ARHGAP21 Rho GTPase activating protein 21 [Homo sapiens (human)] - Gene

Summary

Official Symbol: ARHGAP21provided by HGNC
Official Full Name: Rho GTPase activating protein 21provided by HGNC
Primary source: HGNC:HGNC:23725
See related: Ensembl:ENSG00000107863 MIM:609870; AllianceGenome:HGNC:23725
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: ARHGAP10
Summary: ARHGAP21 functions preferentially as a GTPase-activating protein (GAP) for CDC42 (MIM 116952) and regulates the ARP2/3 complex (MIM 604221) and F-actin dynamics at the Golgi through control of CDC42 activity (Dubois et al., 2005 [PubMed 15793564]).[supplied by OMIM, Mar 2008]
Expression: Ubiquitous expression in brain (RPKM 26.0), fat (RPKM 12.0) and 25 other tissues See more
Orthologs: mouse all
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Genomic context

Location:: 10p12.1; 10p12.3

Exon count:: 33

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCh38.p14 (GCF_000001405.40)	10	NC_000010.11 (24583614..24723887, complement)
RS_2024_08	current	T2T-CHM13v2.0 (GCF_009914755.1)	10	NC_060934.1 (24602382..24742515, complement)
RS_2024_09	previous assembly	GRCh37.p13 (GCF_000001405.25)	10	NC_000010.10 (24872543..25012816, complement)

Chromosome 10 - NC_000010.11 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
BioProject: PRJEB4337
Publication: PMID 24309898
Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

[ARHGAP21 inhibits epithelial-mesenchymal transition by inactivating the WNT signaling pathway in non-small cell lung cancer].
Title: [ARHGAP21 inhibits epithelial-mesenchymal transition by inactivating the WNT signaling pathway in non-small cell lung cancer].
Silencing of ARHGAP21, a Rho GTPase activating protein (RhoGAP), reduces the growth of prostate cancer xenografts in NOD/SCID mice.
Title: Silencing of ARHGAP21, a Rho GTPase activating protein (RhoGAP), reduces the growth of prostate cancer xenografts in NOD/SCID mice.
ARHGAP21 Is Involved in the Carcinogenic Mechanism of Cholangiocarcinoma: A Study Based on Bioinformatic Analyses and Experimental Validation.
Title: ARHGAP21 Is Involved in the Carcinogenic Mechanism of Cholangiocarcinoma: A Study Based on Bioinformatic Analyses and Experimental Validation.
Deficiency of ARHGAP21 alters megakaryocytic cell lineage responses and enhances platelet hemostatic function.
Title: Deficiency of ARHGAP21 alters megakaryocytic cell lineage responses and enhances platelet hemostatic function.
In this paper, we aimed to review the available literature regarding ARHGAP21 to highlight its importance and the mechanisms of action that have been found so far for this still unknown protein involved with cell adhesion, migration, Golgi regulation, cell trafficking, and even insulin secretion.
Title: ARHGAP21 as a master regulator of multiple cellular processes.
Reduced Arhgap21 is associated with Hematopoietic defects.
Title: Hematopoietic defects in response to reduced Arhgap21.
The results show that PTEN controls multicellular assembly through a membrane-associated regulatory protein complex composed of beta-Arrestin1, ARHGAP21 and Cdc42.
Title: PTEN controls glandular morphogenesis through a juxtamembrane β-Arrestin1/ARHGAP21 scaffolding complex.
Gly1121Ser variant in ARHGAP21 gene found to be shared by all MP individuals in arger branch of family with nearly complete penetrance. ARHGAP21 protein strengthens cell-cell adhesions; may be regulated by BMPs influencing mandibular growth.
Title: Genetic association of ARHGAP21 gene variant with mandibular prognathism.
ARHGAP21 is a Rho-GAP involved in cell-cell junction remodeling that affects migration and EMT through alpha-tubulin interaction and acetylation
Title: ARHGAP21 protein, a new partner of α-tubulin involved in cell-cell adhesion formation and essential for epithelial-mesenchymal transition.
Co-immunoprecipitations and in vitro SUMOylation confirmed ARHGAP21 specific modification by SUMO2/3 and mapped the SUMOylation site to ARHGAP21 lysine K1443.
Title: Post-translational modification of the RhoGTPase activating protein 21, ARHGAP21, by SUMO2/3.

