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    Nav2 neuron navigator 2 [ Mus musculus (house mouse) ]

    Gene ID: 78286, updated on 14-Nov-2024

    Summary

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    Official Symbol
    Nav2provided by MGI
    Official Full Name
    neuron navigator 2provided by MGI
    Primary source
    MGI:MGI:2183691
    See related
    Ensembl:ENSMUSG00000052512 AllianceGenome:MGI:2183691
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    HELAD1; RAINB1; RAINB2; POMFIL2; Unc53H2; mKIAA3015; 5330421F07Rik
    Summary
    Enables heparin binding activity. Acts upstream of or within several processes, including cranial nerve development; sensory perception of smell; and sensory perception of sound. Located in interstitial matrix. Is expressed in several structures, including alimentary system; branchial arch; central nervous system; limb ectoderm; and somite. Orthologous to human NAV2 (neuron navigator 2). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Ubiquitous expression in genital fat pad adult (RPKM 5.2), lung adult (RPKM 4.6) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Nav2 in Genome Data Viewer
    Location:
    7 B4; 7 31.23 cM
    Exon count:
    55
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (48608796..49259838)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (48959063..49610090)

    Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E3719 Neighboring gene STARR-positive B cell enhancer ABC_E8174 Neighboring gene STARR-seq mESC enhancer starr_18888 Neighboring gene STARR-seq mESC enhancer starr_18889 Neighboring gene predicted gene 2788 Neighboring gene STARR-seq mESC enhancer starr_18890 Neighboring gene E2F transcription factor 8 Neighboring gene RAN, member RAS oncogene family pseudogene Neighboring gene predicted gene, 32849 Neighboring gene RIKEN cDNA 9130015G15 gene Neighboring gene STARR-seq mESC enhancer starr_18892 Neighboring gene STARR-seq mESC enhancer starr_18893 Neighboring gene STARR-seq mESC enhancer starr_18894 Neighboring gene STARR-seq mESC enhancer starr_18895 Neighboring gene STARR-positive B cell enhancer mm9_chr7:56552487-56552788 Neighboring gene STARR-seq mESC enhancer starr_18896 Neighboring gene STARR-seq mESC enhancer starr_18898 Neighboring gene predicted gene, 51448 Neighboring gene STARR-seq mESC enhancer starr_18899 Neighboring gene predicted gene, 51447 Neighboring gene STARR-seq mESC enhancer starr_18905 Neighboring gene STARR-seq mESC enhancer starr_18907 Neighboring gene STARR-seq mESC enhancer starr_18909 Neighboring gene predicted gene, 32694 Neighboring gene predicted gene, 45985 Neighboring gene developing brain homeobox 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Identification of novel genes including NAV2 associated with isolated tall stature. Weiss B, et al. Front Endocrinol (Lausanne), 2023. PMID 38152138, Free PMC Article
    2. Sensory deficits in mice hypomorphic for a mammalian homologue of unc-53. Peeters PJ, et al. Brain Res Dev Brain Res, 2004 Jun 21. PMID 15158073
    3. Expression pattern of Nav2 in the murine CNS with development. Pook C, et al. Gene Expr Patterns, 2020 Jan. PMID 32081718
    4. Nav2 hypomorphic mutant mice are ataxic and exhibit abnormalities in cerebellar development. McNeill EM, et al. Dev Biol, 2011 May 15. PMID 21419114, Free PMC Article
    5. Pore membrane and/or filament interacting like protein 1 (POMFIL1) is predominantly expressed in the nervous system and encodes different protein isoforms. Coy JF, et al. Gene, 2002 May 15. PMID 12062803

    See all (38) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Identification of novel genes including NAV2 associated with isolated tall stature.
      Title: Identification of novel genes including NAV2 associated with isolated tall stature.
    2. Expression pattern of Nav2 in the murine CNS with development.
      Title: Expression pattern of Nav2 in the murine CNS with development.
    3. essential role for full-length Nav2 in cerebellar development, including axonal elongation and migration of the external granule layer neurond
      Title: Nav2 hypomorphic mutant mice are ataxic and exhibit abnormalities in cerebellar development.
    4. Data show that Nav2 functions in mammalian nervous system development, and is required for normal cranial nerve development and blood pressure regulation in the adult.
      Title: Nav2 is necessary for cranial nerve development and blood pressure regulation.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (4) 
    • Gene trapped (1)  1 citation

