U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Links from GEO Profiles

    • Showing Current items.

    Fut2 fucosyltransferase 2 [ Mus musculus (house mouse) ]

    Gene ID: 14344, updated on 2-Nov-2024

    Summary

    Go to the top of the page Help
    Official Symbol
    Fut2provided by MGI
    Official Full Name
    fucosyltransferase 2provided by MGI
    Primary source
    MGI:MGI:109374
    See related
    Ensembl:ENSMUSG00000055978 AllianceGenome:MGI:109374
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    MFUT-II
    Summary
    This gene is one of three genes in mouse which encode a galactoside 2-L-fucosyltransferase. These genes differ in their developmental- and tissue-specific expression. The encoded type II membrane protein is anchored in the Golgi apparatus and controls the final step in the creation of alpha (1,2) fucosylated carbhohydrates by the addition of a terminal fucose in an alpha (1,2) linkage. This enzyme is involved in the synthesis of the Lewis antigen as well as the H-antigen, a precursor of the A and B antigens of the ABH histo-blood group. The biological function of the fucosylated carbhohydrate products is thought to involve cell-adhesion and interactions with microorganisms. Disruption of this gene results in altered glycosylation of gastric mucosa and uterine epithelia. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2012]
    Expression
    Biased expression in colon adult (RPKM 53.5), stomach adult (RPKM 21.9) and 4 other tissues See more
    Orthologs
    human all
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    Go to the top of the page Help
    See Fut2 in Genome Data Viewer
    Location:
    7 B3; 7 29.41 cM
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (45298015..45315818, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (45648591..45666394, complement)

    Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene Ras interacting protein 1 Neighboring gene RIKEN cDNA A030001D20 gene Neighboring gene STARR-positive B cell enhancer mm9_chr7:52899034-52899335 Neighboring gene MEF2 activating motif and SAP domain containing transcriptional regulator Neighboring gene predicted gene, 39008 Neighboring gene secretory blood group 1 Neighboring gene netrin 5 Neighboring gene carbonic anhydrase 11

    Genomic regions, transcripts, and products

    Go to the top of the page Help

    Go to nucleotide: Graphics FASTA GenBank

    Expression

    Go to the top of the page Help
    • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    Go to the top of the pageHelp

    Related articles in PubMed

    1. Fut2 deficiency aggravates chronic colitis through 2-oxindole-AHR mediated cGAS-STING pathway. Hong G, et al. Int Immunopharmacol, 2024 Aug 20. PMID 38897123
    2. [Cloning and expression of murine alpha1,2-fucosyltransferase gene]. Lin B, et al. Shi Yan Sheng Wu Xue Bao, 2005 Dec. PMID 16416971
    3. Fut2-null mice display an altered glycosylation profile and impaired BabA-mediated Helicobacter pylori adhesion to gastric mucosa. Magalhães A, et al. Glycobiology, 2009 Dec. PMID 19706747, Free PMC Article
    4. LacZ expression in Fut2-LacZ reporter mice reveals estrogen-regulated endocervical glandular expression during estrous cycle, hormone replacement, and pregnancy. Domino SE, et al. Glycobiology, 2004 Feb. PMID 14576173, Free PMC Article
    5. Genetically dictated change in host mucus carbohydrate landscape exerts a diet-dependent effect on the gut microbiota. Kashyap PC, et al. Proc Natl Acad Sci U S A, 2013 Oct 15. PMID 24062455, Free PMC Article

    See all (55) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Fut2 deficiency aggravates chronic colitis through 2-oxindole-AHR mediated cGAS-STING pathway.
      Title: Fut2 deficiency aggravates chronic colitis through 2-oxindole-AHR mediated cGAS-STING pathway.
    2. FUT2 inhibits the EMT and metastasis of colorectal cancer by increasing LRP1 fucosylation.
      Title: FUT2 inhibits the EMT and metastasis of colorectal cancer by increasing LRP1 fucosylation.
    3. FUT2-dependent fucosylation of HYOU1 protects intestinal stem cells against inflammatory injury by regulating unfolded protein response.
      Title: FUT2-dependent fucosylation of HYOU1 protects intestinal stem cells against inflammatory injury by regulating unfolded protein response.
    4. Intestinal epithelium-specific Fut2 deficiency promotes colorectal cancer through down-regulating fucosylation of MCAM.
      Title: Intestinal epithelium-specific Fut2 deficiency promotes colorectal cancer through down-regulating fucosylation of MCAM.
    5. Intestinal commensal microbiota and cytokines regulate Fut2(+) Paneth cells for gut defense.
      Title: Intestinal commensal microbiota and cytokines regulate Fut2(+) Paneth cells for gut defense.
    6. Deficiency of Intestinal alpha1-2-Fucosylation Exacerbates Ethanol-Induced Liver Disease in Mice.
      Title: Deficiency of Intestinal α1-2-Fucosylation Exacerbates Ethanol-Induced Liver Disease in Mice.
    7. Mice lacking fucosyltransferase 2 show reduced innate allergic inflammation in the airways.
      Title: Mice lacking fucosyltransferase 2 show reduced innate allergic inflammation in the airways.
    8. Our data suggest that Fut2 plays a key role in immune responses in the lung and could be a novel therapeutic target of asthma.
      Title: Fucosyltransferase 2 induces lung epithelial fucosylation and exacerbates house dust mite-induced airway inflammation.
    9. Results indicate that the fucosyltransferase 2 (FUT2) determines the O-glycosylation pattern of mucin-5AC (Muc5ac).
      Title: Muc5ac gastric mucin glycosylation is shaped by FUT2 activity and functionally impacts Helicobacter pylori binding.
    10. Fut2 gene expression is responsible for disease progression in mice with primary sclerosing cholangitis.
      Title: Knockout of the primary sclerosing cholangitis-risk gene Fut2 causes liver disease in mice.
    Submit: New GeneRIF Correction See all GeneRIFs (18)

