Tgfbr3 transforming growth factor, beta receptor III [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Tgfbr3provided by MGI
Official Full Name: transforming growth factor, beta receptor IIIprovided by MGI
Primary source: MGI:MGI:104637
See related: Ensembl:ENSMUSG00000029287 AllianceGenome:MGI:104637
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: TBRIII; 1110036H20Rik
Summary: Enables several functions, including PDZ domain binding activity; transforming growth factor beta binding activity; and transforming growth factor beta receptor activity. Involved in several processes, including definitive erythrocyte differentiation; heart development; and positive regulation of SMAD protein signal transduction. Acts upstream of or within several processes, including positive regulation of NF-kappaB transcription factor activity; positive regulation of transmembrane receptor protein serine/threonine kinase signaling pathway; and vasculogenesis. Located in cell surface and endoplasmic reticulum. Is expressed in several structures, including central nervous system; early conceptus; gonad; heart; and jaw. Orthologous to human TGFBR3 (transforming growth factor beta receptor 3). [provided by Alliance of Genome Resources, Oct 2024]
Expression: Broad expression in adrenal adult (RPKM 38.6), bladder adult (RPKM 20.1) and 20 other tissues See more
Orthologs: human all
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Genomic context

Location:: 5 E5; 5 51.9 cM

Exon count:: 17

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	5	NC_000071.7 (107254433..107437495, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	5	NC_000071.6 (107106567..107289629, complement)

Chromosome 5 - NC_000071.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

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Expression

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See details

Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Transforming growth factor receptor III (Betaglycan) regulates the generation of pathogenic Th17 cells in EAE.
Title: Transforming growth factor receptor III (Betaglycan) regulates the generation of pathogenic Th17 cells in EAE.
Ablation of TGFBR3 (betaglycan) in oocytes does not affect fertility in female mice.
Title: Ablation of TGFBR3 (betaglycan) in oocytes does not affect fertility in female mice.
A novel mechanism that let-7a regulate angiogenesis through post-transcriptional regulation of TGFBR3.
Title: MicroRNA let-7a regulates angiogenesis by targeting TGFBR3 mRNA.
Both TGF-beta1 and TGF-beta3 induced endocytosis of amelogenin
Title: Potential function of TGF-β isoforms in maturation-stage ameloblasts.
Plau and Tgfbr3 are YAP-regulated genes that promote keratinocyte proliferation.
Title: Plau and Tgfbr3 are YAP-regulated genes that promote keratinocyte proliferation.
TGFBR3 (betaglycan) functions as an inhibin A, but not an inhibin B, coreceptor in gonadotrope cells in vivo. Mechanisms of inhibin B action merit further investigation.
Title: Betaglycan (TGFBR3) Functions as an Inhibin A, but Not Inhibin B, Coreceptor in Pituitary Gonadotrope Cells in Mice.
TGFbetaR3 promotes apoptosis of cardiomyocytes via a p38 pathway-associated mechanism, and loss of TGFbetaR3 reduces myocardial infarction injury.
Title: Transforming Growth Factor-β Receptor III is a Potential Regulator of Ischemia-Induced Cardiomyocyte Apoptosis.
BMP2 also requires Src for filamentous actin polymerization in Tgfbr3(-/-) epicardial cells.
Title: BMP2 rescues deficient cell migration in Tgfbr3(-/-) epicardial cells and requires Src kinase.
describe a detailed characterization of TbetaRIII expression in lymphocyte subpopulations demonstrating that this co-receptor is significantly expressed in T but not B lymphocytes and among them, preferentially expressed on naive and central memory T cells
Title: TβRIII is induced by TCR signaling and downregulated in FoxP3(+) regulatory T cells.
Study identified a novel major binding site for TGF-beta-like growth factors in TGFR-3. Findings potentially provide novel experimental insight into the general function of zona pellucida domain-containing proteins.
Title: Identification of a Novel TGF-β-Binding Site in the Zona Pellucida C-terminal (ZP-C) Domain of TGF-β-Receptor-3 (TGFR-3).

