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    Lipe lipase, hormone sensitive [ Mus musculus (house mouse) ]

    Gene ID: 16890, updated on 28-Oct-2024

    Summary

    Official Symbol
    Lipeprovided by MGI
    Official Full Name
    lipase, hormone sensitiveprovided by MGI
    Primary source
    MGI:MGI:96790
    See related
    Ensembl:ENSMUSG00000003123 AllianceGenome:MGI:96790
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    HSL; REH; 4933403G17Rik
    Summary
    Enables several functions, including lipase activity; retinyl-palmitate esterase activity; and serine hydrolase activity. Involved in diacylglycerol catabolic process and ether lipid metabolic process. Acts upstream of or within cellular response to cold; long-chain fatty acid catabolic process; and triglyceride catabolic process. Located in cytosol; lipid droplet; and membrane. Is expressed in adipose tissue; ileum; and male reproductive gland or organ. Human ortholog(s) of this gene implicated in arteriosclerosis; familial partial lipodystrophy type 6; and hypertension. Orthologous to human LIPE (lipase E, hormone sensitive type). [provided by Alliance of Genome Resources, Oct 2024]
    Expression
    Biased expression in subcutaneous fat pad adult (RPKM 216.0), mammary gland adult (RPKM 160.3) and 11 other tissues See more
    Orthologs
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    Genomic context

    See Lipe in Genome Data Viewer
    Location:
    7 A3; 7 13.78 cM
    Exon count:
    15
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (25078952..25097911, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (25379527..25398486, complement)

    Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene multiple EGF-like-domains 8 Neighboring gene RIKEN cDNA 4732471J01 gene Neighboring gene cornifelin Neighboring gene STARR-positive B cell enhancer ABC_E2227 Neighboring gene STARR-positive B cell enhancer ABC_E11345 Neighboring gene C-X-C motif chemokine ligand 17 Neighboring gene GrpE-like 2, mitochondrial pseudogene

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    Related articles in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (2) 
    • Targeted (8)  1 citation

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables all-trans-retinyl-palmitate hydrolase, all-trans-retinol forming activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables diacylglycerol lipase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables diacylglycerol lipase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables diacylglycerol lipase activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables hydrolase activity, acting on ester bonds ISO
    Inferred from Sequence Orthology
    more info
     
    enables monoacylglycerol lipase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables monoacylglycerol lipase activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables protein kinase binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables rRNA primary transcript binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    PubMed 
    enables retinyl-palmitate esterase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables retinyl-palmitate esterase activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables serine hydrolase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables sterol ester esterase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables sterol ester esterase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables sterol ester esterase activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables triacylglycerol lipase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables triacylglycerol lipase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables triacylglycerol lipase activity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    enables triacylglycerol lipase activity ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    acts_upstream_of_or_within cellular response to cold IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in cholesterol metabolic process IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within diacylglycerol catabolic process IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in diacylglycerol catabolic process IDA
    Inferred from Direct Assay
    more info
    PubMed 
    acts_upstream_of_or_within diacylglycerol catabolic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in ether lipid metabolic process IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in lipid catabolic process IDA
    Inferred from Direct Assay
    more info
    PubMed 
    acts_upstream_of_or_within long-chain fatty acid catabolic process IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in retinol metabolic process IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in termination of RNA polymerase I transcription ISS
    Inferred from Sequence or Structural Similarity
    more info
    PubMed 
    involved_in transcription initiation at RNA polymerase I promoter ISS
    Inferred from Sequence or Structural Similarity
    more info
    PubMed 
    involved_in triglyceride catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    acts_upstream_of_or_within triglyceride catabolic process IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in triglyceride catabolic process IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within triglyceride catabolic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in triglyceride catabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    located_in caveola ISS
    Inferred from Sequence or Structural Similarity
    more info
    PubMed 
    located_in cytoplasm ISS
    Inferred from Sequence or Structural Similarity
    more info
    PubMed 
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
     
    located_in extracellular space ISO
    Inferred from Sequence Orthology
    more info
     
    located_in lipid droplet IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in mitochondrion ISS
    Inferred from Sequence or Structural Similarity
    more info
    PubMed 
    located_in nucleus ISS
    Inferred from Sequence or Structural Similarity
    more info
    PubMed 

