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    PRSS22 serine protease 22 [ Homo sapiens (human) ]

    Gene ID: 64063, updated on 2-Nov-2024

    Summary

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    Official Symbol
    PRSS22provided by HGNC
    Official Full Name
    serine protease 22provided by HGNC
    Primary source
    HGNC:HGNC:14368
    See related
    Ensembl:ENSG00000005001 MIM:609343; AllianceGenome:HGNC:14368
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    BSSP-4; SP001LA; hBSSP-4
    Summary
    This gene encodes a member of the trypsin family of serine proteases. The enzyme is expressed in the airways in a developmentally regulated manner. The gene is part of a cluster of serine protease genes on chromosome 16. [provided by RefSeq, Jul 2008]
    Expression
    Biased expression in esophagus (RPKM 17.2), stomach (RPKM 8.5) and 11 other tissues See more
    Orthologs
    mouse all
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    Genomic context

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    See PRSS22 in Genome Data Viewer
    Location:
    16p13.3
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 16 NC_000016.10 (2852730..2858170, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 16 NC_060940.1 (2873285..2879250, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 16 NC_000016.9 (2902731..2908171, complement)

    Chromosome 16 - NC_000016.10Genomic Context describing neighboring genes Neighboring gene P300/CBP strongly-dependent group 1 enhancer GRCh37_chr16:2885634-2886833 Neighboring gene uncharacterized LOC124903628 Neighboring gene zymogen granule protein 16B Neighboring gene H3K4me1 hESC enhancer GRCh37_chr16:2892359-2893048 Neighboring gene serine protease 30, pseudogene Neighboring gene H3K4me1 hESC enhancer GRCh37_chr16:2902227-2902726 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr16:2907556-2908156 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr16:2908157-2908757 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr16:2908758-2909357 Neighboring gene uncharacterized LOC101929566 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 10284 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 10285 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 10286 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr16:2932133-2932633 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 7077 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 7078 Neighboring gene FLYWCH family member 2

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. Thyroid hormone enhanced human hepatoma cell motility involves brain-specific serine protease 4 activation via ERK signaling. Chen CY, et al. Mol Cancer, 2014 Jul 1. PMID 24980078, Free PMC Article
    2. A novel serine protease highly expressed in the pancreas is expressed in various kinds of cancer cells. Mitsui S, et al. FEBS J, 2005 Oct. PMID 16176265
    3. Urokinase-type plasminogen activator is a preferred substrate of the human epithelium serine protease tryptase epsilon/PRSS22. Yasuda S, et al. Blood, 2005 May 15. PMID 15701722, Free PMC Article
    4. Human tryptase epsilon (PRSS22), a new member of the chromosome 16p13.3 family of human serine proteases expressed in airway epithelial cells. Wong GW, et al. J Biol Chem, 2001 Dec 28. PMID 11602603
    5. The sequence and analysis of duplication-rich human chromosome 16. Martin J, et al. Nature, 2004 Dec 23. PMID 15616553

    See all (14) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Our findings collectively support a potential role of T3 in cancer cell progression through regulation of the BSSP4 protease via the ERK 1/2-C/EBPbeta-VEGF cascade
      Title: Thyroid hormone enhanced human hepatoma cell motility involves brain-specific serine protease 4 activation via ERK signaling.
    2. Tryptase epsilon also was able to induce pro-uPA-expressing smooth muscle cells to increase their migration
      Title: Urokinase-type plasminogen activator is a preferred substrate of the human epithelium serine protease tryptase epsilon/PRSS22.
    3. prosemin is a novel serine protease of the chromosome 16 cluster that is highly expressed in the pancreas.
      Title: A novel serine protease highly expressed in the pancreas is expressed in various kinds of cancer cells.
    Submit: New GeneRIF Correction

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Genotypes

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Clone Names

    • MGC9599

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables peptidase activator activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables serine-type endopeptidase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in positive regulation of peptidase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in proteolysis IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in extracellular space IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    brain-specific serine protease 4
    Names
    prosemin
    protease, serine 22
    protease, serine S1 family member 22
    serine protease 26
    tryptase epsilon

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_046976.1 RefSeqGene

      Range
      5461..10901
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_022119.4 → NP_071402.1  brain-specific serine protease 4 precursor

      See identical proteins and their annotated locations for NP_071402.1

      Status: REVIEWED

      Source sequence(s)
      AF321182, AW083723, BQ893064
      Consensus CDS
      CCDS10481.1
      UniProtKB/Swiss-Prot
      O43342, Q6UXE0, Q9GZN4
      Related
      ENSP00000161006.3, ENST00000161006.8
      Conserved Domains (1) summary
      cd00190
      Location:50 → 288
      Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000016.10 Reference GRCh38.p14 Primary Assembly

      Range
      2852730..2858170 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_047434451.1 → XP_047290407.1  brain-specific serine protease 4 isoform X1

    Reference GRCh38.p14 PATCHES

    Genomic

    1. NW_013171812.1 Reference GRCh38.p14 PATCHES

      Range
      32208..38173 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054331878.1 → XP_054187853.1  brain-specific serine protease 4 isoform X2

      UniProtKB/Swiss-Prot
      O43342, Q6UXE0, Q9GZN4

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060940.1 Alternate T2T-CHM13v2.0

      Range
      2873285..2879250 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054313605.1 → XP_054169580.1  brain-specific serine protease 4 isoform X2

      UniProtKB/Swiss-Prot
      O43342, Q6UXE0, Q9GZN4

    2. XM_054313604.1 → XP_054169579.1  brain-specific serine protease 4 isoform X3

    3. XM_054313606.1 → XP_054169581.1  brain-specific serine protease 4 isoform X1

    4. XM_054313607.1 → XP_054169582.1  brain-specific serine protease 4 isoform X4

    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9GZN4.1 GenPept UniProtKB/Swiss-Prot:Q9GZN4

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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