG00000037085 AllianceGenome:MGI:1915510
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Tyw2; 4632406N01Rik
    Summary
    Predicted to enable tRNA methyltransferase activity. Predicted to be involved in tRNA methylation and wybutosine biosynthetic process. Predicted to be active in cytoplasm. Orthologous to human TRMT12 (tRNA methyltransferase 12 homolog). [provided by Alliance of Genome Resources, Oct 2024]
    Orthologs
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    Genomic context

    See Trmt12 in Genome Data Viewer
    Location:
    15 D1; 15 25.09 cM
    Exon count:
    1
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 15 NC_000081.7 (58744498..58748630)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 15 NC_000081.6 (58872649..58876781)

    Chromosome 15 - NC_000081.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 41329 Neighboring gene transmembrane protein 65 Neighboring gene STARR-positive B cell enhancer ABC_E5480 Neighboring gene predicted gene, 24041 Neighboring gene STARR-positive B cell enhancer ABC_E3141 Neighboring gene STARR-positive B cell enhancer ABC_E3142 Neighboring gene predicted gene, 36509 Neighboring gene ring finger protein 139 Neighboring gene TatD DNase domain containing 1

    Genomic regions, transcripts, and products

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (2) 

    General gene information

    Markers

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables tRNA 4-demethylwyosine alpha-amino-alpha-carboxypropyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables tRNA methyltransferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    Process Evidence Code Pubs
    involved_in tRNA methylation IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in tRNA modification IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in wybutosine biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
     

    General protein information

    Preferred Names
    tRNA wybutosine-synthesizing protein 2 homolog
    Names
    alpha-amino-alpha-carboxypropyl transferase TYW2
    tRNA methyltranferase 12 homolog
    tRNA(Phe) (4-demethylwyosine(37)-C(7)) aminocarboxypropyltransferase
    tRNA-yW-synthesizing protein 2
    NP_080918.2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_026642.2NP_080918.2  tRNA wybutosine-synthesizing protein 2 homolog

      See identical proteins and their annotated locations for NP_080918.2

      Status: VALIDATED

      Source sequence(s)
      AC107772
      Consensus CDS
      CCDS37081.1
      UniProtKB/Swiss-Prot
      Q0P5W5, Q7TNQ8, Q8BG71, Q9D2N1
      Related
      ENSMUSP00000047831.8, ENSMUST00000036937.9
      Conserved Domains (2) summary
      COG0270
      Location:228313
      Dcm; Site-specific DNA-cytosine methylase [Replication, recombination and repair]
      pfam02475
      Location:122324
      Met_10; Met-10+ like-protein

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000081.7 Reference GRCm39 C57BL/6J

      Range
      58744498..58748630
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)