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    Hdac9 histone deacetylase 9 [ Mus musculus (house mouse) ]

    Gene ID: 79221, updated on 2-Nov-2024

    Summary

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    Official Symbol
    Hdac9provided by MGI
    Official Full Name
    histone deacetylase 9provided by MGI
    Primary source
    MGI:MGI:1931221
    See related
    Ensembl:ENSMUSG00000004698 AllianceGenome:MGI:1931221
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    HD9; HD7B; HDRP; Mitr; Hdac7b; mKIAA0744; D030072B18Rik
    Summary
    Enables DNA-binding transcription factor binding activity; histone H3K deacetylase activity; and transcription corepressor activity. Involved in negative regulation of gene expression, epigenetic. Acts upstream of or within several processes, including determination of adult lifespan; negative regulation of transcription by RNA polymerase II; and regulation of myotube differentiation. Part of histone methyltransferase complex. Is expressed in several structures, including 2-cell stage embryo; heart; musculoskeletal system; nervous system; and trunk myotome. Orthologous to human HDAC9 (histone deacetylase 9). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Broad expression in frontal lobe adult (RPKM 2.7), cortex adult (RPKM 1.4) and 21 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Hdac9 in Genome Data Viewer
    Location:
    12 A3; 12 15.06 cM
    Exon count:
    43
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 12 NC_000078.7 (34097579..34967094, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 12 NC_000078.6 (34047580..34917095, complement)

    Chromosome 12 - NC_000078.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 40383 Neighboring gene STARR-seq mESC enhancer starr_31899 Neighboring gene Fer3 like bHLH transcription factor Neighboring gene twist basic helix-loop-helix transcription factor 1 Neighboring gene STARR-seq mESC enhancer starr_31900 Neighboring gene predicted gene, 40384 Neighboring gene predicted gene, 51984 Neighboring gene ribosomal protein S2 pseudogene Neighboring gene STARR-positive B cell enhancer ABC_E8481 Neighboring gene predicted gene, 40875 Neighboring gene predicted gene, 24429 Neighboring gene predicted gene, 33864 Neighboring gene phosphoribosyl pyrophosphate synthetase 1-like 1 Neighboring gene predicted gene, 40385

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. HDAC9-mediated epithelial cell cycle arrest in G2/M contributes to kidney fibrosis in male mice. Zhang Y, et al. Nat Commun, 2023 May 25. PMID 37230975, Free PMC Article
    2. Increase in HDAC9 suppresses myoblast differentiation via epigenetic regulation of autophagy in hypoxia. Zhang Z, et al. Cell Death Dis, 2019 Jul 18. PMID 31320610, Free PMC Article
    3. Histone Deacetylase 9 Activates IKK to Regulate Atherosclerotic Plaque Vulnerability. Asare Y, et al. Circ Res, 2020 Aug 28. PMID 32546048
    4. HDAC9 deficiency promotes tumor progression by decreasing the CD8(+) dendritic cell infiltration of the tumor microenvironment. Ning Y, et al. J Immunother Cancer, 2020 Jun. PMID 32554611, Free PMC Article
    5. Impaired autophagy triggered by HDAC9 in mesenchymal stem cells accelerates bone mass loss. Zhang L, et al. Stem Cell Res Ther, 2020 Jul 3. PMID 32620134, Free PMC Article

