cers2a ceramide synthase 2a [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: cers2aprovided by ZNC
Official Full Name: ceramide synthase 2aprovided by ZNC
Primary source: ZFIN:ZDB-GENE-020808-2
See related: Ensembl:ENSDARG00000013704 AllianceGenome:ZFIN:ZDB-GENE-020808-2
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: trh3; lass2; fi37a01; wu:fi37a01
Summary: Predicted to enable sphingosine N-acyltransferase activity. Predicted to be involved in ceramide biosynthetic process. Predicted to act upstream of or within lipid metabolic process. Predicted to be located in membrane and nucleus. Is expressed in several structures, including brain; gut; paraxial mesoderm; presumptive rhombomere 5; and solid lens vesicle. Orthologous to human CERS2 (ceramide synthase 2). [provided by Alliance of Genome Resources, Nov 2024]
Orthologs: all
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Genomic context

Location:: chromosome: 19

Exon count:: 11

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCz11 (GCF_000002035.6)	19	NC_007130.7 (8775057..8812926, complement)
105	previous assembly	GRCz10 (GCF_000002035.5)	19	NC_007130.6 (8856132..8893912, complement)

Chromosome 19 - NC_007130.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables DNA binding	IEA Inferred from Electronic Annotation more info
enables sphingosine N-acyltransferase activity	IBA Inferred from Biological aspect of Ancestor more info
enables sphingosine N-acyltransferase activity	IEA Inferred from Electronic Annotation more info
enables transferase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in ceramide biosynthetic process	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within ceramide biosynthetic process	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within lipid metabolic process	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in membrane	IEA Inferred from Electronic Annotation more info
located_in nucleus	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: ceramide synthase 2a

Names: LAG1 homolog, ceramide synthase 2; etID65043.19

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_153671.2 → NP_705957.1 ceramide synthase 2a

See identical proteins and their annotated locations for NP_705957.1

Status: VALIDATED

Source sequence(s)

BX248499, CU468271

UniProtKB/TrEMBL

B2GQE3, Q1LXW0, Q90YY7

Related

ENSDARP00000007330.6, ENSDART00000025385.8

Conserved Domains (2) summary

smart00724
Location:131 → 331

TLC; TRAM, LAG1 and CLN8 homology domains

cd00086
Location:84 → 129

homeodomain; Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic developmental processes; may bind to DNA as monomers or as homo- and/or heterodimers, in a sequence-specific manner.