Nfatc2 nuclear factor of activated T cells, cytoplasmic, calcineurin dependent 2 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Nfatc2provided by MGI
Official Full Name: nuclear factor of activated T cells, cytoplasmic, calcineurin dependent 2provided by MGI
Primary source: MGI:MGI:102463
See related: Ensembl:ENSMUSG00000027544 AllianceGenome:MGI:102463
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: NFAT1; Nfatp; NF-ATp; NF-ATc2; NFAT1-D
Summary: Enables DNA-binding transcription factor activity, RNA polymerase II-specific; RNA polymerase II cis-regulatory region sequence-specific DNA binding activity; and chromatin binding activity. Involved in cartilage development; negative regulation of transcription by RNA polymerase II; and positive regulation of gene expression. Acts upstream of or within several processes, including calcineurin-NFAT signaling cascade; lncRNA transcription; and positive regulation of myoblast fusion. Located in chromatin; cytosol; and nucleus. Part of ribonucleoprotein complex and transcription regulator complex. Is expressed in several structures, including central nervous system; genitourinary system; jaw; lung; and thymus primordium. Orthologous to human NFATC2 (nuclear factor of activated T cells 2). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Broad expression in spleen adult (RPKM 4.4), thymus adult (RPKM 3.6) and 24 other tissues See more
Orthologs: human all
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Genomic context

Location:: 2 H3; 2 88.91 cM

Exon count:: 13

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	2	NC_000068.8 (168318330..168443900, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	2	NC_000068.7 (168476410..168601657, complement)

Chromosome 2 - NC_000068.8 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Genetic deficiency of the transcription factor NFAT1 confers protection against fibrogenic responses independent of immune influx.
Title: Genetic deficiency of the transcription factor NFAT1 confers protection against fibrogenic responses independent of immune influx.
NFAT1 and NFkappaB regulates expression of the common gamma-chain cytokine receptor in activated T cells.
Title: NFAT1 and NFκB regulates expression of the common γ-chain cytokine receptor in activated T cells.
Glycogen synthase kinase 3 controls T-cell exhaustion by regulating NFAT activation.
Title: Glycogen synthase kinase 3 controls T-cell exhaustion by regulating NFAT activation.
WNT16b promotes the proliferation and self-renewal of human limbal epithelial stem/progenitor cells via activating the calcium/calcineurin A/NFATC2 pathway.
Title: WNT16b promotes the proliferation and self-renewal of human limbal epithelial stem/progenitor cells via activating the calcium/calcineurin A/NFATC2 pathway.
Macrophage P2Y6 Receptor Signaling Selectively Activates NFATC2 and Suppresses Allergic Lung Inflammation.
Title: Macrophage P2Y6 Receptor Signaling Selectively Activates NFATC2 and Suppresses Allergic Lung Inflammation.
Genetic inhibition of nuclear factor of activated T-cell c2 prevents atrial fibrillation in CREM transgenic mice.
Title: Genetic inhibition of nuclear factor of activated T-cell c2 prevents atrial fibrillation in CREM transgenic mice.
Thalidomide attenuates oral epithelial cell apoptosis and pro-inflammatory cytokines secretion induced by radiotherapy via the miR-9-3p/NFATC2/NF-kappaB axis.
Title: Thalidomide attenuates oral epithelial cell apoptosis and pro-inflammatory cytokines secretion induced by radiotherapy via the miR-9-3p/NFATC2/NF-κB axis.
Identification of direct transcriptional targets of NFATC2 that promote beta cell proliferation.
Title: Identification of direct transcriptional targets of NFATC2 that promote β cell proliferation.
Nitric oxide attenuates microglia proliferation by sequentially facilitating calcium influx through TRPV2 channels, activating NFATC2, and increasing p21 transcription.
Title: Nitric oxide attenuates microglia proliferation by sequentially facilitating calcium influx through TRPV2 channels, activating NFATC2, and increasing p21 transcription.
Rapid and Efficient Gene Editing for Direct Transplantation of Naive Murine Cas9(+) T Cells.
Title: Rapid and Efficient Gene Editing for Direct Transplantation of Naive Murine Cas9(+) T Cells.

