PRKAR1A protein kinase cAMP-dependent type I regulatory subunit alpha [Homo sapiens (human)] - Gene

Summary

Official Symbol: PRKAR1Aprovided by HGNC
Official Full Name: protein kinase cAMP-dependent type I regulatory subunit alphaprovided by HGNC
Primary source: HGNC:HGNC:9388
See related: Ensembl:ENSG00000108946 MIM:188830; AllianceGenome:HGNC:9388
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: CAR; CNC; CNC1; PKR1; TSE1; ADOHR; PPNAD1; PRKAR1; ACRDYS1; Prkar1alpha
Summary: cAMP is a signaling molecule important for a variety of cellular functions. cAMP exerts its effects by activating the cAMP-dependent protein kinase, which transduces the signal through phosphorylation of different target proteins. The inactive kinase holoenzyme is a tetramer composed of two regulatory and two catalytic subunits. cAMP causes the dissociation of the inactive holoenzyme into a dimer of regulatory subunits bound to four cAMP and two free monomeric catalytic subunits. Four different regulatory subunits and three catalytic subunits have been identified in humans. This gene encodes one of the regulatory subunits. This protein was found to be a tissue-specific extinguisher that down-regulates the expression of seven liver genes in hepatoma x fibroblast hybrids. Mutations in this gene cause Carney complex (CNC). This gene can fuse to the RET protooncogene by gene rearrangement and form the thyroid tumor-specific chimeric oncogene known as PTC2. A nonconventional nuclear localization sequence (NLS) has been found for this protein which suggests a role in DNA replication via the protein serving as a nuclear transport protein for the second subunit of the Replication Factor C (RFC40). Several alternatively spliced transcript variants encoding two different isoforms have been observed. [provided by RefSeq, Jan 2013]
Expression: Ubiquitous expression in heart (RPKM 107.2), thyroid (RPKM 76.1) and 25 other tissues See more
Orthologs: mouse all
NEW: Try the new Gene table
Try the new Transcript table

Genomic context

Location:: 17q24.2

Exon count:: 16

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCh38.p14 (GCF_000001405.40)	17	NC_000017.11 (68413623..68551316)
RS_2024_08	current	T2T-CHM13v2.0 (GCF_009914755.1)	17	NC_060941.1 (69290146..69428169)
RS_2024_09	previous assembly	GRCh37.p13 (GCF_000001405.25)	17	NC_000017.10 (66409764..66547457)

Chromosome 17 - NC_000017.11 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

Go to the top of the page Help

See details

Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
BioProject: PRJEB4337
Publication: PMID 24309898
Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

Go to the top of the page Help

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Frequent protein kinase A regulatory subunit A1 mutations but no GNAS mutations as potential driver in sporadic cardiac myxomas.
Title: Frequent protein kinase A regulatory subunit A1 mutations but no GNAS mutations as potential driver in sporadic cardiac myxomas.
Dualistic Effects of PRKAR1A as a Potential Anticancer Target in Cancer Cells and Cancer-Derived Stem Cells.
Title: Dualistic Effects of PRKAR1A as a Potential Anticancer Target in Cancer Cells and Cancer-Derived Stem Cells.
Somatic Mutation of PRKAR1A in Four Cases of Sporadic Cardiac Myxoma.
Title: Somatic Mutation of PRKAR1A in Four Cases of Sporadic Cardiac Myxoma.
Association between subclinical hyperthyroidism and a PRKAR1A gene variant in Carney complex patients: A case report and systematic review.
Title: Association between subclinical hyperthyroidism and a PRKAR1A gene variant in Carney complex patients: A case report and systematic review.
Phenotypic Variability in a Family with Carney Complex Accompanied by a Novel Mutation Involving PRKAR1A.
Title: Phenotypic Variability in a Family with Carney Complex Accompanied by a Novel Mutation Involving PRKAR1A.
Next-Generation Sequencing Reveals a New Class of Melanocytic Neoplasms With Hybrid Genomic Features of PEM Including Protein Kinase R 1 Alpha Gene Inactivation and Spitz Tumor-Defining Protein Kinase Fusions.
Title: Next-Generation Sequencing Reveals a New Class of Melanocytic Neoplasms With Hybrid Genomic Features of PEM Including Protein Kinase R 1 Alpha Gene Inactivation and Spitz Tumor-Defining Protein Kinase Fusions.
Attempting to Solve the Pigmented Epithelioid Melanocytoma (PEM) Conundrum: PRKAR1A Inactivation Can Occur in Different Genetic Backgrounds (Common, Blue, and Spitz Subgroups) With Variation in Their Clinicopathologic Characteristics.
Title: Attempting to Solve the Pigmented Epithelioid Melanocytoma (PEM) Conundrum: PRKAR1A Inactivation Can Occur in Different Genetic Backgrounds (Common, Blue, and Spitz Subgroups) With Variation in Their Clinicopathologic Characteristics.
Sporadic superficial angiomyxomas demonstrate loss of PRKAR1A expression.
Title: Sporadic superficial angiomyxomas demonstrate loss of PRKAR1A expression.
Superficial Angiomyxomas Frequently Demonstrate Loss of Protein Kinase A Regulatory Subunit 1 Alpha Expression: Immunohistochemical Analysis of 29 Cases and Cutaneous Myxoid Neoplasms With Histopathologic Overlap.
Title: Superficial Angiomyxomas Frequently Demonstrate Loss of Protein Kinase A Regulatory Subunit 1 Alpha Expression: Immunohistochemical Analysis of 29 Cases and Cutaneous Myxoid Neoplasms With Histopathologic Overlap.
A novel break site of EML4-ALK report and a rare PRKAR1A-ALK report analyzed by different ALK detection platforms in non-small cell lung cancer patients.
Title: A novel break site of EML4-ALK report and a rare PRKAR1A-ALK report analyzed by different ALK detection platforms in non-small cell lung cancer patients.

