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    LMTK3 lemur tyrosine kinase 3 [ Homo sapiens (human) ]

    Gene ID: 114783, updated on 2-Nov-2024

    Summary

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    Official Symbol
    LMTK3provided by HGNC
    Official Full Name
    lemur tyrosine kinase 3provided by HGNC
    Primary source
    HGNC:HGNC:19295
    See related
    Ensembl:ENSG00000142235 MIM:619624; AllianceGenome:HGNC:19295
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    LMR3; AATYK3; TYKLM3; PPP1R101
    Summary
    Predicted to enable protein kinase activity. Predicted to be involved in chromatin remodeling and protein phosphorylation. Predicted to be located in Golgi membrane; axon; and dendrite. [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in brain (RPKM 7.4), duodenum (RPKM 0.9) and 5 other tissues See more
    Orthologs
    mouse all
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    Genomic context

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    See LMTK3 in Genome Data Viewer
    Location:
    19q13.33
    Exon count:
    17
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 19 NC_000019.10 (48485271..48513680, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 19 NC_060943.1 (51479429..51507322, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (48988528..49016419, complement)

    Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:48964846-48965804 Neighboring gene glutamate rich WD repeat containing 1 Neighboring gene uncharacterized LOC105372430 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:48971727-48972227 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:48972285-48973278 Neighboring gene potassium inwardly rectifying channel subfamily J member 14 Neighboring gene MPRA-validated peak3539 silencer Neighboring gene cytohesin 2 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:48993225-48993796 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 10882 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 10883 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 10884 Neighboring gene ReSE screen-validated silencer GRCh37_chr19:48996420-48996611 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 10886 Neighboring gene H3K27ac hESC enhancer GRCh37_chr19:48997173-48997673 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 10887 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 10888 Neighboring gene ReSE screen-validated silencer GRCh37_chr19:49017633-49017779 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:49046825-49047364 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:49048751-49049694 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:49054849-49055373 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:49057162-49058100 Neighboring gene Sharpr-MPRA regulatory regions 10218 and 12364 Neighboring gene sulfotransferase family 2B member 1 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 14898 Neighboring gene family with sequence similarity 83 member E Neighboring gene sperm acrosome associated 4

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. Serum lemur tyrosine kinase 3 expression in colorectal cancer patients predicts cancer progression and prognosis. Shi H, et al. Med Oncol, 2013 Dec. PMID 24174317
    2. LMTK3 expression in breast cancer: association with tumor phenotype and clinical outcome. Stebbing J, et al. Breast Cancer Res Treat, 2012 Apr. PMID 21671015
    3. Structural modeling and molecular dynamics studies on the human LMTK3 domain and the mechanism of ATP binding. Anbarasu K, et al. Mol Biosyst, 2014 May. PMID 24619340
    4. Lemur tyrosine kinase-3 (LMTK3) induces chemoresistance to cetuximab in colorectal cancer via the ERK/MAPK pathway. Wang C, et al. Bioengineered, 2021 Dec. PMID 34516351, Free PMC Article
    5. LMTK3 promotes tumorigenesis in bladder cancer via the ERK/MAPK pathway. Jiang T, et al. FEBS Open Bio, 2020 Oct. PMID 32865871, Free PMC Article

    See all (39) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Lemur tyrosine kinase-3 (LMTK3) induces chemoresistance to cetuximab in colorectal cancer via the ERK/MAPK pathway.
      Title: Lemur tyrosine kinase-3 (LMTK3) induces chemoresistance to cetuximab in colorectal cancer via the ERK/MAPK pathway.
    2. LMTK3 promotes tumorigenesis in bladder cancer via the ERK/MAPK pathway.
      Title: LMTK3 promotes tumorigenesis in bladder cancer via the ERK/MAPK pathway.
    3. Our findings support a model in which the MIR2052HG regulates LMTK3 via EGR1, and LMTK3 regulates ERalpha stability via the PKC/MEK/ERK/RSK1 axis. These results reveal a direct role of MIR2052HG in LMTK3 regulation and raise the possibilities of targeting MIR2052HG or LMTK3 in ERalpha-positive breast cancer.
      Title: The lncRNA MIR2052HG regulates ERα levels and aromatase inhibitor resistance through LMTK3 by recruiting EGR1.
    4. targeting of LMTK3 with siRNA delayed KIT-dependent GIST growth in a xenograft model. Our data suggest the potential of LMTK3 as a target for treatment of patients with KIT-mutant cancer, particularly after failure of KIT TKIs.
      Title: LMTK3 is essential for oncogenic KIT expression in KIT-mutant GIST and melanoma.
    5. LMTK3 expression and its role in the drug resistance in breast cancer.
      Title: LMTK3 confers chemo-resistance in breast cancer.
    6. Phosphorylation of RCP at Ser(435) by Lemur tyrosine kinase-3 (LMTK3) and of EphA2 at Ser(897) by Akt are both necessary to promote Rab14-dependent (and Rab11-independent) trafficking of EphA2 which generates cell:cell repulsion events that drive tumour cells apart.
      Title: Phosphorylation of Rab-coupling protein by LMTK3 controls Rab14-dependent EphA2 trafficking to promote cell:cell repulsion.
    7. LMTK-3 increased phosphorylated p38 and JNK, but decreased phosphorylated ERK1/2 and AKT. Overexpression of LMTKs may contribute to biologic behavior changes of PCa, especially cell apoptosis.
      Title: Lemur Tyrosine Kinase-3 Suppresses Growth of Prostate Cancer Via the AKT and MAPK Signaling Pathways.
    8. The serum LMTK3 level was significantly increased in 102 thyroid carcinoma patients compared with 52 benign thyroid tumor patients and 50 healthy volunteers (P=0.001). The protein and mRNA expression of LMTK3 was markedly higher in thyroid cancer patients compared with patients with benign thyroid tumors. LMTK3 knockdown retarded proliferation, invasion and migration in SW579 cells.
      Title: LMTK3 knockdown retards cell growth and invasion and promotes apoptosis in thyroid cancer.
    9. LMTK3 escapes tumour suppressor miRNAs via sequestration of DDX5.
      Title: LMTK3 escapes tumour suppressor miRNAs via sequestration of DDX5.
    10. LMTK3 functions at distal regions in tethering the chromatin to the nuclear periphery, resulting in H3K9me3 modification and gene silencing.
      Title: LMTK3 Represses Tumor Suppressor-like Genes through Chromatin Remodeling in Breast Cancer.
    Submit: New GeneRIF Correction See all GeneRIFs (21)

