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    TRIM15 tripartite motif containing 15 [ Homo sapiens (human) ]

    Gene ID: 89870, updated on 2-Nov-2024

    Summary

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    Official Symbol
    TRIM15provided by HGNC
    Official Full Name
    tripartite motif containing 15provided by HGNC
    Primary source
    HGNC:HGNC:16284
    See related
    Ensembl:ENSG00000204610 AllianceGenome:HGNC:16284
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    RNF93; ZNFB7; ZNF178
    Summary
    The protein encoded by this gene is a member of the tripartite motif (TRIM) family. The TRIM motif includes three zinc-binding domains, a RING, a B-box type 1 and a B-box type 2, and a coiled-coil region. The protein localizes to the cytoplasm. Alternatively spliced transcript variants have been described, but their biological validity has not been determined. [provided by RefSeq, Jul 2008]
    Expression
    Biased expression in duodenum (RPKM 12.6), small intestine (RPKM 9.2) and 6 other tissues See more
    Orthologs
    mouse all
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    Genomic context

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    See TRIM15 in Genome Data Viewer
    Location:
    6p22.1
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 6 NC_000006.12 (30163546..30172693)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 6 NC_060930.1 (30027684..30036952)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 6 NC_000006.11 (30131323..30140470)

    Chromosome 6 - NC_000006.12Genomic Context describing neighboring genes Neighboring gene small nucleolar RNA SNORA48 Neighboring gene tripartite motif containing 40 Neighboring gene tripartite motif containing 10 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr6:30139523-30140072 Neighboring gene MPRA-validated peak5749 silencer Neighboring gene PAIP1 pseudogene 1 Neighboring gene tripartite motif containing 26 Neighboring gene NANOG-H3K27ac hESC enhancer GRCh37_chr6:30168993-30169678 Neighboring gene NANOG-H3K27ac hESC enhancer GRCh37_chr6:30169679-30170363 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr6:30175183-30176130 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr6:30181514-30182402 Neighboring gene tripartite motif containing 26B, pseudogene Neighboring gene HLA complex group 17

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. Knockdown of TRIM15 inhibits the proliferation, migration and invasion of esophageal squamous cell carcinoma cells through inactivation of the Wnt/β-catenin signaling pathway. Zhang L, et al. J Bioenerg Biomembr, 2021 Apr. PMID 33515345
    2. TRIM15 Exerts Anti-Tumor Effects Through Suppressing Cancer Cell Invasion in Gastric Adenocarcinoma. Chen W, et al. Med Sci Monit, 2018 Nov 9. PMID 30412518, Free PMC Article
    3. Isolation of novel non-HLA gene fragments from the hemochromatosis region (6p21.3) by cDNA hybridization selection. Goei VL, et al. Am J Hum Genet, 1994 Feb. PMID 8304341, Free PMC Article
    4. TNF-α-induced E3 ligase, TRIM15 inhibits TNF-α-regulated NF-κB pathway by promoting turnover of K63 linked ubiquitination of TAK1. Roy M, et al. Cell Signal, 2022 Mar. PMID 34871740
    5. TRIM15 promotes the invasion and metastasis of pancreatic cancer cells by mediating APOA1 ubiquitination and degradation. Sun Y, et al. Biochim Biophys Acta Mol Basis Dis, 2021 Nov 1. PMID 34311082

    See all (35) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. TRIM15 forms a regulatory loop with the AKT/FOXO1 axis and LASP1 to modulate the sensitivity of HCC cells to TKIs.
      Title: TRIM15 forms a regulatory loop with the AKT/FOXO1 axis and LASP1 to modulate the sensitivity of HCC cells to TKIs.
    2. E3 ligase TRIM15 facilitates non-small cell lung cancer progression through mediating Keap1-Nrf2 signaling pathway.
      Title: E3 ligase TRIM15 facilitates non-small cell lung cancer progression through mediating Keap1-Nrf2 signaling pathway.
    3. Knockdown of TRIM15 inhibits the proliferation, migration and invasion of esophageal squamous cell carcinoma cells through inactivation of the Wnt/beta-catenin signaling pathway.
      Title: Knockdown of TRIM15 inhibits the proliferation, migration and invasion of esophageal squamous cell carcinoma cells through inactivation of the Wnt/β-catenin signaling pathway.
    4. TRIM15 and CYLD regulate ERK activation via lysine-63-linked polyubiquitination.
      Title: TRIM15 and CYLD regulate ERK activation via lysine-63-linked polyubiquitination.
    5. TCGA database showed that higher TRIM15 RNA transcription indicates poorer overall survival of gastric cancer patients. Besides, low expression of TRIM15 was significantly associated with advanced tumor invasion depth and advanced TNM stage.
      Title: TRIM15 Exerts Anti-Tumor Effects Through Suppressing Cancer Cell Invasion in Gastric Adenocarcinoma.
    6. TRIM15-depleted cells display impaired cell migration and reduced focal adhesion disassembly rates.
      Title: TRIM15 is a focal adhesion protein that regulates focal adhesion disassembly.
    7. TRIM15 may function as a tumor suppressor of colon cancer.
      Title: Role of the focal adhesion protein TRIM15 in colon cancer development.
    8. Clinical trial of gene-disease association and gene-environment interaction. (HuGE Navigator)
      Title: Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.
    9. Observational study of gene-disease association. (HuGE Navigator)
      Title: Refining the association of MHC with multiple sclerosis in African Americans.
    10. Downregulation of TRIM11 and TRIM15 enhanced virus release suggesting that these proteins contribute to the endogenous restriction of retroviruses in cells.
      Title: TRIM E3 ligases interfere with early and late stages of the retroviral life cycle.
    Submit: New GeneRIF Correction