    See all (106) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. LncRNA SNHG12 suppresses adipocyte inflammation and insulin resistance by regulating the HDAC9/Nrf2 axis.
      Title: LncRNA SNHG12 suppresses adipocyte inflammation and insulin resistance by regulating the HDAC9/Nrf2 axis.
    2. Transgenic Overexpression of HDAC9 Promotes Adipocyte Hypertrophy, Insulin Resistance and Hepatic Steatosis in Aging Mice.
      Title: Transgenic Overexpression of HDAC9 Promotes Adipocyte Hypertrophy, Insulin Resistance and Hepatic Steatosis in Aging Mice.
    3. CircHDAC9 regulates myocardial ischemia-reperfusion injury via miR-671-5p/SOX4 signaling axis.
      Title: CircHDAC9 regulates myocardial ischemia-reperfusion injury via miR-671-5p/SOX4 signaling axis.
    4. Identification of HDAC9 and ARRDC4 as potential biomarkers and targets for treatment of type 2 diabetes.
      Title: Identification of HDAC9 and ARRDC4 as potential biomarkers and targets for treatment of type 2 diabetes.
    5. Histone deacetylase 9-mediated phenotypic transformation of vascular smooth muscle cells is a potential target for treating aortic aneurysm/dissection.
      Title: Histone deacetylase 9-mediated phenotypic transformation of vascular smooth muscle cells is a potential target for treating aortic aneurysm/dissection.
    6. Endothelial beta-catenin upregulation and Y142 phosphorylation drive diabetic angiogenesis via upregulating KDR/HDAC9.
      Title: Endothelial β-catenin upregulation and Y142 phosphorylation drive diabetic angiogenesis via upregulating KDR/HDAC9.
    7. HDAC9-mediated calmodulin deacetylation induces memory impairment in Alzheimer's disease.
      Title: HDAC9-mediated calmodulin deacetylation induces memory impairment in Alzheimer's disease.
    8. HDAC9 inhibition reduces skeletal muscle atrophy and enhances regeneration in mice with cigarette smoke-induced COPD.
      Title: HDAC9 inhibition reduces skeletal muscle atrophy and enhances regeneration in mice with cigarette smoke-induced COPD.
    9. Impact of housing temperature on adipose tissue HDAC9 expression and adipogenic differentiation in high fat-fed mice.
      Title: Impact of housing temperature on adipose tissue HDAC9 expression and adipogenic differentiation in high fat-fed mice.
    10. Molecular mechanism and therapeutic potential of HDAC9 in intervertebral disc degeneration.
      Title: Molecular mechanism and therapeutic potential of HDAC9 in intervertebral disc degeneration.
    Submit: New GeneRIF Correction See all GeneRIFs (49)

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables DNA-binding transcription factor binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables DNA-binding transcription factor binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables DNA-binding transcription factor binding TAS
    Traceable Author Statement
    more info
    		 PubMed 
    enables RNA polymerase II-specific DNA-binding transcription factor binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables histone H3K14 deacetylase activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables histone H3K9 deacetylase activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables histone H4K16 deacetylase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables histone deacetylase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    NOT enables histone deacetylase activity TAS
    Traceable Author Statement
    more info
    		 PubMed 
    enables histone deacetylase activity TAS
    Traceable Author Statement
    more info
    		 PubMed 
    enables histone deacetylase binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables protein kinase C binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables protein lysine deacetylase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables transcription corepressor activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in B cell activation TAS
    Traceable Author Statement
    more info
    		 PubMed 
    involved_in B cell differentiation TAS
    Traceable Author Statement
    more info
    		 PubMed 
    acts_upstream_of_or_within DNA repair IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in cellular response to insulin stimulus ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in cholesterol homeostasis ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in chromatin organization TAS
    Traceable Author Statement
    more info
    		 PubMed 
    acts_upstream_of_or_within determination of adult lifespan IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    acts_upstream_of_or_within heart development IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in inflammatory response TAS
    Traceable Author Statement
    more info
    		 PubMed 
    acts_upstream_of_or_within negative regulation of DNA-templated transcription IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in negative regulation of DNA-templated transcription ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of DNA-templated transcription TAS
    Traceable Author Statement
    more info
    		 PubMed 
    involved_in negative regulation of cytokine production ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of gene expression, epigenetic IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in negative regulation of gene expression, epigenetic ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of striated muscle tissue development TAS
    Traceable Author Statement
    more info
    		 PubMed 
    acts_upstream_of_or_within negative regulation of transcription by RNA polymerase II IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    acts_upstream_of_or_within negative regulation of transcription by RNA polymerase II IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within negative regulation of transcription by RNA polymerase II ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of transcription by RNA polymerase II ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in nervous system development TAS
    Traceable Author Statement
    more info
    		 PubMed 
    involved_in peptidyl-lysine deacetylation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of cell migration involved in sprouting angiogenesis ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within regulation of skeletal muscle fiber development IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    acts_upstream_of_or_within regulation of skeletal muscle fiber differentiation IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytoplasm TAS
    Traceable Author Statement
    more info
    		 PubMed 
    part_of histone deacetylase complex TAS
    Traceable Author Statement
    more info
    		 PubMed 
    part_of histone methyltransferase complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleus TAS
    Traceable Author Statement
    more info
    		 PubMed 
    part_of transcription regulator complex ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    histone deacetylase 9
    Names
    MEF2-interacting transcription repressor MITR
    histone deacetylase 7B
    histone deacetylase-related protein
    NP_001258315.1
    NP_077038.2
    XP_006515324.1
    XP_006515325.2
    XP_006515327.1
    XP_006515329.1
    XP_006515334.1
    XP_006515336.3
    XP_006515338.2
    XP_006515339.2
    XP_011242213.1
    XP_011242214.1
    XP_011242215.1
    XP_011242218.1
    XP_011242220.1
    XP_011242223.1
    XP_011242224.1
    XP_017170737.1
    XP_017170738.1
    XP_017170739.1
    XP_017170740.2
    XP_017170741.2
    XP_030102844.1
    XP_030102845.1
    XP_030102846.1
    XP_030102847.1
    XP_030102848.1
    XP_030102850.1
    XP_030102851.1
    XP_030102852.1
    XP_036013562.1
    XP_036013563.1
    XP_036013564.1
    XP_036013565.1
    XP_036013566.1
    XP_036013567.1
    XP_036013568.1
    XP_036013569.1
    XP_036013570.1
    XP_036013571.1
    XP_036013572.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001271386.1 → NP_001258315.1  histone deacetylase 9 isoform 1

