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    Cenpv centromere protein V [ Mus musculus (house mouse) ]

    Gene ID: 73139, updated on 2-Nov-2024

    Summary

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    Official Symbol
    Cenpvprovided by MGI
    Official Full Name
    centromere protein Vprovided by MGI
    Primary source
    MGI:MGI:1920389
    See related
    Ensembl:ENSMUSG00000018509 AllianceGenome:MGI:1920389
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Prr6; 3110013H01Rik
    Summary
    Predicted to enable carbon-sulfur lyase activity and metal ion binding activity. Predicted to be involved in several processes, including centromere complex assembly; pericentric heterochromatin formation; and positive regulation of cytokinesis. Predicted to act upstream of or within ameboidal-type cell migration. Predicted to be located in several cellular components, including microtubule cytoskeleton; midbody; and nucleus. Predicted to be active in kinetochore; nucleus; and spindle midzone. Orthologous to several human genes including CENPV (centromere protein V). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in testis adult (RPKM 146.5), duodenum adult (RPKM 37.7) and 12 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Cenpv in Genome Data Viewer
    Location:
    11 B2; 11 38.43 cM
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (62415770..62430695, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (62524944..62539869, complement)

    Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene tetratricopeptide repeat domain 19 Neighboring gene nuclear receptor co-repressor 1 Neighboring gene STARR-seq mESC enhancer starr_29697 Neighboring gene STARR-seq mESC enhancer starr_29699 Neighboring gene STARR-seq mESC enhancer starr_29702 Neighboring gene STARR-seq mESC enhancer starr_29703 Neighboring gene STARR-seq mESC enhancer starr_29704 Neighboring gene phosphatidylinositol glycan anchor biosynthesis, class L Neighboring gene STARR-seq mESC enhancer starr_29710 Neighboring gene STARR-seq mESC enhancer starr_29712 Neighboring gene STARR-seq mESC enhancer starr_29713 Neighboring gene predicted gene 12279 Neighboring gene ubiquitin B

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. CENP-V is required for proper chromosome segregation through interaction with spindle microtubules in mouse oocytes. Nabi D, et al. Nat Commun, 2021 Nov 11. PMID 34764261, Free PMC Article
    2. CENP-V is required for centromere organization, chromosome alignment and cytokinesis. Tadeu AM, et al. EMBO J, 2008 Oct 8. PMID 18772885, Free PMC Article
    3. Identification of CENP-V as a novel microtubule-associating molecule that activates Src family kinases through SH3 domain interaction. Honda Z, et al. Genes Cells, 2009 Dec. PMID 19930468
    4. Proteomic analysis of the mammalian nuclear pore complex. Cronshaw JM, et al. J Cell Biol, 2002 Sep 2. PMID 12196509, Free PMC Article
    5. PRC1 and PRC2 are not required for targeting of H2A.Z to developmental genes in embryonic stem cells. Illingworth RS, et al. PLoS One, 2012. PMID 22496869, Free PMC Article

    See all (26) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 
    • Targeted (3)  1 citation

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables carbon-sulfur lyase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within ameboidal-type cell migration ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in cell division IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in centromere complex assembly ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    involved_in pericentric heterochromatin formation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in pericentric heterochromatin formation ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    involved_in positive regulation of cytokinesis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in positive regulation of cytokinesis ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    involved_in regulation of chromosome organization IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of chromosome organization ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytosol IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in kinetochore IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in kinetochore ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in kinetochore ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    located_in microtubule cytoskeleton ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in midbody IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in midbody ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nuclear membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nuclear membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleus ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    is_active_in spindle midzone IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in spindle midzone ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in spindle midzone ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    centromere protein V
    Names
    CENP-V
    proline-rich polypeptide 6
    proline-rich protein 6

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_028448.1 → NP_082724.1  centromere protein V

      See identical proteins and their annotated locations for NP_082724.1

      Status: VALIDATED

      Source sequence(s)
      AK014046, AL596181, BP771180
      Consensus CDS
      CCDS48818.1
      UniProtKB/Swiss-Prot
      B2RWK8, B9EK22, Q5SX21, Q6PIA5, Q9CXS4
      Related
      ENSMUSP00000018653.2, ENSMUST00000018653.8
      Conserved Domains (1) summary
      COG3791
      Location:124 → 220
      COG3791; Uncharacterized conserved protein [Function unknown]

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000077.7 Reference GRCm39 C57BL/6J

      Range
      62415770..62430695 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006534333.3 → XP_006534396.1  centromere protein V isoform X1

      Conserved Domains (1) summary
      COG3791
      Location:14 → 110
      COG3791; Uncharacterized conserved protein [Function unknown]

    RNA

    1. XR_001780064.2 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9CXS4.2 GenPept UniProtKB/Swiss-Prot:Q9CXS4

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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