Submit: New GeneRIF Correction See all GeneRIFs (141)

Phenotypes

Go to the top of the page Help

Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Associated conditions

Description	Tests
Acrodysostosis 1 with or without hormone resistance MedGen: C3276228 OMIM: 101800 GeneReviews: Not available	not available
Carney complex, type 1 MedGen: C2607929 OMIM: 160980 GeneReviews: Carney Complex	not available
Familial atrial myxoma MedGen: C2931787 OMIM: 255960 GeneReviews: Not available	not available
Pigmented nodular adrenocortical disease, primary, 1 MedGen: C1864846 OMIM: 610489 GeneReviews: Not available	not available

Copy number response

Description
Copy number response Triplosensitivity No evidence available (Last evaluated 2024-10-09) ClinGen Genome Curation Page Haploinsufficency Sufficient evidence for dosage pathogenicity (Last evaluated 2024-10-09) ClinGen Genome Curation PagePubMed

Variation

Go to the top of the page Help

See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

HIV-1 interactions

Go to the top of the page Help

Protein interactions

Protein	Gene	Interaction	Pubs
Envelope surface glycoprotein gp120	env	The exposure of CD4+ T cells to HIV gp120 results in a long-lasting hyporesponsiveness to antigen stimulation through protein kinase A-mediated signaling	PubMed
	env	Treatment of normal human fibroblasts with HIV-1 gp120 protein results in a significant decrease in the levels of 8-azido-[32P]cAMP binding to RI and RII domains of protein kinase A (PKA) and in PKA activity	PubMed
Nef	nef	Serine residues Ser6 and Ser9 of HIV-1 Nef are phosphorylated by PKA in a cell-free system; intracellularly, only Ser9 of HIV-1 NL4-3 Nef is phosphorylated by PKA in resting peripheral blood mononuclear cells	PubMed
Tat	tat	HIV-1 Tat induces IL-6 and TNF-alpha expression through the activation of cAMP-dependent protein kinase pathways	PubMed
Vif	vif	Protein kinase A (PKA) binds and phosphorylates A3G at Thr32 in vitro and in vivo. This phosphorylation event reduces the binding of A3G to Vif and its subsequent ubiquitination and degradation	PubMed
Vpr	vpr	HIV-1 Vpr directly interacts with PKA and is phosphorylated at position Ser79 by PKA. PKA activity is necessary for virion-delivered Vpr cell cycle arrest	PubMed
matrix	gag	HIV-1 MA increases phosphorylation and the DNA-binding activity of CREB and c-Myc through activation of the cAMP/PKA and MEK/ERK signaling pathways. Both signaling pathways are synergistically activated upon co-stimulation through the CD19 receptor	PubMed
	gag	Protein kinase A (PKA) has been shown to phosphorylate HIV-1 Matrix in vitro	PubMed
	gag	HIV-1 Matrix impairs proliferation of normal lymphocytes in vitro by inducing the activity of the inhibitory protein kinase A (PKA)	PubMed