      See identical proteins and their annotated locations for NP_001258315.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
      Source sequence(s)
      AC113481, AC163669, AK133334, CR974575
      UniProtKB/TrEMBL
      A0A1B0GT67
      Related
      ENSMUSP00000148224.2, ENSMUST00000211752.2
      Conserved Domains (2) summary
      cd10163
      Location:59 → 148
      ClassIIa_HDAC9_Gln-rich-N; Glutamine-rich N-terminal helical domain of HDAC9, a Class IIa histone deacetylase
      cd11681
      Location:653 → 1030
      HDAC_classIIa; Histone deacetylases, class IIa

    2. NM_024124.3 → NP_077038.2  histone deacetylase 9 isoform 2

      See identical proteins and their annotated locations for NP_077038.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the UTRs and has multiple coding region differences, compared to variant 1. These differences cause translation initiation at a downstream AUG and result in an isoform (2) with a shorter N-terminus and a distinct C-terminus, compared to isoform 1.
      Source sequence(s)
      BC098187, EL604734
      Consensus CDS
      CCDS36432.1
      UniProtKB/Swiss-Prot
      Q4QQN7, Q8R4Y6, Q99N13, Q9EPT2
      UniProtKB/TrEMBL
      A0A0R4J1F3
      Related
      ENSMUSP00000106443.3, ENSMUST00000110819.4
      Conserved Domains (1) summary
      cl23765
      Location:38 → 124
      iSH2_PI3K_IA_R; Inter-Src homology 2 (iSH2) helical domain of Class IA Phosphoinositide 3-kinase Regulatory subunits

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000078.7 Reference GRCm39 C57BL/6J

      Range
      34097579..34967094 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006515264.4 → XP_006515327.1  histone deacetylase 9 isoform X7

      See identical proteins and their annotated locations for XP_006515327.1

      UniProtKB/TrEMBL
      A0A1B0GT67
      Conserved Domains (2) summary
      cd10163
      Location:59 → 148
      ClassIIa_HDAC9_Gln-rich-N; Glutamine-rich N-terminal helical domain of HDAC9, a Class IIa histone deacetylase
      cd11681
      Location:653 → 1030
      HDAC_classIIa; Histone deacetylases, class IIa

    2. XM_030246984.2 → XP_030102844.1  histone deacetylase 9 isoform X7

      UniProtKB/TrEMBL
      A0A1B0GT67
      Conserved Domains (2) summary
      cd10163
      Location:59 → 148
      ClassIIa_HDAC9_Gln-rich-N; Glutamine-rich N-terminal helical domain of HDAC9, a Class IIa histone deacetylase
      cd11681
      Location:653 → 1030
      HDAC_classIIa; Histone deacetylases, class IIa

    3. XM_006515266.1 → XP_006515329.1  histone deacetylase 9 isoform X7

      See identical proteins and their annotated locations for XP_006515329.1

      UniProtKB/TrEMBL
      A0A1B0GT67
      Conserved Domains (2) summary
      cd10163
      Location:59 → 148
      ClassIIa_HDAC9_Gln-rich-N; Glutamine-rich N-terminal helical domain of HDAC9, a Class IIa histone deacetylase
      cd11681
      Location:653 → 1030
      HDAC_classIIa; Histone deacetylases, class IIa

