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    CCDST cervical cancer associated DHX9 suppressive transcript [ Homo sapiens (human) ]

    Gene ID: 339400, updated on 22-May-2024

    Summary

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    Official Symbol
    CCDSTprovided by HGNC
    Official Full Name
    cervical cancer associated DHX9 suppressive transcriptprovided by HGNC
    Primary source
    HGNC:HGNC:55988
    See related
    Ensembl:ENSG00000236427
    Gene type
    ncRNA
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    FLG-AS1; LINC02962; lnc-CCDST
    Expression
    Restricted expression toward skin (RPKM 478.1) See more
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    Genomic context

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    See CCDST in Genome Data Viewer
    Location:
    1q21.3
    Exon count:
    14
    Annotation release Status Assembly Chr Location
    RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 1 NC_000001.11 (152189303..152366692)
    RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 1 NC_060925.1 (151312870..151503240)
    105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (152285935..152339168)

    Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene pseudouridine 5'-phosphatase pseudogene 2 Neighboring gene P300/CBP strongly-dependent group 1 enhancer GRCh37_chr1:152140032-152141231 Neighboring gene repetin Neighboring gene H3K27ac hESC enhancer GRCh37_chr1:152168785-152169285 Neighboring gene hornerin Neighboring gene filaggrin Neighboring gene ReSE screen-validated silencer GRCh37_chr1:152350237-152350407 Neighboring gene filaggrin 2 Neighboring gene high mobility group nucleosomal binding domain 3 pseudogene 1 Neighboring gene cornulin

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. LncRNA FLG-AS1 Mitigates Diabetic Retinopathy by Regulating Retinal Epithelial Cell Inflammation, Oxidative Stress, and Apoptosis via miR-380-3p/SOCS6 Axis. Luo R, et al. Inflammation, 2022 Oct. PMID 35461393
    2. Identification of a Novel Six-Long Noncoding RNA Signature for Molecular Diagnosis of Dilated Cardiomyopathy. Zhang H, et al. DNA Cell Biol, 2020 Nov 3. PMID 33146560
    3. Genome-wide association study identifies two new susceptibility loci for atopic dermatitis in the Chinese Han population. Sun LD, et al. Nat Genet, 2011 Jun 12. PMID 21666691
    4. A DHX9-lncRNA-MDM2 interaction regulates cell invasion and angiogenesis of cervical cancer. Ding X, et al. Cell Death Differ, 2019 Sep. PMID 30518908, Free PMC Article
    5. A genome-wide association study of Cloninger's temperament scales: implications for the evolutionary genetics of personality. Verweij KJ, et al. Biol Psychol, 2010 Oct. PMID 20691247, Free PMC Article

    See all (8) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. LncRNA FLG-AS1 Mitigates Diabetic Retinopathy by Regulating Retinal Epithelial Cell Inflammation, Oxidative Stress, and Apoptosis via miR-380-3p/SOCS6 Axis.
      Title: LncRNA FLG-AS1 Mitigates Diabetic Retinopathy by Regulating Retinal Epithelial Cell Inflammation, Oxidative Stress, and Apoptosis via miR-380-3p/SOCS6 Axis.
    Submit: New GeneRIF Correction

    Phenotypes

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    Review eQTL and phenotype association data in this region using PheGenI

    EBI GWAS Catalog

    Description
    A genome-wide association study of Cloninger's temperament scales: implications for the evolutionary genetics of personality.
    EBI GWAS Catalog
    Genetic variants associated with disordered eating.
    EBI GWAS Catalog
    Genome-wide association study identifies two new susceptibility loci for atopic dermatitis in the Chinese Han population.
    EBI GWAS Catalog

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Genotypes

    General gene information

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    Markers

    Other Names

    • FLG antisense RNA 1 (non-protein coding)
    • cervical cancer DExH-box helicase 9 (DHX9) suppressive transcript
    • long intergenic non-protein coding RNA 2962

    Clone Names

    • AL589986.2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    RNA

    1. NR_103778.1 RNA Sequence

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript.
      Source sequence(s)
      AL135842, AL356504

    2. NR_103779.1 RNA Sequence

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) lacks multiple 5' exons and contains an alternate 5' exon, resulting in a shorter transcript, compared to variant 1.
      Source sequence(s)
      AL135842, AL356504
      Related
      ENST00000445097.2

    3. NR_186761.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AL356504, AL589986, AL627110
      Related
      ENST00000655109.1

    4. NR_186762.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AL356504, AL589986
      Related
      ENST00000630125.3

    5. NR_186763.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AL356504, AL589986
      Related
      ENST00000669062.1

    6. NR_186764.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AL356504, AL589986, AL627110
      Related
      ENST00000664213.1

    7. NR_186765.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AL356504, AL589986, AL627110
      Related
      ENST00000659844.1

    8. NR_186766.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AL589986
      Related
      ENST00000429352.2

    9. NR_186767.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AL589986

    10. NR_186768.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AL589986

    11. NR_186769.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AL589986

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000001.11 Reference GRCh38.p14 Primary Assembly

      Range
      152189303..152366692
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060925.1 Alternate T2T-CHM13v2.0

      Range
      151312870..151503240
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein
    Heading Accession and Version

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Molecular Biology Databases
    Research Materials