Submit: New GeneRIF Correction See all GeneRIFs (112)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Chemically induced (ENU) (1)
Endonuclease-mediated (3)
Targeted (5) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

D2Mit414 (e-PCR), detects polymorphism
- UniSTS:129321

U36575 (e-PCR)
- UniSTS:178520

Nfatc2 (e-PCR), detects polymorphism
- UniSTS:144003

Nfatc2 (e-PCR), detects polymorphism
- UniSTS:499100

Nfatc2 (e-PCR), detects polymorphism
- UniSTS:545967

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables 14-3-3 protein binding	ISO Inferred from Sequence Orthology more info
enables DNA-binding transcription activator activity, RNA polymerase II-specific	IDA Inferred from Direct Assay more info	PubMed
enables DNA-binding transcription factor activity	IDA Inferred from Direct Assay more info	PubMed
enables DNA-binding transcription factor activity, RNA polymerase II-specific	IBA Inferred from Biological aspect of Ancestor more info
enables DNA-binding transcription factor activity, RNA polymerase II-specific	IDA Inferred from Direct Assay more info	PubMed
enables DNA-binding transcription repressor activity, RNA polymerase II-specific	IDA Inferred from Direct Assay more info	PubMed
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IBA Inferred from Biological aspect of Ancestor more info
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IDA Inferred from Direct Assay more info	PubMed
enables chromatin binding	IDA Inferred from Direct Assay more info	PubMed
enables molecular adaptor activity	ISO Inferred from Sequence Orthology more info
enables phosphatase binding	IEA Inferred from Electronic Annotation more info
enables phosphatase binding	ISO Inferred from Sequence Orthology more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables sequence-specific DNA binding	IDA Inferred from Direct Assay more info	PubMed
enables sequence-specific double-stranded DNA binding	ISO Inferred from Sequence Orthology more info
enables transcription cis-regulatory region binding	IDA Inferred from Direct Assay more info	PubMed
enables transcription factor binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in B cell receptor signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in B cell receptor signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in DNA damage response	IEA Inferred from Electronic Annotation more info
involved_in DNA damage response	ISO Inferred from Sequence Orthology more info
involved_in calcineurin-NFAT signaling cascade	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within calcineurin-NFAT signaling cascade	IGI Inferred from Genetic Interaction more info	PubMed
involved_in cartilage development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in cartilage development	ISO Inferred from Sequence Orthology more info
involved_in cell migration	ISO Inferred from Sequence Orthology more info
involved_in cell migration	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within cellular response to calcium ion	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within cytokine production	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within gene expression	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within lncRNA transcription	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within myotube cell development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of transcription by RNA polymerase II	IDA Inferred from Direct Assay more info	PubMed
involved_in negative regulation of vascular associated smooth muscle cell differentiation	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of vascular associated smooth muscle cell differentiation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of B cell proliferation	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of B cell proliferation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within positive regulation of DNA-templated transcription	ISO Inferred from Sequence Orthology more info	PubMed
involved_in positive regulation of gene expression	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within positive regulation of myoblast fusion	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of transcription by RNA polymerase II	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within positive regulation of transcription by RNA polymerase II	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within positive regulation of transcription by RNA polymerase II	IGI Inferred from Genetic Interaction more info	PubMed
involved_in positive regulation of transcription by RNA polymerase II	IGI Inferred from Genetic Interaction more info	PubMed
involved_in regulation of transcription by RNA polymerase II	NAS Non-traceable Author Statement more info	PubMed
involved_in response to xenobiotic stimulus	IEA Inferred from Electronic Annotation more info
involved_in response to xenobiotic stimulus	ISO Inferred from Sequence Orthology more info
acts_upstream_of transcription by RNA polymerase II	IGI Inferred from Genetic Interaction more info	PubMed

