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    Slc25a25 solute carrier family 25 (mitochondrial carrier, phosphate carrier), member 25 [ Mus musculus (house mouse) ]

    Gene ID: 227731, updated on 3-Nov-2024

    Summary

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    Official Symbol
    Slc25a25provided by MGI
    Official Full Name
    solute carrier family 25 (mitochondrial carrier, phosphate carrier), member 25provided by MGI
    Primary source
    MGI:MGI:1915913
    See related
    Ensembl:ENSMUSG00000026819 AllianceGenome:MGI:1915913
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    MCSC; SCaMC-2; mKIAA1896; 1110030N17Rik
    Summary
    Predicted to enable ATP:phosphate antiporter activity. Acts upstream of or within several processes, including response to activity; response to dietary excess; and response to food. Located in mitochondrion. Is expressed in several structures, including alimentary system; eye; genitourinary system; hemolymphoid system gland; and nervous system. Orthologous to human SLC25A25 (solute carrier family 25 member 25). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Ubiquitous expression in liver adult (RPKM 15.8), cerebellum adult (RPKM 9.7) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Slc25a25 in Genome Data Viewer
    Location:
    2 B; 2 22.09 cM
    Exon count:
    13
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (32304499..32341482, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (32414487..32451470, complement)

    Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E2612 Neighboring gene prostaglandin E synthase 2 Neighboring gene predicted gene 13413 Neighboring gene STARR-positive B cell enhancer ABC_E4433 Neighboring gene STARR-positive B cell enhancer ABC_E120 Neighboring gene STARR-seq mESC enhancer starr_04193 Neighboring gene nuclear apoptosis inducing factor 1 Neighboring gene STARR-positive B cell enhancer ABC_E4434 Neighboring gene CapStarr-seq enhancer MGSCv37_chr2:32350767-32351080 Neighboring gene STARR-seq mESC enhancer starr_04196 Neighboring gene STARR-seq mESC enhancer starr_04197 Neighboring gene STARR-positive B cell enhancer ABC_E2613 Neighboring gene estrogen-induced osteoclastogenesis regulator 1 Neighboring gene STARR-positive B cell enhancer ABC_E4435 Neighboring gene dolichyl-phosphate mannosyltransferase subunit 2, regulatory

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Ketogenic diet induces expression of the muscle circadian gene Slc25a25 via neural pathway that might be involved in muscle thermogenesis. Nakao R, et al. Sci Rep, 2017 Jun 6. PMID 28588221, Free PMC Article
    2. Inactivation of the mitochondrial carrier SLC25A25 (ATP-Mg2+/Pi transporter) reduces physical endurance and metabolic efficiency in mice. Anunciado-Koza RP, et al. J Biol Chem, 2011 Apr 1. PMID 21296886, Free PMC Article
    3. Glucagon regulation of oxidative phosphorylation requires an increase in matrix adenine nucleotide content through Ca2+ activation of the mitochondrial ATP-Mg/Pi carrier SCaMC-3. Amigo I, et al. J Biol Chem, 2013 Mar 15. PMID 23344948, Free PMC Article
    4. Identification of a novel human subfamily of mitochondrial carriers with calcium-binding domains. del Arco A, et al. J Biol Chem, 2004 Jun 4. PMID 15054102
    5. Targeting a complex transcriptome: the construction of the mouse full-length cDNA encyclopedia. Carninci P, et al. Genome Res, 2003 Jun. PMID 12819125, Free PMC Article

    See all (29) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. These findings suggest that KD feeding induces expression of the muscle circadian gene Slc25a25 via neural pathways, and that SLC25A25 might be involved in muscle thermogenesis under KD-induced hypothermia in mammals.
      Title: Ketogenic diet induces expression of the muscle circadian gene Slc25a25 via neural pathway that might be involved in muscle thermogenesis.
    2. induction of Slc25a25 in mice with an intact gene may contribute to an alternative thermogenic pathway for the maintenance of body temperature during cold stress.
      Title: Inactivation of the mitochondrial carrier SLC25A25 (ATP-Mg2+/Pi transporter) reduces physical endurance and metabolic efficiency in mice.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 
    • Targeted (4)  1 citation