Go to the HIV-1, Human Interaction Database

Interactions

Go to the top of the page Help

Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

Go to the top of the page Help

Markers

SHGC-36616 (e-PCR)
- UniSTS:48146

D17S2143 (e-PCR)
- UniSTS:18724

G62011 (e-PCR)
- UniSTS:139086

RH70215 (e-PCR)
- UniSTS:75101

PRKAR1A_2228 (e-PCR)
- UniSTS:280926

STS-D29564 (e-PCR)
- UniSTS:73324

RH36406 (e-PCR)
- UniSTS:13183

PRKAR1A (e-PCR)
- UniSTS:512649

G62113 (e-PCR)
- UniSTS:139156

D17S1496E (e-PCR)
- UniSTS:151701

RH122590 (e-PCR)
- UniSTS:138653

Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
enables cAMP binding	IBA Inferred from Biological aspect of Ancestor more info
enables cAMP-dependent protein kinase inhibitor activity	IBA Inferred from Biological aspect of Ancestor more info
enables cAMP-dependent protein kinase inhibitor activity	IDA Inferred from Direct Assay more info	PubMed
enables cAMP-dependent protein kinase regulator activity	IDA Inferred from Direct Assay more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein domain specific binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein kinase A catalytic subunit binding	IBA Inferred from Biological aspect of Ancestor more info
enables protein kinase A catalytic subunit binding	IPI Inferred from Physical Interaction more info	PubMed
enables ubiquitin protein ligase binding	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
involved_in adenylate cyclase-activating G protein-coupled receptor signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in cardiac muscle cell proliferation	IEA Inferred from Electronic Annotation more info
involved_in cellular response to glucagon stimulus	IEA Inferred from Electronic Annotation more info
involved_in intracellular signal transduction	TAS Traceable Author Statement more info	PubMed
involved_in mesoderm formation	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of activated T cell proliferation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of cAMP/PKA signal transduction	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of negative regulation of gene expression	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of insulin secretion	IEA Inferred from Electronic Annotation more info
involved_in regulation of transcription by RNA polymerase II	TAS Traceable Author Statement more info	PubMed
involved_in sarcomere organization	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
colocalizes_with axoneme	IDA Inferred from Direct Assay more info	PubMed
part_of cAMP-dependent protein kinase complex	IBA Inferred from Biological aspect of Ancestor more info
located_in centrosome	IEA Inferred from Electronic Annotation more info
located_in ciliary base	TAS Traceable Author Statement more info
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
is_active_in cytosol	IBA Inferred from Biological aspect of Ancestor more info
located_in cytosol	TAS Traceable Author Statement more info
located_in glutamatergic synapse	IEA Inferred from Electronic Annotation more info
colocalizes_with immunological synapse	IDA Inferred from Direct Assay more info	PubMed
located_in membrane	HDA more info	PubMed
located_in multivesicular body	IEA Inferred from Electronic Annotation more info
located_in neuromuscular junction	IEA Inferred from Electronic Annotation more info
part_of nucleotide-activated protein kinase complex	IDA Inferred from Direct Assay more info	PubMed
located_in plasma membrane raft	IDA Inferred from Direct Assay more info	PubMed
part_of protein-containing complex	IDA Inferred from Direct Assay more info	PubMed
located_in sperm head-tail coupling apparatus	IEA Inferred from Electronic Annotation more info

General protein information

Go to the top of the page Help

Preferred Names: cAMP-dependent protein kinase type I-alpha regulatory subunit

Names: Carney complex type 1; cAMP-dependent protein kinase regulatory subunit RIalpha; cAMP-dependent protein kinase type I-alpha regulatory chain; epididymis secretory sperm binding protein; protein kinase A type 1a regulatory subunit; protein kinase, cAMP-dependent, regulatory subunit type I alpha; protein kinase, cAMP-dependent, regulatory, type I, alpha; tissue-specific extinguisher 1