Component	Evidence Code	Pubs
located_in chromatin	IDA Inferred from Direct Assay more info	PubMed
is_active_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in cytosol	IDA Inferred from Direct Assay more info	PubMed
located_in cytosol	ISO Inferred from Sequence Orthology more info
located_in cytosol	TAS Traceable Author Statement more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
located_in nucleoplasm	TAS Traceable Author Statement more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
is_active_in nucleus	IDA Inferred from Direct Assay more info	PubMed
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed
located_in nucleus	ISO Inferred from Sequence Orthology more info
part_of ribonucleoprotein complex	IDA Inferred from Direct Assay more info	PubMed
part_of transcription factor AP-1 complex	ISO Inferred from Sequence Orthology more info
part_of transcription regulator complex	IBA Inferred from Biological aspect of Ancestor more info
part_of transcription regulator complex	IDA Inferred from Direct Assay more info	PubMed
part_of transcription regulator complex	IPI Inferred from Physical Interaction more info	PubMed

General protein information

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Preferred Names: nuclear factor of activated T-cells, cytoplasmic 2

Names: NFAT pre-existing subunit; T-cell transcription factor NFAT1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001037177.2 → NP_001032254.1 nuclear factor of activated T-cells, cytoplasmic 2 isoform b

See identical proteins and their annotated locations for NP_001032254.1

Status: VALIDATED

Description

Transcript Variant: This variant (2, also known as IB-IIL-VIIa) lacks four 3' exons but contains an alternate 3' terminal exon, and it thus differs in the 3' coding region and 3' UTR, compared to variant 1. The encoded isoform (b) has a distinct C-terminus and is shorter than isoform a.

Source sequence(s)

AK135414, AW049827, EU887600

Consensus CDS

CCDS17113.1

UniProtKB/TrEMBL

B5B2R5, Q6P3F6

Related

ENSMUSP00000029057.6, ENSMUST00000029057.13

Conserved Domains (2) summary

cd07881
Location:400 → 574

RHD-n_NFAT; N-terminal sub-domain of the Rel homology domain (RHD) of nuclear factor of activated T-cells (NFAT) proteins

cl15674
Location:579 → 618

IPT; Immunoglobulin-like fold, Plexins, Transcription factors (IPT). IPTs are also known as Transcription factor ImmunoGlobin (TIG) domains. They are present in intracellular transcription factors, cell surface receptors (such as plexins and scatter factor ...
NM_001037178.2 → NP_001032255.1 nuclear factor of activated T-cells, cytoplasmic 2 isoform c

See identical proteins and their annotated locations for NP_001032255.1

Status: VALIDATED

Description

Transcript Variant: This variant (3, also known as IA-IIS-VIIa) contains alternate 5' and 3' exon structure, and it thus differs in both UTRs, initiates translation at a downstream in-frame start codon, and differs in the 3' coding region, compared to variant 1. The encoded isoform (c) is shorter at the N-terminus and has a distinct C-terminus, compared to isoform a. Both variants 3 and 16 encode isoform c.

Source sequence(s)

AK044489, AW049827, EU887601

Consensus CDS

CCDS17114.1

UniProtKB/TrEMBL

Q8C443

Related

ENSMUSP00000130875.2, ENSMUST00000171689.8

Conserved Domains (2) summary

cd07881
Location:179 → 353

RHD-n_NFAT; N-terminal sub-domain of the Rel homology domain (RHD) of nuclear factor of activated T-cells (NFAT) proteins

cl15674
Location:358 → 397

IPT; Immunoglobulin-like fold, Plexins, Transcription factors (IPT). IPTs are also known as Transcription factor ImmunoGlobin (TIG) domains. They are present in intracellular transcription factors, cell surface receptors (such as plexins and scatter factor ...
NM_001136073.2 → NP_001129545.1 nuclear factor of activated T-cells, cytoplasmic 2 isoform d

See identical proteins and their annotated locations for NP_001129545.1

Status: VALIDATED

Description

Transcript Variant: This variant (4, also known as IB-IIL-Xa) contains an additional exon that results in an alternate 3' coding region and 3' UTR, compared to variant 1. The encoded isoform (d) has a distinct C-terminus and is shorter than isoform a.

