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    Ccdc18 coiled-coil domain containing 18 [ Mus musculus (house mouse) ]

    Gene ID: 73254, updated on 2-Nov-2024

    Summary

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    Official Symbol
    Ccdc18provided by MGI
    Official Full Name
    coiled-coil domain containing 18provided by MGI
    Primary source
    MGI:MGI:1922974
    See related
    Ensembl:ENSMUSG00000056531 AllianceGenome:MGI:1922974
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    NY-SAR-41; 1700021E15Rik; 4932411G06Rik
    Summary
    Predicted to be located in centriolar satellite. Orthologous to human CCDC18 (coiled-coil domain containing 18). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in CNS E11.5 (RPKM 1.3), liver E14 (RPKM 0.9) and 12 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Ccdc18 in Genome Data Viewer
    Location:
    5 F; 5 52.55 cM
    Exon count:
    30
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 5 NC_000071.7 (108280583..108388378)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 5 NC_000071.6 (108132661..108240512)

    Chromosome 5 - NC_000071.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_13901 Neighboring gene STARR-seq mESC enhancer starr_13902 Neighboring gene STARR-seq mESC enhancer starr_13904 Neighboring gene metal response element binding transcription factor 2 Neighboring gene STARR-positive B cell enhancer ABC_E2166 Neighboring gene transmembrane p24 trafficking protein 5 Neighboring gene glyceraldehyde-3-phosphate dehydrogenase pseudogene Neighboring gene predicted gene 8190 Neighboring gene STARR-seq mESC enhancer starr_13907 Neighboring gene predicted gene, 54303 Neighboring gene down-regulator of transcription 1 Neighboring gene phosphatidylinositol glycan anchor biosynthesis, class G

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Genome-wide CRISPR Screen to Identify Genes that Suppress Transformation in the Presence of Endogenous Kras(G12D). Huang J, et al. Sci Rep, 2019 Nov 20. PMID 31748650, Free PMC Article
    2. TERRA transcripts are bound by a complex array of RNA-binding proteins. López de Silanes I, et al. Nat Commun, 2010 Jun 29. PMID 20975687
    3. Mouse screen reveals multiple new genes underlying mouse and human hearing loss. Ingham NJ, et al. PLoS Biol, 2019 Apr. PMID 30973865, Free PMC Article
    4. BayGenomics: a resource of insertional mutations in mouse embryonic stem cells. Stryke D, et al. Nucleic Acids Res, 2003 Jan 1. PMID 12520002, Free PMC Article
    5. BraInMap Elucidates the Macromolecular Connectivity Landscape of Mammalian Brain. Pourhaghighi R, et al. Cell Syst, 2020 Apr 22. PMID 32325033, Free PMC Article

    See all (18) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (2) 
    • Targeted (1) 

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC100177

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    involved_in biological_process ND
    No biological Data available
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cellular_component ND
    No biological Data available
    more info
    		  
    located_in centriolar satellite ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in centriolar satellite ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    coiled-coil domain-containing protein 18
    Names
    sarcoma antigen NY-SAR-41
    NP_082757.1
    XP_006535314.1
    XP_006535315.1
    XP_006535316.1
    XP_006535318.1
    XP_036021438.1
    XP_036021439.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_028481.1 → NP_082757.1  coiled-coil domain-containing protein 18

      See identical proteins and their annotated locations for NP_082757.1

      Status: PROVISIONAL

      Source sequence(s)
      BC082598
      Consensus CDS
      CCDS39202.1
      UniProtKB/Swiss-Prot
      Q640L5, Q8BIM9, Q8BIN1, Q9DA43
      Related
      ENSMUSP00000036507.8, ENSMUST00000047677.9
      Conserved Domains (2) summary
      COG1196
      Location:512 → 1290
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      pfam04420
      Location:1209 → 1272
      CHD5; CHD5-like protein

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000071.7 Reference GRCm39 C57BL/6J

      Range
      108280583..108388378
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006535251.5 → XP_006535314.1  coiled-coil domain-containing protein 18 isoform X1

      See identical proteins and their annotated locations for XP_006535314.1

      Conserved Domains (2) summary
      COG1196
      Location:512 → 1290
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      TIGR02168
      Location:115 → 888
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type

    2. XM_006535253.5 → XP_006535316.1  coiled-coil domain-containing protein 18 isoform X2

      Conserved Domains (2) summary
      COG1196
      Location:512 → 1244
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      TIGR02168
      Location:115 → 888
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type

    3. XM_036165545.1 → XP_036021438.1  coiled-coil domain-containing protein 18 isoform X4

      Conserved Domains (1) summary
      TIGR02168
      Location:115 → 863
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type

    4. XM_006535255.5 → XP_006535318.1  coiled-coil domain-containing protein 18 isoform X3

      Conserved Domains (1) summary
      COG1196
      Location:114 → 903
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]

    5. XM_006535252.5 → XP_006535315.1  coiled-coil domain-containing protein 18 isoform X1

      See identical proteins and their annotated locations for XP_006535315.1

      Conserved Domains (2) summary
      COG1196
      Location:512 → 1290
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      TIGR02168
      Location:115 → 888
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type

    6. XM_036165546.1 → XP_036021439.1  coiled-coil domain-containing protein 18 isoform X5

      Conserved Domains (1) summary
      COG1196
      Location:243 → 597
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]

    RNA

    1. XR_003955715.2 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q640L5.1 GenPept UniProtKB/Swiss-Prot:Q640L5

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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