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    Reg3d regenerating islet-derived 3 delta [ Mus musculus (house mouse) ]

    Gene ID: 30053, updated on 2-Nov-2024

    Summary

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    Official Symbol
    Reg3dprovided by MGI
    Official Full Name
    regenerating islet-derived 3 deltaprovided by MGI
    Primary source
    MGI:MGI:1353426
    See related
    Ensembl:ENSMUSG00000068341 AllianceGenome:MGI:1353426
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    INGAP; Ingaprp
    Summary
    Predicted to enable oligosaccharide binding activity; peptidoglycan binding activity; and signaling receptor activity. Predicted to be involved in antimicrobial humoral immune response mediated by antimicrobial peptide; positive regulation of cell population proliferation; and response to peptide hormone. Predicted to be active in extracellular space. [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in small intestine adult (RPKM 13.5), spleen adult (RPKM 3.6) and 2 other tissues See more
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    Genomic context

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    See Reg3d in Genome Data Viewer
    Location:
    6 C3; 6 34.76 cM
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 6 NC_000072.7 (78352857..78355848, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 6 NC_000072.6 (78375874..78378865, complement)

    Chromosome 6 - NC_000072.7Genomic Context describing neighboring genes Neighboring gene predicted pseudogene 5576 Neighboring gene STARR-seq mESC enhancer starr_16386 Neighboring gene STARR-seq mESC enhancer starr_16388 Neighboring gene regenerating islet-derived 3 beta Neighboring gene regenerating islet-derived 3 alpha Neighboring gene regenerating islet-derived 2

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Molecular cloning and tissue-specific expression of a new member of the regenerating protein family, islet neogenesis-associated protein-related protein. Sasahara K, et al. Biochim Biophys Acta, 2000 Jan 3. PMID 10564727
    2. Targeted expression of islet neogenesis associated protein to beta cells enhances glucose tolerance and confers resistance to streptozotocin-induced hyperglycemia. Chang TJ, et al. Mol Cell Endocrinol, 2011 Mar 30. PMID 21187123
    3. Pancreatic islet immunoreactivity to the Reg protein INGAP. Taylor-Fishwick DA, et al. J Histochem Cytochem, 2008 Feb. PMID 17998566, Free PMC Article
    4. The Reg family member INGAP is a marker of endocrine patterning in the embryonic pancreas. Hamblet NS, et al. Pancreas, 2008 Jan. PMID 18192873
    5. Identification of a novel Reg family gene, Reg IIIdelta, and mapping of all three types of Reg family gene in a 75 kilobase mouse genomic region. Abe M, et al. Gene, 2000 Apr 4. PMID 10767532

    See all (20) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 
    • Targeted (2) 

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC130575

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables oligosaccharide binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables peptidoglycan binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables signaling receptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in antimicrobial humoral immune response mediated by antimicrobial peptide IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in positive regulation of cell population proliferation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in response to peptide hormone IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in extracellular space IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    regenerating islet-derived 3 delta
    Names
    Reg III delta
    islet neogenesis associated protein-related protein

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001161741.1 → NP_001155213.1  regenerating islet-derived 3 delta isoform 2 precursor

      See identical proteins and their annotated locations for NP_001155213.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) lacks an alternate in-frame exon compared to variant 1. The resulting isoform (2) has the same N- and C-termini but is shorter compared to isoform 1.
      Source sequence(s)
      AB035204, AI594831, BM055959
      Consensus CDS
      CCDS51815.1
      UniProtKB/TrEMBL
      G3UWG6
      Related
      ENSMUSP00000132220.2, ENSMUST00000167492.4
      Conserved Domains (1) summary
      cl02432
      Location:40 → 127
      CLECT; C-type lectin (CTL)/C-type lectin-like (CTLD) domain

    2. NM_013893.2 → NP_038921.2  regenerating islet-derived 3 delta isoform 1 precursor

      See identical proteins and their annotated locations for NP_038921.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
      Source sequence(s)
      AB035204, AI594831
      Consensus CDS
      CCDS20254.1
      UniProtKB/TrEMBL
      Q9JMH1, Q9QUS9
      Related
      ENSMUSP00000087096.2, ENSMUST00000089667.8
      Conserved Domains (1) summary
      cl02432
      Location:40 → 173
      CLECT; C-type lectin (CTL)/C-type lectin-like (CTLD) domain

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000072.7 Reference GRCm39 C57BL/6J

      Range
      78352857..78355848 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version

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