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    Ntn3 netrin 3 [ Mus musculus (house mouse) ]

    Gene ID: 18209, updated on 2-Nov-2024

    Summary

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    Official Symbol
    Ntn3provided by MGI
    Official Full Name
    netrin 3provided by MGI
    Primary source
    MGI:MGI:1341188
    See related
    Ensembl:ENSMUSG00000117406 AllianceGenome:MGI:1341188
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Ntn2l
    Summary
    Enables signaling receptor binding activity. Predicted to be involved in animal organ morphogenesis; neuron projection development; and tissue development. Predicted to act upstream of or within myoblast fusion and regulation of DNA-templated transcription. Located in Golgi apparatus and extracellular region. Is expressed in several structures, including embryo mesenchyme; genitourinary system; limb; nervous system; and tooth. Orthologous to human NTN3 (netrin 3). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Broad expression in limb E14.5 (RPKM 9.9), ovary adult (RPKM 3.7) and 19 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Ntn3 in Genome Data Viewer
    Location:
    17 A3.3; 17 12.31 cM
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 17 NC_000083.7 (24422805..24428361, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 17 NC_000083.6 (24203831..24209387, complement)

    Chromosome 17 - NC_000083.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_42075 Neighboring gene amidohydrolase domain containing 2 Neighboring gene STARR-positive B cell enhancer ABC_E8658 Neighboring gene ATPase, H+ transporting, lysosomal V0 subunit C Neighboring gene TBC1 domain family, member 24 Neighboring gene STARR-seq mESC enhancer starr_42079 Neighboring gene STARR-positive B cell enhancer ABC_E2472 Neighboring gene tubulin epsilon and delta complex 2 Neighboring gene cyclin F Neighboring gene microRNA 5134

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Netrin-3 Suppresses Diabetic Neuropathic Pain by Gating the Intra-epidermal Sprouting of Sensory Axons. Pan W, et al. Neurosci Bull, 2023 May. PMID 36587114, Free PMC Article
    2. Netrin-3 protein is localized to the axons of motor, sensory, and sympathetic neurons. Seaman C, et al. Mech Dev, 2001 Mar. PMID 11231084
    3. Divergent properties of mouse netrins. PuschelPüschel AW. Mech Dev, 1999 May. PMID 10381568
    4. Axon guidance by diffusible chemoattractants: a gradient of netrin protein in the developing spinal cord. Kennedy TE, et al. J Neurosci, 2006 Aug 23. PMID 16928876, Free PMC Article
    5. Developmentally regulated expression of Netrin-1 and -3 in the embryonic mouse molar tooth germ. Løes S, et al. Dev Dyn, 2003 Aug. PMID 12889066

    See all (28) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Netrin-3 Suppresses Diabetic Neuropathic Pain by Gating the Intra-epidermal Sprouting of Sensory Axons.
      Title: Netrin-3 Suppresses Diabetic Neuropathic Pain by Gating the Intra-epidermal Sprouting of Sensory Axons.
    2. netrin-3 and neogenin may promote myogenic differentiation by an autocrine mechanism as components of a higher order complex of several promyogenic cell surface proteins
      Title: Netrins and neogenin promote myotube formation.
    3. Netrin-3 is expressed by the fetal mucosal epithelium and pancreas.
      Title: Netrins and DCC in the guidance of migrating neural crest-derived cells in the developing bowel and pancreas.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Targeted (1) 

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables signaling receptor binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables signaling receptor binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in animal organ morphogenesis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within axonogenesis TAS
    Traceable Author Statement
    more info
    		 PubMed 
    involved_in dendrite development IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in motor neuron axon guidance IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within myoblast fusion ISA
    Inferred from Sequence Alignment
    more info
    		 PubMed 
    acts_upstream_of_or_within regulation of DNA-templated transcription ISA
    Inferred from Sequence Alignment
    more info
    		 PubMed 
    involved_in tissue development IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in Golgi apparatus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in basement membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in extracellular region IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in extracellular region TAS
    Traceable Author Statement
    more info
    		  

    General protein information

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    Preferred Names
    netrin-3
    Names
    netrin-2-like protein

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_010947.3 → NP_035077.1  netrin-3 precursor

      See identical proteins and their annotated locations for NP_035077.1

      Status: PROVISIONAL

      Source sequence(s)
      BC094362
      Consensus CDS
      CCDS28478.1
      UniProtKB/Swiss-Prot
      Q9QY49, Q9R1A3, Q9WVA6
      UniProtKB/TrEMBL
      Q52KG2
      Related
      ENSMUSP00000024931.5, ENSMUST00000024931.6
      Conserved Domains (4) summary
      cd00055
      Location:373 → 422
      EGF_Lam; Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous components of basement membranes that mediate cell adhesion, growth migration, and differentiation; the laminin-type epidermal growth factor-like module occurs in ...
      cd03579
      Location:456 → 562
      NTR_netrin-1_like; NTR domain, Netrin-1-like subfamily; The C-terminal NTR domain of netrins is also called domain C in the context of C. elegans netrin UNC-6. Netrins are secreted proteins that function as tropic cues in the direction of axon growth and cell migration ...
      pfam00053
      Location:311 → 362
      Laminin_EGF; Laminin EGF domain
      cl02806
      Location:34 → 253
      Laminin_N; Laminin N-terminal (Domain VI)

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000083.7 Reference GRCm39 C57BL/6J

      Range
      24422805..24428361 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9R1A3.1 GenPept UniProtKB/Swiss-Prot:Q9R1A3

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Chemical Information
    Molecular Biology Databases
    Research Materials
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