KIF11 kinesin family member 11 [Homo sapiens (human)] - Gene

Summary

Official Symbol: KIF11provided by HGNC
Official Full Name: kinesin family member 11provided by HGNC
Primary source: HGNC:HGNC:6388
See related: Ensembl:ENSG00000138160 MIM:148760; AllianceGenome:HGNC:6388
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: EG5; HKSP; KNSL1; MCLMR; TRIP5
Summary: This gene encodes a motor protein that belongs to the kinesin-like protein family. Members of this protein family are known to be involved in various kinds of spindle dynamics. The function of this gene product includes chromosome positioning, centrosome separation and establishing a bipolar spindle during cell mitosis. [provided by RefSeq, Jul 2008]
Expression: Broad expression in lymph node (RPKM 9.9), bone marrow (RPKM 8.6) and 18 other tissues See more
Orthologs: mouse all
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Genomic context

Location:: 10q23.33

Exon count:: 22

Annotation release	Status	Assembly	Chr	Location
RS_2023_10	current	GRCh38.p14 (GCF_000001405.40)	10	NC_000010.11 (92593130..92655395)
RS_2023_10	current	T2T-CHM13v2.0 (GCF_009914755.1)	10	NC_060934.1 (93472467..93534736)
105.20220307	previous assembly	GRCh37.p13 (GCF_000001405.25)	10	NC_000010.10 (94352887..94415152)

Chromosome 10 - NC_000010.11 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: HPA RNA-seq normal tissues
Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
BioProject: PRJEB4337
Publication: PMID 24309898
Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Mitotic Functions and Characters of KIF11 in Cancers.
Title: Mitotic Functions and Characters of KIF11 in Cancers.
Human kinesin-5 KIF11 drives the helical motion of anti-parallel and parallel microtubules around each other.
Title: Human kinesin-5 KIF11 drives the helical motion of anti-parallel and parallel microtubules around each other.
KIF11 serves as a cell cycle mediator in childhood acute lymphoblastic leukemia.
Title: KIF11 serves as a cell cycle mediator in childhood acute lymphoblastic leukemia.
UHRF1 promotes spindle assembly and chromosome congression by catalyzing EG5 polyubiquitination.
Title: UHRF1 promotes spindle assembly and chromosome congression by catalyzing EG5 polyubiquitination.
ASPM promotes migration and invasion of anaplastic thyroid carcinoma by stabilizing KIF11.
Title: ASPM promotes migration and invasion of anaplastic thyroid carcinoma by stabilizing KIF11.
Whole exome sequencing revealed novel pathogenic variants in Vietnamese patients with FEVR.
Title: Whole exome sequencing revealed novel pathogenic variants in Vietnamese patients with FEVR.
KIF11 As a Potential Pan-Cancer Immunological Biomarker Encompassing the Disease Staging, Prognoses, Tumor Microenvironment, and Therapeutic Responses.
Title: KIF11 As a Potential Pan-Cancer Immunological Biomarker Encompassing the Disease Staging, Prognoses, Tumor Microenvironment, and Therapeutic Responses.
A non-mitotic role for Eg5 in regulating cilium formation and sonic hedgehog signaling.
Title: A non-mitotic role for Eg5 in regulating cilium formation and sonic hedgehog signaling.
Overexpression of kif11 is a poor prognostic factor in clear cell renal cell carcinoma.
Title: Overexpression of kif11 is a poor prognostic factor in clear cell renal cell carcinoma.
KIF11 manipulates SREBP2-dependent mevalonate cross talk to promote tumor progression in pancreatic ductal adenocarcinoma.
Title: KIF11 manipulates SREBP2-dependent mevalonate cross talk to promote tumor progression in pancreatic ductal adenocarcinoma.