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables 3'-5' DNA helicase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables heparin binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within glossopharyngeal nerve development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within locomotory behavior IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in nervous system development ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within optic nerve development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within regulation of systemic arterial blood pressure by baroreceptor feedback IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within sensory perception of smell IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within sensory perception of sound IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within vagus nerve development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in extracellular matrix IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in interstitial matrix IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    neuron navigator 2
    Names
    retinoic acid inducible in neuroblastoma
    NP_001104486.1
    NP_780481.2
    XP_006541351.1
    XP_006541352.1
    XP_006541356.1
    XP_006541358.1
    XP_006541360.1
    XP_006541361.1
    XP_006541362.1
    XP_006541363.1
    XP_006541365.1
    XP_006541366.1
    XP_006541369.1
    XP_006541370.1
    XP_006541371.1
    XP_006541372.1
    XP_006541373.1
    XP_006541374.1
    XP_017167885.1
    XP_017167886.1
    XP_030098971.1
    XP_030098972.1
    XP_030098973.1
    XP_030098974.1
    XP_030098975.1
    XP_036009461.1
    XP_036009462.1
    XP_036009463.1
    XP_036009464.1
    XP_036009465.1
    XP_036009466.1
    XP_036009467.1
    XP_036009468.1
    XP_036009469.1
    XP_036009470.1
    XP_036009471.1
    XP_036009472.1
    XP_036009473.1
    XP_036009474.1
    XP_036009475.1
    XP_036009476.1
    XP_036009477.1
    XP_036009478.1
    XP_036009479.1
    XP_036009480.1
    XP_036009481.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001111016.1 → NP_001104486.1  neuron navigator 2 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC119848, AK019901, AK040152, AK084063, AK129480, BM936768, BQ964922, CF580688, CF584312, CF584313, CF742564, CF743819, CF744797, CK781037, DV652788
      Consensus CDS
      CCDS71972.1
      UniProtKB/TrEMBL
      V9GXT3
      Related
      ENSMUSP00000139309.2, ENSMUST00000183659.8
      Conserved Domains (5) summary
      smart00382
      Location:2033 → 2141
      AAA; ATPases associated with a variety of cellular activities
      cd00014
      Location:22 → 126
      CH; Calponin homology domain; actin-binding domain which may be present as a single copy or in tandem repeats (which increases binding affinity). The CH domain is found in cytoskeletal and signal transduction proteins, including actin-binding proteins like ...
      pfam11235
      Location:137 → 298
      Med25_SD1; Mediator complex subunit 25 synapsin 1
      pfam13401
      Location:2036 → 2123
      AAA_22; AAA domain
      pfam15898
      Location:1790 → 1842
      PRKG1_interact; cGMP-dependent protein kinase interacting domain

    2. NM_175272.3 → NP_780481.2  neuron navigator 2 isoform 1

      Status: VALIDATED

      Source sequence(s)
      AC107862, AC119848, AK039374, AK040152, AK129480, BM936768, BQ964922, CF580688, CF584312, CF584313, CF742564, CF743819, CF744797, CK781037, DV652788
      Consensus CDS
      CCDS71973.1
      UniProtKB/TrEMBL
      V9GX91
      Related
      ENSMUSP00000139045.2, ENSMUST00000184945.8
      Conserved Domains (4) summary
      smart00382
      Location:2094 → 2202
      AAA; ATPases associated with a variety of cellular activities
      cd00014
      Location:86 → 187
      CH; Calponin homology domain; actin-binding domain which may be present as a single copy or in tandem repeats (which increases binding affinity). The CH domain is found in cytoskeletal and signal transduction proteins, including actin-binding proteins like ...
      pfam13401
      Location:2097 → 2184
      AAA_22; AAA domain
      pfam15898
      Location:1851 → 1903
      PRKG1_interact; cGMP-dependent protein kinase interacting domain

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000073.7 Reference GRCm39 C57BL/6J

      Range
      48608796..49259838
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006541300.5 → XP_006541363.1  neuron navigator 2 isoform X18

      Conserved Domains (6) summary
      PHA03307
      Location:891 → 1242
      PHA03307; transcriptional regulator ICP4; Provisional
      PRK07003
      Location:142 → 335
      PRK07003; DNA polymerase III subunit gamma/tau
      cd00014
      Location:22 → 126
      CH; Calponin homology domain; actin-binding domain which may be present as a single copy or in tandem repeats (which increases binding affinity). The CH domain is found in cytoskeletal and signal transduction proteins, including actin-binding proteins like ...
      TIGR02168
      Location:1571 → 1842
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type
      pfam05109
      Location:249 → 643
      Herpes_BLLF1; Herpes virus major outer envelope glycoprotein (BLLF1)
      pfam13401
      Location:2031 → 2124
      AAA_22; AAA domain

