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    Sprn shadow of prion protein [ Mus musculus (house mouse) ]

    Gene ID: 212518, updated on 2-Nov-2024

    Summary

    Official Symbol
    Sprnprovided by MGI
    Official Full Name
    shadow of prion proteinprovided by MGI
    Primary source
    MGI:MGI:3582583
    See related
    Ensembl:ENSMUSG00000045733 AllianceGenome:MGI:3582583
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    C630041J07
    Summary
    Enables nucleic acid binding activity. Acts upstream of or within protein import into nucleus. Located in several cellular components, including cytosol; nucleolus; and vesicle. Is expressed in cerebellum; embryo; and olfactory epithelium. Orthologous to human SPRN (shadow of prion protein). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in cortex adult (RPKM 34.6), frontal lobe adult (RPKM 31.0) and 5 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See Sprn in Genome Data Viewer
    Location:
    7 F4; 7 85.17 cM
    Exon count:
    2
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (139730541..139734572, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (140150628..140154659, complement)

    Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene fucose mutarotase Neighboring gene enoyl Coenzyme A hydratase, short chain, 1, mitochondrial Neighboring gene polyamine oxidase (exo-N4-amino) Neighboring gene STARR-positive B cell enhancer ABC_E1747 Neighboring gene mitochondrial ribosome-associated GTPase 1 Neighboring gene olfactory receptor family 6 subfamily AE member 1 Neighboring gene olfactory receptor family 6 subfamily F member 2

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    General gene information

    Markers

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables nucleic acid binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables nucleic acid binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Process Evidence Code Pubs
    involved_in protein import into nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    acts_upstream_of_or_within protein import into nucleus IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    Component Evidence Code Pubs
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in nucleolus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in side of membrane IEA
    Inferred from Electronic Annotation
    more info
     
    located_in vesicle IDA
    Inferred from Direct Assay
    more info
    PubMed 

    General protein information

    Preferred Names
    shadow of prion protein
    Names
    Shadoo
    protein shadoo

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_183147.2NP_898970.1  shadow of prion protein precursor

      See identical proteins and their annotated locations for NP_898970.1

      Status: PROVISIONAL

      Source sequence(s)
      BC056484
      Consensus CDS
      CCDS21966.1
      UniProtKB/Swiss-Prot
      Q8BWU1
      Related
      ENSMUSP00000053901.8, ENSMUST00000059241.8
      Conserved Domains (1) summary
      pfam14999
      Location:19132
      Shadoo; Shadow of prion protein, neuroprotective

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000073.7 Reference GRCm39 C57BL/6J

      Range
      139730541..139734572 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)