    4. XM_036157671.1 → XP_036013564.1  histone deacetylase 9 isoform X7

      UniProtKB/TrEMBL
      A0A1B0GT67
      Conserved Domains (2) summary
      cd10163
      Location:59 → 148
      ClassIIa_HDAC9_Gln-rich-N; Glutamine-rich N-terminal helical domain of HDAC9, a Class IIa histone deacetylase
      cd11681
      Location:653 → 1030
      HDAC_classIIa; Histone deacetylases, class IIa

    5. XM_036157672.1 → XP_036013565.1  histone deacetylase 9 isoform X7

      UniProtKB/TrEMBL
      A0A1B0GT67
      Conserved Domains (2) summary
      cd10163
      Location:59 → 148
      ClassIIa_HDAC9_Gln-rich-N; Glutamine-rich N-terminal helical domain of HDAC9, a Class IIa histone deacetylase
      cd11681
      Location:653 → 1030
      HDAC_classIIa; Histone deacetylases, class IIa

    6. XM_036157670.1 → XP_036013563.1  histone deacetylase 9 isoform X7

      UniProtKB/TrEMBL
      A0A1B0GT67
      Conserved Domains (2) summary
      cd10163
      Location:59 → 148
      ClassIIa_HDAC9_Gln-rich-N; Glutamine-rich N-terminal helical domain of HDAC9, a Class IIa histone deacetylase
      cd11681
      Location:653 → 1030
      HDAC_classIIa; Histone deacetylases, class IIa

    7. XM_017315249.2 → XP_017170738.1  histone deacetylase 9 isoform X11

      UniProtKB/TrEMBL
      A0A1B0GSQ5, A0A1B0GT67
      Conserved Domains (2) summary
      cd10163
      Location:38 → 127
      ClassIIa_HDAC9_Gln-rich-N; Glutamine-rich N-terminal helical domain of HDAC9, a Class IIa histone deacetylase
      cd11681
      Location:632 → 1009
      HDAC_classIIa; Histone deacetylases, class IIa

    8. XM_030246985.2 → XP_030102845.1  histone deacetylase 9 isoform X9

      UniProtKB/TrEMBL
      A0A1B0GT67
      Conserved Domains (2) summary
      cd10163
      Location:57 → 143
      ClassIIa_HDAC9_Gln-rich-N; Glutamine-rich N-terminal helical domain of HDAC9, a Class IIa histone deacetylase
      cd11681
      Location:648 → 1025
      HDAC_classIIa; Histone deacetylases, class IIa

    9. XM_017315250.3 → XP_017170739.1  histone deacetylase 9 isoform X8

      UniProtKB/TrEMBL
      A0A1B0GT67
      Conserved Domains (2) summary
      cd10163
      Location:57 → 146
      ClassIIa_HDAC9_Gln-rich-N; Glutamine-rich N-terminal helical domain of HDAC9, a Class IIa histone deacetylase
      cd11681
      Location:651 → 1028
      HDAC_classIIa; Histone deacetylases, class IIa

    10. XM_006515261.4 → XP_006515324.1  histone deacetylase 9 isoform X6

      UniProtKB/TrEMBL
      A0A1B0GT67
      Conserved Domains (2) summary
      cd10163
      Location:71 → 160
      ClassIIa_HDAC9_Gln-rich-N; Glutamine-rich N-terminal helical domain of HDAC9, a Class IIa histone deacetylase
      cd11681
      Location:665 → 1042
      HDAC_classIIa; Histone deacetylases, class IIa

    11. XM_011243911.3 → XP_011242213.1  histone deacetylase 9 isoform X11

      See identical proteins and their annotated locations for XP_011242213.1

      UniProtKB/TrEMBL
      A0A1B0GSQ5, A0A1B0GT67
      Conserved Domains (2) summary
      cd10163
      Location:38 → 127
      ClassIIa_HDAC9_Gln-rich-N; Glutamine-rich N-terminal helical domain of HDAC9, a Class IIa histone deacetylase
      cd11681
      Location:632 → 1009
      HDAC_classIIa; Histone deacetylases, class IIa

