SEC24C SEC24 homolog C, COPII coat complex component [Homo sapiens (human)] - Gene

Summary

Official Symbol: SEC24Cprovided by HGNC
Official Full Name: SEC24 homolog C, COPII coat complex componentprovided by HGNC
Primary source: HGNC:HGNC:10705
See related: Ensembl:ENSG00000176986 MIM:607185; AllianceGenome:HGNC:10705
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary: The protein encoded by this gene is a member of the SEC24 subfamily of the SEC23/SEC24 family, which is involved in vesicle trafficking. The encoded protein has similarity to yeast Sec24p component of COPII. COPII is the coat protein complex responsible for vesicle budding from the ER. The product of this gene may play a role in shaping the vesicle, as well as in cargo selection and concentration. Alternatively spliced transcript variants encoding the same protein have been identified. [provided by RefSeq, Jul 2008]
Expression: Ubiquitous expression in esophagus (RPKM 30.5), thyroid (RPKM 29.8) and 25 other tissues See more
Orthologs: mouse all
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Genomic context

Location:: 10q22.2

Exon count:: 27

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCh38.p14 (GCF_000001405.40)	10	NC_000010.11 (73744372..73772161)
RS_2024_08	current	T2T-CHM13v2.0 (GCF_009914755.1)	10	NC_060934.1 (74615788..74643577)
RS_2024_09	previous assembly	GRCh37.p13 (GCF_000001405.25)	10	NC_000010.10 (75504130..75531919)

Chromosome 10 - NC_000010.11 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
BioProject: PRJEB4337
Publication: PMID 24309898
Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Sec24C is an HIV-1 host dependency factor crucial for virus replication.
Title: Sec24C is an HIV-1 host dependency factor crucial for virus replication.
The role of the C-terminal domain of PCSK9 and SEC24 isoforms in PCSK9 secretion.
Title: The role of the C-terminal domain of PCSK9 and SEC24 isoforms in PCSK9 secretion.
These data suggest that SEC24C is a major cargo adapter for COPII-dependent transport in postmitotic neurons in developing and adult brains and that its functions overlap at least partially with those of SEC24D in mammals.
Title: The COPII cargo adapter SEC24C is essential for neuronal homeostasis.
Here, the authors identified an interaction between claudin-1 and Sec24C, a cargo-sorting component of the coat protein complex II (COPII) vesicular transport system.
Title: Sec24C-Dependent Transport of Claudin-1 Regulates Hepatitis C Virus Entry.
AKT signaling played a role in ATX secretion regulation to facilitate ATX ER export by enhancing the nuclear factor of activated T cell-mediated p23 (Sec24C) expression
Title: Selective export of autotaxin from the endoplasmic reticulum.
Data indicate that a synthetic polypeptide containing the N terminus of bovine AE1 bound the Sec23A-Sec24C complex through a selective interaction with Sec24C.
Title: A new class of endoplasmic reticulum export signal PhiXPhiXPhi for transmembrane proteins and its selective interaction with Sec24C.
a lysine residing in the C terminus of the serotonin transporter specifies its preference for the coat protein complex II component SEC24C
Title: Switching the clientele: a lysine residing in the C terminus of the serotonin transporter specifies its preference for the coat protein complex II component SEC24C.
A triple arg motif mediates alpha(2B)-adrenergic receptor interaction with Sec24C/D and export
Title: A triple arg motif mediates α(2B)-adrenergic receptor interaction with Sec24C/D and export.
The serotonin transporter is an exclusive client of the coat protein complex II (COPII) component SEC24C
Title: The serotonin transporter is an exclusive client of the coat protein complex II (COPII) component SEC24C.
We found that Sec24C, a component of the host COPII vesicular transport system, interacts specifically with VP40 via VP40 amino acids 303 to 307.
Title: Ebola virus matrix protein VP40 uses the COPII transport system for its intracellular transport.

