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    Ube2d2a ubiquitin-conjugating enzyme E2D 2A [ Mus musculus (house mouse) ]

    Gene ID: 56550, updated on 2-Nov-2024

    Summary

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    Official Symbol
    Ube2d2aprovided by MGI
    Official Full Name
    ubiquitin-conjugating enzyme E2D 2Aprovided by MGI
    Primary source
    MGI:MGI:1930715
    See related
    Ensembl:ENSMUSG00000091896 AllianceGenome:MGI:1930715
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    ubc4; Ubc2e; Ube2d2; 1500034D03Rik
    Summary
    Predicted to enable ubiquitin conjugating enzyme activity. Predicted to be involved in protein K48-linked ubiquitination; protein autoubiquitination; and ubiquitin-dependent protein catabolic process. Predicted to be part of ubiquitin ligase complex. Predicted to be active in nucleus. Orthologous to human UBE2D2 (ubiquitin conjugating enzyme E2 D2). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Ubiquitous expression in CNS E14 (RPKM 16.9), CNS E11.5 (RPKM 16.3) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Ube2d2a in Genome Data Viewer
    Location:
    18 B2; 18 19.24 cM
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 18 NC_000084.7 (35904612..35940225)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 18 NC_000084.6 (35771559..35807172)

    Chromosome 18 - NC_000084.7Genomic Context describing neighboring genes Neighboring gene stimulator of interferon response cGAMP interactor 1 Neighboring gene STARR-positive B cell enhancer ABC_E9974 Neighboring gene STARR-seq mESC enhancer starr_44249 Neighboring gene STARR-seq mESC enhancer starr_44252 Neighboring gene 40S ribosomal protein S25 pseudogene Neighboring gene STARR-seq mESC enhancer starr_44255 Neighboring gene STARR-seq mESC enhancer starr_44256 Neighboring gene CapStarr-seq enhancer MGSCv37_chr18:35991804-35992030 Neighboring gene predicted gene 29417 Neighboring gene VISTA enhancer mm1664 Neighboring gene CXXC finger 5 Neighboring gene STARR-positive B cell enhancer mm9_chr18:36003985-36004286 Neighboring gene VISTA enhancer mm1614 Neighboring gene STARR-positive B cell enhancer ABC_E1206 Neighboring gene predicted gene, 41693

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Mice lacking the UBC4-testis gene have a delay in postnatal testis development but normal spermatogenesis and fertility. Bedard N, et al. Mol Cell Biol, 2005 Aug. PMID 16024774, Free PMC Article
    2. RING finger E3 ligase PPP1R11 regulates TLR2 signaling and innate immunity. McKelvey AC, et al. Elife, 2016 Nov 2. PMID 27805901, Free PMC Article
    3. Trim17-mediated ubiquitination and degradation of Mcl-1 initiate apoptosis in neurons. Magiera MM, et al. Cell Death Differ, 2013 Feb. PMID 22976837, Free PMC Article
    4. Physical and functional interactions between ZIP kinase and UbcH5. Ohbayashi N, et al. Biochem Biophys Res Commun, 2008 Aug 8. PMID 18515077
    5. Regulation of synaptic growth and maturation by a synapse-associated E3 ubiquitin ligase at the neuromuscular junction. Lu Z, et al. J Cell Biol, 2007 Jun 18. PMID 17576800, Free PMC Article

    See all (28) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (3) 
    • Gene trapped (1) 
    • Targeted (1)  1 citation

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables ubiquitin conjugating enzyme activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables ubiquitin conjugating enzyme activity ISO
    Inferred from Sequence Orthology
    more info
    		 PubMed 
    enables ubiquitin protein ligase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ubiquitin-protein transferase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables ubiquitin-protein transferase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Process Evidence Code Pubs
    involved_in protein K48-linked ubiquitination IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in protein K48-linked ubiquitination IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in protein K48-linked ubiquitination ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in protein autoubiquitination IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in protein autoubiquitination ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in protein polyubiquitination ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in protein ubiquitination ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in ubiquitin-dependent protein catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of protein-containing complex ISO
    Inferred from Sequence Orthology
    more info
    		 PubMed 
    part_of ubiquitin ligase complex ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    ubiquitin-conjugating enzyme E2 D2
    Names
    (E3-independent) E2 ubiquitin-conjugating enzyme D2
    E2 ubiquitin-conjugating enzyme D2
    E2(17)KB 2
    ubiquitin carrier protein D2
    ubiquitin conjugating enzyme 2e
    ubiquitin-conjugating enzyme E2(17)KB 2
    ubiquitin-conjugating enzyme E2-17 kDa 2
    ubiquitin-conjugating enzyme E2D 2
    ubiquitin-protein ligase D2
    NP_064296.1
    XP_006526183.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_019912.2 → NP_064296.1  ubiquitin-conjugating enzyme E2 D2

      See identical proteins and their annotated locations for NP_064296.1

      Status: VALIDATED

      Source sequence(s)
      AK147568, AK148089, BE688817, BY136374
      Consensus CDS
      CCDS50254.1
      UniProtKB/Swiss-Prot
      P62838
      UniProtKB/TrEMBL
      Q3U5V6, Q3UT95, Q9D1S1
      Related
      ENSMUSP00000132446.2, ENSMUST00000170693.9
      Conserved Domains (1) summary
      cl00154
      Location:1 → 146
      UBCc; Ubiquitin-conjugating enzyme E2, catalytic (UBCc) domain. This is part of the ubiquitin-mediated protein degradation pathway in which a thiol-ester linkage forms between a conserved cysteine and the C-terminus of ubiquitin and complexes with ubiquitin ...

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000084.7 Reference GRCm39 C57BL/6J

      Range
      35904612..35940225
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006526120.4 → XP_006526183.1  ubiquitin-conjugating enzyme E2 D2 isoform X1

      See identical proteins and their annotated locations for XP_006526183.1

      UniProtKB/TrEMBL
      Q9D1S1
      Conserved Domains (1) summary
      cl00154
      Location:1 → 117
      UBCc; Ubiquitin-conjugating enzyme E2, catalytic (UBCc) domain. This is part of the ubiquitin-mediated protein degradation pathway in which a thiol-ester linkage forms between a conserved cysteine and the C-terminus of ubiquitin and complexes with ubiquitin ...
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P62838.1 GenPept UniProtKB/Swiss-Prot:P62838

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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