Source sequence(s)

AK135414, BP757417, EU887582

Consensus CDS

CCDS50803.1

UniProtKB/TrEMBL

B5B2P7

Related

ENSMUSP00000104812.2, ENSMUST00000109184.8

Conserved Domains (2) summary

cd07881
Location:400 → 574

RHD-n_NFAT; N-terminal sub-domain of the Rel homology domain (RHD) of nuclear factor of activated T-cells (NFAT) proteins

cd01178
Location:579 → 679

IPT_NFAT; IPT domain of the NFAT family of transcription factors. NFAT transcription complexes are a target of calcineurin, a calcium dependent phosphatase, and activate genes mainly involved in cell-cell-interaction.
NM_001291168.1 → NP_001278097.1 nuclear factor of activated T-cells, cytoplasmic 2 isoform e

See identical proteins and their annotated locations for NP_001278097.1

Status: VALIDATED

Description

Transcript Variant: This variant (5, also known as IA-IIL-deltaXa) contains an alternate 5' terminal exon, and it thus differs in the 5' UTR and 5' coding region, compared to variant 1. The encoded isoform (e) has a distinct N-terminus and is shorter than isoform a.

Source sequence(s)

AK044489, BP757417, EU887585, EU887587

UniProtKB/TrEMBL

B5B2Q2

Conserved Domains (2) summary

cd07881
Location:380 → 554

RHD-n_NFAT; N-terminal sub-domain of the Rel homology domain (RHD) of nuclear factor of activated T-cells (NFAT) proteins

cd01178
Location:559 → 659

IPT_NFAT; IPT domain of the NFAT family of transcription factors. NFAT transcription complexes are a target of calcineurin, a calcium dependent phosphatase, and activate genes mainly involved in cell-cell-interaction.
NM_001291169.1 → NP_001278098.1 nuclear factor of activated T-cells, cytoplasmic 2 isoform f

See identical proteins and their annotated locations for NP_001278098.1

Status: VALIDATED

Description

Transcript Variant: This variant (6, also known as IA-deltaII-Xa) contains an alternate 5' terminal exon, and it thus differs in the 5' UTR and 5' coding region, and it also contains an additional exon that results in an alternate 3' coding region and 3' UTR, compared to variant 1. The encoded isoform (f) has distinct N- and C-termini and is shorter than isoform a.

Source sequence(s)

AK044489, BP757417, EU887581

UniProtKB/TrEMBL

B5B2P6

Conserved Domains (2) summary

cd07881
Location:380 → 554

RHD-n_NFAT; N-terminal sub-domain of the Rel homology domain (RHD) of nuclear factor of activated T-cells (NFAT) proteins

cd01178
Location:559 → 659

IPT_NFAT; IPT domain of the NFAT family of transcription factors. NFAT transcription complexes are a target of calcineurin, a calcium dependent phosphatase, and activate genes mainly involved in cell-cell-interaction.
NM_001291170.1 → NP_001278099.1 nuclear factor of activated T-cells, cytoplasmic 2 isoform g

See identical proteins and their annotated locations for NP_001278099.1

Status: VALIDATED

Description

Transcript Variant: This variant (7, also known as IA-IIS-deltaXa) contains alternate 5' exon structure, and it thus differs in the 5' UTR and initiates translation at a downstream in-frame start codon, compared to variant 1. The encoded isoform (g) is shorter at the N-terminus, compared to isoform a. Both variants 7 and 14 encode isoform g.

Source sequence(s)

AK044489, BP757417, EU887585, EU887589

UniProtKB/TrEMBL

B5B2Q4

Conserved Domains (2) summary

cd07881
Location:179 → 353

RHD-n_NFAT; N-terminal sub-domain of the Rel homology domain (RHD) of nuclear factor of activated T-cells (NFAT) proteins

cd01178
Location:358 → 458

IPT_NFAT; IPT domain of the NFAT family of transcription factors. NFAT transcription complexes are a target of calcineurin, a calcium dependent phosphatase, and activate genes mainly involved in cell-cell-interaction.
NM_001291171.1 → NP_001278100.1 nuclear factor of activated T-cells, cytoplasmic 2 isoform h

See identical proteins and their annotated locations for NP_001278100.1

Status: VALIDATED

Description

Transcript Variant: This variant (8, also known as IA-deltaII-Xa) contains alternate 5' and 3' exon structure, and it thus differs in both UTRs, initiates translation at a downstream in-frame start codon, and differs in the 3' coding region, compared to variant 1. The encoded isoform (h) is shorter at at the N-terminus and has a distinct C-terminus, compared to isoform a. Both variants 8 and 13 encode isoform h.

