Lasp1 LIM and SH3 protein 1 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Lasp1provided by MGI
Official Full Name: LIM and SH3 protein 1provided by MGI
Primary source: MGI:MGI:109656
See related: Ensembl:ENSMUSG00000038366 AllianceGenome:MGI:109656
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Def-4; SH3P6; LASP-1; MLN 50; Tg(Col1a1-lacZ)1Ngma
Summary: Enables actin filament binding activity. Predicted to be involved in monoatomic ion transport. Located in cytoplasm and focal adhesion. Is expressed in several structures, including alimentary system; bone; central nervous system; genitourinary system; and hemolymphoid system gland. Orthologous to human LASP1 (LIM and SH3 protein 1). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Ubiquitous expression in large intestine adult (RPKM 112.9), duodenum adult (RPKM 108.0) and 28 other tissues See more
Orthologs: human all
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Genomic context

Location:: 11 D; 11 61.1 cM

Exon count:: 9

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	11	NC_000077.7 (97689748..97729591)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	11	NC_000077.6 (97799005..97838765)

Chromosome 11 - NC_000077.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Cholesterol uptake in the intestine is regulated by the LASP1-AKT-NPC1L1 signaling pathway.
Title: Cholesterol uptake in the intestine is regulated by the LASP1-AKT-NPC1L1 signaling pathway.
Silenced LASP1 interacts with DNMT1 to promote TJP2 expression and attenuate articular cartilage injury in mice by suppressing TJP2 methylation.
Title: Silenced LASP1 interacts with DNMT1 to promote TJP2 expression and attenuate articular cartilage injury in mice by suppressing TJP2 methylation.
Hippocampal LASP1 ameliorates chronic stress-mediated behavioral responses in a mouse model of unpredictable chronic mild stress.
Title: Hippocampal LASP1 ameliorates chronic stress-mediated behavioral responses in a mouse model of unpredictable chronic mild stress.
Lasp1 regulates adherens junction dynamics and fibroblast transformation in destructive arthritis.
Title: Lasp1 regulates adherens junction dynamics and fibroblast transformation in destructive arthritis.
Results defined LASP1 as a direct target gene for HIF1alpha upregulation that is critical for metastatic progression of PDAC.
Title: LASP1 is a HIF1α target gene critical for metastasis of pancreatic cancer.
Data show that MEFs derived from Lasp1(-/-) mice migrated more rapidly in vitro.
Title: Lasp1 gene disruption is linked to enhanced cell migration and tumor formation.
role of Lasp1 in chondrocyte differentiation during cartilage to bone transition
Title: Lasp1 misexpression influences chondrocyte differentiation in the vertebral column.
The role of Lasp1 in the regulation of hydrochloride secretion in vivo was studied in a murine model with a targeted disruption of the Lasp-1 gene.
Title: Targeted disruption of the Lasp-1 gene is linked to increases in histamine-stimulated gastric HCl secretion.
LIM-nebulette, Lasp-1, and zyxin may play an important role in the organization of focal adhesions
Title: Zyxin interacts with the SH3 domains of the cytoskeletal proteins LIM-nebulette and Lasp-1.
Lasp-1 is a dynamic focal adhesion protein necessary for cell migration and survival in response to growth factors and ECM proteins.
Title: Regulation of cell migration and survival by focal adhesion targeting of Lasp-1.

Submit: New GeneRIF Correction See all GeneRIFs (11)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Chemically induced (ENU) (1)
Endonuclease-mediated (2)
Targeted (1) 1 citation
Transgenic (1) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables actin filament binding	IBA Inferred from Biological aspect of Ancestor more info
enables actin filament binding	IDA Inferred from Direct Assay more info	PubMed
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables monoatomic ion transmembrane transporter activity	ISO Inferred from Sequence Orthology more info
enables monoatomic ion transmembrane transporter activity	ISS Inferred from Sequence or Structural Similarity more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in monoatomic ion transmembrane transport	IEA Inferred from Electronic Annotation more info
involved_in monoatomic ion transport	ISO Inferred from Sequence Orthology more info
involved_in monoatomic ion transport	ISS Inferred from Sequence or Structural Similarity more info

Component	Evidence Code	Pubs
located_in cortical actin cytoskeleton	ISO Inferred from Sequence Orthology more info
located_in cortical actin cytoskeleton	ISS Inferred from Sequence or Structural Similarity more info
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
is_active_in focal adhesion	IBA Inferred from Biological aspect of Ancestor more info
located_in focal adhesion	IDA Inferred from Direct Assay more info	PubMed
is_active_in postsynapse	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: LIM and SH3 domain protein 1

Names: Tg(11Col1a1)NG; metastatic lymph node gene 50 protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001433277.1 → NP_001420206.1 LIM and SH3 domain protein 1

Status: VALIDATED

Source sequence(s)

AL596446

UniProtKB/Swiss-Prot

Q61792, Q62416

UniProtKB/TrEMBL

Q543N3
NM_010688.5 → NP_034818.1 LIM and SH3 domain protein 1

See identical proteins and their annotated locations for NP_034818.1

Status: VALIDATED

Source sequence(s)

AL596446, BE955478

Consensus CDS

CCDS25332.1

UniProtKB/Swiss-Prot

Q61792, Q62416

UniProtKB/TrEMBL

Q543N3

Related

ENSMUSP00000042123.6, ENSMUST00000043843.12

Conserved Domains (3) summary

smart00227
Location:98 → 128

NEBU; The Nebulin repeat is present also in Las1

cd09447
Location:5 → 57

LIM_LASP; The LIM domain of LIM and SH3 Protein (LASP)

cd11934
Location:205 → 263

SH3_Lasp1_C; C-terminal Src Homology 3 domain of LIM and SH3 domain protein 1

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000077.7 Reference GRCm39 C57BL/6J

Range

97689748..97729591

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006532341.2 → XP_006532404.1 LIM and SH3 domain protein 1 isoform X1

Conserved Domains (3) summary

smart00227
Location:98 → 128

NEBU; The Nebulin repeat is present also in Las1

cd09447
Location:5 → 57

LIM_LASP; The LIM domain of LIM and SH3 Protein (LASP)

cd11934
Location:205 → 263

SH3_Lasp1_C; C-terminal Src Homology 3 domain of LIM and SH3 domain protein 1
XM_006532342.1 → XP_006532405.1 LIM and SH3 domain protein 1 isoform X2

UniProtKB/TrEMBL

A2A6H0

Related

ENSMUSP00000123050.2, ENSMUST00000148280.3

Conserved Domains (3) summary

smart00227
Location:62 → 92

NEBU; The Nebulin repeat is present also in Las1

cd11934
Location:169 → 227

SH3_Lasp1_C; C-terminal Src Homology 3 domain of LIM and SH3 domain protein 1

cl02475
Location:1 → 21

LIM; LIM is a small protein-protein interaction domain, containing two zinc fingers