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    ADIPOR2 adiponectin receptor 2 [ Homo sapiens (human) ]

    Gene ID: 79602, updated on 12-Nov-2024

    Summary

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    Official Symbol
    ADIPOR2provided by HGNC
    Official Full Name
    adiponectin receptor 2provided by HGNC
    Primary source
    HGNC:HGNC:24041
    See related
    Ensembl:ENSG00000006831 MIM:607946; AllianceGenome:HGNC:24041
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    PAQR2; ACDCR2
    Summary
    The adiponectin receptors, ADIPOR1 (MIM 607945) and ADIPOR2, serve as receptors for globular and full-length adiponectin (MIM 605441) and mediate increased AMPK (see MIM 602739) and PPAR-alpha (PPARA; MIM 170998) ligand activities, as well as fatty acid oxidation and glucose uptake by adiponectin (Yamauchi et al., 2003 [PubMed 12802337]).[supplied by OMIM, Mar 2008]
    Expression
    Ubiquitous expression in fat (RPKM 49.9), adrenal (RPKM 34.9) and 25 other tissues See more
    Orthologs
    mouse all
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    Genomic context

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    See ADIPOR2 in Genome Data Viewer
    Location:
    12p13.33
    Exon count:
    12
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 12 NC_000012.12 (1691070..1788674)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 12 NC_060936.1 (1687685..1784807)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 12 NC_000012.11 (1800236..1897840)

    Chromosome 12 - NC_000012.12Genomic Context describing neighboring genes Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 4116 Neighboring gene Sharpr-MPRA regulatory region 3814 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 5808 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr12:1755758-1756258 Neighboring gene Wnt family member 5B Neighboring gene H3K4me1 hESC enhancer GRCh37_chr12:1756259-1756759 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 4118 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 4119 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 5809 Neighboring gene microRNA 3649 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 5810 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 5811 Neighboring gene H3K27ac hESC enhancer GRCh37_chr12:1800052-1800630 Neighboring gene SDA1 domain containing 1 pseudogene Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 4122 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr12:1854087-1854680 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr12:1875063-1875563 Neighboring gene ribosomal protein S4X pseudogene 14 Neighboring gene NANOG-H3K27ac hESC enhancer GRCh37_chr12:1885224-1885742 Neighboring gene NANOG-H3K27ac hESC enhancer GRCh37_chr12:1885743-1886260 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr12:1904713-1905280 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr12:1905392-1906297 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr12:1906298-1907202 Neighboring gene uncharacterized LOC105369602 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr12:1913659-1914581 Neighboring gene calcium voltage-gated channel auxiliary subunit alpha2delta 4 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 5812 Neighboring gene uncharacterized LOC105369601

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. Characterisation of the adiponectin receptors: the non-conserved N-terminal region of AdipoR2 prevents its expression at the cell-surface. Keshvari S, et al. Biochem Biophys Res Commun, 2013 Mar 1. PMID 23376713
    2. Tumor expression of adiponectin receptor 2 and lethal prostate cancer. Rider JR, et al. Carcinogenesis, 2015 Jun. PMID 25863129, Free PMC Article
    3. Associations of adiponectin receptor 2 (AdipoR2) gene polymorphisms and AdipoR2 protein expression levels with the risk of colorectal cancer: A case-control study. Zhou L, et al. Mol Med Rep, 2017 Oct. PMID 28765899, Free PMC Article
    4. A Variant in ADIPOR2 Is Associated with Increased Free Fatty Acid Levels in Chinese Population. Yang G, et al. Metab Syndr Relat Disord, 2016 Sep. PMID 27348122
    5. Association between adiponectin receptor 2 gene polymorphisms and cerebral infarction. Yuan B, et al. Genet Mol Res, 2014 Sep 26. PMID 25299095