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    EBI GWAS Catalog

    Description
    Genome-wide association study of proneness to anger.
    EBI GWAS Catalog

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Genotypes

    HIV-1 interactions

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    Protein interactions

    Protein Gene Interaction Pubs
    Pr55(Gag) gag Fluorescence microscope analysis demonstrates a reduction of HIV-1 Gag fluorescence at the plasma membrane in cells containing cytoplasmic TRIM15 bodies PubMed

    Go to the HIV-1, Human Interaction Database

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables molecular sequestering activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables transcription coactivator activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables ubiquitin protein ligase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables zinc ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in innate immune response IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in innate immune response IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in mesodermal cell fate determination TAS
    Traceable Author Statement
    more info
    		 PubMed 
    involved_in negative regulation of intracellular transport of viral material IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in negative regulation of non-canonical NF-kappaB signal transduction IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in positive regulation of DNA-binding transcription factor activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of DNA-templated transcription IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in positive regulation of NF-kappaB transcription factor activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in positive regulation of RIG-I signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of type I interferon production IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in suppression of viral release by host IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in suppression of viral release by host IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in focal adhesion IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    E3 ubiquitin-protein ligase TRIM15
    Names
    RING finger protein 93
    tripartite motif-containing protein 15
    zinc finger protein 178
    zinc finger protein B7
    NP_150232.2
    XP_011513289.1
    XP_011513290.1
    XP_047275459.1
    XP_054184499.1
    XP_054184500.1
    XP_054184501.1
    XP_054185901.1
    XP_054185902.1
    XP_054185903.1
    XP_054186394.1
    XP_054186395.1
    XP_054186396.1
    XP_054186667.1
    XP_054186668.1
    XP_054186669.1
    XP_054186887.1
    XP_054186888.1
    XP_054186889.1
    XP_054187166.1
    XP_054187167.1
    XP_054187168.1
    XP_054187408.1
    XP_054187409.1
    XP_054187410.1
    XP_054212687.1
    XP_054212688.1
    XP_054212689.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_033229.3 → NP_150232.2  E3 ubiquitin-protein ligase TRIM15

      See identical proteins and their annotated locations for NP_150232.2

      Status: REVIEWED

      Source sequence(s)
      AI739162, AL669914, BC038585, BP270476, U34249
      Consensus CDS
      CCDS4677.1
      UniProtKB/Swiss-Prot
      A2BEC9, O95604, Q8IUX9, Q9C018, Q9C019
      UniProtKB/TrEMBL
      A0A0G2JJP1, A0A1U9X8P2, A6NEF7, A8K2L5, Q0EFD1, Q5SRL0
      Related
      ENSP00000365884.4, ENST00000376694.9
      Conserved Domains (5) summary
      smart00336
      Location:80 → 119
      BBOX; B-Box-type zinc finger
      pfam09088
      Location:252 → 327
      MIF4G_like; MIF4G like
      cd15826
      Location:295 → 464
      SPRY_PRY_TRIM15; PRY/SPRY domain in tripartite motif-binding protein 15 (TRIM15)
      cd16543
      Location:16 → 61
      RING-HC_RNF135_like; RING finger, HC subclass, found in RING finger protein 135 (RNF135), tripartite motif-containing protein 15 (TRIM15) and similar proteins
      cl25732
      Location:121 → 241
      SMC_N; RecF/RecN/SMC N terminal domain

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000006.12 Reference GRCh38.p14 Primary Assembly

      Range
      30163546..30172693
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011514987.2 → XP_011513289.1  E3 ubiquitin-protein ligase TRIM15 isoform X1

      Conserved Domains (2) summary
      pfam09088
      Location:147 → 222
      MIF4G_like; MIF4G like
      cd15826
      Location:190 → 359
      SPRY_PRY_TRIM15; PRY/SPRY domain in tripartite motif-binding protein 15 (TRIM15)

    2. XM_047419503.1 → XP_047275459.1  E3 ubiquitin-protein ligase TRIM15 isoform X3

    3. XM_011514988.3 → XP_011513290.1  E3 ubiquitin-protein ligase TRIM15 isoform X2

      See identical proteins and their annotated locations for XP_011513290.1

      Conserved Domains (2) summary
      pfam09088
      Location:45 → 120
      MIF4G_like; MIF4G like
      cd15826
      Location:88 → 257
      SPRY_PRY_TRIM15; PRY/SPRY domain in tripartite motif-binding protein 15 (TRIM15)