Submit: New GeneRIF Correction See all GeneRIFs (12)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

RH25307 (e-PCR)
- UniSTS:90249

RH44071 (e-PCR)
- UniSTS:41392

SEC24C_392 (e-PCR)
- UniSTS:277695

WI-18926 (e-PCR)
- UniSTS:74979

RH44836 (e-PCR)
- UniSTS:73449

D10S2187 (e-PCR)
- UniSTS:18927

Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
enables SNARE binding	IBA Inferred from Biological aspect of Ancestor more info
enables SNARE binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables zinc ion binding	IBA Inferred from Biological aspect of Ancestor more info
enables zinc ion binding	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
involved_in COPII-coated vesicle cargo loading	IBA Inferred from Biological aspect of Ancestor more info
involved_in COPII-coated vesicle cargo loading	IDA Inferred from Direct Assay more info	PubMed
involved_in endoplasmic reticulum to Golgi vesicle-mediated transport	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in endoplasmic reticulum to Golgi vesicle-mediated transport	NAS Non-traceable Author Statement more info	PubMed
involved_in in utero embryonic development	IEA Inferred from Electronic Annotation more info
involved_in intracellular protein transport	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
part_of COPII vesicle coat	IBA Inferred from Biological aspect of Ancestor more info
part_of COPII vesicle coat	IDA Inferred from Direct Assay more info	PubMed
part_of COPII vesicle coat	NAS Non-traceable Author Statement more info	PubMed
located_in ER to Golgi transport vesicle membrane	TAS Traceable Author Statement more info
located_in cytosol	IDA Inferred from Direct Assay more info	PubMed
located_in cytosol	TAS Traceable Author Statement more info
is_active_in endoplasmic reticulum exit site	IBA Inferred from Biological aspect of Ancestor more info
located_in endoplasmic reticulum membrane	TAS Traceable Author Statement more info

General protein information

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Preferred Names: protein transport protein Sec24C

Names: SEC24 family, member C; SEC24 related gene family, member C; SEC24-related protein C

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_004922.4 → NP_004913.2 protein transport protein Sec24C

See identical proteins and their annotated locations for NP_004913.2

Status: REVIEWED

Description

Transcript Variant: This variant (1) represents the longer transcript. Both variants 1 and 2 encode the same protein.

Source sequence(s)

AC022400, AL596994, BQ710971, CA419040, D38555

Consensus CDS

CCDS7332.1

UniProtKB/Swiss-Prot

B4DZT4, P53992, Q8WV25

UniProtKB/TrEMBL

G5EA31

Related

ENSP00000343405.2, ENST00000339365.2

Conserved Domains (9) summary

COG5028
Location:181 → 1090

COG5028; Vesicle coat complex COPII, subunit SEC24/subunit SFB2/subunit SFB3 [Intracellular trafficking and secretion]

cd01479
Location:499 → 758

Sec24-like; Sec24-like: Protein and membrane traffic in eukaryotes is mediated by at least in part by the budding and fusion of intracellular transport vesicles that selectively carry cargo proteins and lipids from donor to acceptor organelles. The two main classes ...

pfam00626
Location:961 → 1036

Gelsolin; Gelsolin repeat

pfam04810
Location:422 → 459

zf-Sec23_Sec24; Sec23/Sec24 zinc finger

pfam04815
Location:847 → 943

Sec23_helical; Sec23/Sec24 helical domain

pfam04959
Location:221 → 306

ARS2; Arsenite-resistance protein 2

pfam07001
Location:142 → 248

BAT2_N; BAT2 N-terminus

pfam08033
Location:748 → 831

Sec23_BS; Sec23/Sec24 beta-sandwich domain

pfam12764
Location:11 → 105

Gly-rich_Ago1; Glycine-rich region of argonaut
NM_198597.3 → NP_940999.1 protein transport protein Sec24C

See identical proteins and their annotated locations for NP_940999.1

Status: REVIEWED

Description

Transcript Variant: This variant (2) lacks a segment in the 5' UTR region, compared to variant 1. Both variants 1 and 2 encode the same protein.

Source sequence(s)

AC022400, AL596994, BC018928, CA419040, D38555

Consensus CDS

CCDS7332.1

UniProtKB/Swiss-Prot

B4DZT4, P53992, Q8WV25

UniProtKB/TrEMBL

G5EA31

Related

ENSP00000321845.6, ENST00000345254.9

Conserved Domains (9) summary

COG5028
Location:181 → 1090

COG5028; Vesicle coat complex COPII, subunit SEC24/subunit SFB2/subunit SFB3 [Intracellular trafficking and secretion]

cd01479
Location:499 → 758

Sec24-like; Sec24-like: Protein and membrane traffic in eukaryotes is mediated by at least in part by the budding and fusion of intracellular transport vesicles that selectively carry cargo proteins and lipids from donor to acceptor organelles. The two main classes ...