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC36388

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables ATP transmembrane transporter activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables ATP:phosphate antiporter activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables ATP:phosphate antiporter activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables calcium ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in ADP transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within ATP metabolic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in ATP transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in ATP transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within adipose tissue development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within calcium ion transmembrane transport IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within camera-type eye development IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    acts_upstream_of_or_within cellular respiration IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within multicellular organism growth IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    acts_upstream_of_or_within response to activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within response to dietary excess IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within response to food IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in mitochondrial inner membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in mitochondrion HDA PubMed 
    located_in mitochondrion IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in mitochondrion ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    mitochondrial adenyl nucleotide antiporter SLC25A25
    Names
    calcium-binding mitochondrial carrier protein SCaMC-2
    mitochondrial Ca2+-dependent solute carrier
    short calcium-binding mitochondrial carrier protein 2
    small calcium-binding mitochondrial carrier protein 2
    solute carrier family 25 member 25

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001164357.1 → NP_001157829.1  mitochondrial adenyl nucleotide antiporter SLC25A25 isoform 2

      See identical proteins and their annotated locations for NP_001157829.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) lacks an alternate in-frame exon in the central coding region, compared to variant 1, resulting in an isoform (2) that is shorter than isoform 1.
      Source sequence(s)
      AK132204, BB653459, CO043296
      Consensus CDS
      CCDS50568.1
      UniProtKB/Swiss-Prot
      A2ASZ8
      Related
      ENSMUSP00000108936.3, ENSMUST00000113310.9
      Conserved Domains (3) summary
      cd00051
      Location:115 → 174
      EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
      pfam00153
      Location:309 → 401
      Mito_carr; Mitochondrial carrier protein
      pfam13499
      Location:52 → 109
      EF-hand_7; EF-hand domain pair

    2. NM_001164358.1 → NP_001157830.1  mitochondrial adenyl nucleotide antiporter SLC25A25 isoform 3

      See identical proteins and their annotated locations for NP_001157830.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) contains an alternate 5' terminal exon and it thus differs in the 5' UTR and 5' coding region, compared to variant 1. The encoded isoform (3) has a distinct N-terminus and is shorter than isoform 1.
      Source sequence(s)
      BC066998, CV784232
      Consensus CDS
      CCDS50567.1
      UniProtKB/Swiss-Prot
      A2ASZ8
      Related
      ENSMUSP00000060581.8, ENSMUST00000052119.14
      Conserved Domains (4) summary
      cd00051
      Location:102 → 173
      EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
      pfam00153
      Location:308 → 400
      Mito_carr; Mitochondrial carrier protein
      pfam13499
      Location:103 → 170
      EF-hand_7; EF-hand domain pair
      cl08302
      Location:63 → 97
      EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...

    3. NM_001290558.1 → NP_001277487.1  mitochondrial adenyl nucleotide antiporter SLC25A25 isoform 4

      See identical proteins and their annotated locations for NP_001277487.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (4) contains an alternate 5' terminal exon and it thus differs in the 5' UTR and 5' coding region, and it lacks an alternate in-frame exon in the central coding region, compared to variant 1. The encoded isoform (4) has a distinct N-terminus and is shorter than isoform 1.
      Source sequence(s)
      AK049392, BC066998, BY772900
      Consensus CDS
      CCDS71028.1
      UniProtKB/Swiss-Prot
      A2ASZ1, A2ASZ5, A2ASZ8, A2ASZ9, Q6NXM8, Q80T78, Q8BHG0, Q8JZT8, Q8VBT4, Q99KD3
      Related
      ENSMUSP00000108932.3, ENSMUST00000113307.9
      Conserved Domains (4) summary
      cd00051
      Location:82 → 141
      EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
      pfam00153
      Location:276 → 368
      Mito_carr; Mitochondrial carrier protein
      pfam13499
      Location:83 → 138
      EF-hand_7; EF-hand domain pair
      cl08302
      Location:29 → 77
      EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...

