Csf3 colony stimulating factor 3 (granulocyte) [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Csf3provided by MGI
Official Full Name: colony stimulating factor 3 (granulocyte)provided by MGI
Primary source: MGI:MGI:1339751
See related: Ensembl:ENSMUSG00000038067 AllianceGenome:MGI:1339751
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Csfg; G-CSF; MGI-IG
Summary: Enables granulocyte colony-stimulating factor receptor binding activity. Acts upstream of or within positive regulation of myeloid cell differentiation. Predicted to be located in endocytic vesicle lumen and extracellular region. Predicted to be active in extracellular space. Is expressed in several structures, including hemolymphoid system; liver; placenta; trunk; and yolk sac. Human ortholog(s) of this gene implicated in several diseases, including allergic cutaneous vasculitis; artery disease (multiple); ischemia (multiple); leukemia (multiple); and lung disease (multiple). Orthologous to human CSF3 (colony stimulating factor 3). [provided by Alliance of Genome Resources, Oct 2024]
Expression: Biased expression in ovary adult (RPKM 3.1), genital fat pad adult (RPKM 0.7) and 4 other tissues See more
Orthologs: human all
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Genomic context

Location:: 11 D; 11 62.45 cM

Exon count:: 5

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	11	NC_000077.7 (98591287..98594457)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	11	NC_000077.6 (98700183..98703631)

Chromosome 11 - NC_000077.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Thymic stromal lymphopoietin contributes to ozone-induced exacerbations of eosinophilic airway inflammation via granulocyte colony-stimulating factor in mice.
Title: Thymic stromal lymphopoietin contributes to ozone-induced exacerbations of eosinophilic airway inflammation via granulocyte colony-stimulating factor in mice.
Tumor-derived GCSF Alters Tumor and Systemic Immune System Cell Subset Composition and Signaling.
Title: Tumor-derived GCSF Alters Tumor and Systemic Immune System Cell Subset Composition and Signaling.
Squamous cell carcinoma-derived G-CSF promotes tumor growth and metastasis in mice through neutrophil recruitment and tumor cell proliferation, associated with poor prognosis of the patients.
Title: Squamous cell carcinoma-derived G-CSF promotes tumor growth and metastasis in mice through neutrophil recruitment and tumor cell proliferation, associated with poor prognosis of the patients.
G-CSF exacerbates liver injury in a mouse model of autoimmune hepatitis.
Title: G-CSF exacerbates liver injury in a mouse model of autoimmune hepatitis.
G-CSF reduces loss of dopaminergic neurons by inhibiting TNF-alpha and IL-1beta in mouse model of Parkinson's disease.
Title: G-CSF reduces loss of dopaminergic neurons by inhibiting TNF-α and IL-1β in mouse model of Parkinson's disease.
Role for Granulocyte Colony-Stimulating Factor in Neutrophilic Extramedullary Myelopoiesis in a Murine Model of Systemic Juvenile Idiopathic Arthritis.
Title: Role for Granulocyte Colony-Stimulating Factor in Neutrophilic Extramedullary Myelopoiesis in a Murine Model of Systemic Juvenile Idiopathic Arthritis.
G-CSF: A vehicle for communication between trophoblasts and macrophages which may cause problems in recurrent spontaneous abortion.
Title: G-CSF: A vehicle for communication between trophoblasts and macrophages which may cause problems in recurrent spontaneous abortion.
Role of melatonin mediated G-CSF induction in hematopoietic system of gamma-irradiated mice.
Title: Role of melatonin mediated G-CSF induction in hematopoietic system of gamma-irradiated mice.
Cytokine exposure mediates transcriptional activation of the orphan nuclear receptor Nur77 in hematopoietic cells.
Title: Cytokine exposure mediates transcriptional activation of the orphan nuclear receptor Nur77 in hematopoietic cells.
Dietary magnesium restriction affects hematopoiesis and triggers neutrophilia by increasing STAT-3 expression and G-CSF production.
Title: Dietary magnesium restriction affects hematopoiesis and triggers neutrophilia by increasing STAT-3 expression and G-CSF production.