pfam00626
Location:961 → 1036

Gelsolin; Gelsolin repeat

pfam04810
Location:422 → 459

zf-Sec23_Sec24; Sec23/Sec24 zinc finger

pfam04815
Location:847 → 943

Sec23_helical; Sec23/Sec24 helical domain

pfam04959
Location:221 → 306

ARS2; Arsenite-resistance protein 2

pfam07001
Location:142 → 248

BAT2_N; BAT2 N-terminus

pfam08033
Location:748 → 831

Sec23_BS; Sec23/Sec24 beta-sandwich domain

pfam12764
Location:11 → 105

Gly-rich_Ago1; Glycine-rich region of argonaut

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

NC_000010.11 Reference GRCh38.p14 Primary Assembly

Range

73744372..73772161

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_047426032.1 → XP_047281988.1 protein transport protein Sec24C isoform X1
XM_047426033.1 → XP_047281989.1 protein transport protein Sec24C isoform X2

UniProtKB/Swiss-Prot

B4DZT4, P53992, Q8WV25
XM_047426031.1 → XP_047281987.1 protein transport protein Sec24C isoform X1
XM_047426034.1 → XP_047281990.1 protein transport protein Sec24C isoform X2

UniProtKB/Swiss-Prot

B4DZT4, P53992, Q8WV25
XM_011540381.4 → XP_011538683.1 protein transport protein Sec24C isoform X1

See identical proteins and their annotated locations for XP_011538683.1

UniProtKB/TrEMBL

G5EA31

Conserved Domains (8) summary

COG5028
Location:323 → 1113

COG5028; Vesicle coat complex COPII, subunit SEC24/subunit SFB2/subunit SFB3 [Intracellular trafficking and secretion]

cd01479
Location:522 → 781

Sec24-like; Sec24-like: Protein and membrane traffic in eukaryotes is mediated by at least in part by the budding and fusion of intracellular transport vesicles that selectively carry cargo proteins and lipids from donor to acceptor organelles. The two main classes ...

pfam00626
Location:984 → 1059

Gelsolin; Gelsolin repeat

pfam04810
Location:445 → 482

zf-Sec23_Sec24; Sec23/Sec24 zinc finger

pfam04815
Location:870 → 966

Sec23_helical; Sec23/Sec24 helical domain

pfam07001
Location:142 → 240

BAT2_N; BAT2 N-terminus

pfam08033
Location:771 → 854

Sec23_BS; Sec23/Sec24 beta-sandwich domain

pfam12764
Location:11 → 105

Gly-rich_Ago1; Glycine-rich region of argonaut
XM_011540380.4 → XP_011538682.1 protein transport protein Sec24C isoform X1

See identical proteins and their annotated locations for XP_011538682.1

UniProtKB/TrEMBL

G5EA31

Conserved Domains (8) summary

COG5028
Location:323 → 1113

COG5028; Vesicle coat complex COPII, subunit SEC24/subunit SFB2/subunit SFB3 [Intracellular trafficking and secretion]

cd01479
Location:522 → 781

Sec24-like; Sec24-like: Protein and membrane traffic in eukaryotes is mediated by at least in part by the budding and fusion of intracellular transport vesicles that selectively carry cargo proteins and lipids from donor to acceptor organelles. The two main classes ...

pfam00626
Location:984 → 1059

Gelsolin; Gelsolin repeat

pfam04810
Location:445 → 482

zf-Sec23_Sec24; Sec23/Sec24 zinc finger

pfam04815
Location:870 → 966

Sec23_helical; Sec23/Sec24 helical domain

pfam07001
Location:142 → 240

BAT2_N; BAT2 N-terminus

pfam08033
Location:771 → 854

Sec23_BS; Sec23/Sec24 beta-sandwich domain

pfam12764
Location:11 → 105

Gly-rich_Ago1; Glycine-rich region of argonaut
XM_047426035.1 → XP_047281991.1 protein transport protein Sec24C isoform X3

Alternate T2T-CHM13v2.0

Genomic

NC_060934.1 Alternate T2T-CHM13v2.0

Range

74615788..74643577

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_054367227.1 → XP_054223202.1 protein transport protein Sec24C isoform X1
XM_054367226.1 → XP_054223201.1 protein transport protein Sec24C isoform X1
XM_054367229.1 → XP_054223204.1 protein transport protein Sec24C isoform X2

UniProtKB/Swiss-Prot

B4DZT4, P53992, Q8WV25
XM_054367230.1 → XP_054223205.1 protein transport protein Sec24C isoform X2

UniProtKB/Swiss-Prot

B4DZT4, P53992, Q8WV25
XM_054367228.1 → XP_054223203.1 protein transport protein Sec24C isoform X1
XM_054367231.1 → XP_054223206.1 protein transport protein Sec24C isoform X3