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    Fibp fibroblast growth factor (acidic) intracellular binding protein [ Mus musculus (house mouse) ]

    Gene ID: 58249, updated on 2-Nov-2024

    Summary

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    Official Symbol
    Fibpprovided by MGI
    Official Full Name
    fibroblast growth factor (acidic) intracellular binding proteinprovided by MGI
    Primary source
    MGI:MGI:1926233
    See related
    Ensembl:ENSMUSG00000024911 AllianceGenome:MGI:1926233
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    2010004G08Rik; 2010005N21Rik; 3010027N18Rik
    Summary
    Predicted to enable fibroblast growth factor binding activity. Predicted to be located in membrane and nuclear speck. Predicted to be active in nucleus. Orthologous to human FIBP (FGF1 intracellular binding protein). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Ubiquitous expression in large intestine adult (RPKM 48.9), CNS E14 (RPKM 48.4) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Fibp in Genome Data Viewer
    Location:
    19 A; 19 4.33 cM
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 19 NC_000085.7 (5510626..5515080)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 19 NC_000085.6 (5460598..5465052)

    Chromosome 19 - NC_000085.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 31070 Neighboring gene fos-like antigen 1 Neighboring gene coiled-coil domain containing 85B Neighboring gene cathepsin W Neighboring gene epidermal growth factor-containing fibulin-like extracellular matrix protein 2 Neighboring gene MUS81 structure-specific endonuclease subunit Neighboring gene CapStarr-seq enhancer MGSCv37_chr19:5488369-5488552

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Organization, chromosomal localization and promoter analysis of the gene encoding human acidic fibroblast growth factor intracellular binding protein. Kolpakova E, et al. Biochem J, 2000 Dec 15. PMID 11104667, Free PMC Article
    2. New roles for the de-ubiquitylating enzyme OTUD4 in an RNA-protein network and RNA granules. Das R, et al. J Cell Sci, 2019 Jun 17. PMID 31138677, Free PMC Article
    3. Integrated analysis of protein composition, tissue diversity, and gene regulation in mouse mitochondria. Mootha VK, et al. Cell, 2003 Nov 26. PMID 14651853
    4. Libraries enriched for alternatively spliced exons reveal splicing patterns in melanocytes and melanomas. Watahiki A, et al. Nat Methods, 2004 Dec. PMID 15782199
    5. BraInMap Elucidates the Macromolecular Connectivity Landscape of Mammalian Brain. Pourhaghighi R, et al. Cell Syst, 2020 Apr 22. PMID 32325033, Free PMC Article

    See all (19) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Targeted (2) 

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables fibroblast growth factor binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables fibroblast growth factor binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in endomembrane system IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nuclear speck ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    acidic fibroblast growth factor intracellular-binding protein
    Names
    FGF-1 intracellular-binding protein
    aFGF intracellular binding protein

    NCBI Reference Sequences (RefSeq)

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    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001253832.1 → NP_001240761.1  acidic fibroblast growth factor intracellular-binding protein isoform 1

      See identical proteins and their annotated locations for NP_001240761.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
      Source sequence(s)
      AC122861
      Consensus CDS
      CCDS57130.1
      UniProtKB/TrEMBL
      Q8K2D8
      Related
      ENSMUSP00000025847.6, ENSMUST00000025847.7
      Conserved Domains (1) summary
      pfam05427
      Location:3 → 363
      FIBP; Acidic fibroblast growth factor binding (FIBP)

    2. NM_021438.4 → NP_067413.1  acidic fibroblast growth factor intracellular-binding protein isoform 2

      See identical proteins and their annotated locations for NP_067413.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) uses an alternate in-frame splice site in the 3' coding region, compared to variant 1. This results in a shorter protein (isoform 2), compared to isoform 1.
      Source sequence(s)
      AC122861, AK028029
      Consensus CDS
      CCDS89310.1
      UniProtKB/Swiss-Prot
      Q9JI19
      Related
      ENSMUSP00000153409.2, ENSMUST00000225141.2
      Conserved Domains (1) summary
      pfam05427
      Location:3 → 356
      FIBP; Acidic fibroblast growth factor binding (FIBP)

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000085.7 Reference GRCm39 C57BL/6J

      Range
      5510626..5515080
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006531805.3 → XP_006531868.1  acidic fibroblast growth factor intracellular-binding protein isoform X1

      Conserved Domains (1) summary
      pfam05427
      Location:3 → 309
      FIBP; Acidic fibroblast growth factor binding (FIBP)

    2. XM_030251010.1 → XP_030106870.1  acidic fibroblast growth factor intracellular-binding protein isoform X2

      Conserved Domains (1) summary
      pfam05427
      Location:3 → 302
      FIBP; Acidic fibroblast growth factor binding (FIBP)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9JI19.1 GenPept UniProtKB/Swiss-Prot:Q9JI19

    Gene LinkOut

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