metap1 methionyl aminopeptidase 1 [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: metap1provided by ZNC
Official Full Name: methionyl aminopeptidase 1provided by ZNC
Primary source: ZFIN:ZDB-GENE-050626-124
See related: Ensembl:ENSDARG00000033440 AllianceGenome:ZFIN:ZDB-GENE-050626-124
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: fc84e12; im:7047238; wu:fc84e12; zgc:110093
Summary: Predicted to enable initiator methionyl aminopeptidase activity and metalloaminopeptidase activity. Acts upstream of or within intracellular zinc ion homeostasis. Predicted to be located in cytosolic ribosome. Predicted to be active in cytosol. Is expressed in immature eye; myotome; nervous system; pectoral fin; and pharyngeal arch. Orthologous to human METAP1 (methionyl aminopeptidase 1). [provided by Alliance of Genome Resources, Nov 2024]
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 13

Exon count:: 12

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCz11 (GCF_000002035.6)	13	NC_007124.7 (12606613..12633241)
105	previous assembly	GRCz10 (GCF_000002035.5)	13	NC_007124.6 (12474269..12500765)

Chromosome 13 - NC_007124.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Zn-regulated GTPase metalloprotein activator 1 modulates vertebrate zinc homeostasis.
Title: Zn-regulated GTPase metalloprotein activator 1 modulates vertebrate zinc homeostasis.

Submit: New GeneRIF Correction

General gene information

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Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables aminopeptidase activity	IEA Inferred from Electronic Annotation more info
enables hydrolase activity	IEA Inferred from Electronic Annotation more info
enables initiator methionyl aminopeptidase activity	IEA Inferred from Electronic Annotation more info
enables initiator methionyl aminopeptidase activity	ISS Inferred from Sequence or Structural Similarity more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables metalloaminopeptidase activity	IBA Inferred from Biological aspect of Ancestor more info
enables metalloaminopeptidase activity	IEA Inferred from Electronic Annotation more info
enables peptidase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within intracellular zinc ion homeostasis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in protein processing	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within proteolysis	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
is_active_in cytosol	IBA Inferred from Biological aspect of Ancestor more info
located_in cytosolic ribosome	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: methionine aminopeptidase 1

NP_001020336.2

EC 3.4.11.18

XP_017214228.3

EC 3.4.11.18

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001025165.2 → NP_001020336.2 methionine aminopeptidase 1

Status: VALIDATED

Source sequence(s)

CR559943, EH501151

UniProtKB/Swiss-Prot

Q4QRK0, Q6DHD3

UniProtKB/TrEMBL

A0A0R4IWG3, A0A8M1N6S5, B8JIB1

Related

ENSDARP00000113818.1, ENSDART00000140096.3

Conserved Domains (3) summary

PLN03158
Location:33 → 394

PLN03158; methionine aminopeptidase; Provisional

cd01086
Location:154 → 391

MetAP1; Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides.

pfam15801
Location:31 → 72

zf-C6H2; zf-MYND-like zinc finger, mRNA-binding