    12. XM_017315248.2 → XP_017170737.1  histone deacetylase 9 isoform X5

      UniProtKB/TrEMBL
      A0A1B0GSE4
      Conserved Domains (2) summary
      cd10163
      Location:38 → 124
      ClassIIa_HDAC9_Gln-rich-N; Glutamine-rich N-terminal helical domain of HDAC9, a Class IIa histone deacetylase
      cd11681
      Location:585 → 962
      HDAC_classIIa; Histone deacetylases, class IIa

    13. XM_011243912.2 → XP_011242214.1  histone deacetylase 9 isoform X2

      See identical proteins and their annotated locations for XP_011242214.1

      UniProtKB/TrEMBL
      A0A1B0GRH0, A0A1B0GSE4
      Related
      ENSMUSP00000147519.2, ENSMUST00000209902.2
      Conserved Domains (2) summary
      cd10163
      Location:38 → 124
      ClassIIa_HDAC9_Gln-rich-N; Glutamine-rich N-terminal helical domain of HDAC9, a Class IIa histone deacetylase
      cd11681
      Location:629 → 1006
      HDAC_classIIa; Histone deacetylases, class IIa

    14. XM_036157669.1 → XP_036013562.1  histone deacetylase 9 isoform X4

      UniProtKB/TrEMBL
      A0A1B0GT67
      Conserved Domains (2) summary
      cd10163
      Location:38 → 127
      ClassIIa_HDAC9_Gln-rich-N; Glutamine-rich N-terminal helical domain of HDAC9, a Class IIa histone deacetylase
      cd11681
      Location:586 → 963
      HDAC_classIIa; Histone deacetylases, class IIa

    15. XM_006515262.3 → XP_006515325.2  histone deacetylase 9 isoform X1

      UniProtKB/TrEMBL
      A0A1B0GT67
      Conserved Domains (2) summary
      cd10163
      Location:38 → 127
      ClassIIa_HDAC9_Gln-rich-N; Glutamine-rich N-terminal helical domain of HDAC9, a Class IIa histone deacetylase
      cd11681
      Location:630 → 1007
      HDAC_classIIa; Histone deacetylases, class IIa

    16. XM_011243913.2 → XP_011242215.1  histone deacetylase 9 isoform X3

      UniProtKB/TrEMBL
      A0A1B0GR65, A0A1B0GT67
      Related
      ENSMUSP00000147395.2, ENSMUST00000209990.2
      Conserved Domains (2) summary
      cd10163
      Location:38 → 127
      ClassIIa_HDAC9_Gln-rich-N; Glutamine-rich N-terminal helical domain of HDAC9, a Class IIa histone deacetylase
      cd11681
      Location:588 → 965
      HDAC_classIIa; Histone deacetylases, class IIa

    17. XM_011243916.2 → XP_011242218.1  histone deacetylase 9 isoform X10

      UniProtKB/TrEMBL
      A0A1B0GSE4
      Related
      ENSMUSP00000147903.2, ENSMUST00000210724.2
      Conserved Domains (2) summary
      cd10163
      Location:38 → 127
      ClassIIa_HDAC9_Gln-rich-N; Glutamine-rich N-terminal helical domain of HDAC9, a Class IIa histone deacetylase
      cd11681
      Location:545 → 922
      HDAC_classIIa; Histone deacetylases, class IIa

    18. XM_011243922.4 → XP_011242224.1  histone deacetylase 9 isoform X14

      Conserved Domains (1) summary
      cd11681
      Location:598 → 975
      HDAC_classIIa; Histone deacetylases, class IIa

    19. XM_006515271.4 → XP_006515334.1  histone deacetylase 9 isoform X2

      See identical proteins and their annotated locations for XP_006515334.1

      UniProtKB/TrEMBL
      A0A1B0GRH0, A0A1B0GSE4
      Conserved Domains (2) summary
      cd10163
      Location:38 → 124
      ClassIIa_HDAC9_Gln-rich-N; Glutamine-rich N-terminal helical domain of HDAC9, a Class IIa histone deacetylase
      cd11681
      Location:629 → 1006
      HDAC_classIIa; Histone deacetylases, class IIa

