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    bdh2 3-hydroxybutyrate dehydrogenase, type 2 [ Danio rerio (zebrafish) ]

    Gene ID: 550507, updated on 12-Sep-2024

    Summary

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    Official Symbol
    bdh2provided by ZNC
    Official Full Name
    3-hydroxybutyrate dehydrogenase, type 2provided by ZNC
    Primary source
    ZFIN:ZDB-GENE-050417-343
    See related
    Ensembl:ENSDARG00000052696 Ensembl:ENSDARG00000052700 AllianceGenome:ZFIN:ZDB-GENE-050417-343
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    zgc:110323
    Summary
    Predicted to enable 3-hydroxybutyrate dehydrogenase activity and oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor. Involved in heme metabolic process. Acts upstream of or within erythrocyte maturation and hemoglobin biosynthetic process. Predicted to be active in cytoplasm. Orthologous to human BDH2 (3-hydroxybutyrate dehydrogenase 2). [provided by Alliance of Genome Resources, Apr 2022]
    Orthologs
    human mouse all
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    Genomic context

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    See bdh2 in Genome Data Viewer
    Location:
    chromosome: 1
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 1 NC_007112.7 (43714149..43727555, complement)
    105 previous assembly GRCz10 (GCF_000002035.5) 1 NC_007112.6 (43012883..43026414, complement)

    Chromosome 1 - NC_007112.7Genomic Context describing neighboring genes Neighboring gene si:dkey-162b23.4 Neighboring gene CDGSH iron sulfur domain 2 Neighboring gene tachykinin receptor 3a Neighboring gene cyclic nucleotide gated channel subunit alpha 1a

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. Inactivation of 3-hydroxybutyrate dehydrogenase 2 delays zebrafish erythroid maturation by conferring premature mitophagy. Davuluri G, et al. Proc Natl Acad Sci U S A, 2016 Mar 15. PMID 26929344, Free PMC Article
    2. A mammalian siderophore synthesized by an enzyme with a bacterial homolog involved in enterobactin production. Devireddy LR, et al. Cell, 2010 Jun 11. PMID 20550936, Free PMC Article
    3. The NOTCH1-dependent HIF1α/VGLL4/IRF2BP2 oxygen sensing pathway triggers erythropoiesis terminal differentiation. Wang Y, et al. Redox Biol, 2020 Jan. PMID 31539803, Free PMC Article
    4. Hematopoietic gene expression profile in zebrafish kidney marrow. Song HD, et al. Proc Natl Acad Sci U S A, 2004 Nov 16. PMID 15520368, Free PMC Article
    5. 15000 unique zebrafish EST clusters and their future use in microarray for profiling gene expression patterns during embryogenesis. Lo J, et al. Genome Res, 2003 Mar. PMID 12618376, Free PMC Article

    See all (8) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. The Bdh2 role in erythrocyte maturation and mitophagy
      Title: Inactivation of 3-hydroxybutyrate dehydrogenase 2 delays zebrafish erythroid maturation by conferring premature mitophagy.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    General gene information

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    Homology

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables 3-hydroxybutyrate dehydrogenase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables 3-hydroxybutyrate dehydrogenase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables 4-oxoproline reductase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables oxidoreductase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within erythrocyte maturation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in heme metabolic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within hemoglobin biosynthetic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_positive_effect intracellular sequestering of iron ion ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    acts_upstream_of_or_within lipid metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in siderophore biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in siderophore biosynthetic process ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    dehydrogenase/reductase SDR family member 6
    Names
    (R)-beta-hydroxybutyrate dehydrogenase
    4-oxo-L-proline reductase
    R-beta-hydroxybutyrate dehydrogenase
    oxidoreductase UCPA
    short chain dehydrogenase/reductase family 15C member 1
    NP_001017809.1
    XP_005160124.1
    XP_005160125.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001017809.1 → NP_001017809.1  dehydrogenase/reductase SDR family member 6

      See identical proteins and their annotated locations for NP_001017809.1

      Status: PROVISIONAL

      Source sequence(s)
      BC092874
      UniProtKB/Swiss-Prot
      B8JI04, Q561X9
      UniProtKB/TrEMBL
      B2GSA5
      Related
      ENSDARP00000069085.3, ENSDART00000074597.5
      Conserved Domains (2) summary
      cd05368
      Location:5 → 245
      DHRS6_like_SDR_c; human DHRS6-like, classical (c) SDRs
      PRK06138
      Location:2 → 243
      PRK06138; short chain dehydrogenase; Provisional

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007112.7 Reference GRCz11 Primary Assembly

      Range
      43714149..43727555 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_005160067.5 → XP_005160124.1  dehydrogenase/reductase SDR family member 6 isoform X1

      See identical proteins and their annotated locations for XP_005160124.1

      UniProtKB/Swiss-Prot
      B8JI04, Q561X9
      UniProtKB/TrEMBL
      B2GSA5
      Related
      ENSDARP00000119021.1, ENSDART00000132542.3
      Conserved Domains (2) summary
      cd05368
      Location:5 → 245
      DHRS6_like_SDR_c; human DHRS6-like, classical (c) SDRs
      PRK06138
      Location:2 → 243
      PRK06138; short chain dehydrogenase; Provisional

    2. XM_005160068.5 → XP_005160125.1  dehydrogenase/reductase SDR family member 6 isoform X1

      See identical proteins and their annotated locations for XP_005160125.1

      UniProtKB/Swiss-Prot
      B8JI04, Q561X9
      UniProtKB/TrEMBL
      B2GSA5
      Related
      ENSDARP00000152451.1, ENSDART00000181792.1
      Conserved Domains (2) summary
      cd05368
      Location:5 → 245
      DHRS6_like_SDR_c; human DHRS6-like, classical (c) SDRs
      PRK06138
      Location:2 → 243
      PRK06138; short chain dehydrogenase; Provisional
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q561X9.1 GenPept UniProtKB/Swiss-Prot:Q561X9

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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