    2. XM_036153585.1 → XP_036009478.1  neuron navigator 2 isoform X28

      Conserved Domains (6) summary
      PHA03307
      Location:890 → 1255
      PHA03307; transcriptional regulator ICP4; Provisional
      PRK07003
      Location:142 → 335
      PRK07003; DNA polymerase III subunit gamma/tau
      TIGR04523
      Location:1382 → 1654
      Mplasa_alph_rch; helix-rich Mycoplasma protein
      pfam05109
      Location:249 → 643
      Herpes_BLLF1; Herpes virus major outer envelope glycoprotein (BLLF1)
      pfam13401
      Location:1842 → 1935
      AAA_22; AAA domain
      cd21285
      Location:15 → 127
      CH_NAV2; calponin homology (CH) domain found in neuron navigator 2

    3. XM_006541297.5 → XP_006541360.1  neuron navigator 2 isoform X14

      Conserved Domains (5) summary
      PHA03307
      Location:914 → 1265
      PHA03307; transcriptional regulator ICP4; Provisional
      cd00014
      Location:22 → 126
      CH; Calponin homology domain; actin-binding domain which may be present as a single copy or in tandem repeats (which increases binding affinity). The CH domain is found in cytoskeletal and signal transduction proteins, including actin-binding proteins like ...
      TIGR02168
      Location:1594 → 1865
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type
      pfam05109
      Location:272 → 666
      Herpes_BLLF1; Herpes virus major outer envelope glycoprotein (BLLF1)
      pfam13401
      Location:2054 → 2147
      AAA_22; AAA domain

    4. XM_036153579.1 → XP_036009472.1  neuron navigator 2 isoform X23

      Conserved Domains (5) summary
      PHA03307
      Location:833 → 1184
      PHA03307; transcriptional regulator ICP4; Provisional
      TIGR04523
      Location:1513 → 1785
      Mplasa_alph_rch; helix-rich Mycoplasma protein
      pfam05109
      Location:191 → 585
      Herpes_BLLF1; Herpes virus major outer envelope glycoprotein (BLLF1)
      pfam13401
      Location:1973 → 2066
      AAA_22; AAA domain
      cl00030
      Location:1 → 46
      CH_SF; calponin homology (CH) domain superfamily

    5. XM_036153580.1 → XP_036009473.1  neuron navigator 2 isoform X24

      Conserved Domains (6) summary
      PHA03307
      Location:810 → 1161
      PHA03307; transcriptional regulator ICP4; Provisional
      PRK07003
      Location:61 → 254
      PRK07003; DNA polymerase III subunit gamma/tau
      TIGR04523
      Location:1490 → 1762
      Mplasa_alph_rch; helix-rich Mycoplasma protein
      pfam05109
      Location:168 → 562
      Herpes_BLLF1; Herpes virus major outer envelope glycoprotein (BLLF1)
      pfam13401
      Location:1950 → 2043
      AAA_22; AAA domain
      cl00030
      Location:1 → 46
      CH_SF; calponin homology (CH) domain superfamily

    6. XM_036153582.1 → XP_036009475.1  neuron navigator 2 isoform X25

      Conserved Domains (6) summary
      PHA03307
      Location:809 → 1160
      PHA03307; transcriptional regulator ICP4; Provisional
      PRK07003
      Location:61 → 254
      PRK07003; DNA polymerase III subunit gamma/tau
      TIGR04523
      Location:1489 → 1761
      Mplasa_alph_rch; helix-rich Mycoplasma protein
      pfam05109
      Location:168 → 562
      Herpes_BLLF1; Herpes virus major outer envelope glycoprotein (BLLF1)
      pfam13401
      Location:1949 → 2042
      AAA_22; AAA domain
      cl00030
      Location:1 → 46
      CH_SF; calponin homology (CH) domain superfamily

    7. XM_036153586.1 → XP_036009479.1  neuron navigator 2 isoform X31

      Conserved Domains (6) summary
      PHA03307
      Location:810 → 1175
      PHA03307; transcriptional regulator ICP4; Provisional
      PRK07003
      Location:61 → 254
      PRK07003; DNA polymerase III subunit gamma/tau
      TIGR04523
      Location:1302 → 1378
      Mplasa_alph_rch; helix-rich Mycoplasma protein
      pfam05109
      Location:168 → 562
      Herpes_BLLF1; Herpes virus major outer envelope glycoprotein (BLLF1)
      pfam13401
      Location:1759 → 1852
      AAA_22; AAA domain
      cl00030
      Location:1 → 46
      CH_SF; calponin homology (CH) domain superfamily

    8. XM_036153568.1 → XP_036009461.1  neuron navigator 2 isoform X1

      Conserved Domains (5) summary
      PHA03307
      Location:991 → 1342
      PHA03307; transcriptional regulator ICP4; Provisional
      TIGR04523
      Location:1671 → 1943
      Mplasa_alph_rch; helix-rich Mycoplasma protein
      pfam05109
      Location:349 → 743
      Herpes_BLLF1; Herpes virus major outer envelope glycoprotein (BLLF1)
      pfam13401
      Location:2131 → 2224
      AAA_22; AAA domain
      cd21285
      Location:74 → 204
      CH_NAV2; calponin homology (CH) domain found in neuron navigator 2