    20. XM_030246986.2 → XP_030102846.1  histone deacetylase 9 isoform X11

      UniProtKB/TrEMBL
      A0A1B0GSQ5, A0A1B0GT67
      Conserved Domains (2) summary
      cd10163
      Location:38 → 127
      ClassIIa_HDAC9_Gln-rich-N; Glutamine-rich N-terminal helical domain of HDAC9, a Class IIa histone deacetylase
      cd11681
      Location:632 → 1009
      HDAC_classIIa; Histone deacetylases, class IIa

    21. XM_011243921.2 → XP_011242223.1  histone deacetylase 9 isoform X13

      Conserved Domains (1) summary
      cd11681
      Location:622 → 999
      HDAC_classIIa; Histone deacetylases, class IIa

    22. XM_011243918.4 → XP_011242220.1  histone deacetylase 9 isoform X11

      See identical proteins and their annotated locations for XP_011242220.1

      UniProtKB/TrEMBL
      A0A1B0GSQ5, A0A1B0GT67
      Conserved Domains (2) summary
      cd10163
      Location:38 → 127
      ClassIIa_HDAC9_Gln-rich-N; Glutamine-rich N-terminal helical domain of HDAC9, a Class IIa histone deacetylase
      cd11681
      Location:632 → 1009
      HDAC_classIIa; Histone deacetylases, class IIa

    23. XM_030246992.2 → XP_030102852.1  histone deacetylase 9 isoform X15

      Conserved Domains (1) summary
      cd11681
      Location:314 → 691
      HDAC_classIIa; Histone deacetylases, class IIa

    24. XM_030246991.2 → XP_030102851.1  histone deacetylase 9 isoform X15

      Conserved Domains (1) summary
      cd11681
      Location:314 → 691
      HDAC_classIIa; Histone deacetylases, class IIa

    25. XM_036157678.1 → XP_036013571.1  histone deacetylase 9 isoform X15

      Conserved Domains (1) summary
      cd11681
      Location:314 → 691
      HDAC_classIIa; Histone deacetylases, class IIa

    26. XM_030246990.2 → XP_030102850.1  histone deacetylase 9 isoform X15

      Conserved Domains (1) summary
      cd11681
      Location:314 → 691
      HDAC_classIIa; Histone deacetylases, class IIa

    27. XM_036157676.1 → XP_036013569.1  histone deacetylase 9 isoform X12

      UniProtKB/TrEMBL
      A0A1B0GSE4
      Conserved Domains (2) summary
      cd10163
      Location:38 → 124
      ClassIIa_HDAC9_Gln-rich-N; Glutamine-rich N-terminal helical domain of HDAC9, a Class IIa histone deacetylase
      cd11681
      Location:627 → 1004
      HDAC_classIIa; Histone deacetylases, class IIa

    28. XM_030246987.2 → XP_030102847.1  histone deacetylase 9 isoform X2

      UniProtKB/TrEMBL
      A0A1B0GRH0, A0A1B0GSE4
      Conserved Domains (2) summary
      cd10163
      Location:38 → 124
      ClassIIa_HDAC9_Gln-rich-N; Glutamine-rich N-terminal helical domain of HDAC9, a Class IIa histone deacetylase
      cd11681
      Location:629 → 1006
      HDAC_classIIa; Histone deacetylases, class IIa

    29. XM_036157677.1 → XP_036013570.1  histone deacetylase 9 isoform X4

      UniProtKB/TrEMBL
      A0A1B0GT67
      Conserved Domains (2) summary
      cd10163
      Location:38 → 127
      ClassIIa_HDAC9_Gln-rich-N; Glutamine-rich N-terminal helical domain of HDAC9, a Class IIa histone deacetylase
      cd11681
      Location:586 → 963
      HDAC_classIIa; Histone deacetylases, class IIa

    30. XM_030246988.2 → XP_030102848.1  histone deacetylase 9 isoform X3

      UniProtKB/TrEMBL
      A0A1B0GR65, A0A1B0GT67
      Conserved Domains (2) summary
      cd10163
      Location:38 → 127
      ClassIIa_HDAC9_Gln-rich-N; Glutamine-rich N-terminal helical domain of HDAC9, a Class IIa histone deacetylase
      cd11681
      Location:588 → 965
      HDAC_classIIa; Histone deacetylases, class IIa