Source sequence(s)

AK044489, BP757417, EU887585

UniProtKB/TrEMBL

Q3TTU8

Related

ENSMUST00000151292.8

Conserved Domains (2) summary

cd01178
Location:129 → 229

IPT_NFAT; IPT domain of the NFAT family of transcription factors. NFAT transcription complexes are a target of calcineurin, a calcium dependent phosphatase, and activate genes mainly involved in cell-cell-interaction.

cl08275
Location:1 → 124

RHD-n; N-terminal sub-domain of the Rel homology domain (RHD)
NM_001291172.1 → NP_001278101.1 nuclear factor of activated T-cells, cytoplasmic 2 isoform i

See identical proteins and their annotated locations for NP_001278101.1

Status: VALIDATED

Description

Transcript Variant: This variant (9, also known as IA-IIL-VIIa) contains alternate 5' and 3' exon structure, and it thus differs in both UTRs and in the 5' and 3' coding regions, compared to variant 1. The encoded isoform (i) has distinct N- and C-termini and is shorter than isoform a.

Source sequence(s)

AK044489, AW049827, EU887599

Consensus CDS

CCDS71201.1

UniProtKB/TrEMBL

A2AQC8, Q6P3F6

Related

ENSMUSP00000118329.2, ENSMUST00000137451.2

Conserved Domains (2) summary

cd07881
Location:380 → 554

RHD-n_NFAT; N-terminal sub-domain of the Rel homology domain (RHD) of nuclear factor of activated T-cells (NFAT) proteins

cl15674
Location:559 → 598

IPT; Immunoglobulin-like fold, Plexins, Transcription factors (IPT). IPTs are also known as Transcription factor ImmunoGlobin (TIG) domains. They are present in intracellular transcription factors, cell surface receptors (such as plexins and scatter factor ...
NM_001291173.1 → NP_001278102.1 nuclear factor of activated T-cells, cytoplasmic 2 isoform j

See identical proteins and their annotated locations for NP_001278102.1

Status: VALIDATED

Description

Transcript Variant: This variant (10, also known as IA-deltaII-deltaXa) contains alternate 5' exon structure, and it thus differs in the 5' UTR and initiates translation at a downstream in-frame start codon, compared to variant 1. The encoded isoform (j) is shorter at the N-terminus, compared to isoform a. Both variants 10 and 15 encode isoform j.

Source sequence(s)

AK044489, BP757417, EU887585, EU887591

UniProtKB/TrEMBL

B5B2Q6

Conserved Domains (2) summary

cd01178
Location:129 → 229

IPT_NFAT; IPT domain of the NFAT family of transcription factors. NFAT transcription complexes are a target of calcineurin, a calcium dependent phosphatase, and activate genes mainly involved in cell-cell-interaction.

cl08275
Location:1 → 124

RHD-n; N-terminal sub-domain of the Rel homology domain (RHD)
NM_001291174.1 → NP_001278103.1 nuclear factor of activated T-cells, cytoplasmic 2 isoform k

See identical proteins and their annotated locations for NP_001278103.1

Status: VALIDATED

Description

Transcript Variant: This variant (11, also known as IA-IIS-Xa) contains alternate 5' and 3' exon structure, and it thus differs in both UTRs, initiates translation at a downstream in-frame start codon, and differs in the 3' coding region, compared to variant 1. The encoded isoform (k) is shorter at the N-terminus and has a distinct C-terminus, compared to isoform a. Both variants 11 and 12 encode isoform k.