    4. NM_001362905.1 → NP_001349834.1  mitochondrial adenyl nucleotide antiporter SLC25A25 isoform 5

      Status: VALIDATED

      Source sequence(s)
      AL928710
      Consensus CDS
      CCDS89474.1
      Related
      ENSMUSP00000108933.2, ENSMUST00000113308.8
      Conserved Domains (3) summary
      cd15897
      Location:73 → 97
      EFh_PEF; EF-hand motif [structural motif]
      cl25352
      Location:73 → 159
      EFh_PEF; The penta-EF hand (PEF) family
      cl28162
      Location:211 → 465
      Mito_carr; Mitochondrial carrier protein

    5. NM_001362906.1 → NP_001349835.1  mitochondrial adenyl nucleotide antiporter SLC25A25 isoform 6

      Status: VALIDATED

      Source sequence(s)
      AL928710, BM947090
      Conserved Domains (5) summary
      cd15898
      Location:67 → 96
      EFh_PI-PLC; EF-hand motif [structural motif]
      cd15897
      Location:36 → 62
      EFh_PEF; EF-hand motif [structural motif]
      cl25352
      Location:31 → 110
      EFh_PEF; The penta-EF hand (PEF) family
      cl28162
      Location:188 → 442
      Mito_carr; Mitochondrial carrier protein
      cl28895
      Location:67 → 156
      EFh_PI-PLC; EF-hand motif found in eukaryotic phosphoinositide-specific phospholipase C (PI-PLC, EC 3.1.4.11) isozymes

    6. NM_001362907.1 → NP_001349836.1  mitochondrial adenyl nucleotide antiporter SLC25A25 isoform 7

      Status: VALIDATED

      Source sequence(s)
      AL928710
      Conserved Domains (3) summary
      cd15897
      Location:36 → 62
      EFh_PEF; EF-hand motif [structural motif]
      cl25352
      Location:31 → 124
      EFh_PEF; The penta-EF hand (PEF) family
      cl28162
      Location:176 → 430
      Mito_carr; Mitochondrial carrier protein

    7. NM_146118.3 → NP_666230.2  mitochondrial adenyl nucleotide antiporter SLC25A25 isoform 1

      See identical proteins and their annotated locations for NP_666230.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) encodes the longest isoform (1).
      Source sequence(s)
      AL928710
      Consensus CDS
      CCDS15915.1
      UniProtKB/Swiss-Prot
      A2ASZ8
      Related
      ENSMUSP00000028160.9, ENSMUST00000028160.15
      Conserved Domains (3) summary
      cd00051
      Location:53 → 110
      EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
      pfam00153
      Location:321 → 413
      Mito_carr; Mitochondrial carrier protein
      pfam13499
      Location:52 → 109
      EF-hand_7; EF-hand domain pair

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000068.8 Reference GRCm39 C57BL/6J

      Range
      32304499..32341482 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006497955.5 → XP_006498018.1  mitochondrial adenyl nucleotide antiporter SLC25A25 isoform X1

      Conserved Domains (5) summary
      PTZ00169
      Location:203 → 457
      PTZ00169; ADP/ATP transporter on adenylate translocase; Provisional
      cd15898
      Location:82 → 111
      EFh_PI-PLC; EF-hand motif [structural motif]
      cd15897
      Location:53 → 77
      EFh_PEF; EF-hand motif [structural motif]
      cl28895
      Location:82 → 171
      EFh_PI-PLC; EF-hand motif found in eukaryotic phosphoinositide-specific phospholipase C (PI-PLC, EC 3.1.4.11) isozymes
      cl25352
      Location:53 → 125
      EFh_PEF; The penta-EF hand (PEF) family
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    A2ASZ8.1 GenPept UniProtKB/Swiss-Prot:A2ASZ8

    Gene LinkOut

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