    31. XM_036157675.1 → XP_036013568.1  histone deacetylase 9 isoform X11

      UniProtKB/TrEMBL
      A0A1B0GSQ5, A0A1B0GT67
      Related
      ENSMUSP00000148029.2, ENSMUST00000209750.2
      Conserved Domains (2) summary
      cd10163
      Location:38 → 127
      ClassIIa_HDAC9_Gln-rich-N; Glutamine-rich N-terminal helical domain of HDAC9, a Class IIa histone deacetylase
      cd11681
      Location:632 → 1009
      HDAC_classIIa; Histone deacetylases, class IIa

    32. XM_036157674.1 → XP_036013567.1  histone deacetylase 9 isoform X11

      UniProtKB/TrEMBL
      A0A1B0GSQ5, A0A1B0GT67
      Conserved Domains (2) summary
      cd10163
      Location:38 → 127
      ClassIIa_HDAC9_Gln-rich-N; Glutamine-rich N-terminal helical domain of HDAC9, a Class IIa histone deacetylase
      cd11681
      Location:632 → 1009
      HDAC_classIIa; Histone deacetylases, class IIa

    33. XM_017315252.3 → XP_017170741.2  histone deacetylase 9 isoform X1

      UniProtKB/TrEMBL
      A0A1B0GT67
      Conserved Domains (2) summary
      cd10163
      Location:38 → 127
      ClassIIa_HDAC9_Gln-rich-N; Glutamine-rich N-terminal helical domain of HDAC9, a Class IIa histone deacetylase
      cd11681
      Location:630 → 1007
      HDAC_classIIa; Histone deacetylases, class IIa

    34. XM_036157673.1 → XP_036013566.1  histone deacetylase 9 isoform X11

      UniProtKB/TrEMBL
      A0A1B0GSQ5, A0A1B0GT67
      Conserved Domains (2) summary
      cd10163
      Location:38 → 127
      ClassIIa_HDAC9_Gln-rich-N; Glutamine-rich N-terminal helical domain of HDAC9, a Class IIa histone deacetylase
      cd11681
      Location:632 → 1009
      HDAC_classIIa; Histone deacetylases, class IIa

    35. XM_017315251.2 → XP_017170740.2  histone deacetylase 9 isoform X20

      UniProtKB/TrEMBL
      A0A668KL98
      Conserved Domains (1) summary
      cd10163
      Location:59 → 148
      ClassIIa_HDAC9_Gln-rich-N; Glutamine-rich N-terminal helical domain of HDAC9, a Class IIa histone deacetylase

    36. XM_006515275.5 → XP_006515338.2  histone deacetylase 9 isoform X19

      UniProtKB/TrEMBL
      A0A668KL98
      Related
      ENSMUSP00000159253.2, ENSMUST00000239321.2
      Conserved Domains (1) summary
      cd10163
      Location:59 → 148
      ClassIIa_HDAC9_Gln-rich-N; Glutamine-rich N-terminal helical domain of HDAC9, a Class IIa histone deacetylase

    37. XM_006515273.3 → XP_006515336.3  histone deacetylase 9 isoform X18

      UniProtKB/Swiss-Prot
      Q4QQN7, Q8R4Y6, Q99N13, Q9EPT2
      Conserved Domains (1) summary
      cl25407
      Location:57 → 143
      ClassIIa_HDAC_Gln-rich-N; Glutamine-rich N-terminal helical domain of various Class IIa histone deacetylases (HDAC4, HDAC5 and HDCA9)

    38. XM_006515276.2 → XP_006515339.2  histone deacetylase 9 isoform X16

      UniProtKB/TrEMBL
      A0A1B0GS15
      Related
      ENSMUSP00000159264.2, ENSMUST00000239340.2
      Conserved Domains (1) summary
      cl25407
      Location:38 → 124
      ClassIIa_HDAC_Gln-rich-N; Glutamine-rich N-terminal helical domain of various Class IIa histone deacetylases (HDAC4, HDAC5 and HDCA9)

    39. XM_036157679.1 → XP_036013572.1  histone deacetylase 9 isoform X17

      UniProtKB/Swiss-Prot
      Q4QQN7, Q8R4Y6, Q99N13, Q9EPT2
      Conserved Domains (1) summary
      cd10163
      Location:86 → 175
      ClassIIa_HDAC9_Gln-rich-N; Glutamine-rich N-terminal helical domain of HDAC9, a Class IIa histone deacetylase
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q99N13.2 GenPept UniProtKB/Swiss-Prot:Q99N13

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