SEMG2 semenogelin 2 [Homo sapiens (human)] - Gene

Summary

Official Symbol: SEMG2provided by HGNC
Official Full Name: semenogelin 2provided by HGNC
Primary source: HGNC:HGNC:10743
See related: Ensembl:ENSG00000124157 MIM:182141; AllianceGenome:HGNC:10743
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: SGII
Summary: The secreted protein encoded by this gene is involved in the formation of a gel matrix that encases ejaculated spermatozoa. Proteolysis by the prostate-specific antigen (PSA) breaks down the gel matrix and allows the spermatozoa to move more freely. The encoded protein is found in lesser abundance than a similar semenogelin protein. An antibacterial activity has been found for a antimicrobial peptide isolated from this protein. The genes encoding these two semenogelin proteins are found in a cluster on chromosome 20. [provided by RefSeq, Jan 2015]
Expression: Low expression observed in reference dataset See more
Orthologs: all
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Genomic context

Location:: 20q13.12

Exon count:: 3

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCh38.p14 (GCF_000001405.40)	20	NC_000020.11 (45221373..45224458)
RS_2024_08	current	T2T-CHM13v2.0 (GCF_009914755.1)	20	NC_060944.1 (46957268..46960353)
RS_2024_09	previous assembly	GRCh37.p13 (GCF_000001405.25)	20	NC_000020.10 (43850014..43853099)

Chromosome 20 - NC_000020.11 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
BioProject: PRJEB4337
Publication: PMID 24309898
Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

SEMG1/2 augment energy metabolism of tumor cells.
Title: SEMG1/2 augment energy metabolism of tumor cells.
Peptides released by physiological cleavage of Semg1 and Semg2 form amyloids that enhance HIV infection.
Title: Peptides released by physiological cleavage of semen coagulum proteins form amyloids that enhance HIV infection.
These results suggest the involvement of semenogelins in prostate cancer and their prognostic values in predicting cancer progression after radical prostatectomy.
Title: Expression of semenogelins I and II and its prognostic significance in human prostate cancer.
Semenogelins (Sgs) modifies the membrane structure, indirectly inhibiting motility, and provides suggestions for a therapy for male infertility through selection of a functional sperm population using Sgs.
Title: Functional implications of membrane modification with semenogelins for inhibition of sperm motility in humans.
antibacterial activity of the semenogelin-derived peptides generated in seminal plasma was strictly zinc-dependent both at neutral and low pH
Title: The major bactericidal activity of human seminal plasma is zinc-dependent and derived from fragmentation of the semenogelins.
semenogelins I and II were directly cleaved by KLK14. Semenogelins were also able to reverse KLK14 inhibition by Zn2+, providing a novel regulatory mechanism for KLK14 activity.
Title: Major role of human KLK14 in seminal clot liquefaction.
SGII is a novel target for protein S-nitrosylation in spermatozoa.
Title: Human spermatozoa contain multiple targets for protein S-nitrosylation: an alternative mechanism of the modulation of sperm function by nitric oxide?
SgII transcripts were demonstrated in several tissues, with the strongest signals coming from seminal vesicles, vas deferens, prostate, epididymis and trachea.
Title: Semenogelin I and II, the predominant human seminal plasma proteins, are also expressed in non-genital tissues.
The binding of Zn2+ to SgI and SgII and their involvment in regulating the activity of PSA are reported.
Title: Semenogelins I and II bind zinc and regulate the activity of prostate-specific antigen.
Seminal plasma motility inhibitor, one of the fragments of Sg, has its inhibitory effect on ejaculated spermatozoa in liquefied semen under physiological conditions.
Title: Quantification of seminal plasma motility inhibitor/semenogelin in human seminal plasma.

Submit: New GeneRIF Correction See all GeneRIFs (11)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

HIV-1 interactions

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Protein interactions

Protein	Gene	Interaction	Pubs
Pr55(Gag)	gag	Cellular biotinylated semenogelin II protein (SEMG2) is incorporated into HIV-1 Gag virus-like particles	PubMed

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
enables protease binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables zinc ion binding	IMP Inferred from Mutant Phenotype more info	PubMed

Process	Evidence Code	Pubs
involved_in antibacterial humoral response	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in coagulation	IDA Inferred from Direct Assay more info	PubMed
involved_in negative regulation of flagellated sperm motility	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of serine-type endopeptidase activity	IDA Inferred from Direct Assay more info	PubMed
involved_in sperm capacitation	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
located_in extracellular exosome	HDA more info	PubMed
located_in extracellular space	IDA Inferred from Direct Assay more info	PubMed
located_in extracellular space	TAS Traceable Author Statement more info	PubMed
located_in nucleus	HDA more info	PubMed

General protein information

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Preferred Names: semenogelin-2

Names: semenogelin II

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.