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    OR51F1 olfactory receptor family 51 subfamily F member 1 [ Homo sapiens (human) ]

    Gene ID: 256892, updated on 2-Nov-2024

    Summary

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    Official Symbol
    OR51F1provided by HGNC
    Official Full Name
    olfactory receptor family 51 subfamily F member 1provided by HGNC
    Primary source
    HGNC:HGNC:15196
    See related
    Ensembl:ENSG00000280021 AllianceGenome:HGNC:15196
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    OR11-21; OR51F1P
    Summary
    Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. This olfactory receptor gene is a segregating pseudogene, where some individuals have an allele that encodes a functional olfactory receptor, while other individuals have an allele encoding a protein that is predicted to be non-functional. [provided by RefSeq, Jun 2015]
    Annotation information
    Note: Genetic polymorphisms result in both protein coding and non-coding alleles of this gene.
    Orthologs
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    Genomic context

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    See OR51F1 in Genome Data Viewer
    Location:
    11p15.4
    Exon count:
    1
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 11 NC_000011.10 (4768979..4769938, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 11 NC_060935.1 (4834501..4835460, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 11 NC_000011.9 (4790209..4791168, complement)

    Chromosome 11 - NC_000011.10Genomic Context describing neighboring genes Neighboring gene matrix metallopeptidase 26 Neighboring gene small nucleolar RNA SNORA62/SNORA6 family Neighboring gene olfactory receptor family 51 subfamily F member 4 pseudogene Neighboring gene olfactory receptor family 51 subfamily N member 1 pseudogene Neighboring gene olfactory receptor family 52 subfamily Y member 1 pseudogene

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Imputation-based meta-analysis of severe malaria in three African populations. Band G, et al. PLoS Genet, 2013 May. PMID 23717212, Free PMC Article
    2. Population differences in the human functional olfactory repertoire. Gilad Y, et al. Mol Biol Evol, 2003 Mar. PMID 12644552
    3. A probabilistic classifier for olfactory receptor pseudogenes. Menashe I, et al. BMC Bioinformatics, 2006 Aug 29. PMID 16939646, Free PMC Article
    4. Personal receptor repertoires: olfaction as a model. Olender T, et al. BMC Genomics, 2012 Aug 21. PMID 22908908, Free PMC Article
    5. The human olfactory receptor gene family. Malnic B, et al. Proc Natl Acad Sci U S A, 2004 Feb 24. PMID 14983052, Free PMC Article

    See all (6) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    EBI GWAS Catalog

    Description
    Imputation-based meta-analysis of severe malaria in three African populations.
    EBI GWAS Catalog

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Genotypes

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables G protein-coupled receptor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables olfactory receptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in G protein-coupled receptor signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in detection of chemical stimulus involved in sensory perception of smell IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    olfactory receptor 51F1
    Names
    olfactory receptor OR11-21 pseudogene
    olfactory receptor, family 51, subfamily F, member 1 pseudogene

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001004752.2 → NP_001004752.2  olfactory receptor 51F1

      Status: VALIDATED

      Source sequence(s)
      AC103710
      Consensus CDS
      CCDS31359.1
      UniProtKB/Swiss-Prot
      A6NGY5
      UniProtKB/TrEMBL
      A6NLW9
      Related
      ENSP00000485387.2, ENST00000624103.2

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000011.10 Reference GRCh38.p14 Primary Assembly

      Range
      4768979..4769938 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060935.1 Alternate T2T-CHM13v2.0

      Range
      4834501..4835460 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    A6NGY5.1 GenPept UniProtKB/Swiss-Prot:A6NGY5

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Chemical Information
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