NP_001263218.1

EC 2.7.11.1

NP_001263219.1

EC 2.7.11.1

NP_001265362.1

EC 2.7.11.1

NP_001356318.1

EC 2.7.11.1

NP_001356319.1

EC 2.7.11.1

NP_002725.1

EC 2.7.11.1

NP_997636.1

EC 2.7.11.1

NP_997637.1

EC 2.7.11.1

XP_011523286.1

EC 2.7.11.1

XP_047292325.1

EC 2.7.11.1

XP_047292326.1

EC 2.7.11.1

XP_054172611.1

EC 2.7.11.1

XP_054172612.1

EC 2.7.11.1

XP_054172613.1

EC 2.7.11.1

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

NG_007093.3 RefSeqGene

Range

5001..142694

Download

GenBank, FASTA, Sequence Viewer (Graphics), LRG_514

mRNA and Protein(s)

NM_001276289.2 → NP_001263218.1 cAMP-dependent protein kinase type I-alpha regulatory subunit isoform a

See identical proteins and their annotated locations for NP_001263218.1

Status: REVIEWED

Source sequence(s)

AC079210, AY007115, BC093042, DA219203

Consensus CDS

CCDS11678.1

UniProtKB/Swiss-Prot

K7ER48, P10644, Q567S7

UniProtKB/TrEMBL

B2R5T5, Q68DQ4

Related

ENSP00000445625.1, ENST00000536854.6

Conserved Domains (2) summary

cd12101
Location:14 → 63

DD_RIalpha_PKA; Dimerization/Docking domain of the Type I alpha Regulatory subunit of cAMP-dependent protein kinase

cd00038
Location:255 → 370

CAP_ED; effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO ...
NM_001276290.1 → NP_001263219.1 cAMP-dependent protein kinase type I-alpha regulatory subunit isoform b

Status: REVIEWED

Source sequence(s)

AW732104, BC093042

Consensus CDS

CCDS62307.1

UniProtKB/TrEMBL

K7EM13

Related

ENSP00000518555.1, ENST00000711037.1

Conserved Domains (2) summary

cd00038
Location:137 → 246

CAP_ED; effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO ...

cd12101
Location:14 → 63

DD_RIalpha_PKA; dimerization/docking (D/D) domain of the Type I alpha Regulatory subunit of cAMP-dependent protein kinase
NM_001278433.2 → NP_001265362.1 cAMP-dependent protein kinase type I-alpha regulatory subunit isoform a

See identical proteins and their annotated locations for NP_001265362.1

Status: REVIEWED

Source sequence(s)

AY007115, BC036285, BC093042, DA108801, M18468

Consensus CDS

CCDS11678.1

UniProtKB/Swiss-Prot

K7ER48, P10644, Q567S7

UniProtKB/TrEMBL

B2R5T5, Q68DQ4

Conserved Domains (2) summary

cd12101
Location:14 → 63

DD_RIalpha_PKA; Dimerization/Docking domain of the Type I alpha Regulatory subunit of cAMP-dependent protein kinase

cd00038
Location:255 → 370

CAP_ED; effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO ...
NM_001369389.1 → NP_001356318.1 cAMP-dependent protein kinase type I-alpha regulatory subunit isoform a

Status: REVIEWED

Source sequence(s)

AC079210

Consensus CDS

CCDS11678.1

UniProtKB/Swiss-Prot

K7ER48, P10644, Q567S7

UniProtKB/TrEMBL

B2R5T5, Q68DQ4

Related

ENSP00000465445.2, ENST00000589017.6

Conserved Domains (2) summary

cd12101
Location:14 → 63

DD_RIalpha_PKA; Dimerization/Docking domain of the Type I alpha Regulatory subunit of cAMP-dependent protein kinase

cd00038
Location:255 → 370

CAP_ED; effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO ...
NM_001369390.1 → NP_001356319.1 cAMP-dependent protein kinase type I-alpha regulatory subunit isoform a

Status: REVIEWED

Source sequence(s)

AC079210

Consensus CDS

CCDS11678.1

UniProtKB/Swiss-Prot

K7ER48, P10644, Q567S7

UniProtKB/TrEMBL

B2R5T5, Q68DQ4

Related

ENSP00000466459.1, ENST00000586397.5

Conserved Domains (2) summary

cd12101
Location:14 → 63

DD_RIalpha_PKA; Dimerization/Docking domain of the Type I alpha Regulatory subunit of cAMP-dependent protein kinase

cd00038
Location:255 → 370

CAP_ED; effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO ...
NM_002734.5 → NP_002725.1 cAMP-dependent protein kinase type I-alpha regulatory subunit isoform a

See identical proteins and their annotated locations for NP_002725.1

Status: REVIEWED

Source sequence(s)

