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    Prrc2a proline-rich coiled-coil 2A [ Rattus norvegicus (Norway rat) ]

    Gene ID: 294250, updated on 17-Aug-2024

    Summary

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    Official Symbol
    Prrc2aprovided by RGD
    Official Full Name
    proline-rich coiled-coil 2Aprovided by RGD
    Primary source
    RGD:1303025
    See related
    EnsemblRapid:ENSRNOG00000000852 AllianceGenome:RGD:1303025
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Bat2
    Summary
    Predicted to be involved in cell differentiation. Predicted to be located in cytosol; nucleoplasm; and plasma membrane. Human ortholog(s) of this gene implicated in type 1 diabetes mellitus. Orthologous to human PRRC2A (proline rich coiled-coil 2A). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in Adrenal (RPKM 130.9), Spleen (RPKM 112.6) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Prrc2a in Genome Data Viewer
    Location:
    20p12
    Exon count:
    33
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 20 NC_086038.1 (3660981..3686715)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 20 NC_051355.1 (3658391..3674143)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 20 NC_005119.4 (5139881..5155371, complement)

    Chromosome 20 - NC_086038.1Genomic Context describing neighboring genes Neighboring gene leukocyte specific transcript 1 Neighboring gene natural cytotoxicity triggering receptor 3 Neighboring gene allograft inflammatory factor 1 Neighboring gene E230034O05Rik gene Neighboring gene small nucleolar RNA SNORA38 Neighboring gene BAG cochaperone 6 Neighboring gene apolipoprotein M Neighboring gene G4 protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. New polymorphic microsatellite markers in the human MHC class III region. Matsuzaka Y, et al. Tissue Antigens, 2001 May. PMID 11556964
    2. Genetic contribution of the BAT2 gene microsatellite polymorphism to the age-at-onset of insulin-dependent diabetes mellitus. Hashimoto M, et al. Hum Genet, 1999 Sep. PMID 10987645
    3. BAT2 and BAT3 polymorphisms as novel genetic risk factors for rejection after HLA-related SCT. Piras IS, et al. Bone Marrow Transplant, 2014 Nov. PMID 25111513, Free PMC Article
    4. Type 1 diabetes in the Spanish population: additional factors to class II HLA-DR3 and -DR4. Urcelay E, et al. BMC Genomics, 2005 Apr 20. PMID 15842729, Free PMC Article
    5. Quantitative phosphoproteomics of vasopressin-sensitive renal cells: regulation of aquaporin-2 phosphorylation at two sites. Hoffert JD, et al. Proc Natl Acad Sci U S A, 2006 May 2. PMID 16641100, Free PMC Article

    See all (12) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Process Evidence Code Pubs
    involved_in biological_process ND
    No biological Data available
    more info
    		  
    involved_in cell differentiation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytosol IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    protein PRRC2A
    Names
    HLA-B-associated transcript 2
    large proline-rich protein BAT2
    proline-rich and coiled-coil-containing protein 2A

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_212462.2 → NP_997627.1  protein PRRC2A

      See identical proteins and their annotated locations for NP_997627.1

      Status: VALIDATED

      Source sequence(s)
      BX883046
      UniProtKB/Swiss-Prot
      Q6MG48
      UniProtKB/TrEMBL
      A0A8I5ZLV3
      Conserved Domains (1) summary
      pfam07001
      Location:1 → 187
      BAT2_N; BAT2 N-terminus

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086038.1 Reference GRCr8

      Range
      3660981..3686715
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039098488.2 → XP_038954416.1  protein PRRC2A isoform X1

      UniProtKB/TrEMBL
      A0A8I5ZLV3
      Conserved Domains (2) summary
      PHA03247
      Location:1189 → 1526
      PHA03247; large tegument protein UL36; Provisional
      pfam07001
      Location:1 → 186
      BAT2_N; BAT2 N-terminus

    2. XM_063279001.1 → XP_063135071.1  protein PRRC2A isoform X3

      UniProtKB/TrEMBL
      A0A8I5ZLV3

    3. XM_063279002.1 → XP_063135072.1  protein PRRC2A isoform X6

      UniProtKB/TrEMBL
      A0A0U1RRZ5, A0A8I5ZLV3
      Related
      ENSRNOP00000075873.2, ENSRNOT00000092322.3

    4. XM_006256051.5 → XP_006256113.1  protein PRRC2A isoform X3

      UniProtKB/TrEMBL
      A0A8I5ZLV3
      Related
      ENSRNOP00000001133.6, ENSRNOT00000001133.8
      Conserved Domains (1) summary
      pfam07001
      Location:1 → 187
      BAT2_N; BAT2 N-terminus

    5. XM_006256053.5 → XP_006256115.1  protein PRRC2A isoform X5

      UniProtKB/TrEMBL
      A0A8I5ZLV3
      Conserved Domains (1) summary
      pfam07001
      Location:1 → 187
      BAT2_N; BAT2 N-terminus

    6. XM_063279003.1 → XP_063135073.1  protein PRRC2A isoform X7

      UniProtKB/TrEMBL
      A0A8I5ZLV3

    7. XM_006256048.5 → XP_006256110.1  protein PRRC2A isoform X1

      UniProtKB/TrEMBL
      A0A8I5ZLV3
      Related
      ENSRNOP00000098146.1, ENSRNOT00000120486.2
      Conserved Domains (2) summary
      PHA03247
      Location:1189 → 1526
      PHA03247; large tegument protein UL36; Provisional
      pfam07001
      Location:1 → 186
      BAT2_N; BAT2 N-terminus

    8. XM_006256050.5 → XP_006256112.1  protein PRRC2A isoform X2

      UniProtKB/TrEMBL
      A0A8I5ZLV3
      Conserved Domains (1) summary
      pfam07001
      Location:1 → 187
      BAT2_N; BAT2 N-terminus

    9. XM_006256052.5 → XP_006256114.1  protein PRRC2A isoform X4

      See identical proteins and their annotated locations for XP_006256114.1

      UniProtKB/Swiss-Prot
      Q6MG48
      UniProtKB/TrEMBL
      A0A8I5ZLV3
      Conserved Domains (1) summary
      pfam07001
      Location:1 → 187
      BAT2_N; BAT2 N-terminus
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q6MG48.1 GenPept UniProtKB/Swiss-Prot:Q6MG48

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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