    9. XM_036153570.1 → XP_036009463.1  neuron navigator 2 isoform X3

      Conserved Domains (5) summary
      PHA03307
      Location:991 → 1342
      PHA03307; transcriptional regulator ICP4; Provisional
      TIGR04523
      Location:1671 → 1747
      Mplasa_alph_rch; helix-rich Mycoplasma protein
      pfam05109
      Location:349 → 743
      Herpes_BLLF1; Herpes virus major outer envelope glycoprotein (BLLF1)
      pfam13401
      Location:2128 → 2221
      AAA_22; AAA domain
      cd21285
      Location:74 → 204
      CH_NAV2; calponin homology (CH) domain found in neuron navigator 2

    10. XM_036153571.1 → XP_036009464.1  neuron navigator 2 isoform X4

      Conserved Domains (5) summary
      PHA03307
      Location:991 → 1342
      PHA03307; transcriptional regulator ICP4; Provisional
      TIGR04523
      Location:1656 → 1928
      Mplasa_alph_rch; helix-rich Mycoplasma protein
      pfam05109
      Location:349 → 743
      Herpes_BLLF1; Herpes virus major outer envelope glycoprotein (BLLF1)
      pfam13401
      Location:2116 → 2209
      AAA_22; AAA domain
      cd21285
      Location:74 → 204
      CH_NAV2; calponin homology (CH) domain found in neuron navigator 2

    11. XM_036153575.1 → XP_036009468.1  neuron navigator 2 isoform X10

      Conserved Domains (5) summary
      PHA03307
      Location:991 → 1342
      PHA03307; transcriptional regulator ICP4; Provisional
      TIGR04523
      Location:1634 → 1906
      Mplasa_alph_rch; helix-rich Mycoplasma protein
      pfam05109
      Location:349 → 743
      Herpes_BLLF1; Herpes virus major outer envelope glycoprotein (BLLF1)
      pfam13401
      Location:2094 → 2187
      AAA_22; AAA domain
      cd21285
      Location:74 → 204
      CH_NAV2; calponin homology (CH) domain found in neuron navigator 2

    12. XM_036153583.1 → XP_036009476.1  neuron navigator 2 isoform X26

      Conserved Domains (5) summary
      PHA03307
      Location:991 → 1356
      PHA03307; transcriptional regulator ICP4; Provisional
      TIGR04523
      Location:1483 → 1755
      Mplasa_alph_rch; helix-rich Mycoplasma protein
      pfam05109
      Location:349 → 743
      Herpes_BLLF1; Herpes virus major outer envelope glycoprotein (BLLF1)
      pfam13401
      Location:1943 → 2036
      AAA_22; AAA domain
      cd21285
      Location:74 → 204
      CH_NAV2; calponin homology (CH) domain found in neuron navigator 2

    13. XM_036153569.1 → XP_036009462.1  neuron navigator 2 isoform X2

      Conserved Domains (5) summary
      PHA03307
      Location:990 → 1341
      PHA03307; transcriptional regulator ICP4; Provisional
      TIGR04523
      Location:1670 → 1942
      Mplasa_alph_rch; helix-rich Mycoplasma protein
      pfam05109
      Location:349 → 743
      Herpes_BLLF1; Herpes virus major outer envelope glycoprotein (BLLF1)
      pfam13401
      Location:2130 → 2223
      AAA_22; AAA domain
      cd21285
      Location:74 → 204
      CH_NAV2; calponin homology (CH) domain found in neuron navigator 2

    14. XM_036153572.1 → XP_036009465.1  neuron navigator 2 isoform X7

      Conserved Domains (6) summary
      PHA03307
      Location:968 → 1319
      PHA03307; transcriptional regulator ICP4; Provisional
      PRK07003
      Location:219 → 412
      PRK07003; DNA polymerase III subunit gamma/tau
      TIGR04523
      Location:1648 → 1920
      Mplasa_alph_rch; helix-rich Mycoplasma protein
      pfam05109
      Location:326 → 720
      Herpes_BLLF1; Herpes virus major outer envelope glycoprotein (BLLF1)
      pfam13401
      Location:2108 → 2201
      AAA_22; AAA domain
      cd21285
      Location:74 → 204
      CH_NAV2; calponin homology (CH) domain found in neuron navigator 2