Submit: New GeneRIF Correction See all GeneRIFs (17)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

SHGC-146218 (e-PCR)
- UniSTS:172567

D10S275 (e-PCR)
- UniSTS:147992

RH45030 (e-PCR)
- UniSTS:68637

PMC156606P1 (e-PCR)
- UniSTS:271408

RH65067 (e-PCR)
- UniSTS:83611

RH66951 (e-PCR)
- UniSTS:88505

SHGC-144197 (e-PCR)
- UniSTS:182213

RH68400 (e-PCR)
- UniSTS:84449

RH37461 (e-PCR)
- UniSTS:49146

Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
enables GTPase activator activity	TAS Traceable Author Statement more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in Golgi localization	IBA Inferred from Biological aspect of Ancestor more info
involved_in Golgi organization	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in establishment of Golgi localization	IDA Inferred from Direct Assay more info	PubMed
involved_in maintenance of Golgi location	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in organelle transport along microtubule	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of small GTPase mediated signal transduction	TAS Traceable Author Statement more info
involved_in signal transduction	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in Golgi apparatus	IDA Inferred from Direct Assay more info	PubMed
located_in Golgi membrane	IEA Inferred from Electronic Annotation more info
located_in actin cytoskeleton	IDA Inferred from Direct Assay more info
located_in anchoring junction	IEA Inferred from Electronic Annotation more info
located_in cell junction	IDA Inferred from Direct Assay more info
located_in cytoplasmic vesicle membrane	IEA Inferred from Electronic Annotation more info
located_in cytosol	TAS Traceable Author Statement more info
located_in plasma membrane	IDA Inferred from Direct Assay more info

General protein information

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Preferred Names: rho GTPase-activating protein 21

Names: Rho-GTPase activating protein 10; rho GTPase-activating protein 10; rho-type GTPase-activating protein 21

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001367447.1 → NP_001354376.1 rho GTPase-activating protein 21 isoform b

Status: VALIDATED

Description

Transcript Variant: This variant (4), as well as variants 5 and 6, encodes isoform b.

Source sequence(s)

AL355979, AL392104

Consensus CDS

CCDS91222.1

UniProtKB/TrEMBL

A0A2X0SF83, A0A805TBS0
NM_001367448.1 → NP_001354377.1 rho GTPase-activating protein 21 isoform a

Status: VALIDATED

Description

Transcript Variant: This variant (2), as well as variants 1 and 3, encodes isoform a.

Source sequence(s)

AL355979, AL392104

Consensus CDS

CCDS7144.2

UniProtKB/Swiss-Prot

Q0VF98, Q5T5U3, Q7Z3P7, Q8N3A2, Q8NI19, Q8TBV5, Q9P2C3

UniProtKB/TrEMBL

A0A2X0SF83

Related

ENSP00000506388.1, ENST00000680286.1

Conserved Domains (3) summary

cd00992
Location:48 → 155

PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

cd04395
Location:1144 → 1339

RhoGAP_ARHGAP21; RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ArhGAP21-like proteins. ArhGAP21 is a multi-domain protein, containing RhoGAP, PH and PDZ domains, and is believed to play a role in the organization of the cell-cell junction ...

cd01253
Location:933 → 1042

PH_ARHGAP21-like; ARHGAP21 and related proteins pleckstrin homology (PH) domain
NM_001367449.1 → NP_001354378.1 rho GTPase-activating protein 21 isoform c

Status: VALIDATED

Description

Transcript Variant: This variant (7), as well as variant 8, encodes isoform c.

Source sequence(s)

AL355979, AL392104

UniProtKB/TrEMBL

A0A2X0SF83
NM_001367450.1 → NP_001354379.1 rho GTPase-activating protein 21 isoform c

Status: VALIDATED

Description

Transcript Variant: This variant (8), as well as variant 7, encodes isoform c.

Source sequence(s)

AL355979, AL392104

UniProtKB/TrEMBL

A0A2X0SF83
NM_001367451.1 → NP_001354380.1 rho GTPase-activating protein 21 isoform b

Status: VALIDATED

Description

Transcript Variant: This variant (5), as well as variants 4 and 6, encodes isoform b.

Source sequence(s)

AL355979, AL392104

Consensus CDS

CCDS91222.1

UniProtKB/TrEMBL

A0A2X0SF83, A0A805TBS0

Related

ENSP00000365592.3, ENST00000376410.7
NM_001367452.1 → NP_001354381.1 rho GTPase-activating protein 21 isoform d

Status: VALIDATED

Source sequence(s)

AL355979, AL392104

UniProtKB/TrEMBL

A0A2X0SF83
NM_001367453.1 → NP_001354382.1 rho GTPase-activating protein 21 isoform b

Status: VALIDATED

Description

Transcript Variant: This variant (6), as well as variants 4 and 5, encodes isoform b.