Source sequence(s)

AK044489, BP757417, EU887583

UniProtKB/TrEMBL

B5B2P8

Conserved Domains (2) summary

cd07881
Location:179 → 353

RHD-n_NFAT; N-terminal sub-domain of the Rel homology domain (RHD) of nuclear factor of activated T-cells (NFAT) proteins

cd01178
Location:358 → 458

IPT_NFAT; IPT domain of the NFAT family of transcription factors. NFAT transcription complexes are a target of calcineurin, a calcium dependent phosphatase, and activate genes mainly involved in cell-cell-interaction.
NM_001291175.1 → NP_001278104.1 nuclear factor of activated T-cells, cytoplasmic 2 isoform k

See identical proteins and their annotated locations for NP_001278104.1

Status: VALIDATED

Description

Transcript Variant: This variant (12, also known as IB-IIS-Xa) contains alternate 5' and 3' exon structure, and it thus differs in both UTRs, initiates translation at a downstream in-frame start codon, and differs in the 3' coding region, compared to variant 1. The encoded isoform (k) is shorter at the N-terminus and has a distinct C-terminus, compared to isoform a. Both variants 11 and 12 encode isoform k.

Source sequence(s)

AK135414, BP757417, EU887584

UniProtKB/TrEMBL

B5B2P8

Conserved Domains (2) summary

cd07881
Location:179 → 353

RHD-n_NFAT; N-terminal sub-domain of the Rel homology domain (RHD) of nuclear factor of activated T-cells (NFAT) proteins

cd01178
Location:358 → 458

IPT_NFAT; IPT domain of the NFAT family of transcription factors. NFAT transcription complexes are a target of calcineurin, a calcium dependent phosphatase, and activate genes mainly involved in cell-cell-interaction.
NM_001291176.1 → NP_001278105.1 nuclear factor of activated T-cells, cytoplasmic 2 isoform h

See identical proteins and their annotated locations for NP_001278105.1

Status: VALIDATED

Description

Transcript Variant: This variant (13, also known as IB-deltaII-Xa) contains alternate 5' and 3' exon structure, and it thus differs in both UTRs, initiates translation at a downstream in-frame start codon, and differs in the 3' coding region, compared to variant 1. The encoded isoform (h) is shorter at at the N-terminus and has a distinct C-terminus, compared to isoform a. Both variants 8 and 13 encode isoform h.

Source sequence(s)

AK135414, BP757417, EU887586

UniProtKB/TrEMBL

Q3TTU8

Conserved Domains (2) summary

cd01178
Location:129 → 229

IPT_NFAT; IPT domain of the NFAT family of transcription factors. NFAT transcription complexes are a target of calcineurin, a calcium dependent phosphatase, and activate genes mainly involved in cell-cell-interaction.

cl08275
Location:1 → 124

RHD-n; N-terminal sub-domain of the Rel homology domain (RHD)
NM_001291177.1 → NP_001278106.1 nuclear factor of activated T-cells, cytoplasmic 2 isoform g

See identical proteins and their annotated locations for NP_001278106.1

Status: VALIDATED

Description

Transcript Variant: This variant (14, also known as IB-IIS-deltaXa) contains alternate 5' exon structure, and it thus differs in the 5' UTR and initiates translation at a downstream in-frame start codon, compared to variant 1. The encoded isoform (g) is shorter at the N-terminus, compared to isoform a. Both variants 7 and 14 encode isoform g.

Source sequence(s)

AK135414, BP757417, EU887581, EU887590

UniProtKB/TrEMBL

B5B2Q4

Conserved Domains (2) summary

cd07881
Location:179 → 353

RHD-n_NFAT; N-terminal sub-domain of the Rel homology domain (RHD) of nuclear factor of activated T-cells (NFAT) proteins

cd01178
Location:358 → 458

IPT_NFAT; IPT domain of the NFAT family of transcription factors. NFAT transcription complexes are a target of calcineurin, a calcium dependent phosphatase, and activate genes mainly involved in cell-cell-interaction.
NM_001291178.1 → NP_001278107.1 nuclear factor of activated T-cells, cytoplasmic 2 isoform j

See identical proteins and their annotated locations for NP_001278107.1

Status: VALIDATED

Description

Transcript Variant: This variant (15, also known as IB-deltaII-deltaXa) contains alternate 5' exon structure, and it thus differs in the 5' UTR and initiates translation at a downstream in-frame start codon, compared to variant 1. The encoded isoform (j) is shorter at the N-terminus, compared to isoform a. Both variants 10 and 15 encode isoform j.

