Camk1d calcium/calmodulin-dependent protein kinase ID [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Camk1dprovided by MGI
Official Full Name: calcium/calmodulin-dependent protein kinase IDprovided by MGI
Primary source: MGI:MGI:2442190
See related: Ensembl:ENSMUSG00000039145 AllianceGenome:MGI:2442190
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: CKLiK; mCKLiK; CaMKIdelta; A630059D12Rik; E030025C11Rik
Summary: Predicted to enable calcium/calmodulin-dependent protein kinase activity and calmodulin binding activity. Involved in positive regulation of neuron projection development and positive regulation of neutrophil chemotaxis. Acts upstream of or within negative regulation of apoptotic process and positive regulation of apoptotic process. Predicted to be located in nucleus. Predicted to be active in cytoplasm. Is expressed in central nervous system; liver; and retina. Orthologous to human CAMK1D (calcium/calmodulin dependent protein kinase ID). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Broad expression in cortex adult (RPKM 7.4), frontal lobe adult (RPKM 6.1) and 21 other tissues See more
Orthologs: human all
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Genomic context

Location:: 2 A1; 2 3.39 cM

Exon count:: 14

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	2	NC_000068.8 (5298268..5719665, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	2	NC_000068.7 (5293457..5714860, complement)

Chromosome 2 - NC_000068.8 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Biochemical characterization of four splice variants of mouse Ca2+/calmodulin-dependent protein kinase Idelta.
Title: Biochemical characterization of four splice variants of mouse Ca2+/calmodulin-dependent protein kinase Iδ.
CaMK1d is activated through CaMKK-independent phosphorylation at serine(296).
Title: Autoactivation of C-terminally truncated Ca(2+)/calmodulin-dependent protein kinase (CaMK) Iδ via CaMK kinase-independent autophosphorylation.
Data suggest that, under cell signaling conditions in which Camk1a is significantly dephosphorylated by phosphoprotein phosphatase activity, little Camk1d dephosphorylated is observed.
Title: The Phosphatase-Resistant Isoform of CaMKI, Ca²⁺/Calmodulin-Dependent Protein Kinase Iδ (CaMKIδ), Remains in Its "Primed" Form without Ca²⁺ Stimulation.
CaMKIdelta is involved in nuclear functions through its nuclear translocation in response to stimuli that trigger intracellular Ca2+ influx--Ca2+/calmodulin-dependent protein kinase Idelta.
Title: Prominent expression and activity-dependent nuclear translocation of Ca2+/calmodulin-dependent protein kinase Idelta in hippocampal neurons.
CaMKKalpha was shown to increase during neutrophil differentiation in multiple cell lines, whereas expression of CKLiK increased as multipotent progenitors committed to promyelocytes, but then decreased as cells differentiated into mature neutrophils.
Title: A cascade of Ca(2+)/calmodulin-dependent protein kinases regulates the differentiation and functional activation of murine neutrophils.
CKLiK is up-regulated by the PU.1 transcription factor in murine erythroleukemia cells and is involved in apoptosis of these cells.
Title: Effects of PU.1-induced mouse calcium-calmodulin-dependent kinase I-like kinase (CKLiK) on apoptosis of murine erythroleukemia cells.

Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (1)
Gene trapped (1)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables calcium/calmodulin-dependent protein kinase activity	IBA Inferred from Biological aspect of Ancestor more info
enables calcium/calmodulin-dependent protein kinase activity	ISO Inferred from Sequence Orthology more info
enables calmodulin binding	IBA Inferred from Biological aspect of Ancestor more info
enables calmodulin binding	IEA Inferred from Electronic Annotation more info
enables protein serine kinase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in inflammatory response	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within negative regulation of apoptotic process	IDA Inferred from Direct Assay more info	PubMed
involved_in nervous system development	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of CREB transcription factor activity	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of CREB transcription factor activity	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within positive regulation of apoptotic process	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of neuron projection development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of neutrophil chemotaxis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of phagocytosis	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of phagocytosis	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of respiratory burst	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of respiratory burst	ISS Inferred from Sequence or Structural Similarity more info
involved_in protein phosphorylation	IEA Inferred from Electronic Annotation more info
involved_in regulation of dendrite development	ISO Inferred from Sequence Orthology more info
involved_in regulation of dendrite development	ISS Inferred from Sequence or Structural Similarity more info
involved_in regulation of granulocyte chemotaxis	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of granulocyte chemotaxis	ISO Inferred from Sequence Orthology more info
involved_in regulation of granulocyte chemotaxis	ISS Inferred from Sequence or Structural Similarity more info
involved_in regulation of neuron projection development	IBA Inferred from Biological aspect of Ancestor more info
involved_in signal transduction	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in cytoplasm	ISS Inferred from Sequence or Structural Similarity more info
located_in nucleus	ISO Inferred from Sequence Orthology more info
located_in nucleus	ISS Inferred from Sequence or Structural Similarity more info

General protein information

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Preferred Names: calcium/calmodulin-dependent protein kinase type 1D

Names: caM kinase I delta; caM kinase ID; caM-KI delta; caMKI delta; calcium/calmodulin-dependent protein kinase 1D; camKI-like protein kinase