    See all (162) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Reduced hepatic AdipoR2 by increased glucocorticoid mediates effect of psychosocial stress to elevate serum cholesterol.
      Title: Reduced hepatic AdipoR2 by increased glucocorticoid mediates effect of psychosocial stress to elevate serum cholesterol.
    2. AdipoR2 recruits protein interactors to promote fatty acid elongation and membrane fluidity.
      Title: AdipoR2 recruits protein interactors to promote fatty acid elongation and membrane fluidity.
    3. Association of Adiponectin Receptors with Metabolic and Immune Homeostasis Parameters in Colorectal Cancer: In Silico Analysis and Observational Findings.
      Title: Association of Adiponectin Receptors with Metabolic and Immune Homeostasis Parameters in Colorectal Cancer: In Silico Analysis and Observational Findings.
    4. AdipoR2 inhibits human glioblastoma cell growth through the AMPK/mTOR pathway.
      Title: AdipoR2 inhibits human glioblastoma cell growth through the AMPK/mTOR pathway.
    5. Extensive transcription mis-regulation and membrane defects in AdipoR2-deficient cells challenged with saturated fatty acids.
      Title: Extensive transcription mis-regulation and membrane defects in AdipoR2-deficient cells challenged with saturated fatty acids.
    6. The expression and relationship of AdipoR1/R2 in gastric intestinal metaplasia.
      Title: The expression and relationship of AdipoR1/R2 in gastric intestinal metaplasia.
    7. Adiponectin is associated with cardio-metabolic traits in Mexican children.
      Title: Adiponectin is associated with cardio-metabolic traits in Mexican children.
    8. Leveraging a gain-of-function allele of Caenorhabditis elegans paqr-1 to elucidate membrane homeostasis by PAQR proteins.
      Title: Leveraging a gain-of-function allele of Caenorhabditis elegans paqr-1 to elucidate membrane homeostasis by PAQR proteins.
    9. The primary cellular function of AdipoR2 is to maintain membrane fluidity in most human cell types and that adiponectin is not required for this function.
      Title: AdipoR1 and AdipoR2 maintain membrane fluidity in most human cell types and independently of adiponectin.
    10. Human diabetic kidneys show decreased intraglomerular AdipoR1/AdipoR2 expression.
      Title: The Adiponectin Receptor Agonist AdipoRon Ameliorates Diabetic Nephropathy in a Model of Type 2 Diabetes.
    Submit: New GeneRIF Correction See all GeneRIFs (130)

    Phenotypes

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    Review eQTL and phenotype association data in this region using PheGenI

    EBI GWAS Catalog

    Description
    Genome-wide mapping for clinically relevant predictors of lamotrigine- and phenytoin-induced hypersensitivity reactions.
    EBI GWAS Catalog

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Genotypes

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC4640, FLJ21432

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables adipokinetic hormone receptor activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables adiponectin binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables identical protein binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables signaling receptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in adiponectin-activated signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in adiponectin-activated signaling pathway IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in fatty acid oxidation ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    involved_in glucose homeostasis ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in hormone-mediated signaling pathway ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    involved_in positive regulation of cold-induced thermogenesis ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    involved_in vascular wound healing ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Component Evidence Code Pubs
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in plasma membrane TAS
    Traceable Author Statement
    more info
    		  

    General protein information

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    Preferred Names
    adiponectin receptor protein 2
    Names
    progestin and adipoQ receptor family member 2
    progestin and adipoQ receptor family member II

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001375363.1 → NP_001362292.1  adiponectin receptor protein 2 isoform 1

      Status: VALIDATED

      Source sequence(s)
      AC005183, AC005343
      Conserved Domains (1) summary
      pfam03006
      Location:140 → 396
      HlyIII; Haemolysin-III related

    2. NM_001375364.1 → NP_001362293.1  adiponectin receptor protein 2 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC005183, AC005343
      Consensus CDS
      CCDS8511.1
      UniProtKB/Swiss-Prot
      Q53YY5, Q86V24, Q9H737
      Conserved Domains (1) summary
      pfam03006
      Location:140 → 363
      HlyIII; Haemolysin-III related

    3. NM_001375365.1 → NP_001362294.1  adiponectin receptor protein 2 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC005183, AC005343
      Consensus CDS
      CCDS8511.1
      UniProtKB/Swiss-Prot
      Q53YY5, Q86V24, Q9H737
      Conserved Domains (1) summary
      pfam03006
      Location:140 → 363
      HlyIII; Haemolysin-III related

