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    Tmem163 transmembrane protein 163 [ Mus musculus (house mouse) ]

    Gene ID: 72160, updated on 12-Nov-2024

    Summary

    Official Symbol
    Tmem163provided by MGI
    Official Full Name
    transmembrane protein 163provided by MGI
    Primary source
    MGI:MGI:1919410
    See related
    Ensembl:ENSMUSG00000026347 AllianceGenome:MGI:1919410
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    SV31; A-cre; Act-Cre; actin-cre; cre<actin>; 2610024A01Rik; Tg(ACTB-cre)2Mrt
    Summary
    Predicted to enable zinc ion binding activity. Predicted to be involved in myelination; zinc export across plasma membrane; and zinc ion import into synaptic vesicle. Located in synaptic vesicle membrane. Is active in intracellular vesicle and plasma membrane. Is expressed in cerebral cortex; cortical layer V; cortical subplate; heart; and limb. Human ortholog(s) of this gene implicated in hypomyelinating leukodystrophy 25. Orthologous to human TMEM163 (transmembrane protein 163). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in cerebellum adult (RPKM 15.9), lung adult (RPKM 9.4) and 9 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See Tmem163 in Genome Data Viewer
    Location:
    1 E3; 1 55.77 cM
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 1 NC_000067.7 (127418079..127605758, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 1 NC_000067.6 (127490342..127678021, complement)

    Chromosome 1 - NC_000067.7Genomic Context describing neighboring genes Neighboring gene mannoside acetylglucosaminyltransferase 5 Neighboring gene STARR-seq mESC enhancer starr_02135 Neighboring gene STARR-positive B cell enhancer mm9_chr1:129321878-129322179 Neighboring gene predicted gene, 51746 Neighboring gene STARR-positive B cell enhancer mm9_chr1:129355594-129355895 Neighboring gene predicted gene, 41947 Neighboring gene STARR-positive B cell enhancer ABC_E3299 Neighboring gene STARR-seq mESC enhancer starr_02141 Neighboring gene STARR-positive B cell enhancer ABC_E3300 Neighboring gene VISTA enhancer mm790 Neighboring gene STARR-positive B cell enhancer ABC_E9476 Neighboring gene STARR-positive B cell enhancer mm9_chr1:129576446-129576747 Neighboring gene STARR-seq mESC enhancer starr_02145 Neighboring gene RIKEN cDNA 2900009J06 gene Neighboring gene STARR-positive B cell enhancer ABC_E3301 Neighboring gene predicted gene, 35993 Neighboring gene amino carboxymuconate semialdehyde decarboxylase

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from PubChem

    General gene information

    Markers

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables zinc ion binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables zinc ion binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables zinc ion binding ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    Process Evidence Code Pubs
    involved_in myelination ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in myelination ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in zinc export across plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in zinc export across plasma membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in zinc ion import into synaptic vesicle IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in zinc ion import into synaptic vesicle ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    located_in early endosome membrane ISO
    Inferred from Sequence Orthology
    more info
     
    located_in early endosome membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    is_active_in intracellular vesicle EXP
    Inferred from Experiment
    more info
    PubMed 
    located_in late endosome membrane IEA
    Inferred from Electronic Annotation
    more info
     
    located_in lysosomal membrane IEA
    Inferred from Electronic Annotation
    more info
     
    is_active_in plasma membrane EXP
    Inferred from Experiment
    more info
    PubMed 
    is_active_in synaptic vesicle membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in synaptic vesicle membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    is_active_in synaptic vesicle membrane ISO
    Inferred from Sequence Orthology
    more info
     
    located_in synaptic vesicle membrane ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    transmembrane protein 163
    Names
    TgN(ACTB-cre)2Mrt
    beta-actin-cre
    synaptic vesicle membrane protein of 31 kDa

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_028135.2NP_082411.1  transmembrane protein 163

      See identical proteins and their annotated locations for NP_082411.1

      Status: VALIDATED

      Source sequence(s)
      AC130527, AK042650, CA319657
      Consensus CDS
      CCDS35696.1
      UniProtKB/Swiss-Prot
      Q8C8I2, Q8C996, Q9D0E0
      Related
      ENSMUSP00000140828.2, ENSMUST00000185560.2
      Conserved Domains (1) summary
      pfam01545
      Location:100273
      Cation_efflux; Cation efflux family

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000067.7 Reference GRCm39 C57BL/6J

      Range
      127418079..127605758 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)