Ampd2 adenosine monophosphate deaminase 2 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Ampd2provided by RGD
Official Full Name: adenosine monophosphate deaminase 2provided by RGD
Primary source: RGD:2110
See related: EnsemblRapid:ENSRNOG00000019240 AllianceGenome:RGD:2110
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Ampd
Summary: Predicted to enable AMP deaminase activity and identical protein binding activity. Predicted to be involved in purine nucleotide metabolic process. Predicted to act upstream of or within several processes, including cholesterol homeostasis; energy homeostasis; and podocyte development. Predicted to be active in cytosol. Human ortholog(s) of this gene implicated in hereditary spastic paraplegia 63 and pontocerebellar hypoplasia type 9. Orthologous to human AMPD2 (adenosine monophosphate deaminase 2). [provided by Alliance of Genome Resources, Oct 2024]
Expression: Biased expression in Adrenal (RPKM 142.1), Kidney (RPKM 94.2) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 2q34

Exon count:: 21

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	2	NC_086020.1 (198395767..198408514, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	2	NC_051337.1 (195707609..195720454, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	2	NC_005101.4 (210861624..210874348, complement)

Chromosome 2 - NC_086020.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

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Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Markers

RH131246 (e-PCR)
- UniSTS:214529

MARC_6295-6296:992007206:1 (e-PCR)
- UniSTS:231224

MARC_6295-6296:997299508:1 (e-PCR)
- UniSTS:231224

MARC_5351-5352:996690313:1 (e-PCR)
- UniSTS:269491

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables AMP deaminase activity	IBA Inferred from Biological aspect of Ancestor more info
enables AMP deaminase activity	IEA Inferred from Electronic Annotation more info
enables AMP deaminase activity	ISO Inferred from Sequence Orthology more info
enables identical protein binding	ISO Inferred from Sequence Orthology more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in AMP metabolic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in AMP metabolic process	ISO Inferred from Sequence Orthology more info
involved_in ATP metabolic process	ISO Inferred from Sequence Orthology more info
involved_in GTP metabolic process	ISO Inferred from Sequence Orthology more info
involved_in IMP biosynthetic process	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within IMP biosynthetic process	ISO Inferred from Sequence Orthology more info
involved_in IMP salvage	IEA Inferred from Electronic Annotation more info
involved_in IMP salvage	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within cholesterol homeostasis	ISO Inferred from Sequence Orthology more info
involved_in cyclic purine nucleotide metabolic process	ISO Inferred from Sequence Orthology more info
involved_in cyclic purine nucleotide metabolic process	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within energy homeostasis	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within nucleotide metabolic process	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within podocyte development	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
is_active_in cytosol	IBA Inferred from Biological aspect of Ancestor more info
located_in cytosol	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: AMP deaminase 2

Names: adenosine monophosphate deaminase 2 (isoform L)

NP_001095151.1

EC 3.5.4.6

XP_006233230.4

EC 3.5.4.6

XP_006233231.1

EC 3.5.4.6

XP_008759629.1

EC 3.5.4.6

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001101681.2 → NP_001095151.1 AMP deaminase 2

See identical proteins and their annotated locations for NP_001095151.1

Status: PROVISIONAL

Source sequence(s)

BC166402

UniProtKB/Swiss-Prot

B2GUT6, Q02356

UniProtKB/TrEMBL

A6HUX6

Related

ENSRNOP00000026051.5, ENSRNOT00000026051.7

Conserved Domains (1) summary

cd01319
Location:301 → 797

AMPD; AMP deaminase (AMPD) catalyzes the hydrolytic deamination of adensosine monophosphate (AMP) at position 6 of the adenine nucleotide ring. AMPD is a diverse and highly regulated eukaryotic key enzyme of the adenylate catabolic pathway.

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086020.1 Reference GRCr8

Range

198395767..198408514 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006233168.4 → XP_006233230.4 AMP deaminase 2 isoform X1

UniProtKB/TrEMBL

A0A0G2K3U1

Related

ENSRNOP00000105424.1, ENSRNOT00000169239.1
XM_006233169.5 → XP_006233231.1 AMP deaminase 2 isoform X1

UniProtKB/TrEMBL

A0A0G2K3U1

Related

ENSRNOP00000072776.1, ENSRNOT00000088657.3

Conserved Domains (2) summary

PLN03055
Location:172 → 774

PLN03055; AMP deaminase; Provisional

cd01319
Location:275 → 771

AMPD; AMP deaminase (AMPD) catalyzes the hydrolytic deamination of adensosine monophosphate (AMP) at position 6 of the adenine nucleotide ring. AMPD is a diverse and highly regulated eukaryotic key enzyme of the adenylate catabolic pathway.
XM_008761407.4 → XP_008759629.1 AMP deaminase 2 isoform X2

Conserved Domains (2) summary

PLN03055
Location:174 → 776

PLN03055; AMP deaminase; Provisional

cd01319
Location:277 → 773

AMPD; AMP deaminase (AMPD) catalyzes the hydrolytic deamination of adensosine monophosphate (AMP) at position 6 of the adenine nucleotide ring. AMPD is a diverse and highly regulated eukaryotic key enzyme of the adenylate catabolic pathway.