TSPAN15 tetraspanin 15 [Homo sapiens (human)] - Gene

Summary

Official Symbol: TSPAN15provided by HGNC
Official Full Name: tetraspanin 15provided by HGNC
Primary source: HGNC:HGNC:23298
See related: Ensembl:ENSG00000099282 MIM:613140; AllianceGenome:HGNC:23298
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: NET7; NET-7; TM4SF15; 2700063A19Rik
Summary: The protein encoded by this gene is a member of the transmembrane 4 superfamily, also known as the tetraspanin family. Most of these members are cell-surface proteins that are characterized by the presence of four hydrophobic domains. The proteins mediate signal transduction events that play a role in the regulation of cell development, activation, growth and motility. The use of alternate polyadenylation sites has been found for this gene. [provided by RefSeq, Jul 2008]
Expression: Broad expression in fat (RPKM 7.7), stomach (RPKM 7.1) and 21 other tissues See more
Orthologs: mouse all
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Genomic context

Location:: 10q22.1

Exon count:: 14

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCh38.p14 (GCF_000001405.40)	10	NC_000010.11 (69451465..69549508)
RS_2024_08	current	T2T-CHM13v2.0 (GCF_009914755.1)	10	NC_060934.1 (70319512..70417621)
RS_2024_09	previous assembly	GRCh37.p13 (GCF_000001405.25)	10	NC_000010.10 (71211221..71267422)

Chromosome 10 - NC_000010.11 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
BioProject: PRJEB4337
Publication: PMID 24309898
Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Crystal structure of the Tspan15 LEL domain reveals a conserved ADAM10 binding site.
Title: Crystal structure of the Tspan15 LEL domain reveals a conserved ADAM10 binding site.
The tetraspanin Tspan15 is an essential subunit of an ADAM10 scissor complex.
Title: The tetraspanin Tspan15 is an essential subunit of an ADAM10 scissor complex.
Tspan15 is a new stemness-related marker in hepatocellular carcinoma which exhibits high potential of tumor growth and recurrence.
Title: Tspan15 Is a New Stemness-Related Marker in Hepatocellular Carcinoma.
Overexpression of Tspan15 positively regulates development of OSCC.
Title: Tspan15 plays a crucial role in metastasis in oral squamous cell carcinoma.
TSPAN15 interacts with BTRC to promote oesophageal squamous cell carcinoma metastasis via activating NF-kappaB signaling.
Title: TSPAN15 interacts with BTRC to promote oesophageal squamous cell carcinoma metastasis via activating NF-κB signaling.
Meta-analysis of 65,734 individuals identifies TSPAN15 and SLC44A2 as two susceptibility loci for venous thromboembolism.
Title: Meta-analysis of 65,734 individuals identifies TSPAN15 and SLC44A2 as two susceptibility loci for venous thromboembolism.
Observational study of gene-disease association. (HuGE Navigator)
Title: A scan of chromosome 10 identifies a novel locus showing strong association with late-onset Alzheimer disease.

Submit: New GeneRIF Correction

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

EBI GWAS Catalog

Description
Genetic association with overall survival of taxane-treated lung cancer patients - A genome-wide association study in human lymphoblastoid cell lines followed by a clinical association study. EBI GWAS Catalog EBI GWAS CatalogPubMed

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

RH92663 (e-PCR)
- UniSTS:88328

SHGC-143786 (e-PCR)
- UniSTS:172045

Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
enables enzyme binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in negative regulation of Notch signaling pathway	IDA Inferred from Direct Assay more info	PubMed
involved_in protein localization to plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
involved_in protein localization to plasma membrane	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in protein maturation	IBA Inferred from Biological aspect of Ancestor more info
involved_in protein maturation	IDA Inferred from Direct Assay more info	PubMed
involved_in protein maturation	IMP Inferred from Mutant Phenotype more info	PubMed
NOT involved_in regulation of Notch signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of membrane protein ectodomain proteolysis	IDA Inferred from Direct Assay more info	PubMed