    Reference GRCh38.p14 ALT_REF_LOCI_1

    Genomic

    1. NT_167244.2 Reference GRCh38.p14 ALT_REF_LOCI_1

      Range
      1421505..1430773
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054328524.1 → XP_054184499.1  E3 ubiquitin-protein ligase TRIM15 isoform X1

    2. XM_054328526.1 → XP_054184501.1  E3 ubiquitin-protein ligase TRIM15 isoform X3

    3. XM_054328525.1 → XP_054184500.1  E3 ubiquitin-protein ligase TRIM15 isoform X2

    Reference GRCh38.p14 ALT_REF_LOCI_2

    Genomic

    1. NT_113891.3 Reference GRCh38.p14 ALT_REF_LOCI_2

      Range
      1643223..1652491
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054329926.1 → XP_054185901.1  E3 ubiquitin-protein ligase TRIM15 isoform X1

    2. XM_054329928.1 → XP_054185903.1  E3 ubiquitin-protein ligase TRIM15 isoform X3

    3. XM_054329927.1 → XP_054185902.1  E3 ubiquitin-protein ligase TRIM15 isoform X2

    Reference GRCh38.p14 ALT_REF_LOCI_3

    Genomic

    1. NT_167245.2 Reference GRCh38.p14 ALT_REF_LOCI_3

      Range
      1419326..1428594
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054330419.1 → XP_054186394.1  E3 ubiquitin-protein ligase TRIM15 isoform X1

    2. XM_054330421.1 → XP_054186396.1  E3 ubiquitin-protein ligase TRIM15 isoform X3

    3. XM_054330420.1 → XP_054186395.1  E3 ubiquitin-protein ligase TRIM15 isoform X2

    Reference GRCh38.p14 ALT_REF_LOCI_4

    Genomic

    1. NT_167246.2 Reference GRCh38.p14 ALT_REF_LOCI_4

      Range
      1474127..1483395
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054330692.1 → XP_054186667.1  E3 ubiquitin-protein ligase TRIM15 isoform X1

    2. XM_054330694.1 → XP_054186669.1  E3 ubiquitin-protein ligase TRIM15 isoform X3

    3. XM_054330693.1 → XP_054186668.1  E3 ubiquitin-protein ligase TRIM15 isoform X2

    Reference GRCh38.p14 ALT_REF_LOCI_5

    Genomic

    1. NT_167247.2 Reference GRCh38.p14 ALT_REF_LOCI_5

      Range
      1507498..1516766
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054330912.1 → XP_054186887.1  E3 ubiquitin-protein ligase TRIM15 isoform X1

    2. XM_054330914.1 → XP_054186889.1  E3 ubiquitin-protein ligase TRIM15 isoform X3

    3. XM_054330913.1 → XP_054186888.1  E3 ubiquitin-protein ligase TRIM15 isoform X2

    Reference GRCh38.p14 ALT_REF_LOCI_6

    Genomic

    1. NT_167248.2 Reference GRCh38.p14 ALT_REF_LOCI_6

      Range
      1418553..1427821
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054331191.1 → XP_054187166.1  E3 ubiquitin-protein ligase TRIM15 isoform X1

    2. XM_054331193.1 → XP_054187168.1  E3 ubiquitin-protein ligase TRIM15 isoform X3

    3. XM_054331192.1 → XP_054187167.1  E3 ubiquitin-protein ligase TRIM15 isoform X2

    Reference GRCh38.p14 ALT_REF_LOCI_7

    Genomic

    1. NT_167249.2 Reference GRCh38.p14 ALT_REF_LOCI_7

      Range
      1462356..1471624
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054331433.1 → XP_054187408.1  E3 ubiquitin-protein ligase TRIM15 isoform X1

    2. XM_054331435.1 → XP_054187410.1  E3 ubiquitin-protein ligase TRIM15 isoform X3

    3. XM_054331434.1 → XP_054187409.1  E3 ubiquitin-protein ligase TRIM15 isoform X2

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060930.1 Alternate T2T-CHM13v2.0

      Range
      30027684..30036952
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054356712.1 → XP_054212687.1  E3 ubiquitin-protein ligase TRIM15 isoform X1

    2. XM_054356714.1 → XP_054212689.1  E3 ubiquitin-protein ligase TRIM15 isoform X3

    3. XM_054356713.1 → XP_054212688.1  E3 ubiquitin-protein ligase TRIM15 isoform X2

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_052812.1: Suppressed sequence

      Description
      NM_052812.1: This RefSeq was permanently suppressed because currently there is not sufficient data to support this transcript.
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9C019.1 GenPept UniProtKB/Swiss-Prot:Q9C019

    Gene LinkOut

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