Submit: New GeneRIF Correction See all GeneRIFs (145)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Associated conditions

Description	Tests
Microcephaly with or without chorioretinopathy, lymphedema, or intellectual disability MedGen: C1835265 OMIM: 152950 GeneReviews: Not available	Compare labs

Copy number response

Description
Copy number response Triplosensitivity No evidence available (Last evaluated 2013-08-01) ClinGen Genome Curation Page Haploinsufficency Sufficient evidence for dosage pathogenicity (Last evaluated 2013-08-01) ClinGen Genome Curation PagePubMed

EBI GWAS Catalog

Description
Transferability of type 2 diabetes implicated loci in multi-ethnic cohorts from Southeast Asia. EBI GWAS Catalog EBI GWAS CatalogPubMed

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

HIV-1 interactions

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Protein interactions

Protein	Gene	Interaction	Pubs
Tat	tat	HIV-1 Tat modulates EG5 activity allosterically by blocking ADP release from EG5. Residue K85 in EG5 is important for Tat-mediated suppression of EG5 activity and Tat-induced apoptosis during mitotic arrest	PubMed
	tat	Pull-down/immunoprecipitation assays demonstrate that HIV-1 Tat interacts with EG5 in cells. The carboxyl-terminal domain (residues 73-101) of Tat and the amino-terminal half (residues 1-517) of EG5 are involved in the interaction between Tat and EG5	PubMed
Vif	vif	HIV Vif interacts with KIF11	PubMed

Go to the HIV-1, Human Interaction Database

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

RH68796 (e-PCR)
- UniSTS:28420

NoName (e-PCR)
- UniSTS:490247

SHGC-152149 (e-PCR)
- UniSTS:177415

SHGC-151124 (e-PCR)
- UniSTS:173343

STS-U37426 (e-PCR)
- UniSTS:79013

D10S583 (e-PCR)
- UniSTS:68267

Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables microtubule binding	IEA Inferred from Electronic Annotation more info
enables microtubule motor activity	TAS Traceable Author Statement more info	PubMed
enables plus-end-directed microtubule motor activity	IBA Inferred from Biological aspect of Ancestor more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein kinase binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in cell division	IEA Inferred from Electronic Annotation more info
involved_in microtubule-based movement	IEA Inferred from Electronic Annotation more info
involved_in mitotic cell cycle	TAS Traceable Author Statement more info	PubMed
involved_in mitotic centrosome separation	IEA Inferred from Electronic Annotation more info
involved_in mitotic spindle assembly	IBA Inferred from Biological aspect of Ancestor more info
involved_in mitotic spindle assembly	IDA Inferred from Direct Assay more info	PubMed
involved_in mitotic spindle assembly	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in mitotic spindle organization	TAS Traceable Author Statement more info	PubMed
involved_in regulation of mitotic centrosome separation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in spindle elongation	IBA Inferred from Biological aspect of Ancestor more info
involved_in spindle organization	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in cytosol	IDA Inferred from Direct Assay more info
located_in cytosol	TAS Traceable Author Statement more info
part_of kinesin complex	TAS Traceable Author Statement more info	PubMed
located_in membrane	HDA more info	PubMed
located_in microtubule	IDA Inferred from Direct Assay more info	PubMed
is_active_in mitotic spindle	IBA Inferred from Biological aspect of Ancestor more info
located_in mitotic spindle	IDA Inferred from Direct Assay more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
part_of protein-containing complex	IPI Inferred from Physical Interaction more info	PubMed
located_in spindle	IDA Inferred from Direct Assay more info	PubMed
colocalizes_with spindle microtubule	IDA Inferred from Direct Assay more info	PubMed
colocalizes_with spindle pole	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: kinesin-like protein KIF11

Names: TR-interacting protein 5; TRIP-5; kinesin-like protein 1; kinesin-like spindle protein HKSP; kinesin-related motor protein Eg5; thyroid receptor-interacting protein 5

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

NG_032580.1 RefSeqGene

Range

5063..67328

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_004523.4 → NP_004514.2 kinesin-like protein KIF11

See identical proteins and their annotated locations for NP_004514.2

Status: REVIEWED

Source sequence(s)

AA504625, BC136474, BM742618, CU446438, DB078134

Consensus CDS

CCDS7422.1

UniProtKB/Swiss-Prot

A0AV49, B2RMV3, P52732, Q15716, Q5VWX0

UniProtKB/TrEMBL

B2RAM6

Related

ENSP00000260731.3, ENST00000260731.5

Conserved Domains (3) summary

smart00129
Location:18 → 366

KISc; Kinesin motor, catalytic domain. ATPase

cd01364
Location:16 → 368

KISc_BimC_Eg5; Kinesin motor domain, BimC/Eg5 spindle pole proteins

pfam13931
Location:916 → 1053

Microtub_bind; Kinesin-associated microtubule-binding