Source sequence(s)

AL355979, AL392104

Consensus CDS

CCDS91222.1

UniProtKB/TrEMBL

A0A2X0SF83, A0A805TBS0
NM_001367454.1 → NP_001354383.1 rho GTPase-activating protein 21 isoform a

Status: VALIDATED

Description

Transcript Variant: This variant (3), as well as variants 1 and 2, encodes isoform a.

Source sequence(s)

AL355979, AL392104

Consensus CDS

CCDS7144.2

UniProtKB/Swiss-Prot

Q0VF98, Q5T5U3, Q7Z3P7, Q8N3A2, Q8NI19, Q8TBV5, Q9P2C3

UniProtKB/TrEMBL

A0A2X0SF83

Conserved Domains (3) summary

cd00992
Location:48 → 155

PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

cd04395
Location:1144 → 1339

RhoGAP_ARHGAP21; RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ArhGAP21-like proteins. ArhGAP21 is a multi-domain protein, containing RhoGAP, PH and PDZ domains, and is believed to play a role in the organization of the cell-cell junction ...

cd01253
Location:933 → 1042

PH_ARHGAP21-like; ARHGAP21 and related proteins pleckstrin homology (PH) domain
NM_001367455.1 → NP_001354384.1 rho GTPase-activating protein 21 isoform e

Status: VALIDATED

Source sequence(s)

AL392104

UniProtKB/TrEMBL

A0A2X0SF83

Related

ENST00000486374.5
NM_020824.4 → NP_065875.3 rho GTPase-activating protein 21 isoform a

See identical proteins and their annotated locations for NP_065875.3

Status: VALIDATED

Description

Transcript Variant: This variant (1) encodes the longest isoform (a). Variants 1, 2, and 3 all encode the same isoform (a).

Source sequence(s)

AB037845, AF480466, AL355979, AV709499, BI491305, BQ026288

Consensus CDS

CCDS7144.2

UniProtKB/Swiss-Prot

Q0VF98, Q5T5U3, Q7Z3P7, Q8N3A2, Q8NI19, Q8TBV5, Q9P2C3

UniProtKB/TrEMBL

A0A2X0SF83

Related

ENSP00000379709.2, ENST00000396432.7

Conserved Domains (3) summary

cd00992
Location:48 → 155

PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

cd04395
Location:1144 → 1339

RhoGAP_ARHGAP21; RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ArhGAP21-like proteins. ArhGAP21 is a multi-domain protein, containing RhoGAP, PH and PDZ domains, and is believed to play a role in the organization of the cell-cell junction ...

cd01253
Location:933 → 1042

PH_ARHGAP21-like; ARHGAP21 and related proteins pleckstrin homology (PH) domain

RNA

NR_160021.1 RNA Sequence

Status: VALIDATED

Source sequence(s)

AL355979, AL392104
NR_160022.1 RNA Sequence

Status: VALIDATED

Source sequence(s)

AL355979, AL392104
NR_160023.1 RNA Sequence

Status: VALIDATED

Source sequence(s)

AL355979, AL392104
NR_160024.1 RNA Sequence

Status: VALIDATED

Source sequence(s)

AL392104
NR_160025.1 RNA Sequence

Status: VALIDATED

Source sequence(s)

AL392104

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

NC_000010.11 Reference GRCh38.p14 Primary Assembly

Range

24583614..24723887 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_047425561.1 → XP_047281517.1 rho GTPase-activating protein 21 isoform X7
XM_011519605.3 → XP_011517907.1 rho GTPase-activating protein 21 isoform X2

UniProtKB/TrEMBL

A0A2X0SF83

Conserved Domains (4) summary

cd00992
Location:48 → 155

PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

cd04395
Location:1168 → 1363

RhoGAP_ARHGAP21; RhoGAP_ARHGAP21: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ArhGAP21-like proteins. ArhGAP21 is a multi-domain protein, containing RhoGAP, PH and PDZ domains, and is believed to play a role in the organization of the ...

