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    Fam120b family with sequence similarity 120, member B [ Mus musculus (house mouse) ]

    Gene ID: 67544, updated on 2-Nov-2024

    Summary

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    Official Symbol
    Fam120bprovided by MGI
    Official Full Name
    family with sequence similarity 120, member Bprovided by MGI
    Primary source
    MGI:MGI:1914794
    See related
    Ensembl:ENSMUSG00000014763 AllianceGenome:MGI:1914794
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    CCPG; Pgcc1; mKIAA1838; 4932442K08Rik
    Summary
    Acts upstream of or within fat cell differentiation and peroxisome proliferator activated receptor signaling pathway. Located in nucleus. Is expressed in several structures, including brain; cardiovascular system; genitourinary system; gut; and immune system. Orthologous to human FAM120B (family with sequence similarity 120 member B). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Ubiquitous expression in CNS E14 (RPKM 6.5), CNS E18 (RPKM 6.5) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Fam120b in Genome Data Viewer
    Location:
    17 A2; 17 8.95 cM
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 17 NC_000083.7 (15616464..15653843)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 17 NC_000083.6 (15396202..15433581)

    Chromosome 17 - NC_000083.7Genomic Context describing neighboring genes Neighboring gene predicted gene 10510 Neighboring gene RIKEN cDNA A930024N18 gene Neighboring gene delta like canonical Notch ligand 1 Neighboring gene STARR-positive B cell enhancer ABC_E1931 Neighboring gene predicted gene, 49668 Neighboring gene proteasome (prosome, macropain) subunit, beta type 1 Neighboring gene STARR-positive B cell enhancer ABC_E5573 Neighboring gene TATA box binding protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. San1 deficiency leads to cardiomyopathy due to excessive R-loop-associated DNA damage and cardiomyocyte hypoplasia. Liu Z, et al. Biochim Biophys Acta Mol Basis Dis, 2021 Nov 1. PMID 34339838, Free PMC Article
    2. Sulfonylthiadiazoles with an unusual binding mode as partial dual peroxisome proliferator-activated receptor (PPAR) γ/δ agonists with high potency and in vivo efficacy. Keil S, et al. ChemMedChem, 2011 Apr 4. PMID 21400663
    3. A senataxin-associated exonuclease SAN1 is required for resistance to DNA interstrand cross-links. Andrews AM, et al. Nat Commun, 2018 Jul 3. PMID 29968717, Free PMC Article
    4. Constitutive coactivator of peroxisome proliferator-activated receptor (PPARgamma), a novel coactivator of PPARgamma that promotes adipogenesis. Li D, et al. Mol Endocrinol, 2007 Oct. PMID 17595322
    5. Fine haplotype structure of a chromosome 17 region in the laboratory and wild mouse. Trachtulec Z, et al. Genetics, 2008 Mar. PMID 18245833, Free PMC Article

    See all (25) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. San1 deficiency leads to cardiomyopathy due to excessive R-loop-associated DNA damage and cardiomyocyte hypoplasia.
      Title: San1 deficiency leads to cardiomyopathy due to excessive R-loop-associated DNA damage and cardiomyocyte hypoplasia.
    2. Study report a previously uncharacterized protein, SAN1, the Fam120b gene product, as a 5' exonuclease that acts independently of the Fanconi anemia pathway in response to inter-strand DNA cross-links (ICLs). Deletion of SAN1 in HeLa cells and mouse embryonic fibroblasts causes sensitivity to ICLs. SAN1 binds to senataxin (SETX). SAN1-SETX binding is increased by ICLs and is required to prevent cross-link sensitivity.
      Title: A senataxin-associated exonuclease SAN1 is required for resistance to DNA interstrand cross-links.
    3. Sulfonylthiadiazoles with an unusual binding mode were shown as partial dual peroxisome proliferator-activated receptor (PPAR) gamma/delta agonists with high potency and in vivo efficacy.
      Title: Sulfonylthiadiazoles with an unusual binding mode as partial dual peroxisome proliferator-activated receptor (PPAR) γ/δ agonists with high potency and in vivo efficacy.
    4. CCPG is a bona fide coactivator and promotes adipogenesis in a PPARgamma-dependent manner.
      Title: Constitutive coactivator of peroxisome proliferator-activated receptor (PPARgamma), a novel coactivator of PPARgamma that promotes adipogenesis.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • KIAA1838, MGC109687

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in fat cell differentiation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within fat cell differentiation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within fat cell differentiation IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    involved_in peroxisome proliferator activated receptor signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within peroxisome proliferator activated receptor signaling pathway IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in nucleoplasm TAS
    Traceable Author Statement
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    constitutive coactivator of peroxisome proliferator-activated receptor gamma
    Names
    constitutive coactivator of PPAR-gamma
    constitutive coactivator of PPARG

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001357822.1 → NP_001344751.1  constitutive coactivator of peroxisome proliferator-activated receptor gamma

      Status: VALIDATED

      Source sequence(s)
      AC154378, BC085163
      Consensus CDS
      CCDS37453.1
      UniProtKB/Swiss-Prot
      Q5DTU5, Q6RI63, Q8BK59, Q8BVH5, Q8BWQ3, Q8C158, Q99LL4, Q9DAC3

    2. NM_024203.3 → NP_077165.2  constitutive coactivator of peroxisome proliferator-activated receptor gamma

      See identical proteins and their annotated locations for NP_077165.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) encodes a 786aa protein.
      Source sequence(s)
      AK132211, BC085163, BY073650
      Consensus CDS
      CCDS37453.1
      UniProtKB/Swiss-Prot
      Q5DTU5, Q6RI63, Q8BK59, Q8BVH5, Q8BWQ3, Q8C158, Q99LL4, Q9DAC3
      Related
      ENSMUSP00000054420.7, ENSMUST00000055352.8

    RNA

    1. NR_033586.1 RNA Sequence

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) has an additional segment in the 5' CDS, which includes an in-frame stop codon, as compared to variant 1. The transcript is a nonsense-mediated mRNA decay (NMD) candidate.
      Source sequence(s)
      BC066088, BC085163, CB518733
      Related
      ENSMUST00000231274.2

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000083.7 Reference GRCm39 C57BL/6J

      Range
      15616464..15653843
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q6RI63.1 GenPept UniProtKB/Swiss-Prot:Q6RI63

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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