Component	Evidence Code	Pubs
located_in cell junction	IDA Inferred from Direct Assay more info
located_in cell surface	IEA Inferred from Electronic Annotation more info
located_in cytosol	IDA Inferred from Direct Assay more info
located_in endoplasmic reticulum lumen	TAS Traceable Author Statement more info
located_in intracellular membrane-bounded organelle	IDA Inferred from Direct Assay more info
located_in late endosome membrane	IEA Inferred from Electronic Annotation more info
located_in nuclear body	IDA Inferred from Direct Assay more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	IDA Inferred from Direct Assay more info	PubMed
located_in plasma membrane	TAS Traceable Author Statement more info
located_in tetraspanin-enriched microdomain	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: tetraspanin-15

Names: tetraspan NET-7; transmembrane 4 superfamily member 15; transmembrane 4 superfamily member tetraspan NET-7; tspan-15

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001351263.2 → NP_001338192.1 tetraspanin-15 isoform 2

Status: REVIEWED

Source sequence(s)

AC016821, AI612860, BM972680, CA454790, DR158973

Conserved Domains (1) summary

cd03158
Location:33 → 144

penumbra_like_LEL; Tetraspanin, extracellular domain or large extracellular loop (LEL), penumbra_like family. Tetraspanins are trans-membrane proteins with 4 trans-membrane segments. Both the N- and C-termini lie on the intracellular side of the membrane. This alignment ...
NM_012339.5 → NP_036471.1 tetraspanin-15 isoform 1

See identical proteins and their annotated locations for NP_036471.1

Status: REVIEWED

Source sequence(s)

AC016821, AI612860, BC003157, BM972680, CA454790, DR158973

Consensus CDS

CCDS7294.1

UniProtKB/Swiss-Prot

O95858, Q6UW79

Related

ENSP00000362387.2, ENST00000373290.7

Conserved Domains (1) summary

cd03158
Location:114 → 231

penumbra_like_LEL; Tetraspanin, extracellular domain or large extracellular loop (LEL), penumbra_like family. Tetraspanins are trans-membrane proteins with 4 trans-membrane segments. Both the N- and C-termini lie on the intracellular side of the membrane. This alignment ...

RNA

NR_147091.2 RNA Sequence

Status: REVIEWED

Source sequence(s)

AC016821, AI612860, BM972680, BP374322, CA454790, DR158973

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

NC_000010.11 Reference GRCh38.p14 Primary Assembly

Range

69451465..69549508

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_017016010.2 → XP_016871499.1 tetraspanin-15 isoform X1
XM_047424930.1 → XP_047280886.1 tetraspanin-15 isoform X3
XM_005269666.5 → XP_005269723.1 tetraspanin-15 isoform X2

Conserved Domains (2) summary

cd03158
Location:55 → 166

penumbra_like_LEL; Tetraspanin, extracellular domain or large extracellular loop (LEL), penumbra_like family. Tetraspanins are trans-membrane proteins with 4 trans-membrane segments. Both the N- and C-termini lie on the intracellular side of the membrane. This alignment ...

pfam00335
Location:57 → 191

Tetraspannin; Tetraspanin family
XM_011539563.3 → XP_011537865.1 tetraspanin-15 isoform X5

Conserved Domains (2) summary

cd03158
Location:1 → 87

penumbra_like_LEL; Tetraspanin, extracellular domain or large extracellular loop (LEL), penumbra_like family. Tetraspanins are trans-membrane proteins with 4 trans-membrane segments. Both the N- and C-termini lie on the intracellular side of the membrane. This alignment ...

pfam00335
Location:1 → 112

Tetraspannin; Tetraspanin family
XM_011539562.3 → XP_011537864.1 tetraspanin-15 isoform X4

Conserved Domains (2) summary

cd03158
Location:4 → 115

penumbra_like_LEL; Tetraspanin, extracellular domain or large extracellular loop (LEL), penumbra_like family. Tetraspanins are trans-membrane proteins with 4 trans-membrane segments. Both the N- and C-termini lie on the intracellular side of the membrane. This alignment ...

pfam00335
Location:3 → 140

Tetraspannin; Tetraspanin family