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    Copy number response

    Description
    Copy number response
    Triplosensitivity

    No evidence available (Last evaluated 2018-07-25)

    ClinGen Genome Curation Page
    Haploinsufficency

    Little evidence for dosage pathogenicity (Last evaluated 2018-07-25)

    ClinGen Genome Curation PagePubMed

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Genotypes

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • KIAA1883

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H2AS1 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables molecular_function ND
    No biological Data available
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables protein kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein serine kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in chromatin remodeling IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in protein phosphorylation IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in Golgi membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in axon IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in cellular_component ND
    No biological Data available
    more info
    		  
    located_in dendrite IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    serine/threonine-protein kinase LMTK3
    Names
    protein phosphatase 1, regulatory subunit 101
    NP_001073903.2
    NP_001375414.1
    XP_011524713.1
    XP_011524714.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001080434.2 → NP_001073903.2  serine/threonine-protein kinase LMTK3 precursor

      Status: VALIDATED

      Source sequence(s)
      AC008403
      Consensus CDS
      CCDS46136.2
      UniProtKB/Swiss-Prot
      Q4G0U1, Q96Q04
      UniProtKB/TrEMBL
      A0A5F9ZH67
      Related
      ENSP00000500153.1, ENST00000673139.1
      Conserved Domains (2) summary
      PRK07764
      Location:1021 → 1205
      PRK07764; DNA polymerase III subunits gamma and tau; Validated
      cd14206
      Location:135 → 410
      PTKc_Aatyk3; Catalytic domain of the Protein Tyrosine Kinases, Apoptosis-associated tyrosine kinase 3

    2. NM_001388485.1 → NP_001375414.1  serine/threonine-protein kinase LMTK3 precursor

      Status: VALIDATED

      Source sequence(s)
      AC008403
      Consensus CDS
      CCDS46136.2
      UniProtKB/Swiss-Prot
      Q4G0U1, Q96Q04
      UniProtKB/TrEMBL
      A0A5F9ZH67
      Related
      ENSP00000472020.1, ENST00000600059.6
      Conserved Domains (2) summary
      PRK07764
      Location:1021 → 1205
      PRK07764; DNA polymerase III subunits gamma and tau; Validated
      cd14206
      Location:135 → 410
      PTKc_Aatyk3; Catalytic domain of the Protein Tyrosine Kinases, Apoptosis-associated tyrosine kinase 3

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000019.10 Reference GRCh38.p14 Primary Assembly

      Range
      48485271..48513680 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011526412.3 → XP_011524714.1  serine/threonine-protein kinase LMTK3 isoform X2

      UniProtKB/TrEMBL
      A0A5F9ZH67
      Conserved Domains (2) summary
      smart00221
      Location:148 → 423
      STYKc; Protein kinase; unclassified specificity
      cd14206
      Location:150 → 425
      PTKc_Aatyk3; Catalytic domain of the Protein Tyrosine Kinases, Apoptosis-associated tyrosine kinase 3

    2. XM_011526411.3 → XP_011524713.1  serine/threonine-protein kinase LMTK3 isoform X1

      UniProtKB/TrEMBL
      A0A3B3ISL5, A0A5F9ZH67
      Related
      ENSP00000497480.1, ENST00000650440.1
      Conserved Domains (2) summary
      smart00221
      Location:159 → 434
      STYKc; Protein kinase; unclassified specificity
      cd14206
      Location:161 → 436
      PTKc_Aatyk3; Catalytic domain of the Protein Tyrosine Kinases, Apoptosis-associated tyrosine kinase 3

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060943.1 Alternate T2T-CHM13v2.0

      Range
      51479429..51507322 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q96Q04.2 GenPept UniProtKB/Swiss-Prot:Q96Q04

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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