Source sequence(s)

AK135414, BP757417, EU887581, EU887592

UniProtKB/TrEMBL

B5B2Q6

Conserved Domains (2) summary

cd01178
Location:129 → 229

IPT_NFAT; IPT domain of the NFAT family of transcription factors. NFAT transcription complexes are a target of calcineurin, a calcium dependent phosphatase, and activate genes mainly involved in cell-cell-interaction.

cl08275
Location:1 → 124

RHD-n; N-terminal sub-domain of the Rel homology domain (RHD)
NM_001291179.1 → NP_001278108.1 nuclear factor of activated T-cells, cytoplasmic 2 isoform c

See identical proteins and their annotated locations for NP_001278108.1

Status: VALIDATED

Description

Transcript Variant: This variant (16, also known as IB-IIS-VIIa) contains alternate 5' and 3' exon structure, and it thus differs in both UTRs, initiates translation at a downstream in-frame start codon, and differs in the 3' coding region, compared to variant 1. The encoded isoform (c) is shorter at the N-terminus and has a distinct C-terminus, compared to isoform a. Both variants 2 and 16 encode isoform c.

Source sequence(s)

AK135414, AW049827, EU887602

Consensus CDS

CCDS17114.1

UniProtKB/TrEMBL

Q8C443

Conserved Domains (2) summary

cd07881
Location:179 → 353

RHD-n_NFAT; N-terminal sub-domain of the Rel homology domain (RHD) of nuclear factor of activated T-cells (NFAT) proteins

cl15674
Location:358 → 397

IPT; Immunoglobulin-like fold, Plexins, Transcription factors (IPT). IPTs are also known as Transcription factor ImmunoGlobin (TIG) domains. They are present in intracellular transcription factors, cell surface receptors (such as plexins and scatter factor ...
NM_010899.3 → NP_035029.2 nuclear factor of activated T-cells, cytoplasmic 2 isoform a

See identical proteins and their annotated locations for NP_035029.2

Status: VALIDATED

Description

Transcript Variant: This variant (1, also known as IB-IIL-deltaXa) encodes the longest isoform (a).

Source sequence(s)

AK135414, BP757417, EU887581, EU887588

Consensus CDS

CCDS17112.1

UniProtKB/Swiss-Prot

A2APK2, A2APK3, A2AQC5, A2AQC6, A2AQC7, B5B2Q3, Q60591, Q60984, Q60985, Q91Y65

Related

ENSMUSP00000074198.4, ENSMUST00000074618.10

Conserved Domains (2) summary

cd07881
Location:400 → 574

RHD-n_NFAT; N-terminal sub-domain of the Rel homology domain (RHD) of nuclear factor of activated T-cells (NFAT) proteins

cd01178
Location:579 → 679

IPT_NFAT; IPT domain of the NFAT family of transcription factors. NFAT transcription complexes are a target of calcineurin, a calcium dependent phosphatase, and activate genes mainly involved in cell-cell-interaction.

RNA

NR_111897.1 RNA Sequence

Status: VALIDATED

Description

Transcript Variant: This variant (17, also known as IA-deltaII-VIIa) contains alternate 5' and 3' exon structure, compared to variant 1. This variant is represented as non-coding because the predicted protein does not meet RefSeq quality criteria.

Source sequence(s)

AK044489, AW049827, EU887603
NR_111898.1 RNA Sequence

Status: VALIDATED

Description

Transcript Variant: This variant (18, also known as IB-deltaII-VIIa) contains alternate 5' and 3' exon structure, compared to variant 1. This variant is represented as non-coding because the predicted protein does not meet RefSeq quality criteria.

Source sequence(s)

AK135414, AW049827, EU887604

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000068.8 Reference GRCm39 C57BL/6J

Range

168318330..168443900 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_036159313.1 → XP_036015206.1 nuclear factor of activated T-cells, cytoplasmic 2 isoform X1

Conserved Domains (2) summary

cd01178
Location:261 → 361

IPT_NFAT; IPT domain of the NFAT family of transcription factors. NFAT transcription complexes are a target of calcineurin, a calcium dependent phosphatase, and activate genes mainly involved in cell-cell-interaction.

cl08275
Location:128 → 256

RHD-n; N-terminal sub-domain of the Rel homology domain (RHD)