Oaz2 ornithine decarboxylase antizyme 2 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Oaz2provided by MGI
Official Full Name: ornithine decarboxylase antizyme 2provided by MGI
Primary source: MGI:MGI:109492
See related: Ensembl:ENSMUSG00000040652 AllianceGenome:MGI:109492
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: AZ2; AZ-2; Sez15; Oaz2-ps
Summary: The protein encoded by this gene belongs to the ornithine decarboxylase antizyme family, which plays a role in cell growth and proliferation by regulating intracellular polyamine levels. Expression of antizymes requires +1 ribosomal frameshifting, which is enhanced by high levels of polyamines. Antizymes in turn bind to and inhibit ornithine decarboxylase (ODC), the key enzyme in polyamine biosynthesis; thus, completing the auto-regulatory circuit. This gene encodes antizyme 2, the second member of the antizyme family. Like antizyme 1, antizyme 2 has broad tissue distribution, inhibits ODC activity and polyamine uptake, and stimulates ODC degradation in vivo; however, it fails to promote ODC degradation in vitro. Antizyme 2 is expressed at lower levels than antizyme 1, but is evolutionary more conserved, suggesting it likely has an important biological role. Studies also show different subcellular localization of antizymes 1 and 2, indicating specific function for each antizyme in discrete compartments of the cell. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Dec 2014]
Expression: Ubiquitous expression in lung adult (RPKM 83.1), CNS E18 (RPKM 58.2) and 28 other tissues See more
Orthologs: human all
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Genomic context

Location:: 9 C; 9 35.45 cM

Exon count:: 5

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	9	NC_000075.7 (65583830..65597582)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	9	NC_000075.6 (65676548..65690300)

Chromosome 9 - NC_000075.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

The level of AZ2 mRNA decreased during mammary gland development.
Title: Developmental alterations in expression and subcellular localization of antizyme and antizyme inhibitor and their functional importance in the murine mammary gland.
The protein product is generated using polyamine-regulated programmed ribosomal frameshifting.
Title: A second mammalian antizyme: conservation of programmed ribosomal frameshifting.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (2)
Gene trapped (1)

General gene information

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Markers

Oaz2-ps (e-PCR), detects polymorphism
- UniSTS:531479

Oaz2 (e-PCR), detects polymorphism
- UniSTS:527466

RH141096 (e-PCR)
- UniSTS:223094

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables ornithine decarboxylase inhibitor activity	IBA Inferred from Biological aspect of Ancestor more info
enables ornithine decarboxylase inhibitor activity	IGI Inferred from Genetic Interaction more info
enables ornithine decarboxylase inhibitor activity	ISO Inferred from Sequence Orthology more info
enables ornithine decarboxylase inhibitor activity	ISS Inferred from Sequence or Structural Similarity more info
enables protein binding	IPI Inferred from Physical Interaction more info

Process	Evidence Code	Pubs
involved_in negative regulation of polyamine transmembrane transport	IDA Inferred from Direct Assay more info
involved_in polyamine biosynthetic process	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within polyamine metabolic process	TAS Traceable Author Statement more info	PubMed
involved_in positive regulation of intracellular protein transport	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of protein catabolic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of protein catabolic process	IDA Inferred from Direct Assay more info	PubMed
involved_in viral translational frameshifting	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: ornithine decarboxylase antizyme 2

Names: ODC-Az 2; antizyme 2; seizure-related protein 15

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001301307.1 → NP_001288236.1 ornithine decarboxylase antizyme 2 isoform 2

Status: REVIEWED

Description

Transcript Variant: This variant (2) uses an alternate, in-frame acceptor splice site at the second exon compared to variant 1. The resulting isoform (2) is one amino acid shorter than isoform 1.

Source sequence(s)

AK169243, BC083114, CJ072367

Conserved Domains (1) summary

pfam02100
Location:97 → 180

ODC_AZ; Ornithine decarboxylase antizyme
NM_010952.3 → NP_035082.1 ornithine decarboxylase antizyme 2 isoform 1

See identical proteins and their annotated locations for NP_035082.1

Status: REVIEWED

Description

Transcript Variant: This variant (1) encodes the longer isoform (1).

Source sequence(s)

AK169243, BC083114

Consensus CDS

CCDS57683.1

UniProtKB/Swiss-Prot

O08608

Related

ENSMUSP00000136914.2, ENSMUST00000153700.9

Conserved Domains (1) summary

pfam02100
Location:98 → 181

ODC_AZ; Ornithine decarboxylase antizyme