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    Brcc3dc BRCA1/BRCA2-containing complex, subunit 3, domain containing [ Mus musculus (house mouse) ]

    Gene ID: 368203, updated on 2-Nov-2024

    Summary

    Official Symbol
    Brcc3dcprovided by MGI
    Official Full Name
    BRCA1/BRCA2-containing complex, subunit 3, domain containingprovided by MGI
    Primary source
    MGI:MGI:3647286
    See related
    Ensembl:ENSMUSG00000112039 AllianceGenome:MGI:3647286
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    C6.1AL; Gm5136; EG368203
    Summary
    Predicted to enable K63-linked deubiquitinase activity; metal-dependent deubiquitinase activity; and polyubiquitin modification-dependent protein binding activity. Predicted to be involved in several processes, including DNA repair-dependent chromatin remodeling; mitotic G2 DNA damage checkpoint signaling; and positive regulation of NLRP3 inflammasome complex assembly. Predicted to be located in cytoplasm and nucleoplasm. Predicted to be part of BRCA1-A complex; BRISC complex; and nuclear ubiquitin ligase complex. Orthologous to human BRCC3 (BRCA1/BRCA2-containing complex subunit 3). [provided by Alliance of Genome Resources, Nov 2024]
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    Genomic context

    See Brcc3dc in Genome Data Viewer
    Location:
    10 D1; 10 56.63 cM
    Exon count:
    1
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 10 NC_000076.7 (108534905..108536021, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 10 NC_000076.6 (108699044..108700160, complement)

    Chromosome 10 - NC_000076.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 36283 Neighboring gene predicted gene, 36440 Neighboring gene predicted gene, 36601 Neighboring gene STARR-seq mESC enhancer starr_27824 Neighboring gene STARR-seq mESC enhancer starr_27827 Neighboring gene synaptotagmin I Neighboring gene STARR-seq mESC enhancer starr_27829 Neighboring gene STARR-seq mESC enhancer starr_27830 Neighboring gene predicted gene, 53628 Neighboring gene predicted gene, 53629

    Genomic regions, transcripts, and products

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 

    General gene information

    Markers

    Clone Names

    • MGC155743, MGC155745

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables K63-linked deubiquitinase activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables cysteine-type deubiquitinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables metal-dependent deubiquitinase activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables metal-dependent deubiquitinase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables metallopeptidase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables metallopeptidase activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables metallopeptidase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables polyubiquitin modification-dependent protein binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables polyubiquitin modification-dependent protein binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables polyubiquitin modification-dependent protein binding ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    Process Evidence Code Pubs
    involved_in DNA repair-dependent chromatin remodeling ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in DNA repair-dependent chromatin remodeling ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in cellular response to ionizing radiation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in double-strand break repair IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in double-strand break repair ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in double-strand break repair ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in mitotic G2 DNA damage checkpoint signaling ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in mitotic G2 DNA damage checkpoint signaling ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in positive regulation of DNA repair ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of DNA repair ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in positive regulation of NLRP3 inflammasome complex assembly ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in protein K63-linked deubiquitination ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in protein K63-linked deubiquitination ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in proteolysis IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in response to ionizing radiation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in response to ionizing radiation ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    Component Evidence Code Pubs
    part_of BRCA1-A complex IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    part_of BRCA1-A complex ISO
    Inferred from Sequence Orthology
    more info
     
    part_of BRCA1-A complex ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    part_of BRISC complex IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    part_of BRISC complex ISO
    Inferred from Sequence Orthology
    more info
     
    part_of BRISC complex ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    part_of nuclear ubiquitin ligase complex ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nucleus ISS
    Inferred from Sequence or Structural Similarity
    more info
     

    General protein information

    Preferred Names
    lys-63-specific deubiquitinase BRCC36-like
    NP_988991.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_203660.2NP_988991.1  lys-63-specific deubiquitinase BRCC36-like

      See identical proteins and their annotated locations for NP_988991.1

      Status: VALIDATED

      Source sequence(s)
      AK134982, BC120508
      Consensus CDS
      CCDS88084.1
      UniProtKB/Swiss-Prot
      Q3UY45, Q7M757
      Related
      ENSMUSP00000151516.2, ENSMUST00000218023.2
      Conserved Domains (2) summary
      cd08068
      Location:9270
      MPN_BRCC36; Mov34/MPN/PAD-1 family: BRCC36, a subunit of BRCA1-A complex
      pfam06625
      Location:262289
      DUF1151; Protein of unknown function (DUF1151)

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000076.7 Reference GRCm39 C57BL/6J

      Range
      108534905..108536021 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)