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    SLC35G1 solute carrier family 35 member G1 [ Homo sapiens (human) ]

    Gene ID: 159371, updated on 13-Nov-2024

    Summary

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    Official Symbol
    SLC35G1provided by HGNC
    Official Full Name
    solute carrier family 35 member G1provided by HGNC
    Primary source
    HGNC:HGNC:26607
    See related
    Ensembl:ENSG00000176273 MIM:617167; AllianceGenome:HGNC:26607
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    POST; TMEM20; C10orf60
    Summary
    This gene encodes a transmembrane protein which is a member of the drug/metabolite transporter protein superfamily. The encoded protein may play a role in the regulation of calcium levels inside the cell. [provided by RefSeq, Sep 2016]
    Expression
    Biased expression in duodenum (RPKM 26.1), small intestine (RPKM 12.8) and 2 other tissues See more
    Orthologs
    mouse all
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    Genomic context

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    See SLC35G1 in Genome Data Viewer
    Location:
    10q23.33
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 10 NC_000010.11 (93893978..93909830)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 10 NC_060934.1 (94773053..94788891)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 10 NC_000010.10 (95653735..95669587)

    Chromosome 10 - NC_000010.11Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105378437 Neighboring gene leucine rich glioma inactivated 1 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr10:95550082-95550640 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr10:95609025-95609669 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 2630 Neighboring gene RAB11A, member RAS oncogene family pseudogene 1 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 2631 Neighboring gene MED14-independent group 3 enhancer GRCh37_chr10:95686691-95687890 Neighboring gene PIP5K1A and PSMD4 like (pseudogene) Neighboring gene uncharacterized LOC105378438

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. Transcriptome comparisons identify new cell markers for theca interna and granulosa cells from small and large antral ovarian follicles. Hatzirodos N, et al. PLoS One, 2015. PMID 25775029, Free PMC Article
    2. Genome-wide Association Study of Cannabis Dependence Severity, Novel Risk Variants, and Shared Genetic Risks. Sherva R, et al. JAMA Psychiatry, 2016 May 1. PMID 27028160, Free PMC Article
    3. Discovery and Validation of Novel Genes in a Large Chinese Autism Spectrum Disorder Cohort. Wang J, et al. Biol Psychiatry, 2023 Nov 15. PMID 37393044
    4. POST, partner of stromal interaction molecule 1 (STIM1), targets STIM1 to multiple transporters. Krapivinsky G, et al. Proc Natl Acad Sci U S A, 2011 Nov 29. PMID 22084111, Free PMC Article
    5. Nuclear export of ubiquitinated proteins via the UBIN-POST system. Hirayama S, et al. Proc Natl Acad Sci U S A, 2018 May 1. PMID 29666234, Free PMC Article

    See all (21) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. SLC35G1 is a highly chloride-sensitive transporter responsible for the basolateral membrane transport in intestinal citrate absorption.
      Title: SLC35G1 is a highly chloride-sensitive transporter responsible for the basolateral membrane transport in intestinal citrate absorption.
    2. Discovery and Validation of Novel Genes in a Large Chinese Autism Spectrum Disorder Cohort.
      Title: Discovery and Validation of Novel Genes in a Large Chinese Autism Spectrum Disorder Cohort.
    3. results suggest that ubiquitinated proteins are exported from the nucleus to the cytosol in the UBIN-POST complex-dependent manner for the maintenance of nuclear protein homeostasis.
      Title: Nuclear export of ubiquitinated proteins via the UBIN-POST system.
    Submit: New GeneRIF Correction

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • FLJ33990

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in calcium ion export across plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in calcium ion export across plasma membrane IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of cytosolic calcium ion concentration IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of cytosolic calcium ion concentration IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in endoplasmic reticulum membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in endoplasmic reticulum membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    solute carrier family 35 member G1
    Names
    partner of STIM1
    transmembrane protein 20

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_051626.1 RefSeqGene

      Range
      5009..14855
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001134658.3 → NP_001128130.1  solute carrier family 35 member G1 isoform 1

      See identical proteins and their annotated locations for NP_001128130.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
      Source sequence(s)
      AK091309, AL138923, BC041432, BC104814
      Consensus CDS
      CCDS44459.1
      UniProtKB/Swiss-Prot
      Q2M3R5, Q86YG5, Q8NBA5
      UniProtKB/TrEMBL
      B7ZKP1
      Related
      ENSP00000400932.1, ENST00000427197.2
      Conserved Domains (1) summary
      COG0697
      Location:70 → 359
      RhaT; Permease of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism, Amino acid transport and metabolism, General function prediction only]

    2. NM_001345993.2 → NP_001332922.1  solute carrier family 35 member G1 isoform 3

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3) uses an alternate in-frame splice site in the 5' coding region, compared to variant 1. The encoded isoform (3) is shorter than isoform 1.
      Source sequence(s)
      AL138923, BC143283, DA644843
      UniProtKB/TrEMBL
      B7ZKP0
      Conserved Domains (1) summary
      COG0697
      Location:53 → 342
      RhaT; Permease of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism, Amino acid transport and metabolism, General function prediction only]

    3. NM_153226.4 → NP_694958.1  solute carrier family 35 member G1 isoform 2

      See identical proteins and their annotated locations for NP_694958.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) uses an alternate in-frame splice site in the central coding region, compared to variant 1, resulting in a protein (isoform 2) that is one amino acid shorter than isoform 1.
      Source sequence(s)
      AK091309, AL138923, BC041432
      Consensus CDS
      CCDS7432.1
      UniProtKB/TrEMBL
      B7ZKP1
      Related
      ENSP00000360462.3, ENST00000371408.7
      Conserved Domains (2) summary
      COG0697
      Location:69 → 358
      RhaT; Permease of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism, Amino acid transport and metabolism, General function prediction only]
      pfam00892
      Location:68 → 201
      EamA; EamA-like transporter family

    RNA

    1. NR_144335.2 RNA Sequence

      Status: REVIEWED

      Description
      Transcript Variant: This variant (4) uses an alternate splice site in the 5'-terminal exon, and uses alternate internal and 3' exons, compared to variant 1. This variant is represented as non-coding because the predicted protein does not meet RefSeq quality criteria.
      Source sequence(s)
      AL138923, BC036382, DA644843
      Related
      ENST00000483386.5

    2. NR_144336.2 RNA Sequence

      Status: REVIEWED

      Description
      Transcript Variant: This variant (5) uses alternate internal and 3' exons, compared to variant 1. This variant is represented as non-coding because the predicted protein does not meet RefSeq quality criteria.
      Source sequence(s)
      AK091309, AL138923, BC047102, BM677569, BU608007, R56424
      Related
      ENST00000603665.1

    3. NR_144337.2 RNA Sequence

      Status: REVIEWED

      Description
      Transcript Variant: This variant (6) uses alternate internal and 3' exons, compared to variant 1. This variant is represented as non-coding because the predicted protein does not meet RefSeq quality criteria.
      Source sequence(s)
      AL138923

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000010.11 Reference GRCh38.p14 Primary Assembly

      Range
      93893978..93909830
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060934.1 Alternate T2T-CHM13v2.0

      Range
      94773053..94788891
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q2M3R5.1 GenPept UniProtKB/Swiss-Prot:Q2M3R5

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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