    15. XM_036153573.1 → XP_036009466.1  neuron navigator 2 isoform X8

      Conserved Domains (6) summary
      PHA03307
      Location:967 → 1318
      PHA03307; transcriptional regulator ICP4; Provisional
      PRK07003
      Location:219 → 412
      PRK07003; DNA polymerase III subunit gamma/tau
      TIGR04523
      Location:1647 → 1919
      Mplasa_alph_rch; helix-rich Mycoplasma protein
      pfam05109
      Location:326 → 720
      Herpes_BLLF1; Herpes virus major outer envelope glycoprotein (BLLF1)
      pfam13401
      Location:2107 → 2200
      AAA_22; AAA domain
      cd21285
      Location:74 → 204
      CH_NAV2; calponin homology (CH) domain found in neuron navigator 2

    16. XM_006541311.5 → XP_006541374.1  neuron navigator 2 isoform X41

      Conserved Domains (5) summary
      PHA03307
      Location:975 → 1326
      PHA03307; transcriptional regulator ICP4; Provisional
      cd00014
      Location:86 → 187
      CH; Calponin homology domain; actin-binding domain which may be present as a single copy or in tandem repeats (which increases binding affinity). The CH domain is found in cytoskeletal and signal transduction proteins, including actin-binding proteins like ...
      TIGR02168
      Location:1688 → 1959
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type
      pfam05109
      Location:333 → 727
      Herpes_BLLF1; Herpes virus major outer envelope glycoprotein (BLLF1)
      pfam13401
      Location:2148 → 2241
      AAA_22; AAA domain

    17. XM_006541288.5 → XP_006541351.1  neuron navigator 2 isoform X5

      Conserved Domains (5) summary
      PHA03307
      Location:975 → 1326
      PHA03307; transcriptional regulator ICP4; Provisional
      cd00014
      Location:86 → 187
      CH; Calponin homology domain; actin-binding domain which may be present as a single copy or in tandem repeats (which increases binding affinity). The CH domain is found in cytoskeletal and signal transduction proteins, including actin-binding proteins like ...
      TIGR02168
      Location:1655 → 1926
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type
      pfam05109
      Location:333 → 727
      Herpes_BLLF1; Herpes virus major outer envelope glycoprotein (BLLF1)
      pfam13401
      Location:2115 → 2208
      AAA_22; AAA domain

    18. XM_006541289.5 → XP_006541352.1  neuron navigator 2 isoform X6

      Conserved Domains (5) summary
      PHA03307
      Location:974 → 1325
      PHA03307; transcriptional regulator ICP4; Provisional
      cd00014
      Location:86 → 187
      CH; Calponin homology domain; actin-binding domain which may be present as a single copy or in tandem repeats (which increases binding affinity). The CH domain is found in cytoskeletal and signal transduction proteins, including actin-binding proteins like ...
      TIGR02168
      Location:1654 → 1925
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type
      pfam05109
      Location:333 → 727
      Herpes_BLLF1; Herpes virus major outer envelope glycoprotein (BLLF1)
      pfam13401
      Location:2114 → 2207
      AAA_22; AAA domain

    19. XM_006541293.5 → XP_006541356.1  neuron navigator 2 isoform X11

      Conserved Domains (6) summary
      PHA03307
      Location:952 → 1303
      PHA03307; transcriptional regulator ICP4; Provisional
      PRK07003
      Location:203 → 396
      PRK07003; DNA polymerase III subunit gamma/tau
      cd00014
      Location:86 → 187
      CH; Calponin homology domain; actin-binding domain which may be present as a single copy or in tandem repeats (which increases binding affinity). The CH domain is found in cytoskeletal and signal transduction proteins, including actin-binding proteins like ...
      TIGR02168
      Location:1632 → 1903
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type
      pfam05109
      Location:310 → 704
      Herpes_BLLF1; Herpes virus major outer envelope glycoprotein (BLLF1)
      pfam13401
      Location:2092 → 2185
      AAA_22; AAA domain

    20. XM_036153576.1 → XP_036009469.1  neuron navigator 2 isoform X12

      Conserved Domains (5) summary
      PHA03307
      Location:991 → 1342
      PHA03307; transcriptional regulator ICP4; Provisional
      TIGR04523
      Location:1634 → 1710
      Mplasa_alph_rch; helix-rich Mycoplasma protein
      pfam05109
      Location:349 → 743
      Herpes_BLLF1; Herpes virus major outer envelope glycoprotein (BLLF1)
      pfam13401
      Location:2091 → 2184
      AAA_22; AAA domain
      cd21285
      Location:74 → 204
      CH_NAV2; calponin homology (CH) domain found in neuron navigator 2