    Variation

    Go to the top of the page Help

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (4) 
    • Targeted (1)  1 citation

    Pathways from PubChem

    Go to the top of the page

    General gene information

    Go to the top of the page Help

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables alpha-(1,2)-fucosyltransferase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables alpha-(1,2)-fucosyltransferase activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables alpha-(1,2)-fucosyltransferase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables fucosyltransferase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables galactoside 2-alpha-L-fucosyltransferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables galactoside 2-alpha-L-fucosyltransferase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables galactoside 2-alpha-L-fucosyltransferase activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables galactoside 2-alpha-L-fucosyltransferase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in fucosylation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in fucosylation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in fucosylation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in fucosylation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in glycolipid metabolic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in oligosaccharide biosynthetic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in protein glycosylation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within protein glycosylation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in protein glycosylation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of cell adhesion ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in regulation of endothelial cell proliferation ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Component Evidence Code Pubs
    is_active_in Golgi apparatus ISO
    Inferred from Sequence Orthology
    more info
    		 PubMed 
    located_in Golgi cisterna membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

    Go to the top of the page Help
    Preferred Names
    galactoside alpha-(1,2)-fucosyltransferase 2
    Names
    GDP-L-fucose:beta-D-galactoside 2-alpha-L-fucosyltransferase 2
    GDP-fucose: beta-galactoside alpha1,2-fucosyltransferase
    alpha(1,2)FT 2
    galactoside 2-alpha-L-fucosyltransferase 2
    secretory blood group protein 2
    type 1 galactoside alpha-(1,2)-fucosyltransferase FUT2
    type 2 galactoside alpha-(1,2)-fucosyltransferase FUT2
    NP_001258922.1
    NP_061364.2
    XP_011249097.1

    NCBI Reference Sequences (RefSeq)

    Go to the top of the page Help

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001271993.1 → NP_001258922.1  galactoside alpha-(1,2)-fucosyltransferase 2

      See identical proteins and their annotated locations for NP_001258922.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) represents the longer transcript. Both variants 1 and 2 encode the same protein.
      Source sequence(s)
      AK033520, AK033586, BC145831, BQ032725, BY142283
      Consensus CDS
      CCDS21258.1
      UniProtKB/Swiss-Prot
      O70504, Q9JL27
      UniProtKB/TrEMBL
      A6H6C9, Q91VF0
      Conserved Domains (1) summary
      pfam01531
      Location:59 → 337
      Glyco_transf_11; Glycosyl transferase family 11

    2. NM_018876.4 → NP_061364.2  galactoside alpha-(1,2)-fucosyltransferase 2

      See identical proteins and their annotated locations for NP_061364.2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Both variants 1 and 2 encode the same protein.
      Source sequence(s)
      AK033520, AK033586, BC145831, BQ032725
      Consensus CDS
      CCDS21258.1
      UniProtKB/Swiss-Prot
      O70504, Q9JL27
      UniProtKB/TrEMBL
      A6H6C9, Q91VF0
      Related
      ENSMUSP00000063719.5, ENSMUST00000069800.6
      Conserved Domains (1) summary
      pfam01531
      Location:59 → 337
      Glyco_transf_11; Glycosyl transferase family 11

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000073.7 Reference GRCm39 C57BL/6J

      Range
      45298015..45315818 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011250795.3 → XP_011249097.1  galactoside alpha-(1,2)-fucosyltransferase 2 isoform X1

      See identical proteins and their annotated locations for XP_011249097.1

      UniProtKB/Swiss-Prot
      O70504, Q9JL27
      UniProtKB/TrEMBL
      A6H6C9, Q91VF0
      Conserved Domains (1) summary
      pfam01531
      Location:59 → 337
      Glyco_transf_11; Glycosyl transferase family 11
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9JL27.1 GenPept UniProtKB/Swiss-Prot:Q9JL27

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Chemical Information
    Molecular Biology Databases
    Research Materials
    Tools
    Miscellaneous