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    Omd osteomodulin [ Mus musculus (house mouse) ]

    Gene ID: 27047, updated on 2-Nov-2024

    Summary

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    Official Symbol
    Omdprovided by MGI
    Official Full Name
    osteomodulinprovided by MGI
    Primary source
    MGI:MGI:1350918
    See related
    Ensembl:ENSMUSG00000048368 AllianceGenome:MGI:1350918
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    OSAD; SLRR2C
    Summary
    Predicted to be involved in cell adhesion. Located in extracellular matrix. Is expressed in extracellular matrix and jaw. Orthologous to human OMD (osteomodulin). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Low expression observed in reference dataset See more
    Orthologs
    human all
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    Genomic context

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    See Omd in Genome Data Viewer
    Location:
    13 A5; 13 25.33 cM
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 13 NC_000079.7 (49735938..49746088)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 13 NC_000079.6 (49582462..49592612)

    Chromosome 13 - NC_000079.7Genomic Context describing neighboring genes Neighboring gene centromere protein P Neighboring gene extracellular matrix protein 2, female organ and adipocyte specific Neighboring gene asporin Neighboring gene STARR-seq mESC enhancer starr_34480 Neighboring gene osteoglycin Neighboring gene STARR-positive B cell enhancer ABC_E1463 Neighboring gene nucleolar protein 8 Neighboring gene predicted gene, 53786

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Osteomodulin deficiency in mice causes a specific reduction of transversal cortical bone size. Zhao W, et al. J Bone Miner Res, 2024 Aug 5. PMID 38722812, Free PMC Article
    2. Osteoadherin serves roles in the regulation of apoptosis and growth in MC3T3‑E1 osteoblast cells. Hamaya E, et al. Int J Mol Med, 2019 Dec. PMID 31638177
    3. Osteoadherin is upregulated by mature osteoblasts and enhances their in vitro differentiation and mineralization. Rehn AP, et al. Calcif Tissue Int, 2008 Jun. PMID 18496725
    4. Osteoclastic activity induces osteomodulin expression in osteoblasts. Ninomiya K, et al. Biochem Biophys Res Commun, 2007 Oct 19. PMID 17714690
    5. Differential regulation of osteoadherin (OSAD) by TGF-beta1 and BMP-2. Rehn AP, et al. Biochem Biophys Res Commun, 2006 Oct 27. PMID 16970923

    See all (23) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Osteomodulin deficiency in mice causes a specific reduction of transversal cortical bone size.
      Title: Osteomodulin deficiency in mice causes a specific reduction of transversal cortical bone size.
    2. Osteomodulin downregulation is associated with osteoarthritis development.
      Title: Osteomodulin downregulation is associated with osteoarthritis development.
    3. These results demonstrate that Omd expression is regulated during osteoblast differentiation, and that the protein product osteoadherin serves roles in the apoptosis and growth of osteoblast cells
      Title: Osteoadherin serves roles in the regulation of apoptosis and growth in MC3T3‑E1 osteoblast cells.
    4. OSAD overexpression enhanced the differentiation and maturation of osteoblasts in vitro.
      Title: Osteoadherin is upregulated by mature osteoblasts and enhances their in vitro differentiation and mineralization.
    5. found transforming growth factor beta1 to down regulate OSAD, while bone morphogenetic protein 2 up regulates OSAD
      Title: Differential regulation of osteoadherin (OSAD) by TGF-beta1 and BMP-2.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (5) 
    • Targeted (1) 

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Process Evidence Code Pubs
    involved_in cell adhesion IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in extracellular matrix IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in extracellular region IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in extracellular space IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    osteomodulin
    Names
    KSPG osteomodulin
    keratan sulfate proteoglycan osteomodulin
    osteoadherin

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001360708.1 → NP_001347637.1  osteomodulin precursor

      Status: VALIDATED

      Source sequence(s)
      AC160978
      Consensus CDS
      CCDS26504.1
      UniProtKB/Swiss-Prot
      O35103
      UniProtKB/TrEMBL
      Q501L5
      Related
      ENSMUSP00000065706.8, ENSMUST00000065494.8
      Conserved Domains (2) summary
      PRK15370
      Location:68 → 302
      PRK15370; type III secretion system effector E3 ubiquitin transferase SlrP
      sd00033
      Location:94 → 116
      LRR_RI; leucine-rich repeat [structural motif]

    2. NM_012050.3 → NP_036180.1  osteomodulin precursor

      See identical proteins and their annotated locations for NP_036180.1

      Status: VALIDATED

      Source sequence(s)
      AC160978
      Consensus CDS
      CCDS26504.1
      UniProtKB/Swiss-Prot
      O35103
      UniProtKB/TrEMBL
      Q501L5
      Related
      ENSMUSP00000152066.2, ENSMUST00000221170.2
      Conserved Domains (2) summary
      PRK15370
      Location:68 → 302
      PRK15370; type III secretion system effector E3 ubiquitin transferase SlrP
      sd00033
      Location:94 → 116
      LRR_RI; leucine-rich repeat [structural motif]

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000079.7 Reference GRCm39 C57BL/6J

      Range
      49735938..49746088
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    O35103.1 GenPept UniProtKB/Swiss-Prot:O35103

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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