Submit: New GeneRIF Correction See all GeneRIFs (38)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (4)
Gene trapped (1)
Targeted (4) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

D5Mit175 (e-PCR), detects polymorphism
- UniSTS:130306

AF039601 (e-PCR)
- UniSTS:179218

AW215636 (e-PCR)
- UniSTS:165414

Tgfbr3 (e-PCR), detects polymorphism
- UniSTS:496702

RH136866 (e-PCR)
- UniSTS:218955

Tgfbr3 (e-PCR), detects polymorphism
- UniSTS:526927

AU049133 (e-PCR)
- UniSTS:145581

NoName (e-PCR)
- UniSTS:548554

NoName (e-PCR)
- UniSTS:548569

RH143675 (e-PCR)
- UniSTS:232921

AI464151 (e-PCR)
- UniSTS:207839

AU015626 (e-PCR)
- UniSTS:207840

AU015626 (e-PCR)
- UniSTS:207842

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables BMP binding	ISO Inferred from Sequence Orthology more info
enables PDZ domain binding	IPI Inferred from Physical Interaction more info	PubMed
enables SMAD binding	IMP Inferred from Mutant Phenotype more info	PubMed
enables SMAD binding	ISO Inferred from Sequence Orthology more info
enables activin binding	ISO Inferred from Sequence Orthology more info
enables coreceptor activity	ISO Inferred from Sequence Orthology more info
enables fibroblast growth factor binding	ISO Inferred from Sequence Orthology more info
enables glycosaminoglycan binding	IBA Inferred from Biological aspect of Ancestor more info
enables glycosaminoglycan binding	IDA Inferred from Direct Assay more info	PubMed
enables heparin binding	ISO Inferred from Sequence Orthology more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
contributes_to transforming growth factor beta binding	IBA Inferred from Biological aspect of Ancestor more info
enables transforming growth factor beta binding	IDA Inferred from Direct Assay more info	PubMed
contributes_to transforming growth factor beta binding	ISO Inferred from Sequence Orthology more info
enables transforming growth factor beta binding	ISO Inferred from Sequence Orthology more info
enables transforming growth factor beta receptor activity	IBA Inferred from Biological aspect of Ancestor more info
enables transforming growth factor beta receptor activity	IDA Inferred from Direct Assay more info	PubMed
enables transforming growth factor beta receptor activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables transforming growth factor beta receptor activity	ISO Inferred from Sequence Orthology more info
enables transforming growth factor beta receptor activity, type III	ISO Inferred from Sequence Orthology more info
enables transforming growth factor beta receptor binding	ISO Inferred from Sequence Orthology more info
enables transmembrane signaling receptor activity	ISO Inferred from Sequence Orthology more info
enables type II transforming growth factor beta receptor binding	IBA Inferred from Biological aspect of Ancestor more info
enables type II transforming growth factor beta receptor binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
acts_upstream_of BMP signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in BMP signaling pathway	ISO Inferred from Sequence Orthology more info
acts_upstream_of apoptotic process involved in morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within blastocyst development	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within blood vessel development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in blood vessel diameter maintenance	TAS Traceable Author Statement more info	PubMed
acts_upstream_of_or_within blood vessel remodeling	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in cardiac epithelial to mesenchymal transition	ISO Inferred from Sequence Orthology more info
involved_in cardiac muscle cell proliferation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in cell migration	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of cell population proliferation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in collagen metabolic process	IGI Inferred from Genetic Interaction more info	PubMed
involved_in coronary vasculature development	TAS Traceable Author Statement more info	PubMed
involved_in coronary vasculature morphogenesis	TAS Traceable Author Statement more info	PubMed
involved_in definitive erythrocyte differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in definitive hemopoiesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in epicardial cell to mesenchymal cell transition	TAS Traceable Author Statement more info	PubMed
involved_in epicardium-derived cardiac fibroblast cell development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in epithelial to mesenchymal transition	IBA Inferred from Biological aspect of Ancestor more info
involved_in epithelial to mesenchymal transition	ISO Inferred from Sequence Orthology more info
involved_in heart trabecula formation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in heart trabecula morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in immune response	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within in utero embryonic development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in intracellular signal transduction	ISO Inferred from Sequence Orthology more info
involved_in liver development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in muscular septum morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of SMAD protein signal transduction	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within negative regulation of apoptotic process involved in morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of canonical NF-kappaB signal transduction	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of cell migration	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within negative regulation of epithelial cell migration	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of epithelial cell proliferation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within negative regulation of epithelial to mesenchymal transition	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of extracellular matrix assembly	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of gene expression	IDA Inferred from Direct Assay more info	PubMed
involved_in negative regulation of transforming growth factor beta receptor signaling pathway	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within osteoblast differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in outflow tract morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within positive regulation of BMP signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within positive regulation of NF-kappaB transcription factor activity	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of SMAD protein signal transduction	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of SMAD protein signal transduction	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of cardiac muscle cell proliferation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of cell migration involved in sprouting angiogenesis	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within positive regulation of cell population proliferation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of gene expression	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within positive regulation of transforming growth factor beta receptor signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of transforming growth factor beta receptor signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in protein-containing complex assembly	ISO Inferred from Sequence Orthology more info
NOT involved_in regulation of ERK1 and ERK2 cascade	IMP Inferred from Mutant Phenotype more info	PubMed
NOT involved_in regulation of JNK cascade	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of transforming growth factor beta receptor signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in response to follicle-stimulating hormone	ISO Inferred from Sequence Orthology more info
involved_in response to luteinizing hormone	ISO Inferred from Sequence Orthology more info
involved_in response to prostaglandin E	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within roof of mouth development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in secondary palate development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in transforming growth factor beta receptor complex assembly	ISO Inferred from Sequence Orthology more info
involved_in transforming growth factor beta receptor signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in transforming growth factor beta receptor signaling pathway	IDA Inferred from Direct Assay more info	PubMed
involved_in transforming growth factor beta receptor signaling pathway	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of transforming growth factor beta receptor signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in transforming growth factor beta receptor signaling pathway	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within vasculogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in vasculogenesis involved in coronary vascular morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in vasculogenesis involved in coronary vascular morphogenesis	TAS Traceable Author Statement more info	PubMed
involved_in ventricular cardiac muscle tissue morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in ventricular compact myocardium morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in ventricular septum morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in visceral serous pericardium development	TAS Traceable Author Statement more info	PubMed