Submit: New GeneRIF Correction See all GeneRIFs (89)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (5)
Targeted (1) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

Csf3 (e-PCR), detects polymorphism
- UniSTS:257041

NoName (e-PCR)
- UniSTS:493892

Csf3 (e-PCR), detects polymorphism
- UniSTS:141416

PMC316809P1 (e-PCR)
- UniSTS:273048

M13926 (e-PCR)
- UniSTS:160156

Csf3 (e-PCR), detects polymorphism
- UniSTS:516845

PMC101742P2 (e-PCR)
- UniSTS:270064

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables cytokine activity	IBA Inferred from Biological aspect of Ancestor more info
enables cytokine activity	ISO Inferred from Sequence Orthology more info
enables cytokine activity	NAS Non-traceable Author Statement more info	PubMed
enables enzyme binding	IEA Inferred from Electronic Annotation more info
enables enzyme binding	ISO Inferred from Sequence Orthology more info
enables granulocyte colony-stimulating factor receptor binding	IBA Inferred from Biological aspect of Ancestor more info
enables granulocyte colony-stimulating factor receptor binding	IPI Inferred from Physical Interaction more info	PubMed
enables growth factor activity	IBA Inferred from Biological aspect of Ancestor more info
enables growth factor activity	IEA Inferred from Electronic Annotation more info
enables growth factor activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in cellular response to cytokine stimulus	ISO Inferred from Sequence Orthology more info
involved_in cellular response to lipopolysaccharide	IEA Inferred from Electronic Annotation more info
involved_in granulocyte colony-stimulating factor signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in granulocyte colony-stimulating factor signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in granulocyte differentiation	NAS Non-traceable Author Statement more info	PubMed
involved_in immune response	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of actin filament polymerization	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of actin filament polymerization	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of cell population proliferation	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of cell population proliferation	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of cell population proliferation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of myeloid cell differentiation	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within positive regulation of myeloid cell differentiation	IGI Inferred from Genetic Interaction more info	PubMed
involved_in positive regulation of peptidyl-tyrosine phosphorylation	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of peptidyl-tyrosine phosphorylation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of transcription by RNA polymerase II	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of transcription by RNA polymerase II	ISO Inferred from Sequence Orthology more info
involved_in regulation of actin filament organization	ISO Inferred from Sequence Orthology more info
involved_in response to ethanol	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in endocytic vesicle lumen	TAS Traceable Author Statement more info
located_in extracellular region	TAS Traceable Author Statement more info
is_active_in extracellular space	IBA Inferred from Biological aspect of Ancestor more info
located_in extracellular space	IEA Inferred from Electronic Annotation more info
located_in extracellular space	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: granulocyte colony-stimulating factor

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_009971.1 → NP_034101.1 granulocyte colony-stimulating factor precursor

See identical proteins and their annotated locations for NP_034101.1

Status: VALIDATED

Source sequence(s)

M13926

Consensus CDS

CCDS25360.1

UniProtKB/Swiss-Prot

P09920

UniProtKB/TrEMBL

Q0VB73, Q3UM22

Related

ENSMUSP00000037762.3, ENSMUST00000038886.3

Conserved Domains (1) summary

pfam16647
Location:57 → 205

GCSF; Granulocyte colony-stimulating factor

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000077.7 Reference GRCm39 C57BL/6J

Range

98591287..98594457

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_030245517.2 → XP_030101377.1 granulocyte colony-stimulating factor isoform X2

UniProtKB/TrEMBL

Q3UM22

Conserved Domains (1) summary

pfam16647
Location:108 → 256

GCSF; Granulocyte colony-stimulating factor
XM_006532128.5 → XP_006532191.3 granulocyte colony-stimulating factor isoform X1

Conserved Domains (1) summary

pfam16647
Location:241 → 389

GCSF; Granulocyte colony-stimulating factor