cd01253
Location:957 → 1066

PH_ARHGAP21-like; ARHGAP21 and related proteins pleckstrin homology (PH) domain

pfam00169
Location:958 → 1063

PH; PH domain
XM_047425560.1 → XP_047281516.1 rho GTPase-activating protein 21 isoform X6
XM_011519607.3 → XP_011517909.1 rho GTPase-activating protein 21 isoform X4

Conserved Domains (4) summary

cd00992
Location:48 → 155

PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

cd04395
Location:1178 → 1373

RhoGAP_ARHGAP21; RhoGAP_ARHGAP21: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ArhGAP21-like proteins. ArhGAP21 is a multi-domain protein, containing RhoGAP, PH and PDZ domains, and is believed to play a role in the organization of the ...

cd01253
Location:967 → 1076

PH_ARHGAP21-like; ARHGAP21 and related proteins pleckstrin homology (PH) domain

pfam00169
Location:968 → 1073

PH; PH domain
XM_011519602.3 → XP_011517904.1 rho GTPase-activating protein 21 isoform X1

See identical proteins and their annotated locations for XP_011517904.1

UniProtKB/TrEMBL

A0A2X0SF83

Conserved Domains (4) summary

cd00992
Location:48 → 155

PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

cd04395
Location:1178 → 1373

RhoGAP_ARHGAP21; RhoGAP_ARHGAP21: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ArhGAP21-like proteins. ArhGAP21 is a multi-domain protein, containing RhoGAP, PH and PDZ domains, and is believed to play a role in the organization of the ...

cd01253
Location:967 → 1076

PH_ARHGAP21-like; ARHGAP21 and related proteins pleckstrin homology (PH) domain

pfam00169
Location:968 → 1073

PH; PH domain
XM_047425562.1 → XP_047281518.1 rho GTPase-activating protein 21 isoform X7
XM_047425557.1 → XP_047281513.1 rho GTPase-activating protein 21 isoform X2
XM_011519604.3 → XP_011517906.1 rho GTPase-activating protein 21 isoform X1

See identical proteins and their annotated locations for XP_011517906.1

UniProtKB/TrEMBL

A0A2X0SF83

Conserved Domains (4) summary

cd00992
Location:48 → 155

PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

cd04395
Location:1178 → 1373

RhoGAP_ARHGAP21; RhoGAP_ARHGAP21: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ArhGAP21-like proteins. ArhGAP21 is a multi-domain protein, containing RhoGAP, PH and PDZ domains, and is believed to play a role in the organization of the ...

cd01253
Location:967 → 1076

PH_ARHGAP21-like; ARHGAP21 and related proteins pleckstrin homology (PH) domain

pfam00169
Location:968 → 1073

PH; PH domain
XM_047425556.1 → XP_047281512.1 rho GTPase-activating protein 21 isoform X2
XM_011519603.4 → XP_011517905.1 rho GTPase-activating protein 21 isoform X1

See identical proteins and their annotated locations for XP_011517905.1

UniProtKB/TrEMBL

A0A2X0SF83

Conserved Domains (4) summary

cd00992
Location:48 → 155

PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

cd04395
Location:1178 → 1373

RhoGAP_ARHGAP21; RhoGAP_ARHGAP21: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ArhGAP21-like proteins. ArhGAP21 is a multi-domain protein, containing RhoGAP, PH and PDZ domains, and is believed to play a role in the organization of the ...

cd01253
Location:967 → 1076

PH_ARHGAP21-like; ARHGAP21 and related proteins pleckstrin homology (PH) domain

pfam00169
Location:968 → 1073

PH; PH domain
XM_011519606.3 → XP_011517908.1 rho GTPase-activating protein 21 isoform X3

UniProtKB/TrEMBL

A0A2X0SF83

Conserved Domains (4) summary

cd00992
Location:34 → 87

PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

cd04395
Location:1110 → 1305

RhoGAP_ARHGAP21; RhoGAP_ARHGAP21: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ArhGAP21-like proteins. ArhGAP21 is a multi-domain protein, containing RhoGAP, PH and PDZ domains, and is believed to play a role in the organization of the ...

cd01253
Location:899 → 1008

PH_ARHGAP21-like; ARHGAP21 and related proteins pleckstrin homology (PH) domain

pfam00169
Location:900 → 1005

PH; PH domain
XM_047425563.1 → XP_047281519.1 rho GTPase-activating protein 21 isoform X8

Related

ENSP00000490396.1, ENST00000636789.1
XM_047425559.1 → XP_047281515.1 rho GTPase-activating protein 21 isoform X5