Component	Evidence Code	Pubs
located_in cell surface	IDA Inferred from Direct Assay more info	PubMed
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
located_in endoplasmic reticulum	IDA Inferred from Direct Assay more info	PubMed
located_in external side of plasma membrane	ISO Inferred from Sequence Orthology more info
located_in extracellular region	IEA Inferred from Electronic Annotation more info
located_in extracellular space	ISO Inferred from Sequence Orthology more info
part_of inhibin-betaglycan-ActRII complex	ISO Inferred from Sequence Orthology more info
located_in membrane	ISO Inferred from Sequence Orthology more info
located_in plasma membrane	TAS Traceable Author Statement more info	PubMed
part_of receptor complex	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: transforming growth factor beta receptor type 3

Names: TGF-beta receptor type 3; TGF-beta receptor type III; TGFR-3; betaglycan

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_011578.4 → NP_035708.2 transforming growth factor beta receptor type 3 precursor

See identical proteins and their annotated locations for NP_035708.2

Status: VALIDATED

Source sequence(s)

AC133897, AC166776

Consensus CDS

CCDS19499.1

UniProtKB/Swiss-Prot

O88393, Q6NS72

UniProtKB/TrEMBL

A0A0R4J097

Related

ENSMUSP00000031224.9, ENSMUST00000031224.15

Conserved Domains (2) summary

smart00241
Location:454 → 723

ZP; Zona pellucida (ZP) domain

pfam00100
Location:597 → 722

Zona_pellucida; Zona pellucida-like domain