NP_001277303.1

EC 2.7.11.17

NP_001277304.1

EC 2.7.11.17

NP_001277305.1

EC 2.7.11.17

NP_796317.2

EC 2.7.11.17

XP_006497532.1

EC 2.7.11.17

XP_006497533.1

EC 2.7.11.17

XP_006497534.1

EC 2.7.11.17

XP_011237275.1

EC 2.7.11.17

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001290374.1 → NP_001277303.1 calcium/calmodulin-dependent protein kinase type 1D isoform b

See identical proteins and their annotated locations for NP_001277303.1

Status: VALIDATED

Description

Transcript Variant: This variant (2) lacks an alternate in-frame exon in the 5' coding region, and uses an alternate splice site that results in a frameshift in the 3' coding region, compared to variant 1. The encoded isoform (b) has a distinct C-terminus and is shorter than isoform a.

Source sequence(s)

AK147616, AK147657, BC141414, BF460707

UniProtKB/TrEMBL

Q3TDM2

Conserved Domains (1) summary

cl21453
Location:12 → 287

PKc_like; Protein Kinases, catalytic domain
NM_001290375.1 → NP_001277304.1 calcium/calmodulin-dependent protein kinase type 1D isoform c

See identical proteins and their annotated locations for NP_001277304.1

Status: VALIDATED

Description

Transcript Variant: This variant (3) uses an alternate splice site that results in a frameshift in the 3' coding region, compared to variant 1. The encoded isoform (c) has a distinct C-terminus and is shorter than isoform a.

Source sequence(s)

AK147616, AK147657, BC141414, BF460707

UniProtKB/TrEMBL

Q3UH04

Conserved Domains (1) summary

cd14168
Location:12 → 312

STKc_CaMKI_delta; Catalytic domain of the Serine/Threonine kinase, Calcium/calmodulin-dependent protein kinase Type I delta
NM_001290376.1 → NP_001277305.1 calcium/calmodulin-dependent protein kinase type 1D isoform d

See identical proteins and their annotated locations for NP_001277305.1

Status: VALIDATED

Description

Transcript Variant: This variant (4) contains an alternate 5' terminal exon, and it thus differs in the 5' UTR and 5' coding region, compared to variant 1. The encoded isoform (d) has a distinct N-terminus and is shorter than isoform a.

Source sequence(s)

AK147616, AY273822, BC141414, BF460707

Consensus CDS

CCDS70975.1

UniProtKB/Swiss-Prot

Q8BW96

UniProtKB/TrEMBL

B1AW58

Related

ENSMUSP00000110638.4, ENSMUST00000114987.4

Conserved Domains (2) summary

smart00220
Location:23 → 271

S_TKc; Serine/Threonine protein kinases, catalytic domain

cd14083
Location:23 → 270

STKc_CaMKI; Catalytic domain of the Serine/Threonine kinase, Calcium/calmodulin-dependent protein kinase Type I
NM_177343.4 → NP_796317.2 calcium/calmodulin-dependent protein kinase type 1D isoform a

See identical proteins and their annotated locations for NP_796317.2

Status: VALIDATED

Description

Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (a).

Source sequence(s)

AK147616, BC141414, BF460707

Consensus CDS

CCDS15665.1

UniProtKB/Swiss-Prot

Q3U450, Q80W64, Q8BW96, Q8BWI7

UniProtKB/TrEMBL

B1AW58

Related

ENSMUSP00000037028.8, ENSMUST00000044009.14

Conserved Domains (1) summary

cd14168
Location:12 → 312

STKc_CaMKI_delta; Catalytic domain of the Serine/Threonine kinase, Calcium/calmodulin-dependent protein kinase Type I delta

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000068.8 Reference GRCm39 C57BL/6J

Range

5298268..5719665 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006497471.5 → XP_006497534.1 calcium/calmodulin-dependent protein kinase type 1D isoform X4

Conserved Domains (1) summary

cl21453
Location:12 → 268

PKc_like; Protein Kinases, catalytic domain
XM_011238973.4 → XP_011237275.1 calcium/calmodulin-dependent protein kinase type 1D isoform X1

Conserved Domains (1) summary

cd14083
Location:21 → 271

STKc_CaMKI; Catalytic domain of the Serine/Threonine kinase, Calcium/calmodulin-dependent protein kinase Type I
XM_006497469.5 → XP_006497532.1 calcium/calmodulin-dependent protein kinase type 1D isoform X2

Conserved Domains (1) summary

cd14083
Location:3 → 250

STKc_CaMKI; Catalytic domain of the Serine/Threonine kinase, Calcium/calmodulin-dependent protein kinase Type I
XM_006497470.5 → XP_006497533.1 calcium/calmodulin-dependent protein kinase type 1D isoform X3

See identical proteins and their annotated locations for XP_006497533.1

Conserved Domains (1) summary

cd14168
Location:12 → 312

STKc_CaMKI_delta; Catalytic domain of the Serine/Threonine kinase, Calcium/calmodulin-dependent protein kinase Type I delta