Prxl2a peroxiredoxin like 2A [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Prxl2aprovided by RGD
Official Full Name: peroxiredoxin like 2Aprovided by RGD
Primary source: RGD:1309676
See related: EnsemblRapid:ENSRNOG00000011140 AllianceGenome:RGD:1309676
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: PAMM; Fam213a; RGD1309676
Summary: Predicted to enable antioxidant activity. Predicted to be involved in regulation of osteoclast differentiation. Predicted to be located in extracellular region and membrane. Predicted to be active in cytoplasm. Orthologous to human PRXL2A (peroxiredoxin like 2A). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Biased expression in Testes (RPKM 447.1), Adrenal (RPKM 340.2) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 16p14

Exon count:: 7

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	16	NC_086034.1 (16900697..16920521, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	16	NC_051351.1 (16866601..16886378, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	16	NC_005115.4 (17494000..17513781)

Chromosome 16 - NC_086034.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables antioxidant activity	IBA Inferred from Biological aspect of Ancestor more info
enables antioxidant activity	IEA Inferred from Electronic Annotation more info
enables antioxidant activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in cellular oxidant detoxification	IEA Inferred from Electronic Annotation more info
involved_in regulation of osteoclast differentiation	IEA Inferred from Electronic Annotation more info
involved_in regulation of osteoclast differentiation	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in extracellular region	IEA Inferred from Electronic Annotation more info
located_in membrane	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: peroxiredoxin-like 2A

Names: UPF0765 protein C10orf58 homolog; family with sequence similarity 213, member A; peroxiredoxin-like 2 activated in M-CSF stimulated monocytes; redox-regulatory protein FAM213A; redox-regulatory protein PAMM; sperm head protein 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001014140.1 → NP_001014162.1 peroxiredoxin-like 2A

See identical proteins and their annotated locations for NP_001014162.1

Status: PROVISIONAL

Source sequence(s)

BC079275

UniProtKB/Swiss-Prot

P85300, Q6AXX6

UniProtKB/TrEMBL

A6K9L0

Related

ENSRNOP00000078597.1, ENSRNOT00000113272.2

Conserved Domains (1) summary

cd02970
Location:48 → 201

PRX_like2; Peroxiredoxin (PRX)-like 2 family; hypothetical proteins that show sequence similarity to PRXs. Members of this group contain a CXXC motif, similar to TRX. The second cysteine in the motif corresponds to the peroxidatic cysteine of PRX, however, these ...

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086034.1 Reference GRCr8

Range

16900697..16920521 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_063275493.1 → XP_063131563.1 peroxiredoxin-like 2A isoform X1

UniProtKB/TrEMBL

A0A8L2Q6Y2

Related

ENSRNOP00000014819.5, ENSRNOT00000014819.7
XM_006252791.5 → XP_006252853.1 peroxiredoxin-like 2A isoform X2

See identical proteins and their annotated locations for XP_006252853.1

UniProtKB/Swiss-Prot

P85300, Q6AXX6

UniProtKB/TrEMBL

A6K9L0

Related

ENSRNOP00000102558.1, ENSRNOT00000158328.1

Conserved Domains (1) summary

cd02970
Location:48 → 201

PRX_like2; Peroxiredoxin (PRX)-like 2 family; hypothetical proteins that show sequence similarity to PRXs. Members of this group contain a CXXC motif, similar to TRX. The second cysteine in the motif corresponds to the peroxidatic cysteine of PRX, however, these ...