    21. XM_036153584.1 → XP_036009477.1  neuron navigator 2 isoform X27

      Conserved Domains (5) summary
      PHA03307
      Location:991 → 1356
      PHA03307; transcriptional regulator ICP4; Provisional
      TIGR04523
      Location:1483 → 1559
      Mplasa_alph_rch; helix-rich Mycoplasma protein
      pfam05109
      Location:349 → 743
      Herpes_BLLF1; Herpes virus major outer envelope glycoprotein (BLLF1)
      pfam13401
      Location:1940 → 2033
      AAA_22; AAA domain
      cd21285
      Location:74 → 204
      CH_NAV2; calponin homology (CH) domain found in neuron navigator 2

    22. XM_036153574.1 → XP_036009467.1  neuron navigator 2 isoform X9

      Conserved Domains (6) summary
      PHA03307
      Location:968 → 1319
      PHA03307; transcriptional regulator ICP4; Provisional
      PRK07003
      Location:219 → 412
      PRK07003; DNA polymerase III subunit gamma/tau
      TIGR04523
      Location:1648 → 1724
      Mplasa_alph_rch; helix-rich Mycoplasma protein
      pfam05109
      Location:326 → 720
      Herpes_BLLF1; Herpes virus major outer envelope glycoprotein (BLLF1)
      pfam13401
      Location:2105 → 2198
      AAA_22; AAA domain
      cd21285
      Location:74 → 204
      CH_NAV2; calponin homology (CH) domain found in neuron navigator 2

    23. XM_006541295.5 → XP_006541358.1  neuron navigator 2 isoform X13

      Conserved Domains (7) summary
      PHA03307
      Location:952 → 1303
      PHA03307; transcriptional regulator ICP4; Provisional
      PRK07003
      Location:203 → 396
      PRK07003; DNA polymerase III subunit gamma/tau
      cd00014
      Location:86 → 187
      CH; Calponin homology domain; actin-binding domain which may be present as a single copy or in tandem repeats (which increases binding affinity). The CH domain is found in cytoskeletal and signal transduction proteins, including actin-binding proteins like ...
      TIGR04523
      Location:1632 → 1708
      Mplasa_alph_rch; helix-rich Mycoplasma protein
      pfam05109
      Location:310 → 704
      Herpes_BLLF1; Herpes virus major outer envelope glycoprotein (BLLF1)
      pfam15898
      Location:1849 → 1901
      PRKG1_interact; cGMP-dependent protein kinase interacting domain
      pfam13401
      Location:2089 → 2182
      AAA_22; AAA domain

    24. XM_006541299.5 → XP_006541362.1  neuron navigator 2 isoform X16

      Conserved Domains (5) summary
      PHA03307
      Location:906 → 1257
      PHA03307; transcriptional regulator ICP4; Provisional
      cd00014
      Location:15 → 118
      CH; Calponin homology domain; actin-binding domain which may be present as a single copy or in tandem repeats (which increases binding affinity). The CH domain is found in cytoskeletal and signal transduction proteins, including actin-binding proteins like ...
      TIGR02168
      Location:1586 → 1857
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type
      pfam05109
      Location:264 → 658
      Herpes_BLLF1; Herpes virus major outer envelope glycoprotein (BLLF1)
      pfam13401
      Location:2046 → 2139
      AAA_22; AAA domain

    25. XM_017312396.3 → XP_017167885.1  neuron navigator 2 isoform X20

      Conserved Domains (6) summary
      PHA03307
      Location:883 → 1234
      PHA03307; transcriptional regulator ICP4; Provisional
      PRK07003
      Location:134 → 327
      PRK07003; DNA polymerase III subunit gamma/tau
      cd00014
      Location:15 → 118
      CH; Calponin homology domain; actin-binding domain which may be present as a single copy or in tandem repeats (which increases binding affinity). The CH domain is found in cytoskeletal and signal transduction proteins, including actin-binding proteins like ...
      TIGR02168
      Location:1563 → 1834
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type
      pfam05109
      Location:241 → 635
      Herpes_BLLF1; Herpes virus major outer envelope glycoprotein (BLLF1)
      pfam13401
      Location:2023 → 2116
      AAA_22; AAA domain

    26. XM_036153581.1 → XP_036009474.1  neuron navigator 2 isoform X24

      Conserved Domains (6) summary
      PHA03307
      Location:810 → 1161
      PHA03307; transcriptional regulator ICP4; Provisional
      PRK07003
      Location:61 → 254
      PRK07003; DNA polymerase III subunit gamma/tau
      TIGR04523
      Location:1490 → 1762
      Mplasa_alph_rch; helix-rich Mycoplasma protein
      pfam05109
      Location:168 → 562
      Herpes_BLLF1; Herpes virus major outer envelope glycoprotein (BLLF1)
      pfam13401
      Location:1950 → 2043
      AAA_22; AAA domain
      cl00030
      Location:1 → 46
      CH_SF; calponin homology (CH) domain superfamily

