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    Zbtb41 zinc finger and BTB domain containing 41 [ Mus musculus (house mouse) ]

    Gene ID: 226470, updated on 2-Nov-2024

    Summary

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    Official Symbol
    Zbtb41provided by MGI
    Official Full Name
    zinc finger and BTB domain containing 41provided by MGI
    Primary source
    MGI:MGI:2444487
    See related
    Ensembl:ENSMUSG00000033964 AllianceGenome:MGI:2444487
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    9430031N01; 8430415N23Rik; 9830132G07Rik
    Summary
    Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II transcription regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to be active in nucleus. Is expressed in early conceptus; genitourinary system; and heart. Orthologous to human ZBTB41 (zinc finger and BTB domain containing 41). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Ubiquitous expression in CNS E18 (RPKM 5.4), whole brain E14.5 (RPKM 5.0) and 25 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Zbtb41 in Genome Data Viewer
    Location:
    1 F; 1 61.36 cM
    Exon count:
    12
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 1 NC_000067.7 (139349916..139380743)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 1 NC_000067.6 (139422000..139453007)

    Chromosome 1 - NC_000067.7Genomic Context describing neighboring genes Neighboring gene crumbs family member 1, photoreceptor morphogenesis associated Neighboring gene RIKEN cDNA 4933436E23 gene Neighboring gene STARR-seq mESC enhancer starr_02477 Neighboring gene STARR-positive B cell enhancer ABC_E5812 Neighboring gene predicted gene, 34816 Neighboring gene STARR-seq mESC enhancer starr_02479 Neighboring gene abnormal spindle microtubule assembly Neighboring gene STARR-seq mESC enhancer starr_02480 Neighboring gene STARR-seq mESC enhancer starr_02481 Neighboring gene coagulation factor XIII, beta subunit

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. ZBTB20 is crucial for the specification of a subset of callosal projection neurons and astrocytes in the mammalian neocortex. Medeiros de Araújo JA, et al. Development, 2021 Aug 15. PMID 34351428, Free PMC Article
    2. The protein interactome of collapsin response mediator protein-2 (CRMP2/DPYSL2) reveals novel partner proteins in brain tissue. Martins-de-Souza D, et al. Proteomics Clin Appl, 2015 Oct. PMID 25921334
    3. Resolution of cell fate decisions revealed by single-cell gene expression analysis from zygote to blastocyst. Guo G, et al. Dev Cell, 2010 Apr 20. PMID 20412781
    4. Construction of long-transcript enriched cDNA libraries from submicrogram amounts of total RNAs by a universal PCR amplification method. Piao Y, et al. Genome Res, 2001 Sep. PMID 11544199, Free PMC Article
    5. A systems approach reveals that the myogenesis genome network is regulated by the transcriptional repressor RP58. Yokoyama S, et al. Dev Cell, 2009 Dec. PMID 20059953, Free PMC Article

    See all (19) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (2) 

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables RNA polymerase II transcription regulatory region sequence-specific DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    zinc finger and BTB domain-containing protein 41
    Names
    zinc finger and BTB domain containing 41 homolog

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001412694.1 → NP_001399623.1  zinc finger and BTB domain-containing protein 41

      Status: VALIDATED

      Source sequence(s)
      AL606536
      UniProtKB/Swiss-Prot
      A2A706, Q811F1, Q8BI96, Q8BV67, Q8BYV8

    2. NM_172643.6 → NP_766231.2  zinc finger and BTB domain-containing protein 41

      See identical proteins and their annotated locations for NP_766231.2

      Status: VALIDATED

      Source sequence(s)
      AL606536
      Consensus CDS
      CCDS48385.1
      UniProtKB/Swiss-Prot
      A2A706, Q811F1, Q8BI96, Q8BV67, Q8BYV8
      Related
      ENSMUSP00000045570.8, ENSMUST00000039867.10
      Conserved Domains (5) summary
      TIGR01651
      Location:270 → 339
      CobT; cobaltochelatase, CobT subunit
      sd00017
      Location:576 → 596
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:602 → 624
      zf-C2H2; Zinc finger, C2H2 type
      cd18226
      Location:67 → 180
      BTB_POZ_ZBTB41; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 41 (ZBTB41)
      pfam13465
      Location:561 → 585
      zf-H2C2_2; Zinc-finger double domain

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000067.7 Reference GRCm39 C57BL/6J

      Range
      139349916..139380743
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006529448.4 → XP_006529511.1  zinc finger and BTB domain-containing protein 41 isoform X1

      See identical proteins and their annotated locations for XP_006529511.1

      UniProtKB/Swiss-Prot
      A2A706, Q811F1, Q8BI96, Q8BV67, Q8BYV8
      Conserved Domains (5) summary
      TIGR01651
      Location:270 → 339
      CobT; cobaltochelatase, CobT subunit
      sd00017
      Location:576 → 596
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:602 → 624
      zf-C2H2; Zinc finger, C2H2 type
      cd18226
      Location:67 → 180
      BTB_POZ_ZBTB41; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 41 (ZBTB41)
      pfam13465
      Location:561 → 585
      zf-H2C2_2; Zinc-finger double domain

    2. XM_036163983.1 → XP_036019876.1  zinc finger and BTB domain-containing protein 41 isoform X2

      Conserved Domains (3) summary
      sd00017
      Location:362 → 382
      ZF_C2H2; C2H2 Zn finger [structural motif]
      cd18226
      Location:67 → 180
      BTB_POZ_ZBTB41; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 41 (ZBTB41)
      pfam13465
      Location:476 → 501
      zf-H2C2_2; Zinc-finger double domain

    3. XM_006529447.5 → XP_006529510.1  zinc finger and BTB domain-containing protein 41 isoform X1

      See identical proteins and their annotated locations for XP_006529510.1

      UniProtKB/Swiss-Prot
      A2A706, Q811F1, Q8BI96, Q8BV67, Q8BYV8
      Conserved Domains (5) summary
      TIGR01651
      Location:270 → 339
      CobT; cobaltochelatase, CobT subunit
      sd00017
      Location:576 → 596
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:602 → 624
      zf-C2H2; Zinc finger, C2H2 type
      cd18226
      Location:67 → 180
      BTB_POZ_ZBTB41; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 41 (ZBTB41)
      pfam13465
      Location:561 → 585
      zf-H2C2_2; Zinc-finger double domain
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q811F1.4 GenPept UniProtKB/Swiss-Prot:Q811F1

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