    4. NM_024551.3 → NP_078827.2  adiponectin receptor protein 2 isoform 2

      See identical proteins and their annotated locations for NP_078827.2

      Status: VALIDATED

      Source sequence(s)
      AC005183, AC005343
      Consensus CDS
      CCDS8511.1
      UniProtKB/Swiss-Prot
      Q53YY5, Q86V24, Q9H737
      Related
      ENSP00000349616.4, ENST00000357103.5
      Conserved Domains (1) summary
      pfam03006
      Location:140 → 363
      HlyIII; Haemolysin-III related

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000012.12 Reference GRCh38.p14 Primary Assembly

      Range
      1691070..1788674
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011521024.2 → XP_011519326.1  adiponectin receptor protein 2 isoform X1

      See identical proteins and their annotated locations for XP_011519326.1

      UniProtKB/Swiss-Prot
      Q53YY5, Q86V24, Q9H737
      Conserved Domains (1) summary
      pfam03006
      Location:140 → 363
      HlyIII; Haemolysin-III related

    2. XM_006719018.3 → XP_006719081.1  adiponectin receptor protein 2 isoform X1

      See identical proteins and their annotated locations for XP_006719081.1

      UniProtKB/Swiss-Prot
      Q53YY5, Q86V24, Q9H737
      Conserved Domains (1) summary
      pfam03006
      Location:140 → 363
      HlyIII; Haemolysin-III related

    3. XM_047429547.1 → XP_047285503.1  adiponectin receptor protein 2 isoform X2

    4. XM_047429548.1 → XP_047285504.1  adiponectin receptor protein 2 isoform X2

    5. XM_047429545.1 → XP_047285501.1  adiponectin receptor protein 2 isoform X1

      UniProtKB/Swiss-Prot
      Q53YY5, Q86V24, Q9H737

    6. XM_047429546.1 → XP_047285502.1  adiponectin receptor protein 2 isoform X1

      UniProtKB/Swiss-Prot
      Q53YY5, Q86V24, Q9H737

    Reference GRCh38.p14 PATCHES

    Genomic

    1. NW_018654718.1 Reference GRCh38.p14 PATCHES

      Range
      33214..130818
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054332319.1 → XP_054188294.1  adiponectin receptor protein 2 isoform X1

      UniProtKB/Swiss-Prot
      Q53YY5, Q86V24, Q9H737

    2. XM_054332320.1 → XP_054188295.1  adiponectin receptor protein 2 isoform X1

      UniProtKB/Swiss-Prot
      Q53YY5, Q86V24, Q9H737

    3. XM_054332323.1 → XP_054188298.1  adiponectin receptor protein 2 isoform X2

    4. XM_054332324.1 → XP_054188299.1  adiponectin receptor protein 2 isoform X2

    5. XM_054332321.1 → XP_054188296.1  adiponectin receptor protein 2 isoform X1

      UniProtKB/Swiss-Prot
      Q53YY5, Q86V24, Q9H737

    6. XM_054332322.1 → XP_054188297.1  adiponectin receptor protein 2 isoform X1

      UniProtKB/Swiss-Prot
      Q53YY5, Q86V24, Q9H737

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060936.1 Alternate T2T-CHM13v2.0

      Range
      1687685..1784807
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054373229.1 → XP_054229204.1  adiponectin receptor protein 2 isoform X1

      UniProtKB/Swiss-Prot
      Q53YY5, Q86V24, Q9H737

    2. XM_054373230.1 → XP_054229205.1  adiponectin receptor protein 2 isoform X1

      UniProtKB/Swiss-Prot
      Q53YY5, Q86V24, Q9H737

    3. XM_054373233.1 → XP_054229208.1  adiponectin receptor protein 2 isoform X2

    4. XM_054373234.1 → XP_054229209.1  adiponectin receptor protein 2 isoform X2

    5. XM_054373231.1 → XP_054229206.1  adiponectin receptor protein 2 isoform X1

      UniProtKB/Swiss-Prot
      Q53YY5, Q86V24, Q9H737

    6. XM_054373232.1 → XP_054229207.1  adiponectin receptor protein 2 isoform X1

      UniProtKB/Swiss-Prot
      Q53YY5, Q86V24, Q9H737
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q86V24.1 GenPept UniProtKB/Swiss-Prot:Q86V24

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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