Ciapin1 cytokine induced apoptosis inhibitor 1 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Ciapin1provided by RGD
Official Full Name: cytokine induced apoptosis inhibitor 1provided by RGD
Primary source: RGD:1549737
See related: EnsemblRapid:ENSRNOG00000016234 AllianceGenome:RGD:1549737
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Predicted to enable 2 iron, 2 sulfur cluster binding activity and iron ion binding activity. Predicted to be involved in iron-sulfur cluster assembly. Predicted to act upstream of or within hemopoiesis and negative regulation of apoptotic process. Predicted to be located in mitochondrion; nucleolus; and nucleoplasm. Predicted to be active in cytoplasm. Orthologous to human CIAPIN1 (cytokine induced apoptosis inhibitor 1). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Biased expression in Adrenal (RPKM 112.2), Heart (RPKM 108.2) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 19p13

Exon count:: 10

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	19	NC_086037.1 (10185955..10199120)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	19	NC_051354.1 (10179963..10195511)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	19	NC_005118.4 (10596923..10612414)

Chromosome 19 - NC_086037.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Inhibition of miR-322-5p Protects Cardiac Myoblast Cells Against Hypoxia-Induced Apoptosis and Injury Through Regulating CIAPIN1.
Title: Inhibition of miR-322-5p Protects Cardiac Myoblast Cells Against Hypoxia-Induced Apoptosis and Injury Through Regulating CIAPIN1.
The present study illustrates that downregulation of miR16 may protect against H/Rinduced injury partially by targeting CIAPIN1 and the NFkappaB signaling pathway.
Title: Downregulation of miR‑16 protects H9c2(2‑1) cells against hypoxia/reoxygenation damage by targeting CIAPIN1 and regulating the NF‑κB pathway.
the knockdown of CIAPIN1 with small interfering RNAs (siRNAs) efficiently abolished the protective effects of miR-182-5p inhibitor on HICA, demonstrating that miR-182-5p plays a pro-apoptotic role in cardiomyocytes under hypoxic conditions by downregulating CIAPIN1.
Title: Inhibition of miR-182-5p protects cardiomyocytes from hypoxia-induced apoptosis by targeting CIAPIN1.

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General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables 2 iron, 2 sulfur cluster binding	IEA Inferred from Electronic Annotation more info
enables 2 iron, 2 sulfur cluster binding	ISO Inferred from Sequence Orthology more info
enables 2 iron, 2 sulfur cluster binding	ISS Inferred from Sequence or Structural Similarity more info
enables 4 iron, 4 sulfur cluster binding	IEA Inferred from Electronic Annotation more info
enables electron transfer activity	IEA Inferred from Electronic Annotation more info
enables iron ion binding	ISO Inferred from Sequence Orthology more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in apoptotic process	IEA Inferred from Electronic Annotation more info
involved_in hemopoiesis	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within hemopoiesis	ISO Inferred from Sequence Orthology more info
involved_in iron-sulfur cluster assembly	IBA Inferred from Biological aspect of Ancestor more info
involved_in iron-sulfur cluster assembly	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of apoptotic process	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within negative regulation of apoptotic process	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in mitochondrial intermembrane space	IEA Inferred from Electronic Annotation more info
located_in mitochondrion	ISO Inferred from Sequence Orthology more info
located_in nucleolus	IEA Inferred from Electronic Annotation more info
located_in nucleolus	ISO Inferred from Sequence Orthology more info
located_in nucleoplasm	IEA Inferred from Electronic Annotation more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: anamorsin

Names: fe-S cluster assembly protein DRE2 homolog

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001007689.1 → NP_001007690.1 anamorsin

See identical proteins and their annotated locations for NP_001007690.1

Status: PROVISIONAL

Source sequence(s)

BC083753

UniProtKB/Swiss-Prot

Q5XID1

UniProtKB/TrEMBL

A0A8I6ASY3, A6JY45

Related

ENSRNOP00000021769.3, ENSRNOT00000021769.7

Conserved Domains (2) summary

cd02440
Location:21 → 96

AdoMet_MTases; S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). ...

pfam05093
Location:233 → 301

CIAPIN1; Cytokine-induced anti-apoptosis inhibitor 1, Fe-S biogenesis

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086037.1 Reference GRCr8

Range

10185955..10199120

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006255107.5 → XP_006255169.1 anamorsin isoform X1

See identical proteins and their annotated locations for XP_006255169.1

UniProtKB/Swiss-Prot

Q5XID1

UniProtKB/TrEMBL

A0A8I6ASY3, A6JY45

Conserved Domains (2) summary

cd02440
Location:21 → 96

AdoMet_MTases; S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). ...

pfam05093
Location:233 → 301

CIAPIN1; Cytokine-induced anti-apoptosis inhibitor 1, Fe-S biogenesis
XM_006255108.5 → XP_006255170.1 anamorsin isoform X1

See identical proteins and their annotated locations for XP_006255170.1

UniProtKB/Swiss-Prot

Q5XID1

UniProtKB/TrEMBL

A0A8I6ASY3, A6JY45

Related

ENSRNOP00000106580.1, ENSRNOT00000172702.1

Conserved Domains (2) summary

cd02440
Location:21 → 96

AdoMet_MTases; S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). ...

pfam05093
Location:233 → 301

CIAPIN1; Cytokine-induced anti-apoptosis inhibitor 1, Fe-S biogenesis
XM_006255106.5 → XP_006255168.1 anamorsin isoform X1

See identical proteins and their annotated locations for XP_006255168.1

UniProtKB/Swiss-Prot

Q5XID1

UniProtKB/TrEMBL

A0A8I6ASY3, A6JY45

Conserved Domains (2) summary

cd02440
Location:21 → 96

AdoMet_MTases; S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). ...

pfam05093
Location:233 → 301

CIAPIN1; Cytokine-induced anti-apoptosis inhibitor 1, Fe-S biogenesis
XM_063277990.1 → XP_063134060.1 anamorsin isoform X1

UniProtKB/Swiss-Prot

Q5XID1

UniProtKB/TrEMBL

A6JY45

Related

ENSRNOP00000096214.1, ENSRNOT00000116645.2
XM_039097710.2 → XP_038953638.1 anamorsin isoform X1

UniProtKB/Swiss-Prot

Q5XID1

UniProtKB/TrEMBL

A0A8I6ASY3, A6JY45

Conserved Domains (2) summary

cd02440
Location:21 → 96

AdoMet_MTases; S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). ...

pfam05093
Location:233 → 301

CIAPIN1; Cytokine-induced anti-apoptosis inhibitor 1, Fe-S biogenesis