    27. XM_017312397.3 → XP_017167886.1  neuron navigator 2 isoform X23

      Conserved Domains (5) summary
      PHA03307
      Location:833 → 1184
      PHA03307; transcriptional regulator ICP4; Provisional
      TIGR04523
      Location:1513 → 1785
      Mplasa_alph_rch; helix-rich Mycoplasma protein
      pfam05109
      Location:191 → 585
      Herpes_BLLF1; Herpes virus major outer envelope glycoprotein (BLLF1)
      pfam13401
      Location:1973 → 2066
      AAA_22; AAA domain
      cl00030
      Location:1 → 46
      CH_SF; calponin homology (CH) domain superfamily

    28. XM_006541298.5 → XP_006541361.1  neuron navigator 2 isoform X15

      Conserved Domains (5) summary
      PHA03307
      Location:913 → 1264
      PHA03307; transcriptional regulator ICP4; Provisional
      cd00014
      Location:23 → 125
      CH; Calponin homology domain; actin-binding domain which may be present as a single copy or in tandem repeats (which increases binding affinity). The CH domain is found in cytoskeletal and signal transduction proteins, including actin-binding proteins like ...
      TIGR02168
      Location:1593 → 1864
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type
      pfam05109
      Location:271 → 665
      Herpes_BLLF1; Herpes virus major outer envelope glycoprotein (BLLF1)
      pfam13401
      Location:2053 → 2146
      AAA_22; AAA domain

    29. XM_036153578.1 → XP_036009471.1  neuron navigator 2 isoform X19

      Conserved Domains (6) summary
      PHA03307
      Location:889 → 1240
      PHA03307; transcriptional regulator ICP4; Provisional
      PRK07003
      Location:141 → 334
      PRK07003; DNA polymerase III subunit gamma/tau
      TIGR04523
      Location:1569 → 1841
      Mplasa_alph_rch; helix-rich Mycoplasma protein
      pfam05109
      Location:248 → 642
      Herpes_BLLF1; Herpes virus major outer envelope glycoprotein (BLLF1)
      pfam13401
      Location:2029 → 2122
      AAA_22; AAA domain
      cd21285
      Location:22 → 126
      CH_NAV2; calponin homology (CH) domain found in neuron navigator 2

    30. XM_036153577.1 → XP_036009470.1  neuron navigator 2 isoform X17

      Conserved Domains (5) summary
      PHA03307
      Location:897 → 1248
      PHA03307; transcriptional regulator ICP4; Provisional
      TIGR04523
      Location:1577 → 1849
      Mplasa_alph_rch; helix-rich Mycoplasma protein
      pfam05109
      Location:255 → 649
      Herpes_BLLF1; Herpes virus major outer envelope glycoprotein (BLLF1)
      pfam13401
      Location:2037 → 2130
      AAA_22; AAA domain
      cd21285
      Location:1 → 110
      CH_NAV2; calponin homology (CH) domain found in neuron navigator 2

    31. XM_006541302.3 → XP_006541365.1  neuron navigator 2 isoform X21

      Conserved Domains (5) summary
      PHA03307
      Location:867 → 1218
      PHA03307; transcriptional regulator ICP4; Provisional
      TIGR02168
      Location:1547 → 1818
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type
      pfam05109
      Location:225 → 619
      Herpes_BLLF1; Herpes virus major outer envelope glycoprotein (BLLF1)
      pfam13401
      Location:2007 → 2100
      AAA_22; AAA domain
      cl00030
      Location:20 → 79
      CH; Calponin homology domain; actin-binding domain which may be present as a single copy or in tandem repeats (which increases binding affinity). The CH domain is found in cytoskeletal and signal transduction proteins, including actin-binding proteins like ...

    32. XM_006541303.3 → XP_006541366.1  neuron navigator 2 isoform X22

      Conserved Domains (6) summary
      PHA03307
      Location:844 → 1195
      PHA03307; transcriptional regulator ICP4; Provisional
      PRK07003
      Location:95 → 288
      PRK07003; DNA polymerase III subunit gamma/tau
      TIGR02168
      Location:1524 → 1795
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type
      pfam05109
      Location:202 → 596
      Herpes_BLLF1; Herpes virus major outer envelope glycoprotein (BLLF1)
      pfam13401
      Location:1984 → 2077
      AAA_22; AAA domain
      cl00030
      Location:20 → 79
      CH; Calponin homology domain; actin-binding domain which may be present as a single copy or in tandem repeats (which increases binding affinity). The CH domain is found in cytoskeletal and signal transduction proteins, including actin-binding proteins like ...

