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    Lpo lactoperoxidase [ Mus musculus (house mouse) ]

    Gene ID: 76113, updated on 28-Oct-2024

    Summary

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    Official Symbol
    Lpoprovided by MGI
    Official Full Name
    lactoperoxidaseprovided by MGI
    Primary source
    MGI:MGI:1923363
    See related
    Ensembl:ENSMUSG00000009356 AllianceGenome:MGI:1923363
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    5830499B15Rik
    Summary
    Enables peroxidase activity. Predicted to be involved in defense response to bacterium and detection of chemical stimulus involved in sensory perception of bitter taste. Located in cytoplasm. Is expressed in parotid gland and submandibular gland. Orthologous to human LPO (lactoperoxidase). [provided by Alliance of Genome Resources, Oct 2024]
    Expression
    Restricted expression toward colon adult (RPKM 60.4) See more
    Orthologs
    human all
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    Genomic context

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    See Lpo in Genome Data Viewer
    Location:
    11 C; 11 52.22 cM
    Exon count:
    13
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (87697254..87716750, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (87806428..87826114, complement)

    Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene TSPO associated protein 1 Neighboring gene STARR-positive B cell enhancer ABC_E7040 Neighboring gene Mpo distal enhancer region Neighboring gene Mpo proximal enhancer and promoter region Neighboring gene myeloperoxidase Neighboring gene STARR-seq mESC enhancer starr_30300 Neighboring gene MKS transition zone complex subunit 1 Neighboring gene eosinophil peroxidase

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Deletion of the lactoperoxidase gene causes multisystem inflammation and tumors in mice. Yamakaze J, et al. Sci Rep, 2021 Jun 14. PMID 34127712, Free PMC Article
    2. The mechanism and significance of the conversion of xanthine dehydrogenase to xanthine oxidase in mammalian secretory gland cells. Kusano T, et al. Redox Biol, 2023 Feb. PMID 36525890, Free PMC Article
    3. The potential for repositioning antithyroid agents as antiasthma drugs. Suzuki S, et al. J Allergy Clin Immunol, 2016 Nov. PMID 27444178
    4. Expression of lactoperoxidase in differentiated mouse colon epithelial cells. Kim BW, et al. Free Radic Biol Med, 2012 May 1. PMID 22343415, Free PMC Article
    5. The evolutionary conservation of the mammalian peroxidase genes. Sakamaki K, et al. Cytogenet Genome Res, 2002. PMID 12584448

    See all (22) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Deletion of the lactoperoxidase gene causes multisystem inflammation and tumors in mice.
      Title: Deletion of the lactoperoxidase gene causes multisystem inflammation and tumors in mice.
    2. we postulate that Lpo upregulation in the intestinal epithelium of miR-10a deficient mice together with the predominant abundance of estrogens in female animals mainly accounts for the sex-related cancer phenotype we observed
      Title: Loss of miR-10a activates lpo and collaborates with activated Wnt signaling in inducing intestinal neoplasia in female mice.
    3. methylation of the Lpo intragenic CpG island was not directly induced by inflammation, because dextran sulfate sodium-induced colitis did not increase DNA methylation in B6 DKO colon. Also, Lpo DNA methylation is not correlated with gene expression
      Title: Expression of lactoperoxidase in differentiated mouse colon epithelial cells.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables heme binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables lactoperoxidase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables peroxidase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables thiocyanate peroxidase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables thiocyanate peroxidase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables thiocyanate peroxidase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Process Evidence Code Pubs
    involved_in cellular oxidant detoxification IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in defense response to bacterium IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in defense response to bacterium IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in defense response to bacterium ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in detection of chemical stimulus involved in sensory perception of bitter taste IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in detection of chemical stimulus involved in sensory perception of bitter taste ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in response to oxidative stress IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in thiocyanate metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in basolateral plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in basolateral plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in extracellular space IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in extracellular space IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in extracellular space ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    lactoperoxidase
    NP_536345.2
    XP_011247600.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_080420.3 → NP_536345.2  lactoperoxidase precursor

      See identical proteins and their annotated locations for NP_536345.2

      Status: VALIDATED

      Source sequence(s)
      AL604022, AL606805
      Consensus CDS
      CCDS25218.1
      UniProtKB/Swiss-Prot
      Q5SW46
      UniProtKB/TrEMBL
      Q91WA0
      Related
      ENSMUSP00000099466.4, ENSMUST00000103177.10
      Conserved Domains (1) summary
      cd09824
      Location:281 → 692
      myeloperoxidase_like; Myeloperoxidases, eosinophil peroxidases, and lactoperoxidases

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000077.7 Reference GRCm39 C57BL/6J

      Range
      87697254..87716750 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011249298.4 → XP_011247600.1  lactoperoxidase isoform X1

      See identical proteins and their annotated locations for XP_011247600.1

      UniProtKB/Swiss-Prot
      Q5SW46
      UniProtKB/TrEMBL
      Q91WA0
      Conserved Domains (1) summary
      cd09824
      Location:281 → 692
      myeloperoxidase_like; Myeloperoxidases, eosinophil peroxidases, and lactoperoxidases
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q5SW46.1 GenPept UniProtKB/Swiss-Prot:Q5SW46

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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