AC079210, AY007115, BC036285

Consensus CDS

CCDS11678.1

UniProtKB/Swiss-Prot

K7ER48, P10644, Q567S7

UniProtKB/TrEMBL

B2R5T5, Q68DQ4

Related

ENSP00000464977.2, ENST00000589228.6

Conserved Domains (2) summary

cd12101
Location:14 → 63

DD_RIalpha_PKA; Dimerization/Docking domain of the Type I alpha Regulatory subunit of cAMP-dependent protein kinase

cd00038
Location:255 → 370

CAP_ED; effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO ...
NM_212471.3 → NP_997636.1 cAMP-dependent protein kinase type I-alpha regulatory subunit isoform a

See identical proteins and their annotated locations for NP_997636.1

Status: REVIEWED

Source sequence(s)

AC079210, AY007115, BC093042, DA413808

Consensus CDS

CCDS11678.1

UniProtKB/Swiss-Prot

K7ER48, P10644, Q567S7

UniProtKB/TrEMBL

B2R5T5, Q68DQ4

Related

ENSP00000351410.1, ENST00000358598.6

Conserved Domains (2) summary

cd12101
Location:14 → 63

DD_RIalpha_PKA; Dimerization/Docking domain of the Type I alpha Regulatory subunit of cAMP-dependent protein kinase

cd00038
Location:255 → 370

CAP_ED; effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO ...
NM_212472.2 → NP_997637.1 cAMP-dependent protein kinase type I-alpha regulatory subunit isoform a

See identical proteins and their annotated locations for NP_997637.1

Status: REVIEWED

Source sequence(s)

AC079210, AL535889, AY007115, BC093042, DA219203

Consensus CDS

CCDS11678.1

UniProtKB/Swiss-Prot

K7ER48, P10644, Q567S7

UniProtKB/TrEMBL

B2R5T5, Q68DQ4

Related

ENSP00000376475.1, ENST00000392711.5

Conserved Domains (2) summary

cd12101
Location:14 → 63

DD_RIalpha_PKA; Dimerization/Docking domain of the Type I alpha Regulatory subunit of cAMP-dependent protein kinase

cd00038
Location:255 → 370

CAP_ED; effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO ...

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

NC_000017.11 Reference GRCh38.p14 Primary Assembly

Range

68413623..68551316

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_047436369.1 → XP_047292325.1 cAMP-dependent protein kinase type I-alpha regulatory subunit isoform X1

UniProtKB/Swiss-Prot

K7ER48, P10644, Q567S7

UniProtKB/TrEMBL

B2R5T5

Related

ENSP00000465013.2, ENST00000588178.6
XM_047436370.1 → XP_047292326.1 cAMP-dependent protein kinase type I-alpha regulatory subunit isoform X1

UniProtKB/Swiss-Prot

K7ER48, P10644, Q567S7

UniProtKB/TrEMBL

B2R5T5
XM_011524984.4 → XP_011523286.1 cAMP-dependent protein kinase type I-alpha regulatory subunit isoform X1

See identical proteins and their annotated locations for XP_011523286.1

UniProtKB/Swiss-Prot

K7ER48, P10644, Q567S7

UniProtKB/TrEMBL

B2R5T5, Q68DQ4

Related

ENSP00000466649.2, ENST00000589480.6

Conserved Domains (2) summary

cd12101
Location:14 → 63

DD_RIalpha_PKA; Dimerization/Docking domain of the Type I alpha Regulatory subunit of cAMP-dependent protein kinase

cd00038
Location:255 → 370

CAP_ED; effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO ...

Alternate T2T-CHM13v2.0

Genomic

NC_060941.1 Alternate T2T-CHM13v2.0

Range

69290146..69428169

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_054316637.1 → XP_054172612.1 cAMP-dependent protein kinase type I-alpha regulatory subunit isoform X1

UniProtKB/Swiss-Prot

K7ER48, P10644, Q567S7

UniProtKB/TrEMBL

B2R5T5
XM_054316638.1 → XP_054172613.1 cAMP-dependent protein kinase type I-alpha regulatory subunit isoform X1

UniProtKB/Swiss-Prot

K7ER48, P10644, Q567S7

UniProtKB/TrEMBL

B2R5T5
XM_054316636.1 → XP_054172611.1 cAMP-dependent protein kinase type I-alpha regulatory subunit isoform X1

UniProtKB/Swiss-Prot

K7ER48, P10644, Q567S7

UniProtKB/TrEMBL

B2R5T5