    General protein information

    Preferred Names
    hormone-sensitive lipase
    Names
    monoacylglycerol lipase LIPE
    retinyl ester hydrolase
    NP_001034596.1
    NP_034849.2
    XP_006539633.2
    XP_006539635.1
    XP_030098038.1
    XP_030098040.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001039507.2NP_001034596.1  hormone-sensitive lipase isoform 2

      See identical proteins and their annotated locations for NP_001034596.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR, lacks a portion of the 5' coding region, and uses a downstream in-frame start codon, compared to variant 1. The encoded isoform (2) is shorter at the N-terminus, compared to isoform 1.
      Source sequence(s)
      AC169209
      Consensus CDS
      CCDS20982.1
      UniProtKB/Swiss-Prot
      P54310, P97866, Q3TE34, Q6GU16, Q8CDI9
      Related
      ENSMUSP00000050935.8, ENSMUST00000054301.14
      Conserved Domains (2) summary
      pfam06350
      Location:6314
      HSL_N; Hormone-sensitive lipase (HSL) N-terminus
      cl21494
      Location:345493
      Abhydrolase; alpha/beta hydrolases
    2. NM_010719.5NP_034849.2  hormone-sensitive lipase isoform 1

      See identical proteins and their annotated locations for NP_034849.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
      Source sequence(s)
      AK029984, BY513432
      Consensus CDS
      CCDS20981.1
      UniProtKB/Swiss-Prot
      P54310
      Related
      ENSMUSP00000003207.5, ENSMUST00000003207.11
      Conserved Domains (3) summary
      COG0657
      Location:378535
      Aes; Acetyl esterase/lipase [Lipid transport and metabolism]
      pfam06350
      Location:49357
      HSL_N; Hormone-sensitive lipase (HSL) N-terminus
      cl21494
      Location:388536
      Abhydrolase; alpha/beta hydrolases

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000073.7 Reference GRCm39 C57BL/6J

      Range
      25078952..25097911 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006539570.2XP_006539633.2  hormone-sensitive lipase isoform X1

      UniProtKB/TrEMBL
      E9Q4M2
      Related
      ENSMUSP00000123485.2, ENSMUST00000149349.2
      Conserved Domains (2) summary
      pfam06350
      Location:304612
      HSL_N; Hormone-sensitive lipase (HSL) N-terminus
      cl21494
      Location:643791
      Abhydrolase; alpha/beta hydrolases
    2. XM_030242180.1XP_030098040.1  hormone-sensitive lipase isoform X2

      UniProtKB/Swiss-Prot
      P54310, P97866, Q3TE34, Q6GU16, Q8CDI9
      Conserved Domains (2) summary
      pfam06350
      Location:6314
      HSL_N; Hormone-sensitive lipase (HSL) N-terminus
      cl21494
      Location:345493
      Abhydrolase; alpha/beta hydrolases
    3. XM_030242178.1XP_030098038.1  hormone-sensitive lipase isoform X2

      UniProtKB/Swiss-Prot
      P54310, P97866, Q3TE34, Q6GU16, Q8CDI9
      Conserved Domains (2) summary
      pfam06350
      Location:6314
      HSL_N; Hormone-sensitive lipase (HSL) N-terminus
      cl21494
      Location:345493
      Abhydrolase; alpha/beta hydrolases
    4. XM_006539572.4XP_006539635.1  hormone-sensitive lipase isoform X2

      See identical proteins and their annotated locations for XP_006539635.1

      UniProtKB/Swiss-Prot
      P54310, P97866, Q3TE34, Q6GU16, Q8CDI9
      Related
      ENSMUSP00000145665.2, ENSMUST00000206861.2
      Conserved Domains (2) summary
      pfam06350
      Location:6314
      HSL_N; Hormone-sensitive lipase (HSL) N-terminus
      cl21494
      Location:345493
      Abhydrolase; alpha/beta hydrolases