    33. XM_006541307.5 → XP_006541370.1  neuron navigator 2 isoform X30

      Conserved Domains (3) summary
      PHA03307
      Location:626 → 977
      PHA03307; transcriptional regulator ICP4; Provisional
      TIGR02168
      Location:1306 → 1577
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type
      pfam13401
      Location:1766 → 1859
      AAA_22; AAA domain

    34. XM_006541306.5 → XP_006541369.1  neuron navigator 2 isoform X29

      Conserved Domains (4) summary
      PHA03307
      Location:643 → 994
      PHA03307; transcriptional regulator ICP4; Provisional
      TIGR02168
      Location:1323 → 1594
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type
      pfam05109
      Location:8 → 395
      Herpes_BLLF1; Herpes virus major outer envelope glycoprotein (BLLF1)
      pfam13401
      Location:1783 → 1876
      AAA_22; AAA domain

    35. XM_006541308.5 → XP_006541371.1  neuron navigator 2 isoform X32

      Conserved Domains (3) summary
      PHA03307
      Location:63 → 414
      PHA03307; transcriptional regulator ICP4; Provisional
      TIGR02168
      Location:743 → 1014
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type
      pfam13401
      Location:1203 → 1296
      AAA_22; AAA domain

    36. XM_030243111.2 → XP_030098971.1  neuron navigator 2 isoform X32

      Conserved Domains (3) summary
      PHA03307
      Location:63 → 414
      PHA03307; transcriptional regulator ICP4; Provisional
      TIGR02168
      Location:743 → 1014
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type
      pfam13401
      Location:1203 → 1296
      AAA_22; AAA domain

    37. XM_006541309.5 → XP_006541372.1  neuron navigator 2 isoform X33

      Conserved Domains (3) summary
      PHA03307
      Location:33 → 384
      PHA03307; transcriptional regulator ICP4; Provisional
      TIGR02168
      Location:713 → 984
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type
      pfam13401
      Location:1173 → 1266
      AAA_22; AAA domain

    38. XM_030243113.1 → XP_030098973.1  neuron navigator 2 isoform X36

      Conserved Domains (4) summary
      PHA03307
      Location:32 → 383
      PHA03307; transcriptional regulator ICP4; Provisional
      TIGR04523
      Location:675 → 751
      Mplasa_alph_rch; helix-rich Mycoplasma protein
      pfam15898
      Location:892 → 944
      PRKG1_interact; cGMP-dependent protein kinase interacting domain
      pfam13401
      Location:1132 → 1225
      AAA_22; AAA domain

    39. XM_006541310.5 → XP_006541373.1  neuron navigator 2 isoform X34

      Conserved Domains (3) summary
      PHA03307
      Location:32 → 383
      PHA03307; transcriptional regulator ICP4; Provisional
      TIGR02168
      Location:712 → 983
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type
      pfam13401
      Location:1172 → 1265
      AAA_22; AAA domain

    40. XM_030243112.2 → XP_030098972.1  neuron navigator 2 isoform X35

      Conserved Domains (3) summary
      PHA03307
      Location:32 → 383
      PHA03307; transcriptional regulator ICP4; Provisional
      TIGR02168
      Location:675 → 946
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type
      pfam13401
      Location:1135 → 1228
      AAA_22; AAA domain

    41. XM_030243115.2 → XP_030098975.1  neuron navigator 2 isoform X38

      Conserved Domains (3) summary
      PHA03307
      Location:32 → 397
      PHA03307; transcriptional regulator ICP4; Provisional
      TIGR02168
      Location:524 → 795
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type
      pfam13401
      Location:984 → 1077
      AAA_22; AAA domain

    42. XM_036153587.1 → XP_036009480.1  neuron navigator 2 isoform X39

      Conserved Domains (3) summary
      PHA03307
      Location:32 → 397
      PHA03307; transcriptional regulator ICP4; Provisional
      TIGR04523
      Location:524 → 600
      Mplasa_alph_rch; helix-rich Mycoplasma protein
      pfam13401
      Location:981 → 1074
      AAA_22; AAA domain

    43. XM_030243114.2 → XP_030098974.1  neuron navigator 2 isoform X37

      Conserved Domains (3) summary
      PHA03307
      Location:2 → 296
      PHA03307; transcriptional regulator ICP4; Provisional
      TIGR02168
      Location:625 → 896
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type
      pfam13401
      Location:1085 → 1178
      AAA_22; AAA domain

    44. XM_036153588.1 → XP_036009481.1  neuron navigator 2 isoform X40

      Conserved Domains (3) summary
      PHA03307
      Location:2 → 310
      PHA03307; transcriptional regulator ICP4; Provisional
      TIGR04523
      Location:437 → 709
      Mplasa_alph_rch; helix-rich Mycoplasma protein
      pfam13401
      Location:897 → 990
      AAA_22; AAA domain

    RNA

    1. XR_004934220.1